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Original Article |
Stabilizes the T Helper Cell Type 1 Phenotype
hhuang{at}lumc.edu
T helper cell (Th)1-primed CD4 T cells from wild-type donors make little interleukin (IL)-4 when restimulated under Th2 conditions. However, such restimulation of Th1-primed cells from interferon (IFN)-
2/– or IFN-
receptor (IFN-
R)–/– mice resulted in substantial production of IL-4 and other Th2 cytokines. Adding IFN-
to the priming culture markedly diminished the capacity of Th1-primed IFN-
2/– cells to express IL-4. Even IFN-
–producing cells from IFN-
R–/– mice could acquire IL-4–producing capacity. Thus, IFN-
is not required for the development of IFN-
–producing capacity, but it plays a critical role in suppressing the IL-4–producing potential of Th1 cells.
Key Words: IL-4 IL-12 differentiation commitment cell cloning
© 2001 The Rockefeller University Press
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