The Journal of Experimental Medicine
Avanti Polar Lipids, Inc.
  Home | Help | Feedback | Subscriptions | Archive | Search | Table of Contents
Published 4 August 2003. doi:10.1084/jem.20030235
This Article
Right arrow Full Text
Right arrow Full Text (PDF, 154K)
Right arrow PPT slides of all figures
Right arrow Alert me when this article is cited
Right arrow Citation Map
Services
Right arrow Email this article
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new content in the JEM
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via CrossRef
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Dieli, F.
Right arrow Articles by Salerno, A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Dieli, F.
Right arrow Articles by Salerno, A.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati  
What's this?
© Rockefeller University Press, 0022-1007/2003/8/391 $5.00
The Journal of Experimental Medicine, Volume 198, Number 3, 391-397

Differentiation of Effector/Memory V{delta}2 T Cells and Migratory Routes in Lymph Nodes or Inflammatory Sites

Francesco Dieli1, Fabrizio Poccia2, Martin Lipp3, Guido Sireci1, Nadia Caccamo1, Caterina Di Sano4 and Alfredo Salerno1,4

1 Department of Biopathology, University of Palermo, 90134 Palermo, Italy
2 Laboratory of Immunology, National Institute for Infectious Diseases "L. Spallanzani," 00149 Rome, Italy
3 Max-Delbruch Center for Molecular Medicine, 13122 Berlin-Busch, Germany
4 Institute of Biomedicine and Molecular Immunology, National Research Council, 90134 Palermo, Italy

Address correspondence to Francesco Dieli, Dept. of Biopathology, University of Palermo, Corso Tukory 211, Palermo 90134, Italy. Phone: 39-091-655-5916; Fax: 0039-091-655-5924; email: dieli{at}unipa.it

V{delta}2 T lymphocytes recognize nonpeptidic antigens without presentation by MHC molecules and mount both immediate effector functions and memory responses after microbial infection. However, how V{delta}2 T cells mediate different facets of a memory response remains unknown. Here, we show that the expression of CD45RA and CD27 antigens defines four subsets of human V{delta}2 T cells with distinctive compartmentalization routes. Naive CD45RA+CD27+ and memory CD45RA-CD27+ cells express lymph node homing receptors, abound in lymph nodes, and lack immediate effector functions. Conversely, memory CD45RA-CD27- and terminally differentiated CD45RA+CD27- cells, which express receptors for homing to inflamed tissues, are poorly represented in the lymph nodes while abounding at sites of inflammation, and display immediate effector functions. These observations and additional in vitro experiments indicate a lineage differentiation pattern for human V{delta}2 T cells that generates naive cells circulating in lymph nodes, effector/memory cells patrolling the blood, and terminally differentiated effector cells residing in inflamed tissues.

Key Words: {gamma}{delta} cells • effector functions • chemokine receptors • functional subsets • phosphoantigens


Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati    What's this?


This article has been cited by other articles:



  Home | Help | Feedback | Subscriptions | Archive | Search
TABLE OF CONTENTS