GATA-1 as a Regulator of Mast Cell Differentiation Revealed by the Phenotype of the GATA-1low Mouse Mutant

doi:10.1084/jem.20021149

Published 3 February 2003. doi:10.1084/jem.20021149

This Article

	Full Text
	Full Text (PDF, 823K)
	PPT slides of all figures
	Alert me when this article is cited
	Citation Map

Services

	Email this article
	Similar articles in this journal
	Similar articles in PubMed
	Alert me to new content in the JEM
	Download to citation manager

Citing Articles

	Citing Articles via HighWire
	Citing Articles via CrossRef
	Citing Articles via Google Scholar

Google Scholar

	Articles by Migliaccio, A. R.
	Articles by Orkin, S. H.
	Search for Related Content

PubMed

	PubMed Citation
	Articles by Migliaccio, A. R.
	Articles by Orkin, S. H.


Social Bookmarking

	What's this?

© Rockefeller University Press, 0022-1007/2003/2/281 $5.00
The Journal of Experimental Medicine, Volume 197, Number 3, 281-296

GATA-1 as a Regulator of Mast Cell Differentiation Revealed by the Phenotype of the GATA-1^low Mouse Mutant

Anna Rita Migliaccio¹^,2, Rosa Alba Rana¹, Massimo Sanchez³, Rodolfo Lorenzini⁴, Lucia Centurione¹, Lucia Bianchi⁵, Alessandro Maria Vannucchi⁵, Giovanni Migliaccio¹^,3 and Stuart H. Orkin⁶

¹ Department of Biomorphology, University G. D'Annunzio, 66100 Chieti, Italy
² Laboratory of Clinical Biochemistry, Istituto Superiore di Sanità, 00161 Rome, Italy
³ Laboratory of Cell Biology, Istituto Superiore di Sanità, 00161 Rome, Italy
⁴ Laboratory of Servizio Qualità Sicurezza Animale, Istituto Superiore di Sanità, 00161 Rome, Italy
⁵ Department of Hematology, University of Florence, 50139 Florence, Italy
⁶ Department of Pediatric Oncology, Children's Hospital, Dana Farber Cancer Institute, Harvard Medical School and Howard Hughes Medical Institute, Boston, MA 02115

Address correspondence to Anna Rita Migliaccio, Clinical Biochemistry, Istituto Superiore Sanità, Viale Regina Elena 299, 00161 Rome, Italy. Phone: 39-06-4990-2690; Fax: 39-06-4938-7143; E-mail: migliar{at}iss.it

Here it is shown that the phenotype of adult mice lacking thefirst enhancer (DNA hypersensitive site I) and the distal promoterof the GATA-1 gene (neo ${Delta}$ HS or GATA-1^low mutants) reveals defectsin mast cell development. These include the presence of morphologicallyabnormal alcian blue⁺ mast cells and apoptotic metachromatic^-mast cell precursors in connective tissues and peritoneal lavageand numerous (60–70% of all the progenitors) "unique"trilineage cells committed to erythroid, megakaryocytic, andmast pathways in the bone marrow and spleen. These abnormalities,which were mirrored by impaired mast differentiation in vitro,were reversed by retroviral-mediated expression of GATA-1 cDNA.These data indicate an essential role for GATA-1 in mast celldifferentiation.

Key Words: mast cells • GATA-1 • differentiation • commitment • progenitor cells

Add to CiteULike CiteULike Add to Complore Complore Add to Connotea Connotea Add to Del.icio.us Del.icio.us Add to Digg Digg Facebook Add to Reddit Reddit Add to Technorati Technorati Twitter What's this?

This article has been cited by other articles:

Gobel, F., Taschner, S., Jurkin, J., Konradi, S., Vaculik, C., Richter, S., Kneidinger, D., Muhlbacher, C., Bieglmayer, C., Elbe-Burger, A., Strobl, H. (2009). Reciprocal role of GATA-1 and vitamin D receptor in human myeloid dendritic cell differentiation. Blood 114: 3813-3821 [Abstract] [Full Text]
Hoeller, S., Bihl, M. P., Tzankov, A., Kuehne, T., Potthoff, C., Bruder, E. (2009). New GATA1 mutation in codon 2 leads to the earliest known premature stop codon in transient myeloproliferative disorder. Blood 114: 3717-3718 [Full Text]
Migliaccio, A. R., Martelli, F., Verrucci, M., Sanchez, M., Valeri, M., Migliaccio, G., Vannucchi, A. M., Zingariello, M., Di Baldassarre, A., Ghinassi, B., Rana, R. A., van Hensbergen, Y., Fibbe, W. E. (2009). Gata1 expression driven by the alternative HS2 enhancer in the spleen rescues the hematopoietic failure induced by the hypomorphic Gata1low mutation. Blood 114: 2107-2120 [Abstract] [Full Text]
Trainor, C. D., Mas, C., Archambault, P., Di Lello, P., Omichinski, J. G. (2009). GATA-1 associates with and inhibits p53. Blood 114: 165-173 [Abstract] [Full Text]
Tripic, T., Deng, W., Cheng, Y., Zhang, Y., Vakoc, C. R., Gregory, G. D., Hardison, R. C., Blobel, G. A. (2009). SCL and associated proteins distinguish active from repressive GATA transcription factor complexes. Blood 113: 2191-2201 [Abstract] [Full Text]
Bedi, R., Du, J., Sharma, A. K., Gomes, I., Ackerman, S. J. (2009). Human C/EBP-{epsilon} activator and repressor isoforms differentially reprogram myeloid lineage commitment and differentiation. Blood 113: 317-327 [Abstract] [Full Text]
Cheng, Y., King, D. C., Dore, L. C., Zhang, X., Zhou, Y., Zhang, Y., Dorman, C., Abebe, D., Kumar, S. A., Chiaromonte, F., Miller, W., Green, R. D., Weiss, M. J., Hardison, R. C. (2008). Transcriptional enhancement by GATA1-occupied DNA segments is strongly associated with evolutionary constraint on the binding site motif. Genome Res 18: 1896-1905 [Abstract] [Full Text]
Wozniak, R. J., Keles, S., Lugus, J. J., Young, K. H., Boyer, M. E., Tran, T. M., Choi, K., Bresnick, E. H. (2008). Molecular Hallmarks of Endogenous Chromatin Complexes Containing Master Regulators of Hematopoiesis. Mol. Cell. Biol. 28: 6681-6694 [Abstract] [Full Text]
Dobson, J. T., Seibert, J., Teh, E. M., Da'as, S., Fraser, R. B., Paw, B. H., Lin, T.-J., Berman, J. N. (2008). Carboxypeptidase A5 identifies a novel mast cell lineage in the zebrafish providing new insight into mast cell fate determination. Blood 112: 2969-2972 [Abstract] [Full Text]
Kashiwakura, J.-i., Xiao, W., Kitaura, J., Kawakami, Y., Maeda-Yamamoto, M., Pfeiffer, J. R., Wilson, B. S., Blank, U., Kawakami, T. (2008). Pivotal Advance: IgE accelerates in vitro development of mast cells and modifies their phenotype. J. Leukoc. Biol. 84: 357-367 [Abstract] [Full Text]
Cantor, A. B., Iwasaki, H., Arinobu, Y., Moran, T. B., Shigematsu, H., Sullivan, M. R., Akashi, K., Orkin, S. H. (2008). Antagonism of FOG-1 and GATA factors in fate choice for the mast cell lineage. JEM 205: 611-624 [Abstract] [Full Text]
Dore, L. C., Amigo, J. D., dos Santos, C. O., Zhang, Z., Gai, X., Tobias, J. W., Yu, D., Klein, A. M., Dorman, C., Wu, W., Hardison, R. C., Paw, B. H., Weiss, M. J. (2008). A GATA-1-regulated microRNA locus essential for erythropoiesis. Proc. Natl. Acad. Sci. USA 105: 3333-3338 [Abstract] [Full Text]
Sugiyama, D., Tanaka, M., Kitajima, K., Zheng, J., Yen, H., Murotani, T., Yamatodani, A., Nakano, T. (2008). Differential context-dependent effects of friend of GATA-1 (FOG-1) on mast-cell development and differentiation. Blood 111: 1924-1932 [Abstract] [Full Text]
Metcalf, D., Majewski, I., Mifsud, S., Di Rago, L., Alexander, W. S. (2007). Clonogenic mast cell progenitors and their excess numbers in chimeric BALB/c mice with inactivated GATA-1. Proc. Natl. Acad. Sci. USA 104: 18642-18647 [Abstract] [Full Text]
Salmon, J. M., Slater, N. J., Hall, M. A., McCormack, M. P., Nutt, S. L., Jane, S. M., Curtis, D. J. (2007). Aberrant mast-cell differentiation in mice lacking the stem-cell leukemia gene. Blood 110: 3573-3581 [Abstract] [Full Text]
Gutierrez, L., Nikolic, T., van Dijk, T. B., Hammad, H., Vos, N., Willart, M., Grosveld, F., Philipsen, S., Lambrecht, B. N. (2007). Gata1 regulates dendritic-cell development and survival. Blood 110: 1933-1941 [Abstract] [Full Text]
Kobayashi, M., Yamamoto, M. (2007). Regulation of GATA1 Gene Expression. J Biochem 142: 1-10 [Abstract] [Full Text]
Kim, S.-I., Bultman, S. J., Jing, H., Blobel, G. A., Bresnick, E. H. (2007). Dissecting Molecular Steps in Chromatin Domain Activation during Hematopoietic Differentiation. Mol. Cell. Biol. 27: 4551-4565 [Abstract] [Full Text]
Ferreira, R., Wai, A., Shimizu, R., Gillemans, N., Rottier, R., von Lindern, M., Ohneda, K., Grosveld, F., Yamamoto, M., Philipsen, S. (2007). Dynamic regulation of Gata factor levels is more important than their identity. Blood 109: 5481-5490 [Abstract] [Full Text]
Slape, C., Hartung, H., Lin, Y.-W., Bies, J., Wolff, L., Aplan, P. D. (2007). Retroviral Insertional Mutagenesis Identifies Genes that Collaborate with NUP98-HOXD13 during Leukemic Transformation. Cancer Res. 67: 5148-5155 [Abstract] [Full Text]
Crispino, J. D. (2007). On the origins of megakaryocytes. Blood 109: 1340-1341 [Full Text]
Ghinassi, B., Sanchez, M., Martelli, F., Amabile, G., Vannucchi, A. M., Migliaccio, G., Orkin, S. H., Migliaccio, A. R. (2007). The hypomorphic Gata1low mutation alters the proliferation/differentiation potential of the common megakaryocytic-erythroid progenitor. Blood 109: 1460-1471 [Abstract] [Full Text]
Masuda, A., Hashimoto, K., Yokoi, T., Doi, T., Kodama, T., Kume, H., Ohno, K., Matsuguchi, T. (2007). Essential Role of GATA Transcriptional Factors in the Activation of Mast Cells. J. Immunol. 178: 360-368 [Abstract] [Full Text]
Shahlaee, A. H., Brandal, S., Lee, Y.-N., Jie, C., Takemoto, C. M. (2007). Distinct and Shared Transcriptomes Are Regulated by Microphthalmia-Associated Transcription Factor Isoforms in Mast Cells. J. Immunol. 178: 378-388 [Abstract] [Full Text]
Ghinassi, B., Sanchez, M., Martelli, F., Amabile, G., Vannucchi, A. M., Migliaccio, G., Orkin, S. H., Migliaccio, A. R. (2006). The Hypomorphic Gata1low Mutation Alters the Proliferation/Differentiation Potential of the Common Megakaryocytic-Erythroid Progenitor.. ASH ANNUAL MEETING ABSTRACTS 108: 2549-2549 [Abstract]
Iwasaki, H., Mizuno, S.-i., Arinobu, Y., Ozawa, H., Mori, Y., Shigematsu, H., Takatsu, K., Tenen, D. G., Akashi, K. (2006). The order of expression of transcription factors directs hierarchical specification of hematopoietic lineages.. Genes Dev. 20: 3010-3021 [Abstract] [Full Text]
Fulkerson, P. C., Fischetti, C. A., McBride, M. L., Hassman, L. M., Hogan, S. P., Rothenberg, M. E. (2006). A central regulatory role for eosinophils and the eotaxin/CCR3 axis in chronic experimental allergic airway inflammation. Proc. Natl. Acad. Sci. USA 103: 16418-16423 [Abstract] [Full Text]
Swartz, J. M., Dyer, K. D., Cheever, A. W., Ramalingam, T., Pesnicak, L., Domachowske, J. B., Lee, J. J., Lee, N. A., Foster, P. S., Wynn, T. A., Rosenberg, H. F. (2006). Schistosoma mansoni infection in eosinophil lineage-ablated mice. Blood 108: 2420-2427 [Abstract] [Full Text]
Majewski, I. J., Metcalf, D., Mielke, L. A., Krebs, D. L., Ellis, S., Carpinelli, M. R., Mifsud, S., Di Rago, L., Corbin, J., Nicola, N. A., Hilton, D. J., Alexander, W. S. (2006). A mutation in the translation initiation codon of Gata-1 disrupts megakaryocyte maturation and causes thrombocytopenia. Proc. Natl. Acad. Sci. USA 103: 14146-14151 [Abstract] [Full Text]
Kanehira, M., Kaifu, T., Maya, K., Kaji, M., Nakamura, A., Obinata, M., Takai, T. (2006). Novel Mast Cell Lines with Enhanced Proliferative and Degranulative Abilities Established from Temperature-Sensitive SV40 Large T Antigen Transgenic Mice. J Biochem 140: 211-220 [Abstract] [Full Text]
Zhou, D., Pawlik, K. M., Ren, J., Sun, C.-W., Townes, T. M. (2006). Differential Binding of Erythroid Krupple-like Factor to Embryonic/Fetal Globin Gene Promoters during Development. J. Biol. Chem. 281: 16052-16057 [Abstract] [Full Text]
Nigo, Y. I., Yamashita, M., Hirahara, K., Shinnakasu, R., Inami, M., Kimura, M., Hasegawa, A., Kohno, Y., Nakayama, T. (2006). Regulation of allergic airway inflammation through Toll-like receptor 4-mediated modification of mast cell function. Proc. Natl. Acad. Sci. USA 103: 2286-2291 [Abstract] [Full Text]
Oki, T., Kitaura, J., Eto, K., Lu, Y., Maeda-Yamamoto, M., Inagaki, N., Nagai, H., Yamanishi, Y., Nakajina, H., Kumagai, H., Kitamura, T. (2006). Integrin {alpha}IIb{beta}3 Induces the Adhesion and Activation of Mast Cells through Interaction with Fibrinogen. J. Immunol. 176: 52-60 [Abstract] [Full Text]
Stachura, D. L., Chou, S. T., Weiss, M. J. (2006). Early block to erythromegakaryocytic development conferred by loss of transcription factor GATA-1. Blood 107: 87-97 [Abstract] [Full Text]
Martelli, F., Ghinassi, B., Panetta, B., Alfani, E., Gatta, V., Pancrazzi, A., Bogani, C., Vannucchi, A. M., Paoletti, F., Migliaccio, G., Migliaccio, A. R. (2005). Variegation of the phenotype induced by the Gata1low mutation in mice of different genetic backgrounds. Blood 106: 4102-4113 [Abstract] [Full Text]
Kadri, Z., Maouche-Chretien, L., Rooke, H. M., Orkin, S. H., Romeo, P.-H., Mayeux, P., Leboulch, P., Chretien, S. (2005). Phosphatidylinositol 3-Kinase/Akt Induced by Erythropoietin Renders the Erythroid Differentiation Factor GATA-1 Competent for TIMP-1 Gene Transactivation. Mol. Cell. Biol. 25: 7412-7422 [Abstract] [Full Text]
Vannucchi, A. M., Pancrazzi, A., Guglielmelli, P., Di Lollo, S., Bogani, C., Baroni, G., Bianchi, L., Migliaccio, A. R., Bosi, A., Paoletti, F. (2005). Abnormalities of GATA-1 in Megakaryocytes from Patients with Idiopathic Myelofibrosis. Am. J. Pathol. 167: 849-858 [Abstract] [Full Text]
Rosenbauer, F., Koschmieder, S., Steidl, U., Tenen, D. G. (2005). Effect of transcription-factor concentrations on leukemic stem cells. Blood 106: 1519-1524 [Abstract] [Full Text]
Munugalavadla, V., Dore, L. C., Tan, B. L., Hong, L., Vishnu, M., Weiss, M. J., Kapur, R. (2005). Repression of c-Kit and Its Downstream Substrates by GATA-1 Inhibits Cell Proliferation during Erythroid Maturation. Mol. Cell. Biol. 25: 6747-6759 [Abstract] [Full Text]
Nishiyama, C., Ito, T., Nishiyama, M., Masaki, S., Maeda, K., Nakano, N., Ng, W., Fukuyama, K., Yamamoto, M., Okumura, K., Ogawa, H. (2005). GATA-1 is required for expression of Fc{varepsilon}RI on mast cells: analysis of mast cells derived from GATA-1 knockdown mouse bone marrow. Int Immunol 17: 847-856 [Abstract] [Full Text]
Vannucchi, A. M., Bianchi, L., Paoletti, F., Pancrazzi, A., Torre, E., Nishikawa, M., Zingariello, M., Di Baldassarre, A., Rana, R. A., Lorenzini, R., Alfani, E., Migliaccio, G., Migliaccio, A. R. (2005). A pathobiologic pathway linking thrombopoietin, GATA-1, and TGF-{beta}1 in the development of myelofibrosis. Blood 105: 3493-3501 [Abstract] [Full Text]
Ferreira, R., Ohneda, K., Yamamoto, M., Philipsen, S. (2005). GATA1 Function, a Paradigm for Transcription Factors in Hematopoiesis. Mol. Cell. Biol. 25: 1215-1227 [Full Text]
Centurione, L., Di Baldassarre, A., Zingariello, M., Bosco, D., Gatta, V., Rana, R. A., Langella, V., Di Virgilio, A., Vannucchi, A. M., Migliaccio, A. R. (2004). Increased and pathologic emperipolesis of neutrophils within megakaryocytes associated with marrow fibrosis in GATA-1low mice. Blood 104: 3573-3580 [Abstract] [Full Text]
Migliaccio, G., Ghinassi, B., Centurione, L., Zingariello, M., Bianchi, L., Pancrazi, A., Paoletti, F., Vannucchi, A. M., Rana, R. A., Nishikawa, M., Migliaccio, A. R. (2004). Thrombopoietin Regulates Proliferation and Maturation of Murine Mast Cells.. ASH ANNUAL MEETING ABSTRACTS 104: 1707-1707 [Abstract]
Valverde-Garduno, V., Guyot, B., Anguita, E., Hamlett, I., Porcher, C., Vyas, P. (2004). Differences in the chromatin structure and cis-element organization of the human and mouse GATA1 loci: implications for cis-element identification. Blood 104: 3106-3116 [Abstract] [Full Text]
Welch, J. J., Watts, J. A., Vakoc, C. R., Yao, Y., Wang, H., Hardison, R. C., Blobel, G. A., Chodosh, L. A., Weiss, M. J. (2004). Global regulation of erythroid gene expression by transcription factor GATA-1. Blood 104: 3136-3147 [Abstract] [Full Text]
Humbles, A. A., Lloyd, C. M., McMillan, S. J., Friend, D. S., Xanthou, G., McKenna, Erin. E., Ghiran, S., Gerard, N. P., Yu, C., Orkin, S. H., Gerard, C. (2004). A Critical Role for Eosinophils in Allergic Airways Remodeling. Science 305: 1776-1779 [Abstract] [Full Text]
Gurbuxani, S., Vyas, P., Crispino, J. D. (2004). Recent insights into the mechanisms of myeloid leukemogenesis in Down syndrome. Blood 103: 399-406 [Abstract] [Full Text]
Fujiwara, Y., Chang, A. N., Williams, A. M., Orkin, S. H. (2004). Functional overlap of GATA-1 and GATA-2 in primitive hematopoietic development. Blood 103: 583-585 [Abstract] [Full Text]
Katz, S. G., Williams, A., Yang, J., Fujiwara, Y., Tsang, A. P., Epstein, J. A., Orkin, S. H. (2003). Endothelial lineage-mediated loss of the GATA cofactor Friend of GATA 1 impairs cardiac development. Proc. Natl. Acad. Sci. USA 100: 14030-14035 [Abstract] [Full Text]
Suzuki, N., Suwabe, N., Ohneda, O., Obara, N., Imagawa, S., Pan, X., Motohashi, H., Yamamoto, M. (2003). Identification and characterization of 2 types of erythroid progenitors that express GATA-1 at distinct levels. Blood 102: 3575-3583 [Abstract] [Full Text]
Ghirlando, R., Trainor, C. D. (2003). Determinants of GATA-1 Binding to DNA: THE ROLE OF NON-FINGER RESIDUES. J. Biol. Chem. 278: 45620-45628 [Abstract] [Full Text]
Hartmann, K., Artuc, M., Baldus, S. E., Zirbes, T. K., Hermes, B., Thiele, J., Mekori, Y. A., Henz, B. M. (2003). Expression of Bcl-2 and Bcl-xL in Cutaneous and Bone Marrow Lesions of Mastocytosis. Am. J. Pathol. 163: 819-826 [Abstract] [Full Text]
Spivak, J. L., Barosi, G., Tognoni, G., Barbui, T., Finazzi, G., Marchioli, R., Marchetti, M. (2003). Chronic Myeloproliferative Disorders. ASH Education Book 2003: 200-224 [Abstract] [Full Text]