The Journal of Experimental Medicine
Rockland Immunochemicals for Research
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Published 16 August 2004. doi:10.1084/jem.20040131
Rockefeller University Press, 0022-1007 $8.00
JEM, Volume 200, Number 4, 447-458
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CD24 Controls Expansion and Persistence of Autoreactive T Cells in the Central Nervous System during Experimental Autoimmune Encephalomyelitis

Xue-Feng Bai1, Ou Li1, Qunmin Zhou2, Huiming Zhang1, Pramod S. Joshi1, Xincheng Zheng1, Yan Liu1, Yin Wang1, Pan Zheng1, and Yang Liu1

1 Division of Cancer Immunology, Department of Pathology and Comprehensive Cancer Center, Ohio State University Medical Center, Columbus, OH 43210
2 OncoImmune Ltd., Columbus, OH 43212

Address correspondence to Yang Liu, Division of Cancer Immunology, Dept. of Pathology, Ohio State University Medical Center, 129 Hamilton Hall, 1645 Neil Ave., Columbus, OH 43210. Phone: (614) 292-3054; Fax: (614) 688-8152; email: liu-3{at}medctr.osu.edu

In the development of experimental autoimmune encephalomyelitis (EAE), a model for multiple sclerosis (MS), autoreactive T cells must be activated and clonally expand in the lymphoid organs, and then migrate into the central nervous system (CNS) where they undergo further activation. It is unclear whether the autoreactive T cells further expand in the CNS and if so, what interactions are required for this process. We have demonstrated previously that expression by the host cells of the heat-stable antigen (CD24), which was recently identified as a genetic modifier for MS, is essential for their susceptibility to EAE. Here we show that CD24 is essential for local clonal expansion and persistence of T cells after their migration into the CNS, and that expression of CD24 on either hematopoietic cells or nonhematopoietic antigen-presenting cells in the recipient is sufficient to confer susceptibility to EAE.

Key Words: costimulatory molecules • autoimmune diseases • central nervous system • multiple sclerosis • clonal expansion

X.F. Bai and O. Li contributed equally to this work.

Abbreviations used in this paper: BrdU, bromodeoxyuridine; CNS, central nervous system; EAE, experimental autoimmune encephalomyelitis; GFAP, glial fibrillary acidic protein; MOG, myelin oligodendrocyte glycoprotein; MS, multiple sclerosis; RPA, RNase protection assay; VCAM, vascular cell adhesion molecule; VLA, very late antigen.


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