Home | Help | Feedback | Subscriptions | Archive | Search | Table of Contents

This Article Full Text Full Text (PDF, 102K) PPT slides of all figures Alert me when this article is cited Citation Map Services Email this article Similar articles in this journal Similar articles in PubMed Alert me to new content in the JEM Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Ferlazzo, G. Articles by Münz, C. Search for Related Content PubMed PubMed Citation Articles by Ferlazzo, G. Articles by Münz, C. Social Bookmarking                      What's this?

Original Article

¹ Laboratorio di Immunoterapia Cellulare, Unità di Immunologia, Istituto Nazionale per la Ricerca sul Cancro, 16132 Genova, Italy
² Laboratory of Cellular Physiology and Immunology, The Rockefeller University, New York, NY 10021
³ Istituto Giannina Gaslini, 16147 Genova, Italy
⁴ Dipartimento di Medicina Sperimentale (DIMES), Università di Genova, 16132 Genova, Italy

Address correspondence to Guido Ferlazzo, Laboratorio di Immunoterapia Cellulare, Unità di Immunologia, Istituto Nazionale per la Ricerca sul Cancro, Centro di Biotecnologie Avanzate, Largo Rosanna Benzi, 10, 16132 Genova, Italy. Phone: 39-010-573-7453; Fax: 39-010-573-7462; E-mail: ferlazzo{at}cba.unige.it

During the innate response to many inflammatory and infectious stimuli, dendritic cells (DCs) undergo a differentiation process termed maturation. Mature DCs activate antigen-specific naive T cells. Here we show that both immature and mature DCs activate resting human natural killer (NK) cells. Within 1 wk the NK cells increase two– to fourfold in numbers, start secreting interferon (IFN)-, and acquire cytolytic activity against the classical NK target LCL721.221. The DC-activated NK cells then kill immature DCs efficiently, even though the latter express substantial levels of major histocompatibility complex (MHC) class I. Similar results are seen with interleukin (IL)-2–activated NK cell lines and clones, i.e., these NK cells kill and secrete IFN- in response to immature DCs. Mature DCs are protected from activated NK lysis, but lysis takes place if the NK inhibitory signal is blocked by a human histocompatibility leukocyte antigen (HLA)-A,B,C–specific antibody. The NK activating signal mainly involves the NKp30 natural cytotoxicity receptor, and not the NKp46 or NKp44 receptor. However, both immature and mature DCs seem to use a NKp30 independent mechanism to act as potent stimulators for resting NK cells. We suggest that DCs are able to control directly the expansion of NK cells and that the lysis of immature DCs can regulate the afferent limb of innate and adaptive immunity.

Key Words: natural killer cells • dendritic cells • NCR • immune regulation • NKp30

CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this?

This article has been cited by other articles:

• Brandt, C. S., Baratin, M., Yi, E. C., Kennedy, J., Gao, Z., Fox, B., Haldeman, B., Ostrander, C. D., Kaifu, T., Chabannon, C., Moretta, A., West, R., Xu, W., Vivier, E., Levin, S. D. (2009). The B7 family member B7-H6 is a tumor cell ligand for the activating natural killer cell receptor NKp30 in humans. JEM 206: 1495-1503 [Abstract] [Full Text]  
• Bozzano, F., Costa, P., Passalacqua, G., Dodi, F., Ravera, S., Pagano, G., Canonica, G. W., Moretta, L., De Maria, A. (2009). Functionally relevant decreases in activatory receptor expression on NK cells are associated with pulmonary tuberculosis in vivo and persist after successful treatment. Int Immunol 21: 779-791 [Abstract] [Full Text]  
• Robson, N. C., Wei, H., McAlpine, T., Kirkpatrick, N., Cebon, J., Maraskovsky, E. (2009). Activin-A attenuates several human natural killer cell functions. Blood 113: 3218-3225 [Abstract] [Full Text]  
• De Maria, A., Ugolotti, E., Rutjens, E., Mazza, S., Radic, L., Faravelli, A., Koopman, G., Di Marco, E., Costa, P., Ensoli, B., Cafaro, A., Mingari, M. C., Moretta, L., Heeney, J., Biassoni, R. (2009). NKp44 expression, phylogenesis and function in non-human primate NK cells. Int Immunol 21: 245-255 [Abstract] [Full Text]  
• Saghafian-Hedengren, S., Sundstrom, Y., Sohlberg, E., Nilsson, C., Linde, A., Troye-Blomberg, M., Berg, L., Sverremark-Ekstrom, E. (2009). Herpesvirus Seropositivity in Childhood Associates with Decreased Monocyte-Induced NK Cell IFN-{gamma} Production. J. Immunol. 182: 2511-2517 [Abstract] [Full Text]  
• Saez-Borderias, A., Romo, N., Magri, G., Guma, M., Angulo, A., Lopez-Botet, M. (2009). IL-12-Dependent Inducible Expression of the CD94/NKG2A Inhibitory Receptor Regulates CD94/NKG2C+ NK Cell Function. J. Immunol. 182: 829-836 [Abstract] [Full Text]  
• Nausch, N., Galani, I. E., Schlecker, E., Cerwenka, A. (2008). Mononuclear myeloid-derived "suppressor" cells express RAE-1 and activate natural killer cells. Blood 112: 4080-4089 [Abstract] [Full Text]  
• Poupot, M., Fournie, J.-J., Poupot, R. (2008). Trogocytosis and killing of IL-4-polarized monocytes by autologous NK cells. J. Leukoc. Biol. 84: 1298-1305 [Abstract] [Full Text]  
• Lunemann, A., Lunemann, J. D., Roberts, S., Messmer, B., da Silva, R. B., Raine, C. S., Munz, C. (2008). Human NK Cells Kill Resting but Not Activated Microglia via NKG2D- and NKp46-Mediated Recognition. J. Immunol. 181: 6170-6177 [Abstract] [Full Text]  
• Himoudi, N., Nabarro, S., Buddle, J., Eddaoudi, A., Thrasher, A. J., Anderson, J. (2008). Bone Marrow-Derived IFN-Producing Killer Dendritic Cells Account for the Tumoricidal Activity of Unpulsed Dendritic Cells. J. Immunol. 181: 6654-6663 [Abstract] [Full Text]  
• Vacca, P., Cantoni, C., Prato, C., Fulcheri, E., Moretta, A., Moretta, L., Mingari, M. C. (2008). Regulatory role of NKp44, NKp46, DNAM-1 and NKG2D receptors in the interaction between NK cells and trophoblast cells. Evidence for divergent functional profiles of decidual versus peripheral NK cells. Int Immunol 20: 1395-1405 [Abstract] [Full Text]  
• Watt, S. V., Andrews, D. M., Takeda, K., Smyth, M. J., Hayakawa, Y. (2008). IFN-{gamma}-Dependent Recruitment of Mature CD27high NK Cells to Lymph Nodes Primed by Dendritic Cells. J. Immunol. 181: 5323-5330 [Abstract] [Full Text]  
• Marcenaro, E., Ferranti, B., Falco, M., Moretta, L., Moretta, A. (2008). Human NK cells directly recognize Mycobacterium bovis via TLR2 and acquire the ability to kill monocyte-derived DC. Int Immunol 20: 1155-1167 [Abstract] [Full Text]  
• Agaugue, S., Marcenaro, E., Ferranti, B., Moretta, L., Moretta, A. (2008). Human natural killer cells exposed to IL-2, IL-12, IL-18, or IL-4 differently modulate priming of naive T cells by monocyte-derived dendritic cells. Blood 112: 1776-1783 [Abstract] [Full Text]  
• Morel, E., Bellon, T. (2008). HLA Class I Molecules Regulate IFN-{gamma} Production Induced in NK Cells by Target Cells, Viral Products, or Immature Dendritic Cells through the Inhibitory Receptor ILT2/CD85j. J. Immunol. 181: 2368-2381 [Abstract] [Full Text]  
• Iannello, A., Debbeche, O., Samarani, S., Ahmad, A. (2008). Antiviral NK cell responses in HIV infection: II. viral strategies for evasion and lessons for immunotherapy and vaccination. J. Leukoc. Biol. 84: 27-49 [Abstract] [Full Text]  
• Lunemann, J. D., Munz, C. (2008). Do natural killer cells accelerate or prevent autoimmunity in multiple sclerosis?. Brain 131: 1681-1683 [Full Text]  
• Strowig, T., Brilot, F., Munz, C. (2008). Noncytotoxic Functions of NK Cells: Direct Pathogen Restriction and Assistance to Adaptive Immunity. J. Immunol. 180: 7785-7791 [Abstract] [Full Text]  
• Binyamin, L., Alpaugh, R. K., Hughes, T. L., Lutz, C. T., Campbell, K. S., Weiner, L. M. (2008). Blocking NK Cell Inhibitory Self-Recognition Promotes Antibody-Dependent Cellular Cytotoxicity in a Model of Anti-Lymphoma Therapy. J. Immunol. 180: 6392-6401 [Abstract] [Full Text]  
• Terme, M., Chaput, N., Combadiere, B., Ma, A., Ohteki, T., Zitvogel, L. (2008). Regulatory T Cells Control Dendritic Cell/NK Cell Cross-Talk in Lymph Nodes at the Steady State by Inhibiting CD4+ Self-Reactive T Cells. J. Immunol. 180: 4679-4686 [Abstract] [Full Text]  
• Scott, G. B., Meade, J. L., Cook, G. P. (2008). Profiling killers; unravelling the pathways of human natural killer cell function. Brief Funct Genomic Proteomic 0: elm037v1-elm037 [Abstract] [Full Text]  
• Fink, L. N., Zeuthen, L. H., Christensen, H. R., Morandi, B., Frokiaer, H., Ferlazzo, G. (2007). Distinct gut-derived lactic acid bacteria elicit divergent dendritic cell-mediated NK cell responses. Int Immunol 19: 1319-1327 [Abstract] [Full Text]  
• Tha-In, T., Metselaar, H. J., Tilanus, H. W., Groothuismink, Z. M. A., Kuipers, E. J., de Man, R. A., Kwekkeboom, J. (2007). Intravenous immunoglobulins suppress T-cell priming by modulating the bidirectional interaction between dendritic cells and natural killer cells. Blood 110: 3253-3262 [Abstract] [Full Text]  
• Vosshenrich, C. A.J., Lesjean-Pottier, S., Hasan, M., Richard-Le Goff, O., Corcuff, E., Mandelboim, O., Di Santo, J. P. (2007). CD11cloB220+ interferon-producing killer dendritic cells are activated natural killer cells. JEM 204: 2569-2578 [Abstract] [Full Text]  
• Curtis, J. L., Freeman, C. M., Hogg, J. C. (2007). The Immunopathogenesis of Chronic Obstructive Pulmonary Disease: Insights from Recent Research. Proc Am Thorac Soc 4: 512-521 [Abstract] [Full Text]  
• Colmenero, P., Zhang, A. L., Qian, T., Lu, L., Cantor, H., Soderstrom, K., Engleman, E. G. (2007). Qa-1b-Dependent Modulation of Dendritic Cell and NK Cell Cross-Talk In Vivo. J. Immunol. 179: 4608-4615 [Abstract] [Full Text]  
• Ebihara, T., Masuda, H., Akazawa, T., Shingai, M., Kikuta, H., Ariga, T., Matsumoto, M., Seya, T. (2007). Induction of NKG2D ligands on human dendritic cells by TLR ligand stimulation and RNA virus infection. Int Immunol 19: 1145-1155 [Abstract] [Full Text]  
• Zhang, A. L., Colmenero, P., Purath, U., Teixeira de Matos, C., Hueber, W., Klareskog, L., Tarner, I. H., Engleman, E. G., Soderstrom, K. (2007). Natural killer cells trigger differentiation of monocytes into dendritic cells. Blood 110: 2484-2493 [Abstract] [Full Text]  
• Chehimi, J., Azzoni, L., Farabaugh, M., Creer, S. A., Tomescu, C., Hancock, A., Mackiewicz, A., D'Alessandro, L., Ghanekar, S., Foulkes, A. S., Mounzer, K., Kostman, J., Montaner, L. J. (2007). Baseline Viral Load and Immune Activation Determine the Extent of Reconstitution of Innate Immune Effectors in HIV-1-Infected Subjects Undergoing Antiretroviral Treatment. J. Immunol. 179: 2642-2650 [Abstract] [Full Text]  
• Quaranta, M. G., Napolitano, A., Sanchez, M., Giordani, L., Mattioli, B., Viora, M. (2007). HIV-1 Nef impairs the dynamic of DC/NK crosstalk: different outcome of CD56dim and CD56bright NK cell subsets. FASEB J. 21: 2323-2334 [Abstract] [Full Text]  
• Garrod, K. R., Wei, S. H., Parker, I., Cahalan, M. D. (2007). Natural killer cells actively patrol peripheral lymph nodes forming stable conjugates to eliminate MHC-mismatched targets. Proc. Natl. Acad. Sci. USA 104: 12081-12086 [Abstract] [Full Text]  
• Li, C., Hirsch, M., Asokan, A., Zeithaml, B., Ma, H., Kafri, T., Samulski, R. J. (2007). Adeno-Associated Virus Type 2 (AAV2) Capsid-Specific Cytotoxic T Lymphocytes Eliminate Only Vector-Transduced Cells Coexpressing the AAV2 Capsid In Vivo. J. Virol. 81: 7540-7547 [Abstract] [Full Text]  
• Cerboni, C., Zingoni, A., Cippitelli, M., Piccoli, M., Frati, L., Santoni, A. (2007). Antigen-activated human T lymphocytes express cell-surface NKG2D ligands via an ATM/ATR-dependent mechanism and become susceptible to autologous NK- cell lysis. Blood 110: 606-615 [Abstract] [Full Text]  
• Thoren, F. B., Betten, A., Romero, A. I., Hellstrand, K. (2007). Cutting Edge: Antioxidative Properties of Myeloid Dendritic Cells: Protection of T Cells and NK Cells from Oxygen Radical-Induced Inactivation and Apoptosis. J. Immunol. 179: 21-25 [Abstract] [Full Text]  
• Terrazzano, G., Sica, M., Gianfrani, C., Mazzarella, G., Maurano, F., De Giulio, B., de Saint-Mezard, S., Zanzi, D., Maiuri, L., Londei, M., Jabri, B., Troncone, R., Auricchio, S., Zappacosta, S., Carbone, E. (2007). Gliadin Regulates the NK-Dendritic Cell Cross-Talk by HLA-E Surface Stabilization. J. Immunol. 179: 372-381 [Abstract] [Full Text]  
• Guan, H., Moretto, M., Bzik, D. J., Gigley, J., Khan, I. A. (2007). NK Cells Enhance Dendritic Cell Response against Parasite Antigens via NKG2D Pathway. J. Immunol. 179: 590-596 [Abstract] [Full Text]  
• Roda-Navarro, P., Reyburn, H. T. (2007). Intercellular protein transfer at the NK cell immune synapse: mechanisms and physiological significance. FASEB J. 21: 1636-1646 [Abstract] [Full Text]  
• Castriconi, R., Dondero, A., Cantoni, C., Della Chiesa, M., Prato, C., Nanni, M., Fiorini, M., Notarangelo, L., Parolini, S., Moretta, L., Notarangelo, L., Moretta, A., Bottino, C. (2007). Functional characterization of natural killer cells in type I leukocyte adhesion deficiency. Blood 109: 4873-4881 [Abstract] [Full Text]  
• Barber, M. A., Zhang, T., Gagne, B. A., Sentman, C. L. (2007). NK Cells Negatively Regulate Antigen Presentation and Tumor-Specific CTLs in a Syngeneic Lymphoma Model. J. Immunol. 178: 6140-6147 [Abstract] [Full Text]  
• Parolini, S., Santoro, A., Marcenaro, E., Luini, W., Massardi, L., Facchetti, F., Communi, D., Parmentier, M., Majorana, A., Sironi, M., Tabellini, G., Moretta, A., Sozzani, S. (2007). The role of chemerin in the colocalization of NK and dendritic cell subsets into inflamed tissues. Blood 109: 3625-3632 [Abstract] [Full Text]  
• Nedvetzki, S., Sowinski, S., Eagle, R. A., Harris, J., Vely, F., Pende, D., Trowsdale, J., Vivier, E., Gordon, S., Davis, D. M. (2007). Reciprocal regulation of human natural killer cells and macrophages associated with distinct immune synapses. Blood 109: 3776-3785 [Abstract] [Full Text]  
• Xu, J., Chakrabarti, A. K., Tan, J. L., Ge, L., Gambotto, A., Vujanovic, N. L. (2007). Essential role of the TNF-TNFR2 cognate interaction in mouse dendritic cell-natural killer cell crosstalk. Blood 109: 3333-3341 [Abstract] [Full Text]  
• Draghi, M., Pashine, A., Sanjanwala, B., Gendzekhadze, K., Cantoni, C., Cosman, D., Moretta, A., Valiante, N. M., Parham, P. (2007). NKp46 and NKG2D Recognition of Infected Dendritic Cells Is Necessary for NK Cell Activation in the Human Response to Influenza Infection. J. Immunol. 178: 2688-2698 [Abstract] [Full Text]  
• Rutjens, E., Mazza, S., Biassoni, R., Koopman, G., Radic, L., Fogli, M., Costa, P., Mingari, M. C., Moretta, L., Heeney, J., De Maria, A. (2007). Differential NKp30 Inducibility in Chimpanzee NK Cells and Conserved NK Cell Phenotype and Function in Long-Term HIV-1-Infected Animals. J. Immunol. 178: 1702-1712 [Abstract] [Full Text]  
• Semino, C., Ceccarelli, J., Lotti, L. V., Torrisi, M. R., Angelini, G., Rubartelli, A. (2007). The maturation potential of NK cell clones toward autologous dendritic cells correlates with HMGB1 secretion. J. Leukoc. Biol. 81: 92-99 [Abstract] [Full Text]  
• Ralainirina, N., Poli, A., Michel, T., Poos, L., Andres, E., Hentges, F., Zimmer, J. (2007). Control of NK cell functions by CD4+CD25+ regulatory T cells. J. Leukoc. Biol. 81: 144-153 [Abstract] [Full Text]  
• Houtenbos, I., Westers, T. M., Dijkhuis, A., de Gruijl, T. D., Ossenkoppele, G. J., van de Loosdrecht, A. A. (2007). Leukemia-Specific T-Cell Reactivity Induced by Leukemic Dendritic Cells Is Augmented by 4-1BB Targeting. Clin. Cancer Res. 13: 307-315 [Abstract] [Full Text]  
• Chiesa, M. D., Carlomagno, S., Frumento, G., Balsamo, M., Cantoni, C., Conte, R., Moretta, L., Moretta, A., Vitale, M. (2006). The tryptophan catabolite L-kynurenine inhibits the surface expression of NKp46- and NKG2D-activating receptors and regulates NK-cell function. Blood 108: 4118-4125 [Abstract] [Full Text]  
• Wendt, K., Wilk, E., Buyny, S., Buer, J., Schmidt, R. E., Jacobs, R. (2006). Gene and protein characteristics reflect functional diversity of CD56dim and CD56bright NK cells. J. Leukoc. Biol. 80: 1529-1541 [Abstract] [Full Text]  
• He, X.-S., Holmes, T. H., Zhang, C., Mahmood, K., Kemble, G. W., Lewis, D. B., Dekker, C. L., Greenberg, H. B., Arvin, A. M. (2006). Cellular Immune Responses in Children and Adults Receiving Inactivated or Live Attenuated Influenza Vaccines. J. Virol. 80: 11756-11766 [Abstract] [Full Text]  
• Joshi, P. S., Liu, J.-Q., Wang, Y., Chang, X., Richards, J., Assarsson, E., Shi, F.-D., Ljunggren, H.-G., Bai, X.-F. (2006). Cytokine-induced killer T cells kill immature dendritic cells by TCR-independent and perforin-dependent mechanisms. J. Leukoc. Biol. 80: 1345-1353 [Abstract] [Full Text]  
• Chiesa, M. D., Romagnani, C., Thiel, A., Moretta, L., Moretta, A. (2006). Multidirectional interactions are bridging human NK cells with plasmacytoid and monocyte-derived dendritic cells during innate immune responses. Blood 108: 3851-3858 [Abstract] [Full Text]  
• Mavilio, D., Lombardo, G., Kinter, A., Fogli, M., La Sala, A., Ortolano, S., Farschi, A., Follmann, D., Gregg, R., Kovacs, C., Marcenaro, E., Pende, D., Moretta, A., Fauci, A. S. (2006). Characterization of the defective interaction between a subset of natural killer cells and dendritic cells in HIV-1 infection. JEM 203: 2339-2350 [Abstract] [Full Text]  
• McGrath-Morrow, S., Laube, B., Tzou, S.-C., Cho, C., Cleary, J., Kimura, H., Rose, N. R., Caturegli, P. (2006). IL-12 overexpression in mice as a model for Sjogren lung disease. Am. J. Physiol. Lung Cell. Mol. Physiol. 291: L837-L846 [Abstract] [Full Text]  
• Campos-Martin, Y., Colmenares, M., Gozalbo-Lopez, B., Lopez-Nunez, M., Savage, P. B., Martinez-Naves, E. (2006). Immature Human Dendritic Cells Infected with Leishmania infantum Are Resistant to NK-Mediated Cytolysis but Are Efficiently Recognized by NKT Cells. J. Immunol. 176: 6172-6179 [Abstract] [Full Text]  
• Hanabuchi, S., Watanabe, N., Wang, Y.-H., Wang, Y.-H., Ito, T., Shaw, J., Cao, W., Qin, F. X.-F., Liu, Y.-J. (2006). Human plasmacytoid predendritic cells activate NK cells through glucocorticoid-induced tumor necrosis factor receptor-ligand (GITRL). Blood 107: 3617-3623 [Abstract] [Full Text]  
• Ebata, K., Shimizu, Y., Nakayama, Y., Minemura, M., Murakami, J., Kato, T., Yasumura, S., Takahara, T., Sugiyama, T., Saito, S. (2006). Immature NK Cells Suppress Dendritic Cell Functions during the Development of Leukemia in a Mouse Model. J. Immunol. 176: 4113-4124 [Abstract] [Full Text]  
• Bajenoff, M., Breart, B., Huang, A. Y.C., Qi, H., Cazareth, J., Braud, V. M., Germain, R. N., Glaichenhaus, N. (2006). Natural killer cell behavior in lymph nodes revealed by static and real-time imaging. JEM 203: 619-631 [Abstract] [Full Text]  
• Pende, D., Castriconi, R., Romagnani, P., Spaggiari, G. M., Marcenaro, S., Dondero, A., Lazzeri, E., Lasagni, L., Martini, S., Rivera, P., Capobianco, A., Moretta, L., Moretta, A., Bottino, C. (2006). Expression of the DNAM-1 ligands, Nectin-2 (CD112) and poliovirus receptor (CD155), on dendritic cells: relevance for natural killer-dendritic cell interaction. Blood 107: 2030-2036 [Abstract] [Full Text]  
• Dao, T., Gomez-Nunez, M., Antczak, C., Kappel, B., Singh Jaggi, J., Korontsvit, T., Zakhaleva, V., Scheinberg, D. A. (2005). Natural Killer Cells License Dendritic Cell Cross-Presentation of B Lymphoma Cell-Associated Antigens. Clin. Cancer Res. 11: 8763-8772 [Abstract] [Full Text]  
• Zambello, R., Berno, T., Cannas, G., Baesso, I., Binotto, G., Bonoldi, E., Bevilacqua, P., Miorin, M., Facco, M., Trentin, L., Agostini, C., Semenzato, G. (2005). Phenotypic and functional analyses of dendritic cells in patients with lymphoproliferative disease of granular lymphocytes (LDGL). Blood 106: 3926-3931 [Abstract] [Full Text]  
• Poggi, A., Prevosto, C., Massaro, A.-M., Negrini, S., Urbani, S., Pierri, I., Saccardi, R., Gobbi, M., Zocchi, M. R. (2005). Interaction between Human NK Cells and Bone Marrow Stromal Cells Induces NK Cell Triggering: Role of NKp30 and NKG2D Receptors. J. Immunol. 175: 6352-6360 [Abstract] [Full Text]  
• Schierloh, P., Yokobori, N., Aleman, M., Musella, R. M., Beigier-Bompadre, M., Saab, M. A., Alves, L., Abbate, E., de la Barrera, S. S., Sasiain, M. C. (2005). Increased Susceptibility to Apoptosis of CD56dimCD16+ NK Cells Induces the Enrichment of IFN-{gamma}-Producing CD56bright Cells in Tuberculous Pleurisy. J. Immunol. 175: 6852-6860 [Abstract] [Full Text]  
• Mailliard, R. B., Alber, S. M., Shen, H., Watkins, S. C., Kirkwood, J. M., Herberman, R. B., Kalinski, P. (2005). IL-18-induced CD83+CCR7+ NK helper cells. JEM 202: 941-953 [Abstract] [Full Text]  
• Meier, U.-C., Owen, R. E., Taylor, E., Worth, A., Naoumov, N., Willberg, C., Tang, K., Newton, P., Pellegrino, P., Williams, I., Klenerman, P., Borrow, P. (2005). Shared Alterations in NK Cell Frequency, Phenotype, and Function in Chronic Human Immunodeficiency Virus and Hepatitis C Virus Infections. J. Virol. 79: 12365-12374 [Abstract] [Full Text]  
• Vankayalapati, R., Garg, A., Porgador, A., Griffith, D. E., Klucar, P., Safi, H., Girard, W. M., Cosman, D., Spies, T., Barnes, P. F. (2005). Role of NK Cell-Activating Receptors and Their Ligands in the Lysis of Mononuclear Phagocytes Infected with an Intracellular Bacterium. J. Immunol. 175: 4611-4617 [Abstract] [Full Text]  
• Elkord, E., Williams, P. E., Kynaston, H., Rowbottom, A. W. (2005). Differential CTLs specific for prostate-specific antigen in healthy donors and patients with prostate cancer. Int Immunol 17: 1315-1325 [Abstract] [Full Text]  
• Walzer, T., Dalod, M., Robbins, S. H., Zitvogel, L., Vivier, E. (2005). Natural-killer cells and dendritic cells: "l'union fait la force". Blood 106: 2252-2258 [Abstract] [Full Text]  
• Morandi, B., Costa, R., Falco, M., Parolini, S., De Maria, A., Ratto, G., Mingari, M. C., Melioli, G., Moretta, A., Ferlazzo, G. (2005). Distinctive Lack of CD48 Expression in Subsets of Human Dendritic Cells Tunes NK Cell Activation. J. Immunol. 175: 3690-3697 [Abstract] [Full Text]  
• Fauriat, C., Moretta, A., Olive, D., Costello, R. T. (2005). Defective killing of dendritic cells by autologous natural killer cells from acute myeloid leukemia patients. Blood 106: 2186-2188 [Abstract] [Full Text]  
• Atochina, O., Harn, D. (2005). LNFPIII/LeX-Stimulated Macrophages Activate Natural Killer Cells via CD40-CD40L Interaction. CVI 12: 1041-1049 [Abstract] [Full Text]  
• Prlic, M., Gibbs, J., Jameson, S. C. (2005). Characteristics of NK Cell Migration Early after Vaccinia Infection. J. Immunol. 175: 2152-2157 [Abstract] [Full Text]  
• Williams, A. P., Bateman, A. R., Khakoo, S. I. (2005). HANGING IN THE BALANCE: KIR and Their Role in Disease. Mol. Interv. 5: 226-240 [Abstract] [Full Text]  
• Rossi, M., Young, J. W. (2005). Human Dendritic Cells: Potent Antigen-Presenting Cells at the Crossroads of Innate and Adaptive Immunity. J. Immunol. 175: 1373-1381 [Abstract] [Full Text]  
• Terme, M., Borg, C., Guilhot, F., Masurier, C., Flament, C., Wagner, E. F., Caillat-Zucman, S., Bernheim, A., Turhan, A. G., Caignard, A., Zitvogel, L. (2005). BCR/ABL Promotes Dendritic Cell-Mediated Natural Killer Cell Activation. Cancer Res. 65: 6409-6417 [Abstract] [Full Text]  
• Vitale, M., Chiesa, M. D., Carlomagno, S., Pende, D., Arico, M., Moretta, L., Moretta, A. (2005). NK-dependent DC maturation is mediated by TNF{alpha} and IFN{gamma} released upon engagement of the NKp30 triggering receptor. Blood 106: 566-571 [Abstract] [Full Text]  
• Semino, C., Angelini, G., Poggi, A., Rubartelli, A. (2005). NK/iDC interaction results in IL-18 secretion by DCs at the synaptic cleft followed by NK cell activation and release of the DC maturation factor HMGB1. Blood 106: 609-616 [Abstract] [Full Text]  
• Warren, H. S., Jones, A. L., Freeman, C., Bettadapura, J., Parish, C. R. (2005). Evidence That the Cellular Ligand for the Human NK Cell Activation Receptor NKp30 Is Not a Heparan Sulfate Glycosaminoglycan. J. Immunol. 175: 207-212 [Abstract] [Full Text]  
• Zanoni, I., Foti, M., Ricciardi-Castagnoli, P., Granucci, F. (2005). TLR-Dependent Activation Stimuli Associated with Th1 Responses Confer NK Cell Stimulatory Capacity to Mouse Dendritic Cells. J. Immunol. 175: 286-292 [Abstract] [Full Text]  
• Adam, C., King, S., Allgeier, T., Braumuller, H., Luking, C., Mysliwietz, J., Kriegeskorte, A., Busch, D. H., Rocken, M., Mocikat, R. (2005). DC-NK cell cross talk as a novel CD4+ T-cell-independent pathway for antitumor CTL induction. Blood 106: 338-344 [Abstract] [Full Text]  
• Nguyen, S., Dhedin, N., Vernant, J.-P., Kuentz, M., Jijakli, A. A., Rouas-Freiss, N., Carosella, E. D., Boudifa, A., Debre, P., Vieillard, V. (2005). NK-cell reconstitution after haploidentical hematopoietic stem-cell transplantations: immaturity of NK cells and inhibitory effect of NKG2A override GvL effect. Blood 105: 4135-4142 [Abstract] [Full Text]  
• Biassoni, R., Fogli, M., Cantoni, C., Costa, P., Conte, R., Koopman, G., Cafaro, A., Ensoli, B., Moretta, A., Moretta, L., De Maria, A. (2005). Molecular and Functional Characterization of NKG2D, NKp80, and NKG2C Triggering NK Cell Receptors in Rhesus and Cynomolgus Macaques: Monitoring of NK Cell Function during Simian HIV Infection. J. Immunol. 174: 5695-5705 [Abstract] [Full Text]  
• Trivedi, P. P., Roberts, P. C., Wolf, N. A., Swanborg, R. H. (2005). NK Cells Inhibit T Cell Proliferation via p21-Mediated Cell Cycle Arrest. J. Immunol. 174: 4590-4597 [Abstract] [Full Text]  
• Marcenaro, E., Chiesa, M. D., Bellora, F., Parolini, S., Millo, R., Moretta, L., Moretta, A. (2005). IL-12 or IL-4 Prime Human NK Cells to Mediate Functionally Divergent Interactions with Dendritic Cells or Tumors. J. Immunol. 174: 3992-3998 [Abstract] [Full Text]  

Home | Help | Feedback | Subscriptions | Archive | Search

TABLE OF CONTENTS