Home | Help | Feedback | Subscriptions | Archive | Search | Table of Contents

This Article Full Text Full Text (PDF, 348K) PPT slides of all figures Alert me when this article is cited Citation Map Services Email this article Similar articles in this journal Similar articles in PubMed Alert me to new content in the JEM Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Yotsumoto, K. Articles by Shibuya, A. Search for Related Content PubMed PubMed Citation Articles by Yotsumoto, K. Articles by Shibuya, A. Social Bookmarking                            What's this?

Paired Activating and Inhibitory Immunoglobulin-like Receptors, MAIR-I and MAIR-II, Regulate Mast Cell and Macrophage Activation

Katsumi Yotsumoto^1,2, Yasushi Okoshi^1,2, Kazuko Shibuya^1,2, Satoshi Yamazaki^1,2,3, Satoko Tahara-Hanaoka^1,2,3, Shin-ichiro Honda^1,2,3, Mitsujiro Osawa¹, Asato Kuroiwa⁵, Yoichi Matsuda⁵, Daniel G. Tenen⁶, Atsushi Iwama^1,6, Hiromitsu Nakauchi^1,4 and Akira Shibuya^1,2,3

¹ Department of Immunology, Institute of Basic Medical Sciences, University of Tsukuba, Tsukuba, Ibaraki 305-8575, Japan
² Laboratory for Immune Receptor, RIKEN Research Center for Allergy and Immunology, Tsukuba, Ibaraki 305-0034, Japan
³ Precursory Research for Embryonic Science and Technology, Japan Science and Technology Corporation, Tsukuba, Ibaraki 305-8575, Japan
⁴ Core Research for Evolutional Science and Technology, Japan Science and Technology Corporation, Tsukuba, Ibaraki 305-8575, Japan
⁵ Laboratory of Cytogenetics, Division of Bioscience, Graduate School of Environmental Earth Science and Chromosome Research Unit, Faculty of Science, Hokkaido University, Kita-ku, Sapporo 060-0810, Japan
⁶ Harvard Institute of Medicine, Harvard Medical School, Boston, MA 02115

Address correspondence to Akira Shibuya, Laboratory for Immune Receptor, RIKEN Research Center for Allergy and Immunology, 3-1-1 Koyadai, Tsukuba, Ibaraki 305-0074, Japan. Phone: 81-29-836-9174; Fax: 81-29-836-9175; E-mail: ashibuya{at}md.tsukuba.ac.jp

Immune responses are regulated by opposing positive and negative signals triggered by the interaction of activating and inhibitory cell surface receptors with their ligands. Here, we describe novel paired activating and inhibitory immunoglobulin-like receptors, designated myeloid-associated immunoglobulin-like receptor (MAIR) I and MAIR-II, whose extracellular domains are highly conserved by each other. MAIR-I, expressed on the majority of myeloid cells, including macrophages, granulocytes, mast cells, and dendritic cells, contains the tyrosine-based sorting motif and the immunoreceptor tyrosine-based inhibitory motif-like sequences in the cytoplasmic domain and mediates endocytosis of the receptor and inhibition of IgE-mediated degranulation from mast cells. On the other hand, MAIR-II, expressed on subsets of peritoneal macrophages and B cells, associates with the immunoreceptor tyrosine-based activation motif-bearing adaptor DAP12 and stimulates proinflammatory cytokines and chemokine secretions from macrophages. Thus, MAIR-I and MAIR-II play important regulatory roles in cell signaling and immune responses.

Key Words: ITAM • ITIM • innate immunity • DAP12 • myeloid cells

CiteULike    Complore    Connotea    Del.icio.us    Digg    Facebook    Reddit    Technorati    Twitter    What's this?

This article has been cited by other articles:

• Cannon, J. P. (2009). Plasticity of the immunoglobulin domain in the evolution of immunity. Integr. Comp. Biol. 49: 187-196 [Abstract] [Full Text]  
• Izawa, K., Kitaura, J., Yamanishi, Y., Matsuoka, T., Kaitani, A., Sugiuchi, M., Takahashi, M., Maehara, A., Enomoto, Y., Oki, T., Takai, T., Kitamura, T. (2009). An Activating and Inhibitory Signal from an Inhibitory Receptor LMIR3/CLM-1: LMIR3 Augments Lipopolysaccharide Response through Association with FcR{gamma} in Mast Cells. J. Immunol. 183: 925-936 [Abstract] [Full Text]  
• Yamanishi, Y., Kitaura, J., Izawa, K., Matsuoka, T., Oki, T., Lu, Y., Shibata, F., Yamazaki, S., Kumagai, H., Nakajima, H., Maeda-Yamamoto, M., Tybulewicz, V. L. J., Takai, T., Kitamura, T. (2008). Analysis of mouse LMIR5/CLM-7 as an activating receptor: differential regulation of LMIR5/CLM-7 in mouse versus human cells. Blood 111: 688-698 [Abstract] [Full Text]  
• Can, I., Tahara-Hanaoka, S., Hitomi, K., Nakano, T., Nakahashi-Oda, C., Kurita, N., Honda, S.-i., Shibuya, K., Shibuya, A. (2008). Caspase-Independent Cell Death by CD300LF (MAIR-V), an Inhibitory Immunoglobulin-Like Receptor on Myeloid Cells. J. Immunol. 180: 207-213 [Abstract] [Full Text]  
• Izawa, K., Kitaura, J., Yamanishi, Y., Matsuoka, T., Oki, T., Shibata, F., Kumagai, H., Nakajima, H., Maeda-Yamamoto, M., Hauchins, J. P., Tybulewicz, V. L. J., Takai, T., Kitamura, T. (2007). Functional Analysis of Activating Receptor LMIR4 as a Counterpart of Inhibitory Receptor LMIR3. J. Biol. Chem. 282: 17997-18008 [Abstract] [Full Text]  
• Nakahashi, C., Tahara-Hanaoka, S., Totsuka, N., Okoshi, Y., Takai, T., Ohkohchi, N., Honda, S.-i., Shibuya, K., Shibuya, A. (2007). Dual Assemblies of an Activating Immune Receptor, MAIR-II, with ITAM-Bearing Adapters DAP12 and FcR{gamma} Chain on Peritoneal Macrophages. J. Immunol. 178: 765-770 [Abstract] [Full Text]  
• Wilson, M. D., Cheung, J., Martindale, D. W., Scherer, S. W., Koop, B. F. (2006). Comparative analysis of the paired immunoglobulin-like receptor (PILR) locus in six mammalian genomes: duplication, conversion, and the birth of new genes. Physiol. Genomics 27: 201-218 [Abstract] [Full Text]  
• Angata, T., Hayakawa, T., Yamanaka, M., Varki, A., Nakamura, M. (2006). Discovery of Siglec-14, a novel sialic acid receptor undergoing concerted evolution with Siglec-5 in primates. FASEB J. 20: 1964-1973 [Abstract] [Full Text]  
• Fujimoto, M., Takatsu, H., Ohno, H. (2006). CMRF-35-like molecule-5 constitutes novel paired receptors, with CMRF-35-like molecule-1, to transduce activation signal upon association with FcR{gamma}. Int Immunol 18: 1499-1508 [Abstract] [Full Text]  
• Takayanagi, S.-i., Hiroyama, T., Yamazaki, S., Nakajima, T., Morita, Y., Usui, J., Eto, K., Motohashi, T., Shiomi, K., Keino-Masu, K., Masu, M., Oike, Y., Mori, S., Yoshida, N., Iwama, A., Nakauchi, H. (2006). Genetic marking of hematopoietic stem and endothelial cells: identification of the Tmtsp gene encoding a novel cell surface protein with the thrombospondin-1 domain. Blood 107: 4317-4325 [Abstract] [Full Text]  
• Hamerman, J. A., Lanier, L. L. (2006). Inhibition of Immune Responses by ITAM-Bearing Receptors. Sci Signal 2006: re1-re1 [Abstract] [Full Text]  
• Bachelet, I., Munitz, A., Moretta, A., Moretta, L., Levi-Schaffer, F. (2005). The Inhibitory Receptor IRp60 (CD300a) Is Expressed and Functional on Human Mast Cells. J. Immunol. 175: 7989-7995 [Abstract] [Full Text]  
• Okoshi, Y., Tahara-Hanaoka, S., Nakahashi, C., Honda, S.-i., Miyamoto, A., Kojima, H., Nagasawa, T., Shibuya, K., Shibuya, A. (2005). Requirement of the tyrosines at residues 258 and 270 of MAIR-I in inhibitory effect on degranulation from basophilic leukemia RBL-2H3. Int Immunol 17: 65-72 [Abstract] [Full Text]  
• Voehringer, D., Rosen, D. B., Lanier, L. L., Locksley, R. M. (2004). CD200 Receptor Family Members Represent Novel DAP12-associated Activating Receptors on Basophils and Mast Cells. J. Biol. Chem. 279: 54117-54123 [Abstract] [Full Text]  
• Merck, E., Gaillard, C., Gorman, D. M., Montero-Julian, F., Durand, I., Zurawski, S. M., Menetrier-Caux, C., Carra, G., Lebecque, S., Trinchieri, G., Bates, E. E. M. (2004). OSCAR is an FcR{gamma}-associated receptor that is expressed by myeloid cells and is involved in antigen presentation and activation of human dendritic cells. Blood 104: 1386-1395 [Abstract] [Full Text]  

Home | Help | Feedback | Subscriptions | Archive | Search

TABLE OF CONTENTS