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Laboratory of Molecular Oncology, Clinical Research Institute of Montreal, Montréal, Québec, Canada H2W 1R7
Department of Microbiology and Immunology and Department of Medicine, McGill University, Montréal, Québec, Canada H3G 1Y6
Department of Medicine, University of Montréal, Montréal, Québec, Canada H3C 3J7

Address correspondence to André Veillette, IRCM, 110 Pine Ave. West, Montreal, Quebec, Canada H2W 1R7. Phone: (514) 987-5561; Fax: (514) 987-5562; email: veillea{at}ircm.qc.ca

Abstract
Two papers describing mice deficient in signaling lymphocyte activation molecule and 2B4 represent the first accounts of immune phenotypes in animals lacking members of the SLAM family of receptors. The findings provide definitive evidence of the importance of SLAM-related receptors in the regulation of T cell, macrophage, and natural killer cell functions.

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