The Journal of Experimental Medicine
Torrey Pines Biolabs
  Home | Help | Feedback | Subscriptions | Archive | Search | Table of Contents
Published online 23 February 2004 doi:10.1084/jem.20032197
Rockefeller University Press, 0022-1007 $8.00
JEM, Volume 199, Number 5, 717-723
This Article
Right arrow Full Text
Right arrow Full Text (PDF, 161K)
Right arrow PPT slides of all figures
Right arrow Supplemental Material Index
Right arrow Alert me when this article is cited
Right arrow Citation Map
Services
Right arrow Email this article
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new content in the JEM
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via CrossRef
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Clatworthy, M. R.
Right arrow Articles by Smith, K. G.C.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Clatworthy, M. R.
Right arrow Articles by Smith, K. G.C.
Right arrowPubmed/NCBI databases
*Gene*GEO Profiles
*HomoloGene*UniGene
*Compound via MeSH
*Substance via MeSH
Medline Plus Health Information
*Sepsis
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati  
What's this?

Brief Definitive Report

 Fc{gamma}RIIb Balances Efficient Pathogen Clearance and the Cytokine-mediated Consequences of Sepsis

Menna R. Clatworthy and Kenneth G.C. Smith

The Cambridge Institute for Medical Research and the Department of Medicine, University of Cambridge School of Clinical Medicine, Addenbrooke's Hospital, Cambridge CB2 2XY, United Kingdom

Address correspondence to Kenneth G.C. Smith, University of Cambridge School of Clinical Medicine, Lab 5.15, Box 139, Addenbrooke's Hospital, Hills Road, Cambridge CB2 2XY, UK. Phone: 44-1223-762645; Fax: 44-1223-762640; email: kgcs2{at}cam.ac.uk

The immune response to infection must be controlled to ensure it is optimal for defense while avoiding the consequences of excessive inflammation, which include fatal septic shock. Mice deficient in Fc{gamma}RIIb, an inhibitory immunoglobulin G Fc receptor, have enhanced immune responses. Therefore, we examined whether Fc{gamma}RIIb controls the response to Streptococcus pneumoniae. Macrophages from Fc{gamma}RIIb-deficient mice showed increased antibody-dependent phagocytosis of pneumococci in vitro, and consistent with this infected Fc{gamma}RIIb-deficient mice demonstrated increased bacterial clearance and survival. In contrast, previously immunized Fc{gamma}RIIb-deficient mice challenged with large inocula showed reduced survival. This correlated with increased production of the sepsis-associated cytokines tumor necrosis factor {alpha} and interleukin 6. We propose that Fc{gamma}RIIb controls the balance between efficient pathogen clearance and the cytokine-mediated consequences of sepsis, with potential therapeutic implications.

Key Words: Fc{gamma}RIIb • Streptococcus pneumoniae • septic shock • tumor necrosis factor • interleukin 6

The online version of this article contains supplemental material.


Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati    What's this?


This article has been cited by other articles:



  Home | Help | Feedback | Subscriptions | Archive | Search
TABLE OF CONTENTS