The Journal of Experimental Medicine
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Published 3 May 2004. doi:10.1084/jem.20031835
Rockefeller University Press, 0022-1007 $8.00
JEM, Volume 199, Number 9, 1255-1264
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The Cell Surface Receptor SLAM Controls T Cell and Macrophage Functions

Ninghai Wang1, Abhay Satoskar4, William Faubion1, Duncan Howie1, Susumu Okamoto1, Stefan Feske3, Charles Gullo1, Kareem Clarke1, Miriam Rodriguez Sosa4, Arlene H. Sharpe2, and Cox Terhorst1

1 Division of Immunology, Beth Israel Deaconess Medical Center, 2 Department of Pathology, Brigham and Women's Hospital, and 3 Center for Blood Research, Harvard Medical School, Boston, MA 02215
4 Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, MA 02115

Address correspondence to Cox Terhorst, Division of Immunology, RE-204, Beth Israel Deaconess Medical Center, Harvard Medical School, 41 Avenue Louis Pasteur, Boston, MA 02215. Phone: (617) 667-7147; Fax: (617) 667-7140; email: terhorst{at}bidmc.harvard.edu

Signaling lymphocyte activation molecule (SLAM), a glycoprotein expressed on activated lymphocytes and antigen-presenting cells, has been shown to be a coregulator of antigen-driven T cell responses and is one of the two receptors for measles virus. Here we show that T cell receptor–induced interleukin (IL)-4 secretion by SLAM–/– CD4+ cells is down-regulated, whereas interferon {gamma} production by CD4+ T cells is only slightly up-regulated. Although SLAM controls production of IL-12, tumor necrosis factor, and nitric oxide in response to lipopolysaccharide (LPS) by macrophages, SLAM does not regulate phagocytosis and responses to peptidoglycan or CpG. Thus, SLAM acts as a coreceptor that regulates signals transduced by the major LPS receptor Toll-like receptor 4 on the surface of mouse macrophages. A defective macrophage function resulted in an inability of SLAM–/– C57Bl/6 mice to remove the parasite Leishmania major. We conclude that the coreceptor SLAM plays a central role at the interface of acquired and innate immune responses.

Key Words: SLAM • macrophage • T cell • L. major

The online version of this article contains supplemental material.

A. Satoskar's present address is Department of Microbiology, Ohio State University, 484 West 12th Ave., Columbus, OH 43210.

Abbreviations used in this paper: ES, embryonic stem; NO, nitric oxide; SAP, signaling lymphocyte activation molecule–associated protein; SLAM, signaling lymphocyte activation molecule; TLR, Toll-like receptor.


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