The Journal of Experimental Medicine
Torrey Pines Biolabs
  Home | Help | Feedback | Subscriptions | Archive | Search | Table of Contents
Published 1 July 2002. doi:10.1084/jem.20012094
This Article
Right arrow Full Text
Right arrow Full Text (PDF, 103K)
Right arrow PPT slides of all figures
Right arrow Alert me when this article is cited
Right arrow Citation Map
Services
Right arrow Email this article
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new content in the JEM
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via CrossRef
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Cohen, P. L.
Right arrow Articles by Reap, E. A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Cohen, P. L.
Right arrow Articles by Reap, E. A.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati  
What's this?
© Rockefeller University Press, 0022-1007/2002/7/135/ $5.00
The Journal of Experimental Medicine, Volume 196, Number 1, July 1, 2002 135-140

Brief Definitive Report

Delayed Apoptotic Cell Clearance and Lupus-like Autoimmunity in Mice Lacking the c-mer Membrane Tyrosine Kinase

Philip L. Cohen1, Roberto Caricchio1, Valsamma Abraham1, Todd D. Camenisch2, J. Charles Jennette3, Robert A.S. Roubey4, H. Shelton Earp4, Glenn Matsushima5 and Elizabeth A. Reap6

1 Department of Medicine, Division of Rheumatology, University of Pennsylvania, and Philadelphia Veterans Affairs Medical Center, Philadelphia, PA 19104
2 Department of Biochemistry and Molecular Biology, Mayo Clinic, Scottsdale, AZ 85259
3 Department of Pathology, University of North Carolina, Chapel Hill, NC 27599
4 Department of Medicine, University of North Carolina, Chapel Hill, NC 27599
5 Department of Microbiology/Immunology, University of North Carolina, Chapel Hill, NC 27599
6 AlphaVax, Durham, NC 27709

Address correspondence to P.L. Cohen, Department of Medicine, Division of Rheumatology, University of Pennsylvania, 421 Curie Boulevard, Suite 757, Philadelphia, PA 19104. Phone: 215-573-2956; Fax: 215-573-7599; E-mail: philipco{at}mail.med.upenn.edu

Mice lacking the membrane tyrosine kinase c-mer have been shown to have altered macro-phage cytokine production and defective phagocytosis of apoptotic cells despite normal phagocytosis of other particles. We show here that c-mer–deficient mice have impaired clearance of infused apoptotic cells and that they develop progressive lupus-like autoimmunity, with antibodies to chromatin, DNA, and IgG. The autoimmunity appears to be driven by endogenous antigens, with little polyclonal B cell activation. These mice should be an excellent model for studying the role of apoptotic debris as an immunogenic stimulus for systemic autoimmunity.

Key Words: autoimmunity • Lupus Erythematosus, systemic • phagocytosis • apoptosis • macrophages


Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati    What's this?


This article has been cited by other articles:



  Home | Help | Feedback | Subscriptions | Archive | Search
TABLE OF CONTENTS