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Original Article

¹ Laboratory of Immunology and Vascular Biology, Department of Pathology and the Digestive Disease Center, Department of Medicine, Stanford University Medical School, Stanford, CA 94305
² Center for Molecular Biology and Medicine, Veterans Affairs, Palo Alto Health Care System, Palo Alto, CA 94305

Address correspondence to Eugene C. Butcher, Dept. of Pathology (5324), Stanford University School of Medicine, Stanford, CA 94305-8444. Phone: 650-852-3369; Fax: 650-858-3986; E-mail: ebutcher{at}cmgm.stanford.edu

Immunoglobulin A (IgA) provides protection against pathogens at mucosal surfaces. Chemotactic responses have been hypothesized to target IgA plasma cells involved in mucosal immune responses. We show here that thymus-expressed chemokine (TECK, CCL25) is a potent and selective chemoattractant for IgA antibody-secreting cells (ASC), efficiently recruiting IgA-producing cells from spleen, Peyer's patches, and mesenteric lymph node. Cells secreting IgA antibody in response to rotavirus, an intestinal pathogen, also respond well. In contrast, IgG– and IgM–ASC respond poorly. Epithelial cells in the small intestines, a principal site of IgA–ASC localization and IgA production in the body, highly and selectively express TECK. The migration of IgA–ASC to the intestinal epithelial cell chemokine TECK may help target IgA-producing cells to the gut wall, thus helping define and segregate the intestinal immune response.

Key Words: homing • migration • chemokine • B cell • isotype

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