The Journal of Experimental Medicine
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Published 14 January 2002. doi:10.1084/jem.20011453
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© Rockefeller University Press, 0022-1007/2002/1/181/ $5.00
The Journal of Experimental Medicine, Volume 195, Number 2, January 21, 2002 181-188

Original Article

Autoreactive B Cells in the Marginal Zone that Express Dual Receptors

Yijin Li, Hui Li and Martin Weigert

Department of Molecular Biology, Princeton University, Princeton, NJ 08544

Address correspondence to Dr. Martin Weigert, Department of Molecular Biology, Princeton University, Princeton, NJ 08544. Phone: 609-258-2683; Fax: 609-258-2205; E-mail: mweigert{at}molbio.princeton.edu

Allotype and isotype exclusion is a property of most lymphocytes. The reason for this property is not known but it guarantees a high concentration of a single receptor, and threshold numbers of receptors may be required for efficient positive and negative selection. Receptor editing compromises exclusion by sustaining recombination even after a functional receptor is formed. Consequently, B cells expressing multiple receptors arise. We have studied such B cells in which one of the two receptors is anti-self, and find that these partially autoreactive B cells accumulate in the marginal zone. The restriction of these cells in this location may help to prevent them from undergoing diversification and developing into fully autoreactive B cells.

Key Words: editing • autoimmunity • antinuclear antibody • tolerance • allele exclusion


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