The Journal of Experimental Medicine
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Published 20 December 2004. doi:10.1084/jem.20042004
Rockefeller University Press, 0022-1007 $8.00
JEM, Volume 200, Number 12, 1533-1537
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Commentary

 Finding a Place for Tumor-specific T Cells in Targeted Cancer Therapy

Stanley R. Riddell

Clinical Research Division, Fred Hutchinson Cancer Research Center, Department of Medicine, University of Washington, Seattle, WA 98109

Address correspondence to Stanley R. Riddell, Program in Immunology, D3-110, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave. N., Seattle, WA 98109. Phone: (206) 667-5249; Fax: (206) 667-7983; email: sriddell{at}fhcrc.org


Abstract
A goal in cancer therapeutics is to develop targeted modalities that distinguish malignant from normal cells. T cells can discriminate diseased cells based on subtle alterations in peptides displayed in association with MHC molecules at the cell surface. Recent success using the adoptive transfer of tumor-specific T cells has fueled optimism that this approach may find a place as a targeted therapy for some human cancers.


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