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Original Article

Department of Molecular Biology, Princeton University, Princeton, NJ 08544

Address correspondence to Dr. Martin Weigert, Department of Molecular Biology, Princeton University, Princeton, NJ 08544. Phone: 609-258-2683; Fax: 609-258-2205; E-mail: mweigert{at}molbio.princeton.edu

Allotype and isotype exclusion is a property of most lymphocytes. The reason for this property is not known but it guarantees a high concentration of a single receptor, and threshold numbers of receptors may be required for efficient positive and negative selection. Receptor editing compromises exclusion by sustaining recombination even after a functional receptor is formed. Consequently, B cells expressing multiple receptors arise. We have studied such B cells in which one of the two receptors is anti-self, and find that these partially autoreactive B cells accumulate in the marginal zone. The restriction of these cells in this location may help to prevent them from undergoing diversification and developing into fully autoreactive B cells.

Key Words: editing • autoimmunity • antinuclear antibody • tolerance • allele exclusion

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