Home | Help | Feedback | Subscriptions | Archive | Search | Table of Contents

This Article Full Text Full Text (PDF, 56K) Alert me when this article is cited Citation Map Services Email this article Similar articles in this journal Similar articles in PubMed Alert me to new content in the JEM Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Baecher-Allan, C. Articles by Hafler, D. A. Search for Related Content PubMed PubMed Citation Articles by Baecher-Allan, C. Articles by Hafler, D. A. Pubmed/NCBI databases Medline Plus Health Information Joint Disorders Rheumatoid Arthritis Social Bookmarking                      What's this?

Laboratory of Molecular Immunology, Center for Neurologic Diseases, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115

Address correspondence to Clare Baecher-Allan, 77 Ave. Louis Pasteur, Harvard Medical School, Boston, MA 02115. Tel: (617) 525-5330; Fax: (617) 525-5333; email: callan{at}rics.bwh.harvard.edu

Abstract
Although central and peripheral tolerance are important for the regulation of human immune responses to self- and microbial antigens, an important role of suppressor CD4⁺ CD25⁺ T cells is suggested from the recent investigations of human autoimmune diseases and HIV. These new data provide increasing evidence that altered function of CD4⁺ CD25⁺ T cells may be an important factor in a wide range of human inflammatory and infectious diseases.

CiteULike

Complore

Connotea

Del.icio.us

Digg

Reddit

Technorati

This article has been cited by other articles:

• Ouabed, A., Hubert, F.-X., Chabannes, D., Gautreau, L., Heslan, M., Josien, R. (2008). Differential Control of T Regulatory Cell Proliferation and Suppressive Activity by Mature Plasmacytoid versus Conventional Spleen Dendritic Cells. J. Immunol. 180: 5862-5870 [Abstract] [Full Text]  
• Wang, J., Takeuchi, H., Sonobe, Y., Jin, S., Mizuno, T., Miyakawa, S., Fujiwara, M., Nakamura, Y., Kato, T., Muramatsu, H., Muramatsu, T., Suzumura, A. (2008). Inhibition of midkine alleviates experimental autoimmune encephalomyelitis through the expansion of regulatory T cell population. Proc. Natl. Acad. Sci. USA 105: 3915-3920 [Abstract] [Full Text]  
• Oukka, M. (2007). Interplay between pathogenic Th17 and regulatory T cells. Ann Rheum Dis 66: iii87-iii90 [Abstract] [Full Text]  
• de Boer, O. J., van der Loos, C. M., Teeling, P., van der Wal, A. C., Teunissen, M. B.M. (2007). Immunohistochemical Analysis of Regulatory T Cell Markers FOXP3 and GITR on CD4+CD25+ T Cells in Normal Skin and Inflammatory Dermatoses. J. Histochem. Cytochem. 55: 891-898 [Abstract] [Full Text]  
• Feger, U., Tolosa, E., Huang, Y.-H., Waschbisch, A., Biedermann, T., Melms, A., Wiendl, H. (2007). HLA-G expression defines a novel regulatory T-cell subset present in human peripheral blood and sites of inflammation. Blood 110: 568-577 [Abstract] [Full Text]  
• Hillebrands, J.-L., Whalen, B., Visser, J. T. J., Koning, J., Bishop, K. D., Leif, J., Rozing, J., Mordes, J. P., Greiner, D. L., Rossini, A. A. (2006). A Regulatory CD4+ T Cell Subset in the BB Rat Model of Autoimmune Diabetes Expresses Neither CD25 Nor Foxp3. J. Immunol. 177: 7820-7832 [Abstract] [Full Text]  
• Epple, H.-J., Loddenkemper, C., Kunkel, D., Troger, H., Maul, J., Moos, V., Berg, E., Ullrich, R., Schulzke, J.-D., Stein, H., Duchmann, R., Zeitz, M., Schneider, T. (2006). Mucosal but not peripheral FOXP3+ regulatory T cells are highly increased in untreated HIV infection and normalize after suppressive HAART. Blood 108: 3072-3078 [Abstract] [Full Text]  
• Rinaldi, L., Gallo, P., Calabrese, M., Ranzato, F., Luise, D., Colavito, D., Motta, M., Guglielmo, A., Del Giudice, E., Romualdi, C., Ragazzi, E., D'Arrigo, A., Dalle Carbonare, M., Leontino, B., Leon, A. (2006). Longitudinal analysis of immune cell phenotypes in early stage multiple sclerosis: distinctive patterns characterize MRI-active patients.. Brain 129: 1993-2007 [Abstract] [Full Text]  
• Wang, R.-F. (2006). Regulatory T cells and toll-like receptors in cancer therapy.. Cancer Res. 66: 4987-4990 [Abstract] [Full Text]  
• Baecher-Allan, C., Wolf, E., Hafler, D. A. (2006). MHC class II expression identifies functionally distinct human regulatory T cells.. J. Immunol. 176: 4622-4631 [Abstract] [Full Text]  
• Miyara, M., Amoura, Z., Parizot, C., Badoual, C., Dorgham, K., Trad, S., Kambouchner, M., Valeyre, D., Chapelon-Abric, C., Debre, P., Piette, J.-C., Gorochov, G. (2006). The immune paradox of sarcoidosis and regulatory T cells. JEM 203: 359-370 [Abstract] [Full Text]  
• de Kleer, I., Vastert, B., Klein, M., Teklenburg, G., Arkesteijn, G., Yung, G. P., Albani, S., Kuis, W., Wulffraat, N., Prakken, B. (2006). Autologous stem cell transplantation for autoimmunity induces immunologic self-tolerance by reprogramming autoreactive T cells and restoring the CD4+CD25+ immune regulatory network. Blood 107: 1696-1702 [Abstract] [Full Text]  
• Prabhala, R. H., Neri, P., Bae, J. E., Tassone, P., Shammas, M. A., Allam, C. K., Daley, J. F., Chauhan, D., Blanchard, E., Thatte, H. S., Anderson, K. C., Munshi, N. C. (2006). Dysfunctional T regulatory cells in multiple myeloma. Blood 107: 301-304 [Abstract] [Full Text]  
• De, A. K., Miller-Graziano, C. L., Calvano, S. E., Laudanski, K., Lowry, S. F., Moldawer, L. L., Remick, D. G. Jr, Rajicic, N., Schoenfeld, D., Tompkins, R. G. (2005). Selective Activation of Peripheral Blood T Cell Subsets by Endotoxin Infusion in Healthy Human Subjects Corresponds to Differential Chemokine Activation. J. Immunol. 175: 6155-6162 [Abstract] [Full Text]  
• Birdsall, H. H., Porter, W. J., Trial, J., Rossen, R. D. (2005). Monocytes Stimulated by 110-kDa Fibronectin Fragments Suppress Proliferation of Anti-CD3-Activated T Cells. J. Immunol. 175: 3347-3353 [Abstract] [Full Text]  
• Wan, Y. Y., Flavell, R. A. (2005). Identifying Foxp3-expressing suppressor T cells with a bicistronic reporter. Proc. Natl. Acad. Sci. USA 102: 5126-5131 [Abstract] [Full Text]  

Home | Help | Feedback | Subscriptions | Archive | Search

TABLE OF CONTENTS