Home | Help | Feedback | Subscriptions | Archive | Search | Table of Contents

This Article Full Text Full Text (PDF, 70K) PPT slides of all figures Alert me when this article is cited Citation Map Services Email this article Similar articles in this journal Similar articles in PubMed Alert me to new content in the JEM Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Dhodapkar, M. V. Articles by Geller, M. D. Search for Related Content PubMed PubMed Citation Articles by Dhodapkar, M. V. Articles by Geller, M. D. Social Bookmarking                            What's this?

Brief Definitive Report

¹ Laboratory of Tumor Immunology and Immunotherapy, The Rockefeller University
² Hematology Service, Memorial Sloan Kettering Cancer Center, New York, NY 10021

Address correspondence to Madhav V. Dhodapkar, Laboratory of Tumor Immunology and Immunotherapy, The Rockefeller University, 1230 York Ave., New York, NY 10021. Phone: (212) 327-8114; Fax: (212) 327-7119; email: dhodapm{at}mail.rockefeller.edu

Most approaches targeting the immune system against tumors have focused on patients with established tumors. However, whether the immune system can recognize preneoplastic stages of human cancer is not known. Here we show that patients with preneoplastic gammopathy mount a vigorous T cell response to autologous premalignant cells. This preneoplasia-specific CD4⁺ and CD8⁺ T cell response is detected in freshly isolated T cells from the BM. T cells from myeloma marrow lack this tumor-specific rapid effector function. These data provide direct evidence for tumor specific immune recognition in human preneoplasia and suggest a possible role for the immune system in influencing the early growth of transformed cells, long before the development of clinical cancer.

Key Words: myeloma • vaccine • dendritic cells • prevention • gammopathy

CiteULike

Complore

Connotea

Del.icio.us

Digg

Facebook

Reddit

Technorati

Twitter

This article has been cited by other articles:

• Blotta, S., Tassone, P., Prabhala, R. H., Tagliaferri, P., Cervi, D., Amin, S., Jakubikova, J., Tai, Y.-T., Podar, K., Mitsiades, C. S., Zullo, A., Franco, B., Anderson, K. C., Munshi, N. C. (2009). Identification of novel antigens with induced immune response in monoclonal gammopathy of undetermined significance. Blood 114: 3276-3284 [Abstract] [Full Text]  
• Dubovsky, J. A., McNeel, D. G., Powers, J. J., Gordon, J., Sotomayor, E. M., Pinilla-Ibarz, J. A. (2009). Treatment of Chronic Lymphocytic Leukemia with a Hypomethylating Agent Induces Expression of NXF2, an Immunogenic Cancer Testis Antigen. Clin. Cancer Res. 15: 3406-3415 [Abstract] [Full Text]  
• Spanoudakis, E., Hu, M., Naresh, K., Terpos, E., Melo, V., Reid, A., Kotsianidis, I., Abdalla, S., Rahemtulla, A., Karadimitris, A. (2009). Regulation of multiple myeloma survival and progression by CD1d. Blood 113: 2498-2507 [Abstract] [Full Text]  
• Goodyear, O. C., Pratt, G., McLarnon, A., Cook, M., Piper, K., Moss, P. (2008). Differential pattern of CD4+ and CD8+ T-cell immunity to MAGE-A1/A2/A3 in patients with monoclonal gammopathy of undetermined significance (MGUS) and multiple myeloma. Blood 112: 3362-3372 [Abstract] [Full Text]  
• Dhodapkar, K. M., Barbuto, S., Matthews, P., Kukreja, A., Mazumder, A., Vesole, D., Jagannath, S., Dhodapkar, M. V. (2008). Dendritic cells mediate the induction of polyfunctional human IL17-producing cells (Th17-1 cells) enriched in the bone marrow of patients with myeloma. Blood 112: 2878-2885 [Abstract] [Full Text]  
• Jinushi, M., Vanneman, M., Munshi, N. C., Tai, Y.-T., Prabhala, R. H., Ritz, J., Neuberg, D., Anderson, K. C., Carrasco, D. R., Dranoff, G. (2008). MHC class I chain-related protein A antibodies and shedding are associated with the progression of multiple myeloma. Proc. Natl. Acad. Sci. USA 105: 1285-1290 [Abstract] [Full Text]  
• Clark, C. E., Hingorani, S. R., Mick, R., Combs, C., Tuveson, D. A., Vonderheide, R. H. (2007). Dynamics of the Immune Reaction to Pancreatic Cancer from Inception to Invasion. Cancer Res. 67: 9518-9527 [Abstract] [Full Text]  
• Spisek, R., Kukreja, A., Chen, L.-C., Matthews, P., Mazumder, A., Vesole, D., Jagannath, S., Zebroski, H. A., Simpson, A. J.G., Ritter, G., Durie, B., Crowley, J., Shaughnessy, J. D. Jr., Scanlan, M. J., Gure, A. O., Barlogie, B., Dhodapkar, M. V. (2007). Frequent and specific immunity to the embryonal stem cell-associated antigen SOX2 in patients with monoclonal gammopathy. JEM 204: 831-840 [Abstract] [Full Text]  
• Condomines, M., Hose, D., Raynaud, P., Hundemer, M., De Vos, J., Baudard, M., Moehler, T., Pantesco, V., Moos, M., Schved, J.-F., Rossi, J.-F., Reme, T., Goldschmidt, H., Klein, B. (2007). Cancer/Testis Genes in Multiple Myeloma: Expression Patterns and Prognosis Value Determined by Microarray Analysis. J. Immunol. 178: 3307-3315 [Abstract] [Full Text]  
• Montagna, D., Maccario, R., Locatelli, F., Montini, E., Pagani, S., Bonetti, F., Daudt, L., Turin, I., Lisini, D., Garavaglia, C., Dellabona, P., Casorati, G. (2006). Emergence of antitumor cytolytic T cells is associated with maintenance of hematologic remission in children with acute myeloid leukemia. Blood 108: 3843-3850 [Abstract] [Full Text]  
• Kukreja, A., Hutchinson, A., Dhodapkar, K., Mazumder, A., Vesole, D., Angitapalli, R., Jagannath, S., Dhodapkar, M. V. (2006). Enhancement of clonogenicity of human multiple myeloma by dendritic cells. JEM 203: 1859-1865 [Abstract] [Full Text]  
• Girlanda, S., Fortis, C., Belloni, D., Ferrero, E., Ticozzi, P., Sciorati, C., Tresoldi, M., Vicari, A., Spies, T., Groh, V., Caligaris-Cappio, F., Ferrarini, M. (2005). MICA Expressed by Multiple Myeloma and Monoclonal Gammopathy of Undetermined Significance Plasma Cells Costimulates Pamidronate-Activated {gamma}{delta} Lymphocytes. Cancer Res. 65: 7502-7508 [Abstract] [Full Text]  
• Liu, K., Caldwell, S. A., Abrams, S. I. (2005). Immune Selection and Emergence of Aggressive Tumor Variants as Negative Consequences of Fas-Mediated Cytotoxicity and Altered IFN-{gamma}-Regulated Gene Expression. Cancer Res. 65: 4376-4388 [Abstract] [Full Text]  
• Zou, L., Barnett, B., Safah, H., LaRussa, V. F., Evdemon-Hogan, M., Mottram, P., Wei, S., David, O., Curiel, T. J., Zou, W. (2004). Bone Marrow Is a Reservoir for CD4+CD25+ Regulatory T Cells that Traffic through CXCL12/CXCR4 Signals. Cancer Res. 64: 8451-8455 [Abstract] [Full Text]  
• Steinman, R. M., Mellman, I. (2004). Immunotherapy: Bewitched, Bothered, and Bewildered No More. Science 305: 197-200 [Abstract] [Full Text]  
• Finn, O. J. (2003). Premalignant Lesions as Targets for Cancer Vaccines. JEM 198: 1623-1626 [Full Text]  
• Bell, J. (2003). A Call for Papers on Human Subjects. JEM 198: 1621-1621 [Full Text]  

Home | Help | Feedback | Subscriptions | Archive | Search

TABLE OF CONTENTS