Differential T Cell Function and Fate in Lymph Node and Nonlymphoid Tissues

doi:10.1084/jem.20011558

Published 4 February 2002. doi:10.1084/jem.20011558

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© Rockefeller University Press, 0022-1007/2002/2/317/ $5.00
The Journal of Experimental Medicine, Volume 195, Number 3, February 4, 2002 317-326

Original Article

Differential T Cell Function and Fate in Lymph Node and Nonlymphoid Tissues

Nicola L. Harris, Victoria Watt, Franca Ronchese and Graham Le Gros

Malaghan Institute of Medical Research, Wellington School of Medicine, 6002 Wellington, New Zealand

Address correspondence to Nicola L. Harris, Malaghan Institute of Medical Research, PO Box 7060, Wellington South, New Zealand. Phone: 64 4 389 5096; Fax: 64 4 389 5095; E-mail: nharris{at}malaghan.org.nz

The functions and fate of antigen-experienced T cells isolatedfrom lymph node or nonlymphoid tissues were analyzed in a systeminvolving adoptive transfer of in vitro–activated T cellsinto mice. Activated T cells present in the lymph nodes couldbe stimulated by antigen to divide, produce effector cytokines,and migrate to peripheral tissues. By contrast, activated Tcells that had migrated into nonlymphoid tissues (lung and airway)produced substantial effector cytokines upon antigen challenge,but were completely unable to divide or migrate back to thelymph nodes. Therefore, activated T cells can undergo clonalexpansion in the lymph node, but are recruited and retainedas nondividing cells in nonlymphoid tissues. These distinctregulatory events in lymph node and nonlymphoid tissues revealsimple key mechanisms for both inducing and limiting T cellimmunity.

Key Words: T cell • lung • cell migration • cell division • cytokines

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