The Journal of Experimental Medicine
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Published online 3 September 2001. doi:10.1084/jem.194.5.669
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© The Rockefeller University Press, 0022-1007/2001/9/669/ $5.00
The Journal of Experimental Medicine, Volume 194, Number 5, September 3, 2001 669-676

Original Article

A Pathogenic Role for Myelin-Specific Cd8+ T Cells in a Model for Multiple Sclerosis

Eric S. Husebya, Denny Liggittb, Thea Brabbb,c, Bryan Schnabelc, Claes Öhléna, and Joan Govermana,c

a Departments of Immunology, University of Washington, Seattle, Washington 98195
b Comparative Medicine, University of Washington, Seattle, Washington 98195
c Molecular Biotechnology, University of Washington, Seattle, Washington 98195
Box 357650, Dept. of Molecular Biotechnology, University of Washington, Seattle, WA 98195.206-543-1013206-685-7604

goverman{at}u.washington.edu

Multiple sclerosis (MS) is a demyelinating disease of the central nervous system (CNS) characterized by plaques of infiltrating CD4+ and CD8+ T cells. Studies of MS and experimental autoimmune encephalomyelitis (EAE), an animal model of MS, focus on the contribution of CD4+ myelin-specific T cells. The role of CD8+ myelin-specific T cells in mediating EAE or MS has not been described previously. Here, we demonstrate that myelin-specific CD8+ T cells induce severe CNS autoimmunity in mice. The pathology and clinical symptoms in CD8+ T cell–mediated CNS autoimmunity demonstrate similarities to MS not seen in myelin-specific CD4+ T cell–mediated EAE. These data suggest that myelin-specific CD8+ T cells could function as effector cells in the pathogenesis of MS.

Key Words: autoimmunity • central nervous system • experimental autoimmune encephalomyelitis • myelin basic protein • cytotoxic T cell

E.S. Huseby's current address is Howard Hughes Medical Institute, Dept. of Immunology, National Jewish Medical Center, 1400 Jackson St., Denver, CO 80206.

Abbreviations used in this paper: CNS, central nervous system; EAE, experimental autoimmune encephalomyelitis; H&E, hematoxylin and eosin; LFB, Luxol Fast Blue; MBP, myelin basic protein; MBP–CTL, CD8+ T cells specific for MBP; MS, multiple sclerosis; Vac–CTL, Vaccinia-specific CTLs.

© 2001 The Rockefeller University Press


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