The Journal of Experimental Medicine
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Published online 2 April 2001.
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© The Rockefeller University Press, 0022-1007/2001/4/839/ $5.00
The Journal of Experimental Medicine, Volume 193, Number 7, April 2, 2001 839-846

Original Article

B7-Dc, a New Dendritic Cell Molecule with Potent Costimulatory Properties for T Cells

Su-Yi Tsenga, Mizuto Otsujia, Kevin Gorskia, Xin Huanga, Jill E. Slanskya, Sara I. Paia, Ahmed Shalabia, Tahiro Shina, Drew M. Pardolla, and Haruo Tsuchiyaa

a Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205
Department of Oncology, Johns Hopkins School of Medicine, 1650 Orleans St.-1, CRB-Rm. 440, Baltimore, MD 21231.410-614-0549410-955-7866

dmpardol{at}jhmi.edu

Dendritic cells (DCs), unique antigen-presenting cells (APCs) with potent T cell stimulatory capacity, direct the activation and differentiation of T cells by providing costimulatory signals. As such, they are critical regulators of both natural and vaccine-induced immune responses. A new B7 family member, B7-DC, whose expression is highly restricted to DCs, was identified among a library of genes differentially expressed between DCs and activated macrophages. B7-DC fails to bind the B7.1/2 receptors CD28 and cytotoxic T lymphocyte–associated antigen (CTLA)-4, but does bind PD-1, a receptor for B7-H1/PD-L1. B7-DC costimulates T cell proliferation more efficiently than B7.1 and induces a distinct pattern of lymphokine secretion. In particular, B7-DC strongly costimulates interferon {gamma} but not interleukin (IL)-4 or IL-10 production from isolated naive T cells. These properties of B7-DC may account for some of the unique activity of DCs, such as their ability to initiate potent T helper cell type 1 responses.

Key Words: dendritic cells • T cell activation • B7 • interferon {gamma} • costimulatory molecule

S.-Y. Tseng, M. Otsuji, and K. Gorski contributed equally to this work.

Abbreviations used in this paper: aa, amino acid(s); BAC, bacterial artificial chromosome; CTLA, CTL-associated antigen; DC, dendritic cell; HA, hemagglutinin; RACE, rapid amplification of cDNA ends; RT, reverse transcription.

© 2001 The Rockefeller University Press


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