The Journal of Experimental Medicine
Rockland Immunochemicals for Research
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Published 17 May 2004. doi:10.1084/jem.20040111
Rockefeller University Press, 0022-1007 $8.00
JEM, Volume 199, Number 10, 1391-1399
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A Population-based Study of Morbidity and Mortality in Mannose-binding Lectin Deficiency

Morten Dahl1, Anne Tybjærg-Hansen2,3, Peter Schnohr3, and Børge G. Nordestgaard1,3

1 Department of Clinical Biochemistry, Herlev University Hospital, DK-2730 Herlev, Denmark
2 Department of Clinical Biochemistry, Rigshospitalet, Copenhagen University Hospital, DK-2100 Copenhagen, Denmark
3 The Copenhagen City Heart Study, Bispebjerg University Hospital, DK-2400 Copenhagen NV, Denmark

Address correspondence to Børge G. Nordestgaard, Department of Clinical Biochemistry 54M1, Herlev Ringvej 75, Herlev University Hospital, DK-2730 Herlev, Denmark. Phone: 45-4488-3297; Fax: 45-4488-3311; email: brno{at}herlevhosp.kbhamt.dk

Reduced levels of wild-type mannose-binding lectin (MBL) may increase susceptibility for infection, other common diseases, and death. We investigated associations between MBL deficiency and risk of infection, other common diseases, and death during 24, 24, and 8 yr of follow-up, respectively. We genotyped 9,245 individuals from the adult Danish population for three MBL deficiency alleles, B, C, and D, as opposed to the normal noncarrier A allele. Hospitalization incidence per 10,000 person · yr was 644 in noncarriers compared with 631 in heterozygotes (log-rank: P = 0.39) and 658 in deficiency homozygotes (P = 0.53). Death incidence per 10,000 person · yr was 235 in noncarriers compared with 244 in heterozygotes (P = 0.44) and 274 in deficiency homozygotes (P = 0.12). After stratification by specific cause of hospitalization or death, only hospitalization from cardiovascular disorders was increased in deficiency homozygotes versus noncarriers (P = 0.02). When retested in two case control studies, this association could not be confirmed. Incidence of hospitalization or death from infections or other serious common disorders did not differ between deficiency homozygotes and noncarriers. In conclusion, in this large study in an ethnically homogenous Caucasian population, there was no evidence for significant differences in infectious disease or mortality in MBL-deficient individuals versus controls. Our results suggest that MBL deficiency is not a major risk factor for morbidity or death in the adult Caucasian population.

Key Words: complement • mannan • innate immunity • infection • genetics

Abbreviations used in this paper: CI, confidence interval; ICVD, ischemic cerebrovascular disease; IHD, ischemic heart disease; MBL, mannose-binding lectin.


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