Brief Definitive Report

CD11c⁺B220⁺Gr-1⁺ Cells in Mouse Lymph Nodes and Spleen Display Characteristics of Plasmacytoid Dendritic Cells

Correspondence to: Michael Dee Gunn, Box 3547, Duke University Medical Center, Durham, NC 27710. Tel:919-681-0840 Fax:919-684-8591 E-mail:michael.gunn{at}duke.edu.

Human plasmacytoid dendritic cells (pDCs) are major producers of IFN, are activated by CpG motifs, and are believed to enter lymph nodes (LNs) via L-selectin dependent extravasation across high endothelial venules. To identify a similar murine DC type, CD11c⁺ cells in the LNs of L-selectin–deficient and control BALB/c mice were compared, revealing a population of CD11c⁺CD11b^- cells that is reduced 85% in the LNs of L-selectin–deficient mice. These cells are Gr-1⁺B220⁺CD19^-, either CD4⁺ or CD8⁺, and localize within T cell zones of LNs. Freshly isolated CD11c⁺Gr-1⁺ cells express major histocompatibility complex class II at low levels, display a plasmacytoid morphology, and survive poorly in culture. Their survival is increased and they develop a DC-like morphology in interleukin 3 and CpG. Like human pDCs, CD11c⁺Gr-1⁺ cells stimulate T cell proliferation after activation with CpG and produce IFN after stimulation with influenza virus. These cells also display a strain-specific variation in frequency, being fivefold increased in the LNs of BALB/c relative to C57BL/6 mice. These CD11c⁺CD11b^-B220⁺Gr-1⁺ cells appear to be the murine equivalent of human pDCs.

Key Words: dendritic cells, lymph nodes, B220 antigens, L-selectin, interferon type 1

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• Montoya, M., Edwards, M. J., Reid, D. M., Borrow, P. (2005). Rapid Activation of Spleen Dendritic Cell Subsets following Lymphocytic Choriomeningitis Virus Infection of Mice: Analysis of the Involvement of Type 1 IFN. J. Immunol. 174: 1851-1861 [Abstract] [Full Text]  
• Yee, C. S. K., Yao, Y., Xu, Q., McCarthy, B., Sun-Lin, D., Tone, M., Waldmann, H., Chang, C.-H. (2005). Enhanced Production of IL-10 by Dendritic Cells Deficient in CIITA. J. Immunol. 174: 1222-1229 [Abstract] [Full Text]  
• Mack, M., Schneider, M. A., Moll, C., Cihak, J., Bruhl, H., Ellwart, J. W., Hogarth, M. P., Stangassinger, M., Schlondorff, D. (2005). Identification of Antigen-Capturing Cells as Basophils. J. Immunol. 174: 735-741 [Abstract] [Full Text]  
• Oriss, T. B., Ostroukhova, M., Seguin-Devaux, C., Dixon-McCarthy, B., Stolz, D. B., Watkins, S. C., Pillemer, B., Ray, P., Ray, A. (2005). Dynamics of Dendritic Cell Phenotype and Interactions with CD4+ T Cells in Airway Inflammation and Tolerance. J. Immunol. 174: 854-863 [Abstract] [Full Text]  
• McKenna, K., Beignon, A.-S., Bhardwaj, N. (2005). Plasmacytoid Dendritic Cells: Linking Innate and Adaptive Immunity. J. Virol. 79: 17-27 [Full Text]  
• Stephens-Romero, S. D., Mednick, A. J., Feldmesser, M. (2005). The Pathogenesis of Fatal Outcome in Murine Pulmonary Aspergillosis Depends on the Neutrophil Depletion Strategy. Infect. Immun. 73: 114-125 [Abstract] [Full Text]  
• Kared, H., Masson, A., Adle-Biassette, H., Bach, J.-F., Chatenoud, L., Zavala, F. (2005). Treatment With Granulocyte Colony-Stimulating Factor Prevents Diabetes in NOD Mice by Recruiting Plasmacytoid Dendritic Cells and Functional CD4+CD25+ Regulatory T-Cells. Diabetes 54: 78-84 [Abstract] [Full Text]  
• Stephens, G. L., McHugh, R. S., Whitters, M. J., Young, D. A., Luxenberg, D., Carreno, B. M., Collins, M., Shevach, E. M. (2004). Engagement of Glucocorticoid-Induced TNFR Family-Related Receptor on Effector T Cells by its Ligand Mediates Resistance to Suppression by CD4+CD25+ T Cells. J. Immunol. 173: 5008-5020 [Abstract] [Full Text]  
• Fallarino, F., Asselin-Paturel, C., Vacca, C., Bianchi, R., Gizzi, S., Fioretti, M. C., Trinchieri, G., Grohmann, U., Puccetti, P. (2004). Murine Plasmacytoid Dendritic Cells Initiate the Immunosuppressive Pathway of Tryptophan Catabolism in Response to CD200 Receptor Engagement. J. Immunol. 173: 3748-3754 [Abstract] [Full Text]  
• Schlecht, G., Garcia, S., Escriou, N., Freitas, A. A., Leclerc, C., Dadaglio, G. (2004). Murine plasmacytoid dendritic cells induce effector/memory CD8+ T-cell responses in vivo after viral stimulation. Blood 104: 1808-1815 [Abstract] [Full Text]  
• Palamara, F., Meindl, S., Holcmann, M., Luhrs, P., Stingl, G., Sibilia, M. (2004). Identification and Characterization of pDC-Like Cells in Normal Mouse Skin and Melanomas Treated with Imiquimod. J. Immunol. 173: 3051-3061 [Abstract] [Full Text]  
• Burke, F., Stagg, A. J., Bedford, P. A., English, N., Knight, S. C. (2004). IL-10-Producing B220+CD11c- APC in Mouse Spleen. J. Immunol. 173: 2362-2372 [Abstract] [Full Text]  
• Diao, J., Winter, E., Chen, W., Cantin, C., Cattral, M. S. (2004). Characterization of Distinct Conventional and Plasmacytoid Dendritic Cell-Committed Precursors in Murine Bone Marrow. J. Immunol. 173: 1826-1833 [Abstract] [Full Text]  
• de Heer, H. J., Hammad, H., Soullie, T., Hijdra, D., Vos, N., Willart, M. A.M., Hoogsteden, H. C., Lambrecht, B. N. (2004). Essential Role of Lung Plasmacytoid Dendritic Cells in Preventing Asthmatic Reactions to Harmless Inhaled Antigen. JEM 200: 89-98 [Abstract] [Full Text]  

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