Home | Help | Feedback | Subscriptions | Archive | Search | Table of Contents

This Article Full Text Full Text (PDF, 235K) PPT slides of all figures Alert me when this article is cited Citation Map Services Email this article Similar articles in this journal Similar articles in PubMed Alert me to new content in the JEM Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Purdy, A. Articles by Golovkina, T. Search for Related Content PubMed PubMed Citation Articles by Purdy, A. Articles by Golovkina, T. Pubmed/NCBI databases Gene GEO Profiles HomoloGene UniGene Substance via MeSH Social Bookmarking                            What's this?

Unique Resistance of I/LnJ Mice to a Retrovirus Is Due to Sustained Interferon –dependent Production of Virus-neutralizing Antibodies

Alexandra Purdy, Laure Case, Melody Duvall, Max Overstrom-Coleman, Nilah Monnier, Alexander Chervonsky and Tatyana Golovkina

The Jackson Laboratory, Bar Harbor, ME 04609

Address correspondence to Dr. T. Golovkina, The Jackson Laboratory, 600 Main St., Bar Harbor, ME 04609. Phone: 207-288-6287; Fax: 207-288-6078; E-mail: tvg{at}aretha.jax.org

Selection of immune escape variants impairs the ability of the immune system to sustain an efficient antiviral response and to control retroviral infections. Like other retroviruses, mouse mammary tumor virus (MMTV) is not efficiently eliminated by the immune system of susceptible mice. In contrast, MMTV-infected I/LnJ mice are capable of producing IgG2a virus-neutralizing antibodies, sustain this response throughout their life, and secrete antibody-coated virions into the milk, thereby preventing infection of their progeny. Antibodies were produced in response to several MMTV variants and were cross-reactive to them. Resistance to MMTV infection was recessive and was dependent on interferon (IFN)- production, because I/LnJ mice with targeted deletion of the INF- gene failed to produce any virus-neutralizing antibodies. These findings reveal a novel mechanism of resistance to retroviral infection that is based on a robust and sustained IFN-–dependent humoral immune response.

Key Words: IFN- • virus-neutralizing antibodies • retrovirus • infection • resistance

CiteULike    Complore    Connotea    Del.icio.us    Digg    Facebook    Reddit    Technorati    Twitter    What's this?

This article has been cited by other articles:

• Okeoma, C. M., Petersen, J., Ross, S. R. (2009). Expression of Murine APOBEC3 Alleles in Different Mouse Strains and Their Effect on Mouse Mammary Tumor Virus Infection. J. Virol. 83: 3029-3038 [Abstract] [Full Text]  
• Okeoma, C. M., Shen, M., Ross, S. R. (2008). A Novel Block to Mouse Mammary Tumor Virus Infection of Lymphocytes in B10.BR Mice. J. Virol. 82: 1314-1322 [Abstract] [Full Text]  
• Case, L. K., Petell, L., Yurkovetskiy, L., Purdy, A., Savage, K. J., Golovkina, T. V. (2008). Replication of Beta- and Gammaretroviruses Is Restricted in I/LnJ Mice via the Same Genetic Mechanism. J. Virol. 82: 1438-1447 [Abstract] [Full Text]  
• Swanson, I., Jude, B. A., Zhang, A. R., Pucker, A., Smith, Z. E., Golovkina, T. V. (2006). Sequences within the gag Gene of Mouse Mammary Tumor Virus Needed for Mammary Gland Cell Transformation.. J. Virol. 80: 3215-3224 [Abstract] [Full Text]  
• MacDearmid, C. C., Case, L. K., Starling, C. L., Golovkina, T. V. (2006). Gradual Elimination of Retroviruses in YBR/Ei Mice. J. Virol. 80: 2206-2215 [Abstract] [Full Text]  
• Mertz, J. A., Simper, M. S., Lozano, M. M., Payne, S. M., Dudley, J. P. (2005). Mouse Mammary Tumor Virus Encodes a Self-Regulatory RNA Export Protein and Is a Complex Retrovirus. J. Virol. 79: 14737-14747 [Abstract] [Full Text]  
• Case, L. K., Purdy, A., Golovkina, T. V. (2005). Molecular and Cellular Basis of the Retrovirus Resistance in I/LnJ Mice. J. Immunol. 175: 7543-7549 [Abstract] [Full Text]  
• Bhadra, S., Lozano, M. M., Dudley, J. P. (2005). Conversion of Mouse Mammary Tumor Virus to a Lymphomagenic Virus. J. Virol. 79: 12592-12596 [Abstract] [Full Text]  
• Seo, J., Lozano, M. M., Dudley, J. P. (2005). Nuclear Matrix Binding Regulates SATB1-mediated Transcriptional Repression. J. Biol. Chem. 280: 24600-24609 [Abstract] [Full Text]  
• Etkind, P. R., Stewart, A. F. R., Dorai, T., Purcell, D. J., Wiernik, P. H. (2004). Clonal Isolation of Different Strains of Mouse Mammary Tumor Virus-Like DNA Sequences from Both the Breast Tumors and Non-Hodgkin's Lymphomas of Individual Patients Diagnosed with Both Malignancies. Clin. Cancer Res. 10: 5656-5664 [Abstract] [Full Text]  
• Pobezinskaya, Y., Chervonsky, A. V., Golovkina, T. V. (2004). Initial Stages of Mammary Tumor Virus Infection Are Superantigen Independent. J. Immunol. 172: 5582-5587 [Abstract] [Full Text]  
• Zhang, Y., Rassa, J. C., deObaldia, M. E., Albritton, L. M., Ross, S. R. (2003). Identification of the Receptor Binding Domain of the Mouse Mammary Tumor Virus Envelope Protein. J. Virol. 77: 10468-10478 [Abstract] [Full Text]  
• Mpandi, M., Otten, L. A., Lavanchy, C., Acha-Orbea, H., Finke, D. (2003). Passive Immunization with Neutralizing Antibodies Interrupts the Mouse Mammary Tumor Virus Life Cycle. J. Virol. 77: 9369-9377 [Abstract] [Full Text]  
• Xu, L., Shen, Z., Guo, L., Fodera, B., Keogh, A., Joplin, R., O'Donnell, B., Aitken, J., Carman, W., Neuberger, J., Mason, A. (2003). Does a betaretrovirus infection trigger primary biliary cirrhosis?. Proc. Natl. Acad. Sci. USA 100: 8454-8459 [Abstract] [Full Text]  

Home | Help | Feedback | Subscriptions | Archive | Search

TABLE OF CONTENTS