CD4+CD25+ Immunoregulatory T Cells: New Therapeutics for Graft-Versus-Host Disease

doi:10.1084/jem.20020090

Published 5 August 2002. doi:10.1084/jem.20020090

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© Rockefeller University Press, 0022-1007/2002/8/401/ $5.00
The Journal of Experimental Medicine, Volume 196, Number 3, August 5, 2002 401-406

Brief Definitive Report

CD4⁺CD25⁺ Immunoregulatory T Cells : New Therapeutics for Graft-Versus-Host Disease

José L. Cohen, Aurélie Trenado, Douglas Vasey, David Klatzmann and Benoît L. Salomon

Laboratoire de Biologie et Thérapeutique des Pathologies Immunitaires, Centre National de la Recherche Scientifique UMR 7087, Hôpital Pitié-Salpêtrière, 756651 Paris, France

Address correspondence to Benoît L. Salomon, Laboratoire de Biologie et Thérapeutique des Pathologies Immunitaires, CNRS UMR 7087, Hôpital Pitié-Salpêtrière, 83, bd de l'Hôpital, 756651 Paris, France. Phone: 33-1-42-17-74-61; Fax: 33-1-42-17-74-62; E-mail: benoit.salomon{at}chups.jussieu.fr

CD4⁺CD25⁺ immunoregulatory T cells play a pivotal role in preventingorgan-specific autoimmune diseases and in tolerance inductionto allogeneic organ transplants. We investigated whether thesecells could also control graft-versus-host disease (GVHD), themain complication after allogeneic hematopoietic stem cell transplantation(HSCT). Here, we show that the few CD4⁺CD25⁺ T cells naturallypresent in the transplant regulate GVHD because their removalfrom the graft dramatically accelerates this disease. Furthermore,the addition of freshly isolated CD4⁺CD25⁺ T cells at time ofgrafting significantly delays or even prevents GVHD. Ex vivo–expandedCD4⁺CD25⁺ regulatory T cells obtained after stimulation by allogeneicrecipient-type antigen-presenting cells can also modulate GVHD.Thus, CD4⁺CD25⁺ regulatory T cells represent a new therapeutictool for controlling GVHD in allogeneic HSCT. More generally,these results outline the tremendous potential of regulatoryT cells as therapeutics.

Key Words: regulatory T cells • hematopoietic stem cell transplantation • GVHD • tolerance • in vivo animal models

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Xie, Y., Wu, M., Song, R., Ma, J., Shi, Y., Qin, W., Jin, Y. (2009). A glucocorticoid amplifies IL-2-induced selective expansion of CD4+CD25+FOXP3+ regulatory T cells in vivo and suppresses graft-versus-host disease after allogeneic lymphocyte transplantation. Acta Biochim Biophys Sin 41: 781-791 [Abstract] [Full Text]
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Bohana-Kashtan, O., Morisot, S., Hildreth, R., Brayton, C., Levitsky, H. I., Civin, C. I. (2009). Selective Reduction of Graft-versus-Host Disease-Mediating Human T Cells by Ex Vivo Treatment with Soluble Fas Ligand. J. Immunol. 183: 696-705 [Abstract] [Full Text]
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Wang, H., Asavaroengchai, W., Yong Yeap, B., Wang, M.-G., Wang, S., Sykes, M., Yang, Y.-G. (2009). Paradoxical effects of IFN-{gamma} in graft-versus-host disease reflect promotion of lymphohematopoietic graft-versus-host reactions and inhibition of epithelial tissue injury. Blood 113: 3612-3619 [Abstract] [Full Text]
Allenbach, Y., Solly, S., Gregoire, S., Dubourg, O., Salomon, B., Butler-Browne, G., Musset, L., Herson, S., Klatzmann, D., Benveniste, O. (2009). Role of Regulatory T Cells in a New Mouse Model of Experimental Autoimmune Myositis. Am. J. Pathol. 174: 989-998 [Abstract] [Full Text]
Verma, N. D., Plain, K. M., Nomura, M., Tran, G. T., Robinson, C., Boyd, R., Hodgkinson, S. J., Hall, B. M. (2009). CD4+CD25+ T cells alloactivated ex vivo by IL-2 or IL-4 become potent alloantigen-specific inhibitors of rejection with different phenotypes, suggesting separate pathways of activation by Th1 and Th2 responses. Blood 113: 479-487 [Abstract] [Full Text]
Hippen, K. L., Harker-Murray, P., Porter, S. B., Merkel, S. C., Londer, A., Taylor, D. K., Bina, M., Panoskaltsis-Mortari, A., Rubinstein, P., Van Rooijen, N., Golovina, T. N., Suhoski, M. M., Miller, J. S., Wagner, J. E., June, C. H., Riley, J. L., Blazar, B. R. (2008). Umbilical cord blood regulatory T-cell expansion and functional effects of tumor necrosis factor receptor family members OX40 and 4-1BB expressed on artificial antigen-presenting cells. Blood 112: 2847-2857 [Abstract] [Full Text]
Zhao, D., Zhang, C., Yi, T., Lin, C.-L., Todorov, I., Kandeel, F., Forman, S., Zeng, D. (2008). In vivo-activated CD103+CD4+ regulatory T cells ameliorate ongoing chronic graft-versus-host disease. Blood 112: 2129-2138 [Abstract] [Full Text]
Anderson, B. E., Taylor, P. A., McNiff, J. M., Jain, D., Demetris, A. J., Panoskaltsis-Mortari, A., Ager, A., Blazar, B. R., Shlomchik, W. D., Shlomchik, M. J. (2008). Effects of donor T-cell trafficking and priming site on graft-versus-host disease induction by naive and memory phenotype CD4 T cells. Blood 111: 5242-5251 [Abstract] [Full Text]
Ruzek, M. C., Waire, J. S., Hopkins, D., LaCorcia, G., Sullivan, J., Roberts, B. L., Richards, S. M., Nahill, S. R., Williams, J. M., Scaria, A., Dzuris, J., Shankara, S., Garman, R. D. (2008). Characterization of in vitro antimurine thymocyte globulin-induced regulatory T cells that inhibit graft-versus-host disease in vivo. Blood 111: 1726-1734 [Abstract] [Full Text]
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Pallandre, J.-R., Brillard, E., Crehange, G., Radlovic, A., Remy-Martin, J.-P., Saas, P., Rohrlich, P.-S., Pivot, X., Ling, X., Tiberghien, P., Borg, C. (2007). Role of STAT3 in CD4+CD25+FOXP3+ Regulatory Lymphocyte Generation: Implications in Graft-versus-Host Disease and Antitumor Immunity. J. Immunol. 179: 7593-7604 [Abstract] [Full Text]
Giorgini, A., Noble, A. (2007). Blockade of chronic graft-versus-host disease by alloantigen-induced CD4+CD25+Foxp3+ regulatory T cells in nonlymphopenic hosts. J. Leukoc. Biol. 82: 1053-1061 [Abstract] [Full Text]
Taylor, P. A., Ehrhardt, M. J., Lees, C. J., Tolar, J., Weigel, B. J., Panoskaltsis-Mortari, A., Serody, J. S., Brinkmann, V., Blazar, B. R. (2007). Insights into the mechanism of FTY720 and compatibility with regulatory T cells for the inhibition of graft-versus-host disease (GVHD). Blood 110: 3480-3488 [Abstract] [Full Text]
Hubert, P., Jacobs, N., Caberg, J.-H., Boniver, J., Delvenne, P. (2007). The cross-talk between dendritic and regulatory T cells: good or evil?. J. Leukoc. Biol. 82: 781-794 [Abstract] [Full Text]
Taylor, K. N., Shinde-Patil, V. R., Cohick, E., Colson, Y. L. (2007). Induction of FoxP3+CD4+25+ Regulatory T Cells Following Hemopoietic Stem Cell Transplantation: Role of Bone Marrow-Derived Facilitating Cells. J. Immunol. 179: 2153-2162 [Abstract] [Full Text]
Chakraverty, R., Sykes, M. (2007). The role of antigen-presenting cells in triggering graft-versus-host disease and graft-versus-leukemia. Blood 110: 9-17 [Abstract] [Full Text]
Weng, L., Dyson, J., Dazzi, F. (2007). Low-intensity transplant regimens facilitate recruitment of donor-specific regulatory T cells that promote hematopoietic engraftment. Proc. Natl. Acad. Sci. USA 104: 8415-8420 [Abstract] [Full Text]
Luo, X., Tarbell, K. V., Yang, H., Pothoven, K., Bailey, S. L., Ding, R., Steinman, R. M., Suthanthiran, M. (2007). Dendritic cells with TGF-beta1 differentiate naive CD4+CD25- T cells into islet-protective Foxp3+ regulatory T cells. Proc. Natl. Acad. Sci. USA 104: 2821-2826 [Abstract] [Full Text]
Golshayan, D., Jiang, S., Tsang, J., Garin, M. I., Mottet, C., Lechler, R. I. (2007). In vitro-expanded donor alloantigen-specific CD4+CD25+ regulatory T cells promote experimental transplantation tolerance. Blood 109: 827-835 [Abstract] [Full Text]
Hoffmann, P., Eder, R., Boeld, T. J., Doser, K., Piseshka, B., Andreesen, R., Edinger, M. (2006). Only the CD45RA+ subpopulation of CD4+CD25high T cells gives rise to homogeneous regulatory T-cell lines upon in vitro expansion. Blood 108: 4260-4267 [Abstract] [Full Text]
Mutis, T., van Rijn, R. S., Simonetti, E. R., Aarts-Riemens, T., Emmelot, M. E., van Bloois, L., Martens, A., Verdonck, L. F., Ebeling, S. B. (2006). Human Regulatory T Cells Control Xenogeneic Graft-versus-Host Disease Induced by Autologous T Cells in RAG2-/-{gamma}c-/- Immunodeficient Mice.. Clin. Cancer Res. 12: 5520-5525 [Abstract] [Full Text]
Gross, D.-A., Chappert, P., Leboeuf, M., Monteilhet, V., Van Wittenberghe, L., Danos, O., Davoust, J. (2006). Simple conditioning with monospecific CD4+CD25+ regulatory T cells for bone marrow engraftment and tolerance to multiple gene products. Blood 108: 1841-1848 [Abstract] [Full Text]
Billiard, F., Litvinova, E., Saadoun, D., Djelti, F., Klatzmann, D., Cohen, J. L., Marodon, G., Salomon, B. L. (2006). Regulatory and Effector T Cell Activation Levels Are Prime Determinants of In Vivo Immune Regulation. J. Immunol. 177: 2167-2174 [Abstract] [Full Text]
Rezvani, K., Mielke, S., Ahmadzadeh, M., Kilical, Y., Savani, B. N., Zeilah, J., Keyvanfar, K., Montero, A., Hensel, N., Kurlander, R., Barrett, A. J. (2006). High donor FOXP3-positive regulatory T-cell (Treg) content is associated with a low risk of GVHD following HLA-matched allogeneic SCT. Blood 108: 1291-1297 [Abstract] [Full Text]
Valmori, D., Tosello, V., Souleimanian, N. E., Godefroy, E., Scotto, L., Wang, Y., Ayyoub, M. (2006). Rapamycin-Mediated Enrichment of T Cells with Regulatory Activity in Stimulated CD4+ T Cell Cultures Is Not Due to the Selective Expansion of Naturally Occurring Regulatory T Cells but to the Induction of Regulatory Functions in Conventional CD4+ T Cells. J. Immunol. 177: 944-949 [Abstract] [Full Text]
Adeegbe, D., Bayer, A. L., Levy, R. B., Malek, T. R. (2006). Cutting Edge: Allogeneic CD4+CD25+Foxp3+ T Regulatory Cells Suppress Autoimmunity while Establishing Transplantation Tolerance.. J. Immunol. 176: 7149-7153 [Abstract] [Full Text]
Terrada, C., Fisson, S., De Kozak, Y., Kaddouri, M., Lehoang, P., Klatzmann, D., Salomon, B. L., Bodaghi, B. (2006). Regulatory T cells control uveoretinitis induced by pathogenic Th1 cells reacting to a specific retinal neoantigen.. J. Immunol. 176: 7171-7179 [Abstract] [Full Text]
Nishioka, T., Shimizu, J., Iida, R., Yamazaki, S., Sakaguchi, S. (2006). CD4+CD25+Foxp3+ T Cells and CD4+CD25-Foxp3+ T Cells in Aged Mice.. J. Immunol. 176: 6586-6593 [Abstract] [Full Text]
Zhang, C., Todorov, I., Zhang, Z., Liu, Y., Kandeel, F., Forman, S., Strober, S., Zeng, D. (2006). Donor CD4+ T and B cells in transplants induce chronic graft-versus-host disease with autoimmune manifestations. Blood 107: 2993-3001 [Abstract] [Full Text]
Raimondi, G., Shufesky, W. J., Tokita, D., Morelli, A. E., Thomson, A. W. (2006). Regulated Compartmentalization of Programmed Cell Death-1 Discriminates CD4+CD25+ Resting Regulatory T Cells from Activated T Cells.. J. Immunol. 176: 2808-2816 [Abstract] [Full Text]
Yamazaki, S., Patel, M., Harper, A., Bonito, A., Fukuyama, H., Pack, M., Tarbell, K. V., Talmor, M., Ravetch, J. V., Inaba, K., Steinman, R. M. (2006). Effective expansion of alloantigen-specific Foxp3+ CD25+ CD4+ regulatory T cells by dendritic cells during the mixed leukocyte reaction. Proc. Natl. Acad. Sci. USA 103: 2758-2763 [Abstract] [Full Text]
Rieger, K., Loddenkemper, C., Maul, J., Fietz, T., Wolff, D., Terpe, H., Steiner, B., Berg, E., Miehlke, S., Bornhauser, M., Schneider, T., Zeitz, M., Stein, H., Thiel, E., Duchmann, R., Uharek, L. (2006). Mucosal FOXP3+ regulatory T cells are numerically deficient in acute and chronic GvHD. Blood 107: 1717-1723 [Abstract] [Full Text]
Zheng, S. G., Meng, L., Wang, J. H., Watanabe, M., Barr, M. L., Cramer, D. V., Gray, J. D., Horwitz, D. A. (2006). Transfer of regulatory T cells generated ex vivo modifies graft rejection through induction of tolerogenic CD4+CD25+ cells in the recipient. Int Immunol 18: 279-289 [Abstract] [Full Text]
Trenado, A., Sudres, M., Tang, Q., Maury, S., Charlotte, F., Gregoire, S., Bonyhadi, M., Klatzmann, D., Salomon, B. L., Cohen, J. L. (2006). Ex Vivo-Expanded CD4+CD25+ Immunoregulatory T Cells Prevent Graft-versus-Host-Disease by Inhibiting Activation/Differentiation of Pathogenic T Cells. J. Immunol. 176: 1266-1273 [Abstract] [Full Text]
Firan, M., Dhillon, S., Estess, P., Siegelman, M. H. (2006). Suppressor activity and potency among regulatory T cells is discriminated by functionally active CD44. Blood 107: 619-627 [Abstract] [Full Text]
Matsuoka, K.-i., Ichinohe, T., Hashimoto, D., Asakura, S., Tanimoto, M., Teshima, T. (2006). Fetal tolerance to maternal antigens improves the outcome of allogeneic bone marrow transplantation by a CD4+CD25+ T-cell-dependent mechanism. Blood 107: 404-409 [Abstract] [Full Text]
Delgado, M., Chorny, A., Gonzalez-Rey, E., Ganea, D. (2005). Vasoactive intestinal peptide generates CD4+CD25+ regulatory T cells in vivo. J. Leukoc. Biol. 78: 1327-1338 [Abstract] [Full Text]
Brinster, C., Shevach, E. M. (2005). Bone Marrow-Derived Dendritic Cells Reverse the Anergic State of CD4+CD25+ T Cells without Reversing Their Suppressive Function. J. Immunol. 175: 7332-7340 [Abstract] [Full Text]
Romagnoli, P., Hudrisier, D., van Meerwijk, J. P. M. (2005). Molecular Signature of Recent Thymic Selection Events on Effector and Regulatory CD4+ T Lymphocytes. J. Immunol. 175: 5751-5758 [Abstract] [Full Text]
Li, L., Godfrey, W. R., Porter, S. B., Ge, Y., June, C. H., Blazar, B. R., Boussiotis, V. A. (2005). CD4+CD25+ regulatory T-cell lines from human cord blood have functional and molecular properties of T-cell anergy. Blood 106: 3068-3073 [Abstract] [Full Text]
Wysocki, C. A., Jiang, Q., Panoskaltsis-Mortari, A., Taylor, P. A., McKinnon, K. P., Su, L., Blazar, B. R., Serody, J. S. (2005). Critical role for CCR5 in the function of donor CD4+CD25+ regulatory T cells during acute graft-versus-host disease. Blood 106: 3300-3307 [Abstract] [Full Text]
Zorn, E., Kim, H. T., Lee, S. J., Floyd, B. H., Litsa, D., Arumugarajah, S., Bellucci, R., Alyea, E. P., Antin, J. H., Soiffer, R. J., Ritz, J. (2005). Reduced frequency of FOXP3+ CD4+CD25+ regulatory T cells in patients with chronic graft-versus-host disease. Blood 106: 2903-2911 [Abstract] [Full Text]
Funatake, C. J., Marshall, N. B., Steppan, L. B., Mourich, D. V., Kerkvliet, N. I. (2005). Cutting Edge: Activation of the Aryl Hydrocarbon Receptor by 2,3,7,8-Tetrachlorodibenzo-p-dioxin Generates a Population of CD4+CD25+ Cells with Characteristics of Regulatory T Cells. J. Immunol. 175: 4184-4188 [Abstract] [Full Text]
Blazar, B. R, Murphy, W. J (2005). Bone marrow transplantation and approaches to avoid graft-versus-host disease (GVHD). Phil Trans R Soc B 360: 1747-1767 [Abstract] [Full Text]
Solomon, S. R., Mielke, S., Savani, B. N., Montero, A., Wisch, L., Childs, R., Hensel, N., Schindler, J., Ghetie, V., Leitman, S. F., Mai, T., Carter, C. S., Kurlander, R., Read, E. J., Vitetta, E. S., Barrett, A. J. (2005). Selective depletion of alloreactive donor lymphocytes: a novel method to reduce the severity of graft-versus-host disease in older patients undergoing matched sibling donor stem cell transplantation. Blood 106: 1123-1129 [Abstract] [Full Text]
Koenen, H. J. P. M., Fasse, E., Joosten, I. (2005). CD27/CFSE-Based Ex Vivo Selection of Highly Suppressive Alloantigen-Specific Human Regulatory T Cells. J. Immunol. 174: 7573-7583 [Abstract] [Full Text]
Darrasse-Jeze, G., Marodon, G., Salomon, B. L., Catala, M., Klatzmann, D. (2005). Ontogeny of CD4+CD25+ regulatory/suppressor T cells in human fetuses. Blood 105: 4715-4721 [Abstract] [Full Text]
Chung, Y., Lee, S.-H., Kim, D.-H., Kang, C.-Y. (2005). Complementary role of CD4+CD25+ regulatory T cells and TGF-{beta} in oral tolerance. J. Leukoc. Biol. 77: 906-913 [Abstract] [Full Text]
Taylor, P. A., Panoskaltsis-Mortari, A., Freeman, G. J., Sharpe, A. H., Noelle, R. J., Rudensky, A. Y., Mak, T. W., Serody, J. S., Blazar, B. R. (2005). Targeting of inducible costimulator (ICOS) expressed on alloreactive T cells down-regulates graft-versus-host disease (GVHD) and facilitates engraftment of allogeneic bone marrow (BM). Blood 105: 3372-3380 [Abstract] [Full Text]
Haeryfar, S. M. M., DiPaolo, R. J., Tscharke, D. C., Bennink, J. R., Yewdell, J. W. (2005). Regulatory T Cells Suppress CD8+ T Cell Responses Induced by Direct Priming and Cross-Priming and Moderate Immunodominance Disparities. J. Immunol. 174: 3344-3351 [Abstract] [Full Text]
Ermann, J., Hoffmann, P., Edinger, M., Dutt, S., Blankenberg, F. G., Higgins, J. P., Negrin, R. S., Fathman, C. G., Strober, S. (2005). Only the CD62L+ subpopulation of CD4+CD25+ regulatory T cells protects from lethal acute GVHD. Blood 105: 2220-2226 [Abstract] [Full Text]
Lombardi, G. (2005). CD4+CD25+ T cells, transplant engraftment, and allospecific tolerance. Blood 105: 1375-1376 [Full Text]
Veltkamp, C, Sartor, R B, Giese, T, Autschbach, F, Kaden, I, Veltkamp, R, Rost, D, Kallinowski, B, Stremmel, W (2005). Regulatory CD4+CD25+ cells reverse imbalances in the T cell pool of bone marrow transplanted TG{varepsilon}26 mice leading to the prevention of colitis. Gut 54: 207-214 [Abstract] [Full Text]
Godfrey, W. R., Spoden, D. J., Ge, Y. G., Baker, S. R., Liu, B., Levine, B. L., June, C. H., Blazar, B. R., Porter, S. B. (2005). Cord blood CD4+CD25+-derived T regulatory cell lines express FoxP3 protein and manifest potent suppressor function. Blood 105: 750-758 [Abstract] [Full Text]
Taylor, P. A., Panoskaltsis-Mortari, A., Swedin, J. M., Lucas, P. J., Gress, R. E., Levine, B. L., June, C. H., Serody, J. S., Blazar, B. R. (2004). L-Selectinhi but not the L-selectinlo CD4+25+ T-regulatory cells are potent inhibitors of GVHD and BM graft rejection. Blood 104: 3804-3812 [Abstract] [Full Text]
Colson, Y. L., Christopher, K., Glickman, J., Taylor, K. N., Wright, R., Perkins, D. L. (2004). Absence of clinical GVHD and the in vivo induction of regulatory T cells after transplantation of facilitating cells. Blood 104: 3829-3835 [Abstract] [Full Text]
Xystrakis, E., Dejean, A. S., Bernard, I., Druet, P., Liblau, R., Gonzalez-Dunia, D., Saoudi, A. (2004). Identification of a novel natural regulatory CD8 T-cell subset and analysis of its mechanism of regulation. Blood 104: 3294-3301 [Abstract] [Full Text]
Nardelli, D. T., Burchill, M. A., England, D. M., Torrealba, J., Callister, S. M., Schell, R. F. (2004). Association of CD4+ CD25+ T Cells with Prevention of Severe Destructive Arthritis in Borrelia burgdorferi-Vaccinated and Challenged Gamma Interferon-Deficient Mice Treated with Anti-Interleukin-17 Antibody. CVI 11: 1075-1084 [Abstract] [Full Text]
Moseman, E. A., Liang, X., Dawson, A. J., Panoskaltsis-Mortari, A., Krieg, A. M., Liu, Y.-J., Blazar, B. R., Chen, W. (2004). Human Plasmacytoid Dendritic Cells Activated by CpG Oligodeoxynucleotides Induce the Generation of CD4+CD25+ Regulatory T Cells. J. Immunol. 173: 4433-4442 [Abstract] [Full Text]
Miura, Y., Thoburn, C. J., Bright, E. C., Phelps, M. L., Shin, T., Matsui, E. C., Matsui, W. H., Arai, S., Fuchs, E. J., Vogelsang, G. B., Jones, R. J., Hess, A. D. (2004). Association of Foxp3 regulatory gene expression with graft-versus-host disease. Blood 104: 2187-2193 [Abstract] [Full Text]
Anderson, B. E., McNiff, J. M., Matte, C., Athanasiadis, I., Shlomchik, W. D., Shlomchik, M. J. (2004). Recipient CD4+ T cells that survive irradiation regulate chronic graft-versus-host disease. Blood 104: 1565-1573 [Abstract] [Full Text]
Nishimura, E., Sakihama, T., Setoguchi, R., Tanaka, K., Sakaguchi, S. (2004). Induction of antigen-specific immunologic tolerance by in vivo and in vitro antigen-specific expansion of naturally arising Foxp3+CD25+CD4+ regulatory T cells. Int Immunol 16: 1189-1201 [Abstract] [Full Text]
Hoffmann, P., Eder, R., Kunz-Schughart, L. A., Andreesen, R., Edinger, M. (2004). Large-scale in vitro expansion of polyclonal human CD4+CD25high regulatory T cells. Blood 104: 895-903 [Abstract] [Full Text]
Godfrey, W. R., Ge, Y. G., Spoden, D. J., Levine, B. L., June, C. H., Blazar, B. R., Porter, S. B. (2004). In vitro-expanded human CD4+CD25+ T-regulatory cells can markedly inhibit allogeneic dendritic cell-stimulated MLR cultures. Blood 104: 453-461 [Abstract] [Full Text]
Graca, L., Le Moine, A., Lin, C.-Y., Fairchild, P. J., Cobbold, S. P., Waldmann, H. (2004). Donor-specific transplantation tolerance: The paradoxical behavior of CD4+CD25+ T cells. Proc. Natl. Acad. Sci. USA 101: 10122-10126 [Abstract] [Full Text]
Joffre, O., Gorsse, N., Romagnoli, P., Hudrisier, D., van Meerwijk, J. P. M. (2004). Induction of antigen-specific tolerance to bone marrow allografts with CD4+CD25+ T lymphocytes. Blood 103: 4216-4221 [Abstract] [Full Text]
Sasaki, Y., Sakai, M., Miyazaki, S., Higuma, S., Shiozaki, A., Saito, S. (2004). Decidual and peripheral blood CD4+CD25+ regulatory T cells in early pregnancy subjects and spontaneous abortion cases. Mol Hum Reprod 10: 347-353 [Abstract] [Full Text]
Morris, E. S., MacDonald, K. P. A., Rowe, V., Johnson, D. H., Banovic, T., Clouston, A. D., Hill, G. R. (2004). Donor treatment with pegylated G-CSF augments the generation of IL-10-producing regulatory T cells and promotes transplantation tolerance. Blood 103: 3573-3581 [Abstract] [Full Text]
Clark, F. J., Gregg, R., Piper, K., Dunnion, D., Freeman, L., Griffiths, M., Begum, G., Mahendra, P., Craddock, C., Moss, P., Chakraverty, R. (2004). Chronic graft-versus-host disease is associated with increased numbers of peripheral blood CD4+CD25high regulatory T cells. Blood 103: 2410-2416 [Abstract] [Full Text]
Chen, B. J., Cui, X., Sempowski, G. D., Liu, C., Chao, N. J. (2004). Transfer of allogeneic CD62L- memory T cells without graft-versus-host disease. Blood 103: 1534-1541 [Abstract] [Full Text]
Stephens, L. A., Barclay, A. N., Mason, D. (2004). Phenotypic characterization of regulatory CD4+CD25+ T cells in rats. Int Immunol 16: 365-375 [Abstract] [Full Text]
Zheng, S. G., Wang, J. H., Koss, M. N., Quismorio, F. Jr., Gray, J. D., Horwitz, D. A. (2004). CD4+ and CD8+ Regulatory T Cells Generated Ex Vivo with IL-2 and TGF-{beta} Suppress a Stimulatory Graft-versus-Host Disease with a Lupus-Like Syndrome. J. Immunol. 172: 1531-1539 [Abstract] [Full Text]
Stanzani, M., Martins, S. L. R., Saliba, R. M., John, L. S. St., Bryan, S., Couriel, D., McMannis, J., Champlin, R. E., Molldrem, J. J., Komanduri, K. V. (2004). CD25 expression on donor CD4+ or CD8+ T cells is associated with an increased risk for graft-versus-host disease after HLA-identical stem cell transplantation in humans. Blood 103: 1140-1146 [Abstract] [Full Text]
Koenen, H. J. P. M., Fasse, E., Joosten, I. (2003). IL-15 and Cognate Antigen Successfully Expand De Novo-Induced Human Antigen-Specific Regulatory CD4+ T Cells That Require Antigen-Specific Activation for Suppression. J. Immunol. 171: 6431-6441 [Abstract] [Full Text]
Gross, D.-A., Leboeuf, M., Gjata, B., Danos, O., Davoust, J. (2003). CD4+CD25+ regulatory T cells inhibit immune-mediated transgene rejection. Blood 102: 4326-4328 [Abstract] [Full Text]
Fisson, S., Darrasse-Jeze, G., Litvinova, E., Septier, F., Klatzmann, D., Liblau, R., Salomon, B. L. (2003). Continuous Activation of Autoreactive CD4+ CD25+ Regulatory T Cells in the Steady State. JEM 198: 737-746 [Abstract] [Full Text]
Yamazaki, S., Iyoda, T., Tarbell, K., Olson, K., Velinzon, K., Inaba, K., Steinman, R. M. (2003). Direct Expansion of Functional CD25+ CD4+ Regulatory T Cells by Antigen-processing Dendritic Cells. JEM 198: 235-247 [Abstract] [Full Text]
Billiau, A. D., Fevery, S., Rutgeerts, O., Landuyt, W., Waer, M. (2003). Transient expansion of Mac1+Ly6-G+Ly6-C+ early myeloid cells with suppressor activity in spleens of murine radiation marrow chimeras: possible implications for the graft-versus-host and graft-versus-leukemia reactivity of donor lymphocyte infusions. Blood 102: 740-748 [Abstract] [Full Text]
Chen, Z.-m., O'Shaughnessy, M. J., Gramaglia, I., Panoskaltsis-Mortari, A., Murphy, W. J., Narula, S., Roncarolo, M. G., Blazar, B. R. (2003). IL-10 and TGF-{beta} induce alloreactive CD4+CD25- T cells to acquire regulatory cell function. Blood 101: 5076-5083 [Abstract] [Full Text]
Miller, G., Pillarisetty, V. G., Shah, A. B., Lahrs, S., DeMatteo, R. P. (2003). Murine Flt3 Ligand Expands Distinct Dendritic Cells with Both Tolerogenic and Immunogenic Properties. J. Immunol. 170: 3554-3564 [Abstract] [Full Text]