The Journal of Experimental Medicine
VeriKine-HS Human IFN-Beta
  Home | Help | Feedback | Subscriptions | Archive | Search | Table of Contents
Published 20 October 2003. doi:10.1084/jem.20030530
This Article
Right arrow Full Text
Right arrow Full Text (PDF, 129K)
Right arrow PPT slides of all figures
Right arrow Alert me when this article is cited
Right arrow Citation Map
Services
Right arrow Email this article
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new content in the JEM
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via CrossRef
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Amedei, A.
Right arrow Articles by Del Prete, G.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Amedei, A.
Right arrow Articles by Del Prete, G.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Facebook   Add to Reddit   Add to Technorati   Add to Twitter  
What's this?
© Rockefeller University Press, 0022-1007/2003/10/1147 $5.00
The Journal of Experimental Medicine, Volume 198, Number 8, 1147-1156

Molecular Mimicry between Helicobacter pylori Antigens and H+,K+–Adenosine Triphosphatase in Human Gastric Autoimmunity

Amedeo Amedei1, Mathijs P. Bergman2, Ben J. Appelmelk2, Annalisa Azzurri1, Marisa Benagiano1, Carlo Tamburini1, Ruurd van der Zee3, John L. Telford4, Christina M.J.E. Vandenbroucke-Grauls2, Mario M. D'Elios1 and Gianfranco Del Prete1

1 Department of Internal Medicine, University of Florence, 50134 Florence, Italy
2 Department of Medical Microbiology, Vrije Universiteit, Medical School, 1081 BT Amsterdam, Netherlands
3 Department of Infectious Diseases and Immunology, Faculty of Veterinary Medicine, Utrecht University, 3508 TD Utrecht, Netherlands
4 Chiron Vaccines, 53100 Siena, Italy

Address correspondence to Mario M. D'Elios, Dept. of Internal Medicine, Viale Morgagni 85, 50134 Florence, Italy. Phone: 39055-4296445; Fax: 39055-4271494; email: delios{at}unifi.it; or Gianfranco Del Prete, Phone: 39055-4378103; Fax: 39055-4378103; email: gdelprete{at}unifi.it

Autoimmune gastritis and Helicobacter pylori–associated gastric atrophy develop through similar mechanisms involving the proton pump H+,K+–adenosine triphosphatase as autoantigen. Here, we report that H. pylori–infected patients with gastric autoimmunity harbor in vivo–activated gastric CD4+ T cells that recognize both H+,K+–adenosine triphosphatase and H. pylori antigens. We characterized the submolecular specificity of such gastric T cells and identified cross-reactive epitopes from nine H. pylori proteins. Cross-reactive H. pylori peptides induced T cell proliferation and expression of T helper type 1 functions. We suggest that in genetically susceptible individuals, H. pylori infection can activate cross-reactive gastric T cells leading to gastric autoimmunity via molecular mimicry.

Key Words: Helicobacter pylori • T cell epitopes • autoreactive T cells • mimicry • mucosal immunity


Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Facebook Facebook   Add to Reddit Reddit   Add to Technorati Technorati   Add to Twitter Twitter    What's this?


This article has been cited by other articles:



  Home | Help | Feedback | Subscriptions | Archive | Search
TABLE OF CONTENTS