Continuous Activation of Autoreactive CD4+ CD25+ Regulatory T Cells in the Steady State

doi:10.1084/jem.20030686

Published online 25 August 2003 doi:10.1084/jem.20030686

This Article

	Full Text
	Full Text (PDF, 218K)
	PPT slides of all figures
	Alert me when this article is cited
	Citation Map

Services

	Email this article
	Similar articles in this journal
	Similar articles in PubMed
	Alert me to new content in the JEM
	Download to citation manager

Citing Articles

	Citing Articles via HighWire
	Citing Articles via CrossRef
	Citing Articles via Google Scholar

Google Scholar

	Articles by Fisson, S.
	Articles by Salomon, B. L.
	Search for Related Content

PubMed

	PubMed Citation
	Articles by Fisson, S.
	Articles by Salomon, B. L.


Social Bookmarking

	What's this?

© Rockefeller University Press, 0022-1007/2003/9/737 $5.00
The Journal of Experimental Medicine, Volume 198, Number 5, 737-746

Continuous Activation of Autoreactive CD4⁺ CD25⁺ Regulatory T Cells in the Steady State

Sylvain Fisson¹, Guillaume Darrasse-Jèze¹, Elena Litvinova¹, Franck Septier¹, David Klatzmann¹, Roland Liblau² and Benoît L. Salomon¹

¹ CNRS/UPMC UMR 7087, Hôpital de la Pitié-Salpêtrière, 75013 Paris, France
² INSERM U563, Hôpital Purpan, 31059 Toulouse, France

Address correspondence to Benoît Salomon, CNRS UMR 7087, Batiment CERVI, Hôpital de la Pitié-Salpêtrière, 83 Boulevard de l'Hôpital, 75013 Paris, France. Phone: 33-1-42-17-74-66; Fax: 33-1-42-17-74-62; email: benoit.salomon{at}chups.jussieu.fr

Despite a growing interest in CD4⁺ CD25⁺ regulatory T cells(T_reg) that play a major role in self-tolerance and immunoregulation,fundamental parameters of the biology and homeostasis of thesecells are poorly known. Here, we show that this population iscomposed of two T_reg subsets that have distinct phenotypes andhomeostasis in normal unmanipulated mice. In the steady state,some T_reg remain quiescent and have a long lifespan, in theorder of months, whereas the other T_reg are dividing extensivelyand express multiple activation markers. After adoptive transfer,tissue-specific T_reg rapidly divide and expand preferentiallyin lymph nodes draining their target self-antigens. These resultsreveal the existence of a cycling T_reg subset composed of autoreactiveT_reg that are continuously activated by tissue self-antigens.

Key Words: CD4⁺ T lymphocytes • suppressor cells • homeostasis • immune tolerance • self-antigens

Add to CiteULike CiteULike Add to Complore Complore Add to Connotea Connotea Add to Del.icio.us Del.icio.us Add to Digg Digg Facebook Add to Reddit Reddit Add to Technorati Technorati Twitter What's this?

This article has been cited by other articles:

Guerin, L. R., Prins, J. R., Robertson, S. A. (2009). Regulatory T-cells and immune tolerance in pregnancy: a new target for infertility treatment?. Hum Reprod Update 15: 517-535 [Abstract] [Full Text]
Darrasse-Jeze, G., Deroubaix, S., Mouquet, H., Victora, G. D., Eisenreich, T., Yao, K.-h., Masilamani, R. F., Dustin, M. L., Rudensky, A., Liu, K., Nussenzweig, M. C. (2009). Feedback control of regulatory T cell homeostasis by dendritic cells in vivo. JEM 206: 1853-1862 [Abstract] [Full Text]
O'Gorman, W. E., Dooms, H., Thorne, S. H., Kuswanto, W. F., Simonds, E. F., Krutzik, P. O., Nolan, G. P., Abbas, A. K. (2009). The Initial Phase of an Immune Response Functions to Activate Regulatory T Cells. J. Immunol. 183: 332-339 [Abstract] [Full Text]
Swee, L. K., Bosco, N., Malissen, B., Ceredig, R., Rolink, A. (2009). Expansion of peripheral naturally occurring T regulatory cells by Fms-like tyrosine kinase 3 ligand treatment. Blood 113: 6277-6287 [Abstract] [Full Text]
van Olffen, R. W., Koning, N., van Gisbergen, K. P. J. M., Wensveen, F. M., Hoek, R. M., Boon, L., Hamann, J., van Lier, R. A. W., Nolte, M. A. (2009). GITR Triggering Induces Expansion of Both Effector and Regulatory CD4+ T Cells In Vivo. J. Immunol. 182: 7490-7500 [Abstract] [Full Text]
Hirschhorn-Cymerman, D., Rizzuto, G. A., Merghoub, T., Cohen, A. D., Avogadri, F., Lesokhin, A. M., Weinberg, A. D., Wolchok, J. D., Houghton, A. N. (2009). OX40 engagement and chemotherapy combination provides potent antitumor immunity with concomitant regulatory T cell apoptosis. JEM 206: 1103-1116 [Abstract] [Full Text]
Haringer, B., Lozza, L., Steckel, B., Geginat, J. (2009). Identification and characterization of IL-10/IFN-{gamma}-producing effector-like T cells with regulatory function in human blood. JEM 206: 1009-1017 [Abstract] [Full Text]
Taflin, C., Miyara, M., Nochy, D., Valeyre, D., Naccache, J.-M., Altare, F., Salek-Peyron, P., Badoual, C., Bruneval, P., Haroche, J., Mathian, A., Amoura, Z., Hill, G., Gorochov, G. (2009). FoxP3+ Regulatory T Cells Suppress Early Stages of Granuloma Formation but Have Little Impact on Sarcoidosis Lesions. Am. J. Pathol. 174: 497-508 [Abstract] [Full Text]
Schmidt, E. M., Wang, C. J., Ryan, G. A., Clough, L. E., Qureshi, O. S., Goodall, M., Abbas, A. K., Sharpe, A. H., Sansom, D. M., Walker, L. S. K. (2009). CTLA-4 Controls Regulatory T Cell Peripheral Homeostasis and Is Required for Suppression of Pancreatic Islet Autoimmunity. J. Immunol. 182: 274-282 [Abstract] [Full Text]
Lathrop, S. K., Santacruz, N. A., Pham, D., Luo, J., Hsieh, C.-S. (2008). Antigen-specific peripheral shaping of the natural regulatory T cell population. JEM 205: 3105-3117 [Abstract] [Full Text]
Van, V. Q., Darwiche, J., Raymond, M., Lesage, S., Bouguermouh, S., Rubio, M., Sarfati, M. (2008). Cutting Edge: CD47 Controls the In Vivo Proliferation and Homeostasis of Peripheral CD4+CD25+Foxp3+ Regulatory T Cells That Express CD103. J. Immunol. 181: 5204-5208 [Abstract] [Full Text]
Matarese, G., Procaccini, C., De Rosa, V. (2008). The intricate interface between immune and metabolic regulation: a role for leptin in the pathogenesis of multiple sclerosis?. J. Leukoc. Biol. 84: 893-899 [Abstract] [Full Text]
Wuest, T. Y., Willette-Brown, J., Durum, S. K., Hurwitz, A. A. (2008). The influence of IL-2 family cytokines on activation and function of naturally occurring regulatory T cells. J. Leukoc. Biol. 84: 973-980 [Abstract] [Full Text]
Ke, Y., Jiang, G., Sun, D., Kaplan, H. J., Shao, H. (2008). Ocular Regulatory T Cells Distinguish Monophasic from Recurrent Autoimmune Uveitis. IOVS 49: 3999-4007 [Abstract] [Full Text]
Tang, A. L., Teijaro, J. R., Njau, M. N., Chandran, S. S., Azimzadeh, A., Nadler, S. G., Rothstein, D. M., Farber, D. L. (2008). CTLA4 Expression Is an Indicator and Regulator of Steady-State CD4+FoxP3+ T Cell Homeostasis. J. Immunol. 181: 1806-1813 [Abstract] [Full Text]
Lages, C. S., Suffia, I., Velilla, P. A., Huang, B., Warshaw, G., Hildeman, D. A., Belkaid, Y., Chougnet, C. (2008). Functional Regulatory T Cells Accumulate in Aged Hosts and Promote Chronic Infectious Disease Reactivation. J. Immunol. 181: 1835-1848 [Abstract] [Full Text]
Metzler, B., Gfeller, P., Wieczorek, G., Li, J., Nuesslein-Hildesheim, B., Katopodis, A., Mueller, M., Brinkmann, V. (2008). Modulation of T cell homeostasis and alloreactivity under continuous FTY720 exposure. Int Immunol 20: 633-644 [Abstract] [Full Text]
Ouabed, A., Hubert, F.-X., Chabannes, D., Gautreau, L., Heslan, M., Josien, R. (2008). Differential Control of T Regulatory Cell Proliferation and Suppressive Activity by Mature Plasmacytoid versus Conventional Spleen Dendritic Cells. J. Immunol. 180: 5862-5870 [Abstract] [Full Text]
Wakkach, A., Augier, S., Breittmayer, J.-P., Blin-Wakkach, C., Carle, G. F. (2008). Characterization of IL-10-Secreting T Cells Derived from Regulatory CD4+CD25+ Cells by the TIRC7 Surface Marker. J. Immunol. 180: 6054-6063 [Abstract] [Full Text]
Larkin, J. III, Rankin, A. L., Picca, C. C., Riley, M. P., Jenks, S. A., Sant, A. J., Caton, A. J. (2008). CD4+CD25+ Regulatory T Cell Repertoire Formation Shaped by Differential Presentation of Peptides from a Self-Antigen. J. Immunol. 180: 2149-2157 [Abstract] [Full Text]
Li, S., Gowans, E. J., Chougnet, C., Plebanski, M., Dittmer, U. (2008). Natural Regulatory T Cells and Persistent Viral Infection. J. Virol. 82: 21-30 [Full Text]
Nolte-'t Hoen, E. N. M., Boot, E. P. J., Wagenaar-Hilbers, J. P. A., van Bilsen, J. H. M., Arkesteijn, G. J. A., Storm, G., Everse, L. A., van Eden, W., Wauben, M. H. M. (2008). Identification and monitoring of effector and regulatory T cells during experimental arthritis based on differential expression of CD25 and CD134. J. Leukoc. Biol. 83: 112-121 [Abstract] [Full Text]
Siewert, C., Lauer, U., Cording, S., Bopp, T., Schmitt, E., Hamann, A., Huehn, J. (2008). Experience-Driven Development: Effector/Memory-Like {alpha}E+Foxp3+ Regulatory T Cells Originate from Both Naive T Cells and Naturally Occurring Naive-Like Regulatory T Cells. J. Immunol. 180: 146-155 [Abstract] [Full Text]
Chappert, P., Leboeuf, M., Rameau, P., Stockholm, D., Liblau, R., Danos, O., Davoust, J. M., Gross, D.-A. (2008). Antigen-Driven Interactions with Dendritic Cells and Expansion of Foxp3+ Regulatory T Cells Occur in the Absence of Inflammatory Signals. J. Immunol. 180: 327-334 [Abstract] [Full Text]
Saitoh, O., Abiru, N., Nakahara, M., Nagayama, Y. (2007). CD8+CD122+ T Cells, a Newly Identified Regulatory T Subset, Negatively Regulate Graves' Hyperthyroidism in a Murine Model. Endocrinology 148: 6040-6046 [Abstract] [Full Text]
Ribot, J., Enault, G., Pilipenko, S., Huchenq, A., Calise, M., Hudrisier, D., Romagnoli, P., van Meerwijk, J. P. M. (2007). Shaping of the Autoreactive Regulatory T Cell Repertoire by Thymic Cortical Positive Selection. J. Immunol. 179: 6741-6748 [Abstract] [Full Text]
Gonzalez-Rey, E., Anderson, P., Delgado, M. (2007). Emerging roles of vasoactive intestinal peptide: a new approach for autoimmune therapy. Ann Rheum Dis 66: iii70-iii76 [Abstract] [Full Text]
Feunou, P., Vanwetswinkel, S., Gaudray, F., Goldman, M., Matthys, P., Braun, M. Y. (2007). Foxp3+CD25+ T Regulatory Cells Stimulate IFN-{gamma}-Independent CD152-Mediated Activation of Tryptophan Catabolism That Provides Dendritic Cells with Immune Regulatory Activity in Mice Unresponsive to Staphylococcal Enterotoxin B. J. Immunol. 179: 910-917 [Abstract] [Full Text]
O'Connor, R. A., Malpass, K. H., Anderton, S. M. (2007). The Inflamed Central Nervous System Drives the Activation and Rapid Proliferation of Foxp3+ Regulatory T Cells. J. Immunol. 179: 958-966 [Abstract] [Full Text]
Yuan, Q., Bromley, S. K., Means, T. K., Jones, K. J., Hayashi, F., Bhan, A. K., Luster, A. D. (2007). CCR4-dependent regulatory T cell function in inflammatory bowel disease. JEM 204: 1327-1334 [Abstract] [Full Text]
Stephens, G. L., Andersson, J., Shevach, E. M. (2007). Distinct Subsets of FoxP3+ Regulatory T Cells Participate in the Control of Immune Responses. J. Immunol. 178: 6901-6911 [Abstract] [Full Text]
Ait-Oufella, H., Kinugawa, K., Zoll, J., Simon, T., Boddaert, J., Heeneman, S., Blanc-Brude, O., Barateau, V., Potteaux, S., Merval, R., Esposito, B., Teissier, E., Daemen, M. J., Leseche, G., Boulanger, C., Tedgui, A., Mallat, Z. (2007). Lactadherin Deficiency Leads to Apoptotic Cell Accumulation and Accelerated Atherosclerosis in Mice. Circulation 115: 2168-2177 [Abstract] [Full Text]
Andersson, J., Stefanova, I., Stephens, G. L., Shevach, E. M. (2007). CD4+CD25+ regulatory T cells are activated in vivo by recognition of self. Int Immunol 19: 557-566 [Abstract] [Full Text]
Bayer, A. L., Yu, A., Malek, T. R. (2007). Function of the IL-2R for Thymic and Peripheral CD4+CD25+ Foxp3+ T Regulatory Cells. J. Immunol. 178: 4062-4071 [Abstract] [Full Text]
Taylor, S. R. J., Alexander, D. R., Cooper, J. C., Higgins, C. F., Elliott, J. I. (2007). Regulatory T Cells Are Resistant to Apoptosis via TCR but Not P2X7. J. Immunol. 178: 3474-3482 [Abstract] [Full Text]
Nguyen, V. H., Zeiser, R., daSilva, D. L., Chang, D. S., Beilhack, A., Contag, C. H., Negrin, R. S. (2007). In vivo dynamics of regulatory T-cell trafficking and survival predict effective strategies to control graft-versus-host disease following allogeneic transplantation. Blood 109: 2649-2656 [Abstract] [Full Text]
Haribhai, D., Lin, W., Relland, L. M., Truong, N., Williams, C. B., Chatila, T. A. (2007). Regulatory T Cells Dynamically Control the Primary Immune Response to Foreign Antigen. J. Immunol. 178: 2961-2972 [Abstract] [Full Text]
Clark, R. A., Kupper, T. S. (2007). IL-15 and dermal fibroblasts induce proliferation of natural regulatory T cells isolated from human skin. Blood 109: 194-202 [Abstract] [Full Text]
Tellier, J., van Meerwijk, J. P. M., Romagnoli, P. (2006). An MHC-linked locus modulates thymic differentiation of CD4+CD25+Foxp3+ regulatory T lymphocytes. Int Immunol 18: 1509-1519 [Abstract] [Full Text]
Marodon, G., Fisson, S., Levacher, B., Fabre, M., Salomon, B. L., Klatzmann, D. (2006). Induction of antigen-specific tolerance by intrathymic injection of lentiviral vectors. Blood 108: 2972-2978 [Abstract] [Full Text]
Cobb, B. S., Hertweck, A., Smith, J., O'Connor, E., Graf, D., Cook, T., Smale, S. T., Sakaguchi, S., Livesey, F. J., Fisher, A. G., Merkenschlager, M. (2006). A role for Dicer in immune regulation. JEM 203: 2519-2527 [Abstract] [Full Text]
de Latour, R. P., Dujardin, H. C., Mishellany, F., Burlen-Defranoux, O., Zuber, J., Marques, R., Di Santo, J., Cumano, A., Vieira, P., Bandeira, A. (2006). Ontogeny, function, and peripheral homeostasis of regulatory T cells in the absence of interleukin-7. Blood 108: 2300-2306 [Abstract] [Full Text]
Gross, D.-A., Chappert, P., Leboeuf, M., Monteilhet, V., Van Wittenberghe, L., Danos, O., Davoust, J. (2006). Simple conditioning with monospecific CD4+CD25+ regulatory T cells for bone marrow engraftment and tolerance to multiple gene products. Blood 108: 1841-1848 [Abstract] [Full Text]
Billiard, F., Litvinova, E., Saadoun, D., Djelti, F., Klatzmann, D., Cohen, J. L., Marodon, G., Salomon, B. L. (2006). Regulatory and Effector T Cell Activation Levels Are Prime Determinants of In Vivo Immune Regulation. J. Immunol. 177: 2167-2174 [Abstract] [Full Text]
Mohamood, A. S., Trujillo, C. J., Zheng, D., Jie, C., Murillo, F. M., Schneck, J. P., Hamad, A. R. A. (2006). Gld mutation of Fas ligand increases the frequency and up-regulates cell survival genes in CD25+CD4+ TR cells. Int Immunol 18: 1265-1277 [Abstract] [Full Text]
Ribot, J., Romagnoli, P., van Meerwijk, J. P. M. (2006). Agonist Ligands Expressed by Thymic Epithelium Enhance Positive Selection of Regulatory T Lymphocytes from Precursors with a Normally Diverse TCR Repertoire. J. Immunol. 177: 1101-1107 [Abstract] [Full Text]
Eksteen, B., Miles, A., Curbishley, S. M., Tselepis, C., Grant, A. J., Walker, L. S. K., Adams, D. H. (2006). Epithelial Inflammation Is Associated with CCL28 Production and the Recruitment of Regulatory T Cells Expressing CCR10. J. Immunol. 177: 593-603 [Abstract] [Full Text]
Wing, K., Fehervari, Z., Sakaguchi, S. (2006). Emerging possibilities in the development and function of regulatory T cells. Int Immunol 18: 991-1000 [Abstract] [Full Text]
Terrada, C., Fisson, S., De Kozak, Y., Kaddouri, M., Lehoang, P., Klatzmann, D., Salomon, B. L., Bodaghi, B. (2006). Regulatory T cells control uveoretinitis induced by pathogenic Th1 cells reacting to a specific retinal neoantigen.. J. Immunol. 176: 7171-7179 [Abstract] [Full Text]
Shimoda, M., Mmanywa, F., Joshi, S. K., Li, T., Miyake, K., Pihkala, J., Abbas, J. A., Koni, P. A. (2006). Conditional Ablation of MHC-II Suggests an Indirect Role for MHC-II in Regulatory CD4 T Cell Maintenance.. J. Immunol. 176: 6503-6511 [Abstract] [Full Text]
Fallarino, F., Grohmann, U., You, S., McGrath, B. C., Cavener, D. R., Vacca, C., Orabona, C., Bianchi, R., Belladonna, M. L., Volpi, C., Santamaria, P., Fioretti, M. C., Puccetti, P. (2006). The Combined Effects of Tryptophan Starvation and Tryptophan Catabolites Down-Regulate T Cell Receptor {zeta}-Chain and Induce a Regulatory Phenotype in Naive T Cells.. J. Immunol. 176: 6752-6761 [Abstract] [Full Text]
Cabarrocas, J., Cassan, C., Magnusson, F., Piaggio, E., Mars, L., Derbinski, J., Kyewski, B., Gross, D.-A., Salomon, B. L., Khazaie, K., Saoudi, A., Liblau, R. S. (2006). Foxp3+ CD25+ regulatory T cells specific for a neo-self-antigen develop at the double-positive thymic stage. Proc. Natl. Acad. Sci. USA 103: 8453-8458 [Abstract] [Full Text]
Gad, M., Lundsgaard, D., Kjellev, S., Kristensen, N. N, Seremet, T., Straten, P. t., Claesson, M. H (2006). Reactivity of naive CD4+CD25- T cells against gut microflora in healthy mice. Int Immunol 18: 817-825 [Abstract] [Full Text]
Robertson, S. J., Messer, R. J., Carmody, A. B., Hasenkrug, K. J. (2006). In Vitro Suppression of CD8+ T Cell Function by Friend Virus-Induced Regulatory T Cells. J. Immunol. 176: 3342-3349 [Abstract] [Full Text]
Raimondi, G., Shufesky, W. J., Tokita, D., Morelli, A. E., Thomson, A. W. (2006). Regulated Compartmentalization of Programmed Cell Death-1 Discriminates CD4+CD25+ Resting Regulatory T Cells from Activated T Cells.. J. Immunol. 176: 2808-2816 [Abstract] [Full Text]
Zwar, T. D., Read, S., van Driel, I. R., Gleeson, P. A. (2006). CD4+CD25+ Regulatory T Cells Inhibit the Antigen-Dependent Expansion of Self-Reactive T Cells In Vivo. J. Immunol. 176: 1609-1617 [Abstract] [Full Text]
Setiady, Y. Y., Ohno, K., Samy, E. T., Bagavant, H., Qiao, H., Sharp, C., She, J. X., Tung, K. S. K. (2006). Physiologic self antigens rapidly capacitate autoimmune disease-specific polyclonal CD4+CD25+ regulatory T cells. Blood 107: 1056-1062 [Abstract] [Full Text]
DiPaolo, R. J., Glass, D. D., Bijwaard, K. E., Shevach, E. M. (2005). CD4+CD25+ T Cells Prevent the Development of Organ-Specific Autoimmune Disease by Inhibiting the Differentiation of Autoreactive Effector T Cells. J. Immunol. 175: 7135-7142 [Abstract] [Full Text]
Romagnoli, P., Hudrisier, D., van Meerwijk, J. P. M. (2005). Molecular Signature of Recent Thymic Selection Events on Effector and Regulatory CD4+ T Lymphocytes. J. Immunol. 175: 5751-5758 [Abstract] [Full Text]
Siegmund, K., Feuerer, M., Siewert, C., Ghani, S., Haubold, U., Dankof, A., Krenn, V., Schon, M. P., Scheffold, A., Lowe, J. B., Hamann, A., Syrbe, U., Huehn, J. (2005). Migration matters: regulatory T-cell compartmentalization determines suppressive activity in vivo. Blood 106: 3097-3104 [Abstract] [Full Text]
Wysocki, C. A., Jiang, Q., Panoskaltsis-Mortari, A., Taylor, P. A., McKinnon, K. P., Su, L., Blazar, B. R., Serody, J. S. (2005). Critical role for CCR5 in the function of donor CD4+CD25+ regulatory T cells during acute graft-versus-host disease. Blood 106: 3300-3307 [Abstract] [Full Text]
Huang, X., Zhu, J., Yang, Y. (2005). Protection against Autoimmunity in Nonlymphopenic Hosts by CD4+CD25+ Regulatory T Cells Is Antigen-Specific and Requires IL-10 and TGF-{beta}. J. Immunol. 175: 4283-4291 [Abstract] [Full Text]
Hickman, S. P, Turka, L. A (2005). Homeostatic T cell proliferation as a barrier to T cell tolerance. Phil Trans R Soc B 360: 1713-1721 [Abstract] [Full Text]
Samy, E. T., Parker, L. A., Sharp, C. P., Tung, K. S.K. (2005). Continuous control of autoimmune disease by antigen-dependent polyclonal CD4+CD25+ regulatory T cells in the regional lymph node. JEM 202: 771-781 [Abstract] [Full Text]
McGeachy, M. J., Stephens, L. A., Anderton, S. M. (2005). Natural Recovery and Protection from Autoimmune Encephalomyelitis: Contribution of CD4+CD25+ Regulatory Cells within the Central Nervous System. J. Immunol. 175: 3025-3032 [Abstract] [Full Text]
Koenen, H. J. P. M., Fasse, E., Joosten, I. (2005). CD27/CFSE-Based Ex Vivo Selection of Highly Suppressive Alloantigen-Specific Human Regulatory T Cells. J. Immunol. 174: 7573-7583 [Abstract] [Full Text]
Darrasse-Jeze, G., Marodon, G., Salomon, B. L., Catala, M., Klatzmann, D. (2005). Ontogeny of CD4+CD25+ regulatory/suppressor T cells in human fetuses. Blood 105: 4715-4721 [Abstract] [Full Text]
Ji, J., Masterson, J., Sun, J., Soong, L. (2005). CD4+CD25+ Regulatory T Cells Restrain Pathogenic Responses during Leishmania amazonensis Infection. J. Immunol. 174: 7147-7153 [Abstract] [Full Text]
Verginis, P., Li, H. S., Carayanniotis, G. (2005). Tolerogenic Semimature Dendritic Cells Suppress Experimental Autoimmune Thyroiditis by Activation of Thyroglobulin-Specific CD4+CD25+ T Cells. J. Immunol. 174: 7433-7439 [Abstract] [Full Text]
Kojima, H., Kanno, Y., Hase, H., Kobata, T. (2005). CD4+CD25+ Regulatory T Cells Attenuate the Phosphatidylinositol 3-Kinase/Akt Pathway in Antigen-Primed Immature CD8+ CTLs during Functional Maturation. J. Immunol. 174: 5959-5967 [Abstract] [Full Text]
Brusko, T. M., Wasserfall, C. H., Clare-Salzler, M. J., Schatz, D. A., Atkinson, M. A. (2005). Functional Defects and the Influence of Age on the Frequency of CD4+CD25+ T-Cells in Type 1 Diabetes. Diabetes 54: 1407-1414 [Abstract] [Full Text]
Pop, S. M., Wong, C. P., Culton, D. A., Clarke, S. H., Tisch, R. (2005). Single cell analysis shows decreasing FoxP3 and TGF{beta}1 coexpressing CD4+CD25+ regulatory T cells during autoimmune diabetes. JEM 201: 1333-1346 [Abstract] [Full Text]
Kleinewietfeld, M., Puentes, F., Borsellino, G., Battistini, L., Rotzschke, O., Falk, K. (2005). CCR6 expression defines regulatory effector/memory-like cells within the CD25+CD4+ T-cell subset. Blood 105: 2877-2886 [Abstract] [Full Text]
Setoguchi, R., Hori, S., Takahashi, T., Sakaguchi, S. (2005). Homeostatic maintenance of natural Foxp3+ CD25+ CD4+ regulatory T cells by interleukin (IL)-2 and induction of autoimmune disease by IL-2 neutralization. JEM 201: 723-735 [Abstract] [Full Text]
Bayer, A. L., Yu, A., Adeegbe, D., Malek, T. R. (2005). Essential role for interleukin-2 for CD4+CD25+ T regulatory cell development during the neonatal period. JEM 201: 769-777 [Abstract] [Full Text]
Antony, P. A., Piccirillo, C. A., Akpinarli, A., Finkelstein, S. E., Speiss, P. J., Surman, D. R., Palmer, D. C., Chan, C.-C., Klebanoff, C. A., Overwijk, W. W., Rosenberg, S. A., Restifo, N. P. (2005). CD8+ T Cell Immunity Against a Tumor/Self-Antigen Is Augmented by CD4+ T Helper Cells and Hindered by Naturally Occurring T Regulatory Cells. J. Immunol. 174: 2591-2601 [Abstract] [Full Text]
Ermann, J., Hoffmann, P., Edinger, M., Dutt, S., Blankenberg, F. G., Higgins, J. P., Negrin, R. S., Fathman, C. G., Strober, S. (2005). Only the CD62L+ subpopulation of CD4+CD25+ regulatory T cells protects from lethal acute GVHD. Blood 105: 2220-2226 [Abstract] [Full Text]
Hanash, A. M., Levy, R. B. (2005). Donor CD4+CD25+ T cells promote engraftment and tolerance following MHC-mismatched hematopoietic cell transplantation. Blood 105: 1828-1836 [Abstract] [Full Text]
Chen, M.-L., Pittet, M. J., Gorelik, L., Flavell, R. A., Weissleder, R., von Boehmer, H., Khazaie, K. (2005). Regulatory T cells suppress tumor-specific CD8 T cell cytotoxicity through TGF-{beta} signals in vivo. Proc. Natl. Acad. Sci. USA 102: 419-424 [Abstract] [Full Text]
Baldwin, T. A., Hogquist, K. A., Jameson, S. C. (2004). The Fourth Way? Harnessing Aggressive Tendencies in the Thymus. J. Immunol. 173: 6515-6520 [Abstract] [Full Text]
Nishimura, E., Sakihama, T., Setoguchi, R., Tanaka, K., Sakaguchi, S. (2004). Induction of antigen-specific immunologic tolerance by in vivo and in vitro antigen-specific expansion of naturally arising Foxp3+CD25+CD4+ regulatory T cells. Int Immunol 16: 1189-1201 [Abstract] [Full Text]
Hoffmann, P., Eder, R., Kunz-Schughart, L. A., Andreesen, R., Edinger, M. (2004). Large-scale in vitro expansion of polyclonal human CD4+CD25high regulatory T cells. Blood 104: 895-903 [Abstract] [Full Text]
Viguier, M., Lemaitre, F., Verola, O., Cho, M.-S., Gorochov, G., Dubertret, L., Bachelez, H., Kourilsky, P., Ferradini, L. (2004). Foxp3 Expressing CD4+CD25high Regulatory T Cells Are Overrepresented in Human Metastatic Melanoma Lymph Nodes and Inhibit the Function of Infiltrating T Cells. J. Immunol. 173: 1444-1453 [Abstract] [Full Text]
Tarbell, K. V., Yamazaki, S., Olson, K., Toy, P., Steinman, R. M. (2004). CD25+ CD4+ T Cells, Expanded with Dendritic Cells Presenting a Single Autoantigenic Peptide, Suppress Autoimmune Diabetes. JEM 199: 1467-1477 [Abstract] [Full Text]
Herman, A. E., Freeman, G. J., Mathis, D., Benoist, C. (2004). CD4+CD25+ T Regulatory Cells Dependent on ICOS Promote Regulation of Effector Cells in the Prediabetic Lesion. JEM 199: 1479-1489 [Abstract] [Full Text]
Joffre, O., Gorsse, N., Romagnoli, P., Hudrisier, D., van Meerwijk, J. P. M. (2004). Induction of antigen-specific tolerance to bone marrow allografts with CD4+CD25+ T lymphocytes. Blood 103: 4216-4221 [Abstract] [Full Text]
Apostolou, I., von Boehmer, H. (2004). In Vivo Instruction of Suppressor Commitment in Naive T Cells. JEM 199: 1401-1408 [Abstract] [Full Text]
Hayashi, Y., Tsukumo, S.-i., Shiota, H., Kishihara, K., Yasutomo, K. (2004). Antigen-Specific T Cell Repertoire Modification of CD4+CD25+ Regulatory T Cells. J. Immunol. 172: 5240-5248 [Abstract] [Full Text]
Clark, F. J., Gregg, R., Piper, K., Dunnion, D., Freeman, L., Griffiths, M., Begum, G., Mahendra, P., Craddock, C., Moss, P., Chakraverty, R. (2004). Chronic graft-versus-host disease is associated with increased numbers of peripheral blood CD4+CD25high regulatory T cells. Blood 103: 2410-2416 [Abstract] [Full Text]
Cozzo, C., Larkin, J. III, Caton, A. J. (2003). Cutting Edge: Self-Peptides Drive the Peripheral Expansion of CD4+CD25+ Regulatory T Cells. J. Immunol. 171: 5678-5682 [Abstract] [Full Text]
von Boehmer, H. (2003). Dynamics of Suppressor T Cells: In Vivo Veritas. JEM 198: 845-849 [Full Text]