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Jean-Laurent Casanova^1,2 and Laurent Abel²

¹ Pediatric Hematology-Immunology Unit, Necker Enfants-Malades Hospital, and ² Laboratory of Human Genetics of Infectious Diseases, University of Paris René Descartes-INSERM U550, Necker Medical School, Paris 75015, France

Address correspondence to Jean-Laurent Casanova, Laboratory of Human Genetics of Infectious Diseases, University of Paris René Descartes-INSERM U550, Necker Medical School, 156 rue de Vaugirard, Paris 75015, France. Phone: 33-1-40-64-56-87; Fax: 33-1-40-64-56-88; email: casanova{at}necker.fr

Abstract
Human mannose-binding lectin (MBL) recognizes a wide range of microorganisms and triggers the most ancient pathway of complement activation. However, 5% of individuals lack functional serum MBL and have not been found to be prone to severe infections in prospective studies. These data suggest that human MBL is largely redundant for protective immunity and may even have been subject to counter selection because of a deleterious impact.

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