Original Article

A Pathogenic Role for Myelin-specific CD8⁺ T Cells in a Model for Multiple Sclerosis

Correspondence to: Joan Goverman, Box 357650, Dept. of Molecular Biotechnology, University of Washington, Seattle, WA 98195. Tel:206-685-7604 Fax:206-543-1013 E-mail:goverman{at}u.washington.edu.

Multiple sclerosis (MS) is a demyelinating disease of the central nervous system (CNS) characterized by plaques of infiltrating CD4⁺ and CD8⁺ T cells. Studies of MS and experimental autoimmune encephalomyelitis (EAE), an animal model of MS, focus on the contribution of CD4⁺ myelin-specific T cells. The role of CD8⁺ myelin-specific T cells in mediating EAE or MS has not been described previously. Here, we demonstrate that myelin-specific CD8⁺ T cells induce severe CNS autoimmunity in mice. The pathology and clinical symptoms in CD8⁺ T cell–mediated CNS autoimmunity demonstrate similarities to MS not seen in myelin-specific CD4⁺ T cell–mediated EAE. These data suggest that myelin-specific CD8⁺ T cells could function as effector cells in the pathogenesis of MS.

Key Words: autoimmunity, central nervous system, experimental autoimmune encephalomyelitis, myelin basic protein, cytotoxic T cell

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