The Journal of Experimental Medicine
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Published 16 August 2004. doi:10.1084/jem.20041110
Rockefeller University Press, 0022-1007 $8.00
JEM, Volume 200, Number 4, 405-409
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Commentary

 The Ins and Outs of CCR7 in the Thymus

Colleen M. Witt and Ellen A. Robey

Division of Immunology, Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720

Address correspondence to Colleen M. Witt, Dept. of Molecular and Cell Biology, 471 Life Sciences Addition, University of California, Berkeley, CA 94720. Tel.: (510) 643-6957; Fax: (510) 643-9500; email: cwitt{at}uclink.berkeley.edu


Abstract
Although it is widely supposed that chemokines play a role in the thymus, most existing evidence is circumstantial. In this issue, two groups provide direct evidence that the chemokine receptor CCR7 is required for normal thymocyte migration (Ueno, T., F. Saito, D. Gray, S. Kuse, K. Hieshima, H. Nakano, T. Kakiuchi, M. Lipp, R. Boyd, and Y. Takahama. 2004. J. Exp. Med. 200:493–505; Misslitz, A., O. Pabst, G. Hintzen, L. Ohl, E. Kremmer, H. T. Petrie, and R. Forster. 2004. J. Exp. Med. 200:481–491). The two papers focus on distinct and opposite migration events, an early outward migration and a later inward migration. Together these papers provide a fascinating picture of the complex role of CCR7 in orchestrating thymocyte migration.


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