Home | Help | Feedback | Subscriptions | Archive | Search | Table of Contents

This Article Full Text Full Text (PDF, 177K) PPT slides of all figures Alert me when this article is cited Citation Map Services Email this article Similar articles in this journal Similar articles in PubMed Alert me to new content in the JEM Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Wright, D. E. Articles by Weissman, I. L. Search for Related Content PubMed PubMed Citation Articles by Wright, D. E. Articles by Weissman, I. L. Pubmed/NCBI databases Substance via MeSH Medline Plus Health Information Stem Cells Social Bookmarking                            What's this?

Hematopoietic Stem Cells Are Uniquely Selective in Their Migratory Response to Chemokines

Douglas E. Wright¹, Edward P. Bowman^2,3,4,5, Amy J. Wagers¹, Eugene C. Butcher^2,3,4 and Irving L. Weissman¹

¹ Departments of Pathology and Developmental Biology, Department of Pathology
² Laboratory of Immunology and Vascular Biology, Department of Pathology
³ Digestive Disease Center, Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305
⁴ Center for Molecular Biology and Medicine, Veterans Affairs, Palo Alto Health Care System, Palo Alto, CA 94305
⁵ Department of Immunology, DNAX Research Institute, Palo Alto, CA 94304

Address correspondence to Douglas E. Wright, Department of Pathology (5324), Beckman B-261, 279 Campus Drive, Stanford University School of Medicine, Stanford, CA 94305. Phone: 650-725-5808; Fax: 650-498-6255; E-mail: doug.wright{at}stanford.edu

Although hematopoietic stem cell (HSC) migration into and out of sites of active hematopoiesis is poorly understood, it is a critical process that underlies modern clinical stem cell transplantation and may be important for normal hematopoietic homeostasis. Given the established roles of chemotactic cytokine (chemokine)-directed migration of other leukocyte subsets, the migration of murine HSC to a large panel of CC and CXC chemokines was investigated. HSC migrated only in response to stromal derived factor-1, the ligand for the CXC chemokine receptor 4 (CXCR4). CXCR4 expression by HSC was confirmed by reverse transcription polymerase chain reaction analysis. Surprisingly, HSC also expressed mRNA for CCR3 and CCR9, although they failed to migrate to the ligands for these receptors. The sharply restricted chemotactic responsiveness of HSC is unique among leukocytes and may be necessary for the specific homing of circulating HSC to bone marrow, as well as for the maintenance of HSC in hematopoietic microenvironments.

Key Words: chemokines • chemokine receptors • chemotaxis • mobilization • bone marrow

CiteULike    Complore    Connotea    Del.icio.us    Digg    Facebook    Reddit    Technorati    Twitter    What's this?

This article has been cited by other articles:

• Basu, S., Broxmeyer, H. E. (2009). CCR5 Ligands Modulate CXCL12-Induced Chemotaxis, Adhesion, and Akt Phosphorylation of Human Cord Blood CD34+ Cells. J. Immunol. 183: 7478-7488 [Abstract] [Full Text]  
• Forsberg, E. C., Smith-Berdan, S. (2009). Parsing the niche code: the molecular mechanisms governing hematopoietic stem cell adhesion and differentiation. haematol 94: 1477-1481 [Full Text]  
• Drake, P. M., Stock, C. M., Nathan, J. K., Gip, P., Golden, K. P. K., Weinhold, B., Gerardy-Schahn, R., Bertozzi, C. R. (2009). Polysialic acid governs T-cell development by regulating progenitor access to the thymus. Proc. Natl. Acad. Sci. USA 106: 11995-12000 [Abstract] [Full Text]  
• Xu, J., Gonzalez, E. T., Iyer, S. S., Mac, V., Mora, A. L., Sutliff, R. L., Reed, A., Brigham, K. L., Kelly, P., Rojas, M. (2009). Use of Senescence-Accelerated Mouse Model in Bleomycin-Induced Lung Injury Suggests That Bone Marrow-Derived Cells Can Alter the Outcome of Lung Injury in Aged Mice. J Gerontol A Biol Sci Med Sci 64A: 731-739 [Abstract] [Full Text]  
• Niedermeier, M., Hennessy, B. T., Knight, Z. A., Henneberg, M., Hu, J., Kurtova, A. V., Wierda, W. G., Keating, M. J., Shokat, K. M., Burger, J. A. (2009). Isoform-selective phosphoinositide 3'-kinase inhibitors inhibit CXCR4 signaling and overcome stromal cell-mediated drug resistance in chronic lymphocytic leukemia: a novel therapeutic approach. Blood 113: 5549-5557 [Abstract] [Full Text]  
• Chao, M.P., Seita, J., Weissman, I.L. (2008). Establishment of a Normal Hematopoietic and Leukemia Stem Cell Hierarchy. Cold Spring Harb Symp Quant Biol 0: sqb.2008.73.031v1-sqb.2008.73.031 [Abstract]  
• Schober, A. (2008). Chemokines in Vascular Dysfunction and Remodeling. Arterioscler. Thromb. Vasc. Bio. 28: 1950-1959 [Abstract] [Full Text]  
• Bonaros, N., Sondermejer, H., Schuster, M., Rauf, R., Wang, S.F., Seki, T., Skerrett, D., Itescu, S., Kocher, A.A. (2008). CCR3- and CXCR4-mediated interactions regulate migration of CD34+ human bone marrow progenitors to ischemic myocardium and subsequent tissue repair.. J. Thorac. Cardiovasc. Surg. 136: 1044-1053 [Abstract] [Full Text]  
• Shivtiel, S., Kollet, O., Lapid, K., Schajnovitz, A., Goichberg, P., Kalinkovich, A., Shezen, E., Tesio, M., Netzer, N., Petit, I., Sharir, A., Lapidot, T. (2008). CD45 regulates retention, motility, and numbers of hematopoietic progenitors, and affects osteoclast remodeling of metaphyseal trabecules. JEM 205: 2381-2395 [Abstract] [Full Text]  
• Spiegel, A., Zcharia, E., Vagima, Y., Itkin, T., Kalinkovich, A., Dar, A., Kollet, O., Netzer, N., Golan, K., Shafat, I., Ilan, N., Nagler, A., Vlodavsky, I., Lapidot, T. (2008). Heparanase regulates retention and proliferation of primitive Sca-1+/c-Kit+/Lin- cells via modulation of the bone marrow microenvironment. Blood 111: 4934-4943 [Abstract] [Full Text]  
• Mallat, Z. (2008). PI3K{gamma} Helps an SDF Seeking Home ... for EPCs. Circ. Res. 102: 871-872 [Full Text]  
• Nie, Y., Han, Y.-C., Zou, Y.-R. (2008). CXCR4 is required for the quiescence of primitive hematopoietic cells. JEM 205: 777-783 [Abstract] [Full Text]  
• Rezzoug, F., Huang, Y., Tanner, M. K., Wysoczynski, M., Schanie, C. L., Chilton, P. M., Ratajczak, M. Z., Fugier-Vivier, I. J., Ildstad, S. T. (2008). TNF-{alpha} Is Critical to Facilitate Hemopoietic Stem Cell Engraftment and Function. J. Immunol. 180: 49-57 [Abstract] [Full Text]  
• White, F. A., Jung, H., Miller, R. J. (2007). Chemokines and the pathophysiology of neuropathic pain. Proc. Natl. Acad. Sci. USA 104: 20151-20158 [Abstract] [Full Text]  
• Tongers, J., Losordo, D. W. (2007). Frontiers in Nephrology: The Evolving Therapeutic Applications of Endothelial Progenitor Cells. J. Am. Soc. Nephrol. 18: 2843-2852 [Abstract] [Full Text]  
• Rookmaaker, M. B., Verhaar, M. C., de Boer, H. C., Goldschmeding, R., Joles, J. A., Koomans, H. A., Grone, H.-J., Rabelink, T. J. (2007). Met-RANTES reduces endothelial progenitor cell homing to activated (glomerular) endothelium in vitro and in vivo. Am. J. Physiol. Renal Physiol. 293: F624-F630 [Abstract] [Full Text]  
• Ip, J. E., Wu, Y., Huang, J., Zhang, L., Pratt, R. E., Dzau, V. J. (2007). Mesenchymal Stem Cells Use Integrin beta1 Not CXC Chemokine Receptor 4 for Myocardial Migration and Engraftment. Mol. Biol. Cell 18: 2873-2882 [Abstract] [Full Text]  
• Spoo, A. C., Lubbert, M., Wierda, W. G., Burger, J. A. (2007). CXCR4 is a prognostic marker in acute myelogenous leukemia. Blood 109: 786-791 [Abstract] [Full Text]  
• Rossi, L., Manfredini, R., Bertolini, F., Ferrari, D., Fogli, M., Zini, R., Salati, S., Salvestrini, V., Gulinelli, S., Adinolfi, E., Ferrari, S., Di Virgilio, F., Baccarani, M., Lemoli, R. M. (2007). The extracellular nucleotide UTP is a potent inducer of hematopoietic stem cell migration. Blood 109: 533-542 [Abstract] [Full Text]  
• Schatteman, G. C., Dunnwald, M., Jiao, C. (2007). Biology of bone marrow-derived endothelial cell precursors. Am. J. Physiol. Heart Circ. Physiol. 292: H1-H18 [Abstract] [Full Text]  
• Kikuchi, K., Kondo, M. (2006). Developmental switch of mouse hematopoietic stem cells from fetal to adult type occurs in bone marrow after birth. Proc. Natl. Acad. Sci. USA 103: 17852-17857 [Abstract] [Full Text]  
• Selleri, C., Montuori, N., Ricci, P., Visconte, V., Baiano, A., Carriero, M. V., Rotoli, B., Rossi, G., Ragno, P. (2006). In vivo Activity of the Cleaved Form of Soluble Urokinase Receptor: A New Hematopoietic Stem/Progenitor Cell Mobilizer.. Cancer Res. 66: 10885-10890 [Abstract] [Full Text]  
• Zhang, X., Dong, H., Lin, W., Voss, S., Hinkley, L., Westergren, M., Tian, G., Berry, D., Lewellen, D., Vile, R. G., Chen, L., Farber, D. L., Strome, S. E. (2006). Human Bone Marrow: A Reservoir for "Enhanced Effector Memory" CD8+ T Cells with Potent Recall Function. J. Immunol. 177: 6730-6737 [Abstract] [Full Text]  
• Aghi, M., Cohen, K. S., Klein, R. J., Scadden, D. T., Chiocca, E. A. (2006). Tumor Stromal-Derived Factor-1 Recruits Vascular Progenitors to Mitotic Neovasculature, where Microenvironment Influences Their Differentiated Phenotypes.. Cancer Res. 66: 9054-9064 [Abstract] [Full Text]  
• Ghiaur, G., Lee, A., Bailey, J., Cancelas, J. A., Zheng, Y., Williams, D. A. (2006). Inhibition of RhoA GTPase activity enhances hematopoietic stem and progenitor cell proliferation and engraftment. Blood 108: 2087-2094 [Abstract] [Full Text]  
• Diao, J., Winter, E., Cantin, C., Chen, W., Xu, L., Kelvin, D., Phillips, J., Cattral, M. S. (2006). In Situ Replication of Immediate Dendritic Cell (DC) Precursors Contributes to Conventional DC Homeostasis in Lymphoid Tissue.. J. Immunol. 176: 7196-7206 [Abstract] [Full Text]  
• Desponts, C., Hazen, A. L., Paraiso, K. H. T., Kerr, W. G. (2006). SHIP deficiency enhances HSC proliferation and survival but compromises homing and repopulation. Blood 107: 4338-4345 [Abstract] [Full Text]  
• Harris, J. R., Brown, G. A. J., Jorgensen, M., Kaushal, S., Ellis, E. A., Grant, M. B., Scott, E. W. (2006). Bone Marrow-Derived Cells Home to and Regenerate Retinal Pigment Epithelium after Injury. IOVS 47: 2108-2113 [Abstract] [Full Text]  
• Li, Y., Reca, R. G., Atmaca-Sonmez, P., Ratajczak, M. Z., Ildstad, S. T., Kaplan, H. J., Enzmann, V. (2006). Retinal pigment epithelium damage enhances expression of chemoattractants and migration of bone marrow-derived stem cells.. IOVS 47: 1646-1652 [Abstract] [Full Text]  
• Takizawa, H., Kubo-Akashi, C., Nobuhisa, I., Kwon, S.-M., Iseki, M., Taga, T., Takatsu, K., Takaki, S. (2006). Enhanced engraftment of hematopoietic stem/progenitor cells by the transient inhibition of an adaptor protein, Lnk. Blood 107: 2968-2975 [Abstract] [Full Text]  
• Foudi, A., Jarrier, P., Zhang, Y., Wittner, M., Geay, J.-F., Lecluse, Y., Nagasawa, T., Vainchenker, W., Louache, F. (2006). Reduced retention of radioprotective hematopoietic cells within the bone marrow microenvironment in CXCR4-/- chimeric mice. Blood 107: 2243-2251 [Abstract] [Full Text]  
• Burger, J. A., Kipps, T. J. (2006). CXCR4: a key receptor in the crosstalk between tumor cells and their microenvironment. Blood 107: 1761-1767 [Abstract] [Full Text]  
• Goichberg, P., Kalinkovich, A., Borodovsky, N., Tesio, M., Petit, I., Nagler, A., Hardan, I., Lapidot, T. (2006). cAMP-induced PKC{zeta} activation increases functional CXCR4 expression on human CD34+ hematopoietic progenitors. Blood 107: 870-879 [Abstract] [Full Text]  
• Walter, D. H., Haendeler, J., Reinhold, J., Rochwalsky, U., Seeger, F., Honold, J., Hoffmann, J., Urbich, C., Lehmann, R., Arenzana-Seisdesdos, F., Aicher, A., Heeschen, C., Fichtlscherer, S., Zeiher, A. M., Dimmeler, S. (2005). Impaired CXCR4 Signaling Contributes to the Reduced Neovascularization Capacity of Endothelial Progenitor Cells From Patients With Coronary Artery Disease. Circ. Res. 97: 1142-1151 [Abstract] [Full Text]  
• Rosu-Myles, M., Stewart, E., Trowbridge, J., Ito, C. Y., Zandstra, P., Bhatia, M. (2005). A unique population of bone marrow cells migrates to skeletal muscle via hepatocyte growth factor/c-met axis. J. Cell Sci. 118: 4343-4352 [Abstract] [Full Text]  
• Tabatabai, G., Bahr, O., Mohle, R., Eyupoglu, I. Y., Boehmler, A. M., Wischhusen, J., Rieger, J., Blumcke, I., Weller, M., Wick, W. (2005). Lessons from the bone marrow: how malignant glioma cells attract adult haematopoietic progenitor cells. Brain 128: 2200-2211 [Abstract] [Full Text]  
• Guleng, B., Tateishi, K., Ohta, M., Kanai, F., Jazag, A., Ijichi, H., Tanaka, Y., Washida, M., Morikane, K., Fukushima, Y., Yamori, T., Tsuruo, T., Kawabe, T., Miyagishi, M., Taira, K., Sata, M., Omata, M. (2005). Blockade of the Stromal Cell-Derived Factor-1/CXCR4 Axis Attenuates In vivo Tumor Growth by Inhibiting Angiogenesis in a Vascular Endothelial Growth Factor-Independent Manner. Cancer Res. 65: 5864-5871 [Abstract] [Full Text]  
• Haider, H. K., Ashraf, M. (2005). Bone marrow stem cell transplantation for cardiac repair. Am. J. Physiol. Heart Circ. Physiol. 288: H2557-H2567 [Abstract] [Full Text]  
• Broxmeyer, H. E., Orschell, C. M., Clapp, D. W., Hangoc, G., Cooper, S., Plett, P. A., Liles, W. C., Li, X., Graham-Evans, B., Campbell, T. B., Calandra, G., Bridger, G., Dale, D. C., Srour, E. F. (2005). Rapid mobilization of murine and human hematopoietic stem and progenitor cells with AMD3100, a CXCR4 antagonist. JEM 201: 1307-1318 [Abstract] [Full Text]  
• Chilton, P. M., Rezzoug, F., Ratajczak, M. Z., Fugier-Vivier, I., Ratajczak, J., Kucia, M., Huang, Y., Tanner, M. K., Ildstad, S. T. (2005). Hematopoietic stem cells from NOD mice exhibit autonomous behavior and a competitive advantage in allogeneic recipients. Blood 105: 2189-2197 [Abstract] [Full Text]  
• Selleri, C., Montuori, N., Ricci, P., Visconte, V., Carriero, M. V., Sidenius, N., Serio, B., Blasi, F., Rotoli, B., Rossi, G., Ragno, P. (2005). Involvement of the urokinase-type plasminogen activator receptor in hematopoietic stem cell mobilization. Blood 105: 2198-2205 [Abstract] [Full Text]  
• Nemeth, M. J., Cline, A. P., Anderson, S. M., Garrett-Beal, L. J., Bodine, D. M. (2005). Hmgb3 deficiency deregulates proliferation and differentiation of common lymphoid and myeloid progenitors. Blood 105: 627-634 [Abstract] [Full Text]  
• Singh, S., Singh, U. P., Stiles, J. K., Grizzle, W. E., Lillard, J. W. Jr. (2004). Expression and Functional Role of CCR9 in Prostate Cancer Cell Migration and Invasion. Clin. Cancer Res. 10: 8743-8750 [Abstract] [Full Text]  
• De Falco, E., Porcelli, D., Torella, A. R., Straino, S., Iachininoto, M. G., Orlandi, A., Truffa, S., Biglioli, P., Napolitano, M., Capogrossi, M. C., Pesce, M. (2004). SDF-1 involvement in endothelial phenotype and ischemia-induced recruitment of bone marrow progenitor cells. Blood 104: 3472-3482 [Abstract] [Full Text]  
• Xia, L., McDaniel, J. M., Yago, T., Doeden, A., McEver, R. P. (2004). Surface fucosylation of human cord blood cells augments binding to P-selectin and E-selectin and enhances engraftment in bone marrow. Blood 104: 3091-3096 [Abstract] [Full Text]  
• Garzon, R., Soriano, S. F., Rodriguez-Frade, J. M., Gomez, L., Martin de Ana, A., Sanchez-Gomez, M., Martinez-A, C., Mellado, M. (2004). CXCR4-mediated Suppressor of Cytokine Signaling Up-regulation Inactivates Growth Hormone Function. J. Biol. Chem. 279: 44460-44466 [Abstract] [Full Text]  
• Monfardini, E., Van Merris, V., Paape, M., Duchateau, L., Burvenich, C. (2004). L-Selectin and Chemotaxis Throughout Bone Marrow Granulocyte Maturation in the Bovine. J DAIRY SCI 87: 3350-3357 [Abstract] [Full Text]  
• Urbich, C., Dimmeler, S. (2004). Endothelial Progenitor Cells: Characterization and Role in Vascular Biology. Circ. Res. 95: 343-353 [Abstract] [Full Text]  
• Hidalgo, A., Peired, A. J., Weiss, L. A., Katayama, Y., Frenette, P. S. (2004). The integrin {alpha}M{beta}2 anchors hematopoietic progenitors in the bone marrow during enforced mobilization. Blood 104: 993-1001 [Abstract] [Full Text]  
• Christopherson, K. W. II, Hangoc, G., Mantel, C. R., Broxmeyer, H. E. (2004). Modulation of Hematopoietic Stem Cell Homing and Engraftment by CD26. Science 305: 1000-1003 [Abstract] [Full Text]  
• Lee, M. S., Hanspers, K., Barker, C. S., Korn, A. P., McCune, J. M. (2004). Gene expression profiles during human CD4+ T cell differentiation. Int Immunol 16: 1109-1124 [Abstract] [Full Text]  
• Gulino, A. V., Moratto, D., Sozzani, S., Cavadini, P., Otero, K., Tassone, L., Imberti, L., Pirovano, S., Notarangelo, L. D., Soresina, R., Mazzolari, E., Nelson, D. L., Notarangelo, L. D., Badolato, R. (2004). Altered leukocyte response to CXCL12 in patients with warts hypogammaglobulinemia, infections, myelokathexis (WHIM) syndrome. Blood 104: 444-452 [Abstract] [Full Text]  
• Liang, Z., Wu, T., Lou, H., Yu, X., Taichman, R. S., Lau, S. K., Nie, S., Umbreit, J., Shim, H. (2004). Inhibition of Breast Cancer Metastasis by Selective Synthetic Polypeptide against CXCR4. Cancer Res. 64: 4302-4308 [Abstract] [Full Text]  
• Tavor, S., Petit, I., Porozov, S., Avigdor, A., Dar, A., Leider-Trejo, L., Shemtov, N., Deutsch, V., Naparstek, E., Nagler, A., Lapidot, T. (2004). CXCR4 Regulates Migration and Development of Human Acute Myelogenous Leukemia Stem Cells in Transplanted NOD/SCID Mice. Cancer Res. 64: 2817-2824 [Abstract] [Full Text]  
• Spiegel, A., Kollet, O., Peled, A., Abel, L., Nagler, A., Bielorai, B., Rechavi, G., Vormoor, J., Lapidot, T. (2004). Unique SDF-1-induced activation of human precursor-B ALL cells as a result of altered CXCR4 expression and signaling. Blood 103: 2900-2907 [Abstract] [Full Text]  
• Kahn, J., Byk, T., Jansson-Sjostrand, L., Petit, I., Shivtiel, S., Nagler, A., Hardan, I., Deutsch, V., Gazit, Z., Gazit, D., Karlsson, S., Lapidot, T. (2004). Overexpression of CXCR4 on human CD34+ progenitors increases their proliferation, migration, and NOD/SCID repopulation. Blood 103: 2942-2949 [Abstract] [Full Text]  
• Avigdor, A., Goichberg, P., Shivtiel, S., Dar, A., Peled, A., Samira, S., Kollet, O., Hershkoviz, R., Alon, R., Hardan, I., Ben-Hur, H., Naor, D., Nagler, A., Lapidot, T. (2004). CD44 and hyaluronic acid cooperate with SDF-1 in the trafficking of human CD34+ stem/progenitor cells to bone marrow. Blood 103: 2981-2989 [Abstract] [Full Text]  
• Papayannopoulou, T. (2004). Current mechanistic scenarios in hematopoietic stem/progenitor cell mobilization. Blood 103: 1580-1585 [Abstract] [Full Text]  
• Underhill, G. H., Kolli, K. P., Kansas, G. S. (2003). Complexity within the plasma cell compartment of mice deficient in both E- and P-selectin: implications for plasma cell differentiation. Blood 102: 4076-4083 [Abstract] [Full Text]  
• Kayali, A. G., Van Gunst, K., Campbell, I. L., Stotland, A., Kritzik, M., Liu, G., Flodstrom-Tullberg, M., Zhang, Y.-Q., Sarvetnick, N. (2003). The stromal cell-derived factor-1{alpha}/CXCR4 ligand-receptor axis is critical for progenitor survival and migration in the pancreas. JCB 163: 859-869 [Abstract] [Full Text]  
• Herzog, E. L., Chai, L., Krause, D. S. (2003). Plasticity of marrow-derived stem cells. Blood 102: 3483-3493 [Abstract] [Full Text]  
• Whetton, A. D., Lu, Y., Pierce, A., Carney, L., Spooncer, E. (2003). Lysophospholipids synergistically promote primitive hematopoietic cell chemotaxis via a mechanism involving Vav 1. Blood 102: 2798-2802 [Abstract] [Full Text]  
• Korbling, M., Estrov, Z. (2003). Adult Stem Cells for Tissue Repair -- A New Therapeutic Concept?. NEJM 349: 570-582 [Full Text]  
• Torrente, Y., Camirand, G., Pisati, F., Belicchi, M., Rossi, B., Colombo, F., El Fahime, M., Caron, N. J., Issekutz, A. C., Constantin, G., Tremblay, J. P., Bresolin, N. (2003). Identification of a putative pathway for the muscle homing of stem cells in a muscular dystrophy model. JCB 162: 511-520 [Abstract] [Full Text]  
• Papayannopoulou, T., Priestley, G. V., Bonig, H., Nakamoto, B. (2003). The role of G-protein signaling in hematopoietic stem/progenitor cell mobilization. Blood 101: 4739-4747 [Abstract] [Full Text]  
• Broxmeyer, H. E., Kohli, L., Kim, C. H., Lee, Y., Mantel, C., Cooper, S., Hangoc, G., Shaheen, M., Li, X., Clapp, D. W. (2003). Stromal cell-derived factor-1/CXCL12 directly enhances survival/antiapoptosis of myeloid progenitor cells through CXCR4 and G{alpha}i proteins and enhances engraftment of competitive, repopulating stem cells. J. Leukoc. Biol. 73: 630-638 [Abstract] [Full Text]  
• Kollet, O., Petit, I., Kahn, J., Samira, S., Dar, A., Peled, A., Deutsch, V., Gunetti, M., Piacibello, W., Nagler, A., Lapidot, T. (2002). Human CD34+CXCR4- sorted cells harbor intracellular CXCR4, which can be functionally expressed and provide NOD/SCID repopulation. Blood 100: 2778-2786 [Abstract] [Full Text]  

Home | Help | Feedback | Subscriptions | Archive | Search

TABLE OF CONTENTS