Interleukin (IL)-15R{alpha}-deficient Natural Killer Cells Survive in Normal but Not IL-15R{alpha}-deficient Mice

doi:10.1084/jem.20021836

Published online 14 April 2003 doi:10.1084/jem.20021836

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© Rockefeller University Press, 0022-1007/2003/4/977 $5.00
The Journal of Experimental Medicine, Volume 197, Number 8, 977-984

Interleukin (IL)-15R ${alpha}$ –deficient Natural Killer Cells Survive in Normal but Not IL-15R ${alpha}$ –deficient Mice

Rima Koka, Patrick R. Burkett, Marcia Chien, Sophia Chai, Faye Chan, James P. Lodolce, David L. Boone and Averil Ma

Department of Medicine and the Ben May Institute for Cancer Research, University of Chicago, Chicago, IL 60637

Address correspondence to D.L. Boone or A. Ma, Department of Medicine and the Ben May Institute for Cancer Research, University of Chicago, 5841 S. Maryland Ave., MC6084, Chicago, IL 60637. Phone: 773-834-0687; Fax: 773-702-2281; E-mail: ama{at}medicine.bsd.uchicago.edu or dboone{at}medicine.bsd.uchicago.edu

Natural killer (NK) cells protect hosts against viral pathogensand transformed cells. IL-15 is thought to play a critical rolein NK cell development, but its role in the regulation of peripheralNK cells is less well defined. We now find that adoptive transferof normal NK cells into mice lacking the high affinity interleukin(IL)-15 receptor, IL-15R ${alpha}$ , surprisingly results in the abruptloss of these cells. Moreover, IL-15R ${alpha}$ –deficient NK cellscan differentiate successfully in radiation bone marrow chimerabearing normal cells. Finally, adoptively transferred IL-15R ${alpha}$ –deficientNK cells survive in normal but not IL-15R ${alpha}$ –deficient mice.These findings demonstrate that NK cell–independent IL-15R ${alpha}$ expression is critical for maintaining peripheral NK cells,while IL-15R ${alpha}$ expression on NK cells is not required for thisfunction.

Key Words: IL-15 • NK cell homeostasis • NK cell survival • NK cell development

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