The Journal of Experimental Medicine
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Published online 1 June 2004 doi:10.1084/jem.20040719
Rockefeller University Press, 0022-1007 $8.00
JEM, Volume 199, Number 11, 1451-1454
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Commentary

 Targeting Plasma Cells in Autoimmune Diseases

David M. Tarlinton and Philip D. Hodgkin

The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria 3050, Australia

Address correspondence to David M. Tarlinton, Immunology Div., The Walter and Eliza Hall Institute, 1G Royal Parade, Parkville, Victoria 3050, Australia. Phone: 61-3-9345-2615; Fax: 61-3-9347-0852; email: tarlinton{at}wehi.edu.au


Abstract
Antibodies specific for self-antigens mediate life-threatening pathology in several autoimmune diseases. Clearly the ability to target the plasma cells (PCs) producing the autoantibodies would be of great clinical benefit. Current immunosuppressive therapies are based on the premise that autoreactive PCs are short-lived and replenished from ongoing immune responses. However, recent results question this assumption and suggest that optimizing the treatment of severe autoimmune conditions will require a significant investment in elucidating the details of PC biology.


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