A Dendritic Cell-Specific Intercellular Adhesion Molecule 3-Grabbing Nonintegrin (Dc-Sign)-Related Protein Is Highly Expressed on Human Liver Sinusoidal Endothelial Cells and Promotes HIV-1 Infection

doi:10.1084/jem.193.6.671

Published online 19 March 2001.

This Article

	Full Text
	Full Text (PDF, 276K)
	PPT slides of all figures
	Alert me when this article is cited
	Citation Map

Services

	Email this article
	Similar articles in this journal
	Similar articles in PubMed
	Alert me to new content in the JEM
	Download to citation manager

Citing Articles

	Citing Articles via HighWire
	Citing Articles via CrossRef
	Citing Articles via Google Scholar

Google Scholar

	Articles by Bashirova, A. A.
	Articles by Carrington, M.
	Search for Related Content

PubMed

	PubMed Citation
	Articles by Bashirova, A. A.
	Articles by Carrington, M.


Social Bookmarking

	What's this?

© The Rockefeller University Press, 0022-1007/2001/3/671/ $5.00
The Journal of Experimental Medicine, Volume 193, Number 6, March 19, 2001 671-678

Original Article

A Dendritic Cell–Specific Intercellular Adhesion Molecule 3–Grabbing Nonintegrin (Dc-Sign)–Related Protein Is Highly Expressed on Human Liver Sinusoidal Endothelial Cells and Promotes HIV-1 Infection

Arman A. Bashirova^a, Teunis B.H. Geijtenbeek^d, Gerard C.F. van Duijnhoven^d, Sandra J. van Vliet^d, Jeroen B.G. Eilering^d, Maureen P. Martin^b, Li Wu^c, Thomas D. Martin^c, Nicola Viebig^e, Percy A. Knolle^e, Vineet N. KewalRamani^c, Yvette van Kooyk^d, and Mary Carrington^b

^a Laboratory of Genomic Diversity, Science Applications International Corporation-Frederick,
^b Intramural Research Support Program, Science Applications International Corporation-Frederick,
^c HIV Drug Resistance Program, National Cancer Institute-Frederick, Frederick, Maryland 21702
^d Tumor Immunology Department, University Medical Center St. Radbound, Nijmegen 6525 EX, The Netherlands
^e Zentrum für Moleculare Biologie Heidelberg (ZMBH), D-69120 Heidelberg, Germany
P.O. Box B, NCI-FCRDC, Frederick, MD 21702.301-846-1909301-846-1390

carringt{at}mail.ncifcrf.gov

The discovery of dendritic cell (DC)-specific intercellularadhesion molecule (ICAM)-3–grabbing nonintegrin (DC-SIGN)as a DC-specific ICAM-3 binding receptor that enhances HIV-1infection of T cells in trans has indicated a potentially importantrole for adhesion molecules in AIDS pathogenesis. A relatedmolecule called DC-SIGNR exhibits 77% amino acid sequence identitywith DC-SIGN. The DC-SIGN and DC-SIGNR genes map within a 30-kbregion on chromosome 19p13.2-3. Their strong homology and closephysical location indicate a recent duplication of the originalgene. Messenger RNA and protein expression patterns demonstratethat the DC-SIGN–related molecule is highly expressedon liver sinusoidal cells and in the lymph node but not on DCs,in contrast to DC-SIGN. Therefore, we suggest that a more appropriatename for the DC-SIGN–related molecule is L-SIGN, liver/lymphnode–specific ICAM-3–grabbing nonintegrin. We showthat in the liver, L-SIGN is expressed by sinusoidal endothelialcells. Functional studies indicate that L-SIGN behaves similarlyto DC-SIGN in that it has a high affinity for ICAM-3, capturesHIV-1 through gp120 binding, and enhances HIV-1 infection ofT cells in trans. We propose that L-SIGN may play an importantrole in the interaction between liver sinusoidal endotheliumand trafficking lymphocytes, as well as function in the pathogenesisof HIV-1.

Key Words: L-SIGN • adhesion receptor • chromosome 19p13.2-3 • ICAM-3 • HIV-1 gp120

A.A. Bashirova and T.B.H. Geijtenbeek contributed equally tothis work.

Abbreviations used in this paper: CCR, CC chemokine receptor;DC, dendritic cell; DC-SIGN, DC-specific ICAM-3–grabbingnonintegrin; EST, expressed sequence tag; ICAM, intercellularadhesion molecule; L-SIGN, liver/lymph node–specific ICAM-3–grabbingnonintegrin; LSEC, liver sinusoidal endothelial cell; nt, nucleotides;RH, radiation hybrid; RT, reverse transcription; UTR, untranslatedregion.

Add to CiteULike CiteULike Add to Complore Complore Add to Connotea Connotea Add to Del.icio.us Del.icio.us Add to Digg Digg Facebook Add to Reddit Reddit Add to Technorati Technorati Twitter What's this?

This article has been cited by other articles:

Chung, N. P. Y., Breun, S. K. J., Bashirova, A., Baumann, J. G., Martin, T. D., Karamchandani, J. M., Rausch, J. W., Le Grice, S. F. J., Wu, L., Carrington, M., KewalRamani, V. N. (2010). HIV-1 Transmission by Dendritic Cell-specific ICAM-3-grabbing Nonintegrin (DC-SIGN) Is Regulated by Determinants in the Carbohydrate Recognition Domain That Are Absent in Liver/Lymph Node-SIGN (L-SIGN). J. Biol. Chem. 285: 2100-2112 [Abstract] [Full Text]
Vollmar, B., Menger, M. D. (2009). The Hepatic Microcirculation: Mechanistic Contributions and Therapeutic Targets in Liver Injury and Repair. Physiol. Rev. 89: 1269-1339 [Abstract] [Full Text]
Reynoso, E. D., Turley, S. J. (2009). Unconventional antigen-presenting cells in the induction of peripheral CD8+ T cell tolerance. J. Leukoc. Biol. 86: 795-801 [Abstract] [Full Text]
Luallen, R. J., Fu, H., Agrawal-Gamse, C., Mboudjeka, I., Huang, W., Lee, F.-H., Wang, L.-X., Doms, R. W., Geng, Y. (2009). A Yeast Glycoprotein Shows High-Affinity Binding to the Broadly Neutralizing Human Immunodeficiency Virus Antibody 2G12 and Inhibits gp120 Interactions with 2G12 and DC-SIGN. J. Virol. 83: 4861-4870 [Abstract] [Full Text]
Elvevold, K., Smedsrod, B., Martinez, I. (2008). The liver sinusoidal endothelial cell: a cell type of controversial and confusing identity. Am. J. Physiol. Gastrointest. Liver Physiol. 294: G391-G400 [Abstract] [Full Text]
Meyer, S., Tefsen, B., Imberty, A., Geyer, R., van Die, I. (2007). The C-type lectin L-SIGN differentially recognizes glycan antigens on egg glycosphingolipids and soluble egg glycoproteins from Schistosoma mansoni. Glycobiology 17: 1104-1119 [Abstract] [Full Text]
Malcherek, G., Mayr, L., Roda-Navarro, P., Rhodes, D., Miller, N., Trowsdale, J. (2007). The B7 Homolog Butyrophilin BTN2A1 Is a Novel Ligand for DC-SIGN. J. Immunol. 179: 3804-3811 [Abstract] [Full Text]
Thibault, S., Tardif, M. R., Gilbert, C., Tremblay, M. J. (2007). Virus-associated host CD62L increases attachment of human immunodeficiency virus type 1 to endothelial cells and enhances trans infection of CD4+ T lymphocytes. J. Gen. Virol. 88: 2568-2573 [Abstract] [Full Text]
Dominguez-Soto, A., Aragoneses-Fenoll, L., Martin-Gayo, E., Martinez-Prats, L., Colmenares, M., Naranjo-Gomez, M., Borras, F. E., Munoz, P., Zubiaur, M., Toribio, M. L., Delgado, R., Corbi, A. L. (2007). The DC-SIGN-related lectin LSECtin mediates antigen capture and pathogen binding by human myeloid cells. Blood 109: 5337-5345 [Abstract] [Full Text]
Gu, J., Korteweg, C. (2007). Pathology and Pathogenesis of Severe Acute Respiratory Syndrome. Am. J. Pathol. 170: 1136-1147 [Abstract] [Full Text]
Karrar, A, Broome, U, Uzunel, M, Qureshi, A R, Sumitran-Holgersson, S (2007). Human liver sinusoidal endothelial cells induce apoptosis in activated T cells: a role in tolerance induction. Gut 56: 243-252 [Abstract] [Full Text]
Bobardt, M. D., Chatterji, U., Selvarajah, S., Van der Schueren, B., David, G., Kahn, B., Gallay, P. A. (2007). Cell-Free Human Immunodeficiency Virus Type 1 Transcytosis through Primary Genital Epithelial Cells. J. Virol. 81: 395-405 [Abstract] [Full Text]
Shih, Y.-P., Chen, C.-Y., Liu, S.-J., Chen, K.-H., Lee, Y.-M., Chao, Y.-C., Chen, Y.-M. A. (2006). Identifying Epitopes Responsible for Neutralizing Antibody and DC-SIGN Binding on the Spike Glycoprotein of the Severe Acute Respiratory Syndrome Coronavirus. J. Virol. 80: 10315-10324 [Abstract] [Full Text]
Falkowska, E., Durso, R. J., Gardner, J. P., Cormier, E. G., Arrigale, R. A., Ogawa, R. N., Donovan, G. P., Maddon, P. J., Olson, W. C., Dragic, T. (2006). L-SIGN (CD209L) isoforms differently mediate trans-infection of hepatoma cells by hepatitis C virus pseudoparticles. J. Gen. Virol. 87: 2571-2576 [Abstract] [Full Text]
Marzi, A., Akhavan, A., Simmons, G., Gramberg, T., Hofmann, H., Bates, P., Lingappa, V. R., Pohlmann, S. (2006). The Signal Peptide of the Ebolavirus Glycoprotein Influences Interaction with the Cellular Lectins DC-SIGN and DC-SIGNR. J. Virol. 80: 6305-6317 [Abstract] [Full Text]
Lai, W. K., Sun, P. J., Zhang, J., Jennings, A., Lalor, P. F., Hubscher, S., McKeating, J. A., Adams, D. H. (2006). Expression of DC-SIGN and DC-SIGNR on Human Sinusoidal Endothelium: A Role for Capturing Hepatitis C Virus Particles. Am. J. Pathol. 169: 200-208 [Abstract] [Full Text]
Cocquerel, L., Voisset, C., Dubuisson, J. (2006). Hepatitis C virus entry: potential receptors and their biological functions.. J. Gen. Virol. 87: 1075-1084 [Abstract] [Full Text]
McGreal, E. P., Rosas, M., Brown, G. D., Zamze, S., Wong, S. Y.C., Gordon, S., Martinez-Pomares, L., Taylor, P. R. (2006). The carbohydrate-recognition domain of Dectin-2 is a C-type lectin with specificity for high mannose. Glycobiology 16: 422-430 [Abstract] [Full Text]
Davis, C. W., Nguyen, H.-Y., Hanna, S. L., Sanchez, M. D., Doms, R. W., Pierson, T. C. (2006). West Nile Virus Discriminates between DC-SIGN and DC-SIGNR for Cellular Attachment and Infection. J. Virol. 80: 1290-1301 [Abstract] [Full Text]
Dakappagari, N., Maruyama, T., Renshaw, M., Tacken, P., Figdor, C., Torensma, R., Wild, M. A., Wu, D., Bowdish, K., Kretz-Rommel, A. (2006). Internalizing Antibodies to the C-Type Lectins, L-SIGN and DC-SIGN, Inhibit Viral Glycoprotein Binding and Deliver Antigen to Human Dendritic Cells for the Induction of T Cell Responses. J. Immunol. 176: 426-440 [Abstract] [Full Text]
Balasubramanian, A., Munshi, N., Koziel, M. J., Hu, Z., Liang, T. J., Groopman, J. E., Ganju, R. K. (2005). Structural proteins of Hepatitis C virus induce interleukin 8 production and apoptosis in human endothelial cells. J. Gen. Virol. 86: 3291-3301 [Abstract] [Full Text]
Granelli-Piperno, A., Pritsker, A., Pack, M., Shimeliovich, I., Arrighi, J.-F., Park, C. G., Trumpfheller, C., Piguet, V., Moran, T. M., Steinman, R. M. (2005). Dendritic Cell-Specific Intercellular Adhesion Molecule 3-Grabbing Nonintegrin/CD209 Is Abundant on Macrophages in the Normal Human Lymph Node and Is Not Required for Dendritic Cell Stimulation of the Mixed Leukocyte Reaction. J. Immunol. 175: 4265-4273 [Abstract] [Full Text]
Ji, X., Olinger, G. G., Aris, S., Chen, Y., Gewurz, H., Spear, G. T. (2005). Mannose-binding lectin binds to Ebola and Marburg envelope glycoproteins, resulting in blocking of virus interaction with DC-SIGN and complement-mediated virus neutralization. J. Gen. Virol. 86: 2535-2542 [Abstract] [Full Text]
Goffard, A., Callens, N., Bartosch, B., Wychowski, C., Cosset, F.-L., Montpellier, C., Dubuisson, J. (2005). Role of N-Linked Glycans in the Functions of Hepatitis C Virus Envelope Glycoproteins. J. Virol. 79: 8400-8409 [Abstract] [Full Text]
van Gisbergen, K. P.J.M., Aarnoudse, C. A., Meijer, G. A., Geijtenbeek, T. B.H., van Kooyk, Y. (2005). Dendritic Cells Recognize Tumor-Specific Glycosylation of Carcinoembryonic Antigen on Colorectal Cancer Cells through Dendritic Cell-Specific Intercellular Adhesion Molecule-3-Grabbing Nonintegrin. Cancer Res. 65: 5935-5944 [Abstract] [Full Text]
Nair, M. P. N., Mahajan, S. D., Schwartz, S. A., Reynolds, J., Whitney, R., Bernstein, Z., Chawda, R. P., Sykes, D., Hewitt, R., Hsiao, C. B. (2005). Cocaine Modulates Dendritic Cell-Specific C Type Intercellular Adhesion Molecule-3-Grabbing Nonintegrin Expression by Dendritic Cells in HIV-1 Patients. J. Immunol. 174: 6617-6626 [Abstract] [Full Text]
Tang, B. S. F., Chan, K.-h., Cheng, V. C. C., Woo, P. C. Y., Lau, S. K. P., Lam, C. C. K., Chan, T.-l., Wu, A. K. L., Hung, I. F. N., Leung, S.-y., Yuen, K.-y. (2005). Comparative Host Gene Transcription by Microarray Analysis Early after Infection of the Huh7 Cell Line by Severe Acute Respiratory Syndrome Coronavirus and Human Coronavirus 229E. J. Virol. 79: 6180-6193 [Abstract] [Full Text]
Cheynet, V., Ruggieri, A., Oriol, G., Blond, J.-L., Boson, B., Vachot, L., Verrier, B., Cosset, F.-L., Mallet, F. (2005). Synthesis, Assembly, and Processing of the Env ERVWE1/Syncytin Human Endogenous Retroviral Envelope. J. Virol. 79: 5585-5593 [Abstract] [Full Text]
Reyes-del Valle, J., Chavez-Salinas, S., Medina, F., del Angel, R. M. (2005). Heat Shock Protein 90 and Heat Shock Protein 70 Are Components of Dengue Virus Receptor Complex in Human Cells. J. Virol. 79: 4557-4567 [Abstract] [Full Text]
Snyder, G. A., Ford, J., Torabi-Parizi, P., Arthos, J. A., Schuck, P., Colonna, M., Sun, P. D. (2005). Characterization of DC-SIGN/R Interaction with Human Immunodeficiency Virus Type 1 gp120 and ICAM Molecules Favors the Receptor's Role as an Antigen-Capturing Rather than an Adhesion Receptor. J. Virol. 79: 4589-4598 [Abstract] [Full Text]
Arrighi, J.-F., Pion, M., Garcia, E., Escola, J.-M., van Kooyk, Y., Geijtenbeek, T. B., Piguet, V. (2004). DC-SIGN-mediated Infectious Synapse Formation Enhances X4 HIV-1 Transmission from Dendritic Cells to T Cells. JEM 200: 1279-1288 [Abstract] [Full Text]
Jeffers, S. A., Tusell, S. M., Gillim-Ross, L., Hemmila, E. M., Achenbach, J. E., Babcock, G. J., Thomas, W. D. Jr., Thackray, L. B., Young, M. D., Mason, R. J., Ambrosino, D. M., Wentworth, D. E., DeMartini, J. C., Holmes, K. V. (2004). CD209L (L-SIGN) is a receptor for severe acute respiratory syndrome coronavirus. Proc. Natl. Acad. Sci. USA 101: 15748-15753 [Abstract] [Full Text]
Marzi, A., Gramberg, T., Simmons, G., Moller, P., Rennekamp, A. J., Krumbiegel, M., Geier, M., Eisemann, J., Turza, N., Saunier, B., Steinkasserer, A., Becker, S., Bates, P., Hofmann, H., Pohlmann, S. (2004). DC-SIGN and DC-SIGNR Interact with the Glycoprotein of Marburg Virus and the S Protein of Severe Acute Respiratory Syndrome Coronavirus. J. Virol. 78: 12090-12095 [Abstract] [Full Text]
Arrighi, J.-F., Pion, M., Wiznerowicz, M., Geijtenbeek, T. B., Garcia, E., Abraham, S., Leuba, F., Dutoit, V., Ducrey-Rundquist, O., van Kooyk, Y., Trono, D., Piguet, V. (2004). Lentivirus-Mediated RNA Interference of DC-SIGN Expression Inhibits Human Immunodeficiency Virus Transmission from Dendritic Cells to T Cells. J. Virol. 78: 10848-10855 [Abstract] [Full Text]
Cormier, E. G., Durso, R. J., Tsamis, F., Boussemart, L., Manix, C., Olson, W. C., Gardner, J. P., Dragic, T. (2004). L-SIGN (CD209L) and DC-SIGN (CD209) mediate transinfection of liver cells by hepatitis C virus. Proc. Natl. Acad. Sci. USA 101: 14067-14072 [Abstract] [Full Text]
Van Liempt, E., Imberty, A., Bank, C. M. C., Van Vliet, S. J., Van Kooyk, Y., Geijtenbeek, T. B. H., Van Die, I. (2004). Molecular Basis of the Differences in Binding Properties of the Highly Related C-type Lectins DC-SIGN and L-SIGN to Lewis X Trisaccharide and Schistosoma mansoni Egg Antigens. J. Biol. Chem. 279: 33161-33167 [Abstract] [Full Text]
Ludwig, I. S., Lekkerkerker, A. N., Depla, E., Bosman, F., Musters, R. J. P., Depraetere, S., van Kooyk, Y., Geijtenbeek, T. B. H. (2004). Hepatitis C Virus Targets DC-SIGN and L-SIGN To Escape Lysosomal Degradation. J. Virol. 78: 8322-8332 [Abstract] [Full Text]
Lozach, P.-Y., Amara, A., Bartosch, B., Virelizier, J.-L., Arenzana-Seisdedos, F., Cosset, F.-L., Altmeyer, R. (2004). C-type Lectins L-SIGN and DC-SIGN Capture and Transmit Infectious Hepatitis C Virus Pseudotype Particles. J. Biol. Chem. 279: 32035-32045 [Abstract] [Full Text]
Bobardt, M. D., Salmon, P., Wang, L., Esko, J. D., Gabuzda, D., Fiala, M., Trono, D., Van der Schueren, B., David, G., Gallay, P. A. (2004). Contribution of Proteoglycans to Human Immunodeficiency Virus Type 1 Brain Invasion. J. Virol. 78: 6567-6584 [Abstract] [Full Text]
Galustian, C., Park, C. G., Chai, W., Kiso, M., Bruening, S. A., Kang, Y.-S., Steinman, R. M., Feizi, T. (2004). High and low affinity carbohydrate ligands revealed for murine SIGN-R1 by carbohydrate array and cell binding approaches, and differing specificities for SIGN-R3 and langerin. Int Immunol 16: 853-866 [Abstract] [Full Text]
Engering, A., van Vliet, S. J., Hebeda, K., Jackson, D. G., Prevo, R., Singh, S. K., Geijtenbeek, T. B. H., van Krieken, H., van Kooyk, Y. (2004). Dynamic Populations of Dendritic Cell-Specific ICAM-3 Grabbing Nonintegrin-Positive Immature Dendritic Cells and Liver/Lymph Node-Specific ICAM-3 Grabbing Nonintegrin-Positive Endothelial Cells in the Outer Zones of the Paracortex of Human Lymph Nodes. Am. J. Pathol. 164: 1587-1595 [Abstract] [Full Text]
Liu, W., Tang, L., Zhang, G., Wei, H., Cui, Y., Guo, L., Gou, Z., Chen, X., Jiang, D., Zhu, Y., Kang, G., He, F. (2004). Characterization of a Novel C-type Lectin-like Gene, LSECtin: DEMONSTRATION OF CARBOHYDRATE BINDING AND EXPRESSION IN SINUSOIDAL ENDOTHELIAL CELLS OF LIVER AND LYMPH NODE. J. Biol. Chem. 279: 18748-18758 [Abstract] [Full Text]
Smith, A. E., Helenius, A. (2004). How Viruses Enter Animal Cells. Science 304: 237-242 [Abstract] [Full Text]
Takada, A., Fujioka, K., Tsuiji, M., Morikawa, A., Higashi, N., Ebihara, H., Kobasa, D., Feldmann, H., Irimura, T., Kawaoka, Y. (2004). Human Macrophage C-Type Lectin Specific for Galactose and N-Acetylgalactosamine Promotes Filovirus Entry. J. Virol. 78: 2943-2947 [Abstract] [Full Text]
Cole, G, Coleman, N, Soilleux, E (2004). HCV and HIV binding lectin, DC-SIGNR, is expressed at all stages of HCV induced liver disease. J. Clin. Pathol. 57: 79-80 [Abstract] [Full Text]
Lasala, F., Arce, E., Otero, J. R., Rojo, J., Delgado, R. (2003). Mannosyl Glycodendritic Structure Inhibits DC-SIGN-Mediated Ebola Virus Infection in cis and in trans. Antimicrob. Agents Chemother. 47: 3970-3972 [Abstract] [Full Text]
Gummuluru, S., Rogel, M., Stamatatos, L., Emerman, M. (2003). Binding of Human Immunodeficiency Virus Type 1 to Immature Dendritic Cells Can Occur Independently of DC-SIGN and Mannose Binding C-Type Lectin Receptors via a Cholesterol-Dependent Pathway. J. Virol. 77: 12865-12874 [Abstract] [Full Text]
Klimstra, W. B., Nangle, E. M., Smith, M. S., Yurochko, A. D., Ryman, K. D. (2003). DC-SIGN and L-SIGN Can Act as Attachment Receptors for Alphaviruses and Distinguish between Mosquito Cell- and Mammalian Cell-Derived Viruses. J. Virol. 77: 12022-12032 [Abstract] [Full Text]
Lozach, P.-Y., Lortat-Jacob, H., De Lacroix De Lavalette, A., Staropoli, I., Foung, S., Amara, A., Houles, C., Fieschi, F., Schwartz, O., Virelizier, J.-L., Arenzana-Seisdedos, F., Altmeyer, R. (2003). DC-SIGN and L-SIGN Are High Affinity Binding Receptors for Hepatitis C Virus Glycoprotein E2. J. Biol. Chem. 278: 20358-20366 [Abstract] [Full Text]
Gardner, J. P., Durso, R. J., Arrigale, R. R., Donovan, G. P., Maddon, P. J., Dragic, T., Olson, W. C. (2003). L-SIGN (CD 209L) is a liver-specific capture receptor for hepatitis C virus. Proc. Natl. Acad. Sci. USA 100: 4498-4503 [Abstract] [Full Text]
Tassaneetrithep, B., Burgess, T. H., Granelli-Piperno, A., Trumpfheller, C., Finke, J., Sun, W., Eller, M. A., Pattanapanyasat, K., Sarasombath, S., Birx, D. L., Steinman, R. M., Schlesinger, S., Marovich, M. A. (2003). DC-SIGN (CD209) Mediates Dengue Virus Infection of Human Dendritic Cells. JEM 197: 823-829 [Abstract] [Full Text]
Pohlmann, S., Zhang, J., Baribaud, F., Chen, Z., Leslie, G. J., Lin, G., Granelli-Piperno, A., Doms, R. W., Rice, C. M., McKeating, J. A. (2003). Hepatitis C Virus Glycoproteins Interact with DC-SIGN and DC-SIGNR. J. Virol. 77: 4070-4080 [Abstract] [Full Text]
Lin, G., Simmons, G., Pohlmann, S., Baribaud, F., Ni, H., Leslie, G. J., Haggarty, B. S., Bates, P., Weissman, D., Hoxie, J. A., Doms, R. W. (2003). Differential N-Linked Glycosylation of Human Immunodeficiency Virus and Ebola Virus Envelope Glycoproteins Modulates Interactions with DC-SIGN and DC-SIGNR. J. Virol. 77: 1337-1346 [Abstract] [Full Text]
Bashirova, A. A., Wu, L., Cheng, J., Martin, T. D., Martin, M. P., Benveniste, R. E., Lifson, J. D., KewalRamani, V. N., Hughes, A., Carrington, M. (2003). Novel Member of the CD209 (DC-SIGN) Gene Family in Primates. J. Virol. 77: 217-227 [Abstract] [Full Text]
Gummuluru, S., KewalRamani, V. N., Emerman, M. (2002). Dendritic Cell-Mediated Viral Transfer to T Cells Is Required for Human Immunodeficiency Virus Type 1 Persistence in the Face of Rapid Cell Turnover. J. Virol. 76: 10692-10701 [Abstract] [Full Text]
Geijtenbeek, T. B. H., Groot, P. C., Nolte, M. A., van Vliet, S. J., Gangaram-Panday, S. T., van Duijnhoven, G. C. F., Kraal, G., van Oosterhout, A. J. M., van Kooyk, Y. (2002). Marginal zone macrophages express a murine homologue of DC-SIGN that captures blood-borne antigens in vivo. Blood 100: 2908-2916 [Abstract] [Full Text]
Baribaud, F., Pohlmann, S., Leslie, G., Mortari, F., Doms, R. W. (2002). Quantitative Expression and Virus Transmission Analysis of DC-SIGN on Monocyte-Derived Dendritic Cells. J. Virol. 76: 9135-9142 [Abstract] [Full Text]
Alvarez, C. P., Lasala, F., Carrillo, J., Muniz, O., Corbi, A. L., Delgado, R. (2002). C-Type Lectins DC-SIGN and L-SIGN Mediate Cellular Entry by Ebola Virus in cis and in trans. J. Virol. 76: 6841-6844 [Abstract] [Full Text]
Wu, L., Martin, T. D., Vazeux, R., Unutmaz, D., KewalRamani, V. N. (2002). Functional Evaluation of DC-SIGN Monoclonal Antibodies Reveals DC-SIGN Interactions with ICAM-3 Do Not Promote Human Immunodeficiency Virus Type 1 Transmission. J. Virol. 76: 5905-5914 [Abstract] [Full Text]
Geijtenbeek, T. B. H., Engering, A., van Kooyk, Y. (2002). DC-SIGN, a C-type lectin on dendritic cells that unveils many aspects of dendritic cell biology. J. Leukoc. Biol. 71: 921-931 [Abstract] [Full Text]
Geijtenbeek, T. B. H., van Duijnhoven, G. C. F., van Vliet, S. J., Krieger, E., Vriend, G., Figdor, C. G., van Kooyk, Y. (2002). Identification of Different Binding Sites in the Dendritic Cell-specific Receptor DC-SIGN for Intercellular Adhesion Molecule 3 and HIV-1. J. Biol. Chem. 277: 11314-11320 [Abstract] [Full Text]
Soilleux, E. J., Morris, L. S., Leslie, G., Chehimi, J., Luo, Q., Levroney, E., Trowsdale, J., Montaner, L. J., Doms, R. W., Weissman, D., Coleman, N., Lee, B. (2002). Constitutive and induced expression of DC-SIGN on dendritic cell and macrophage subpopulations in situ and in vitro. J. Leukoc. Biol. 71: 445-457 [Abstract] [Full Text]
Jameson, B., Baribaud, F., Pohlmann, S., Ghavimi, D., Mortari, F., Doms, R. W., Iwasaki, A. (2002). Expression of DC-SIGN by Dendritic Cells of Intestinal and Genital Mucosae in Humans and Rhesus Macaques. J. Virol. 76: 1866-1875 [Abstract] [Full Text]
Lee, B., Leslie, G., Soilleux, E., O'Doherty, U., Baik, S., Levroney, E., Flummerfelt, K., Swiggard, W., Coleman, N., Malim, M., Doms, R. W. (2001). cis Expression of DC-SIGN Allows for More Efficient Entry of Human and Simian Immunodeficiency Viruses via CD4 and a Coreceptor. J. Virol. 75: 12028-12038 [Abstract] [Full Text]
Feinberg, H., Mitchell, D. A., Drickamer, K., Weis, W. I. (2001). Structural Basis for Selective Recognition of Oligosaccharides by DC-SIGN and DC-SIGNR. Science 294: 2163-2166 [Abstract] [Full Text]
Lin, G., Lee, B., Haggarty, B. S., Doms, R. W., Hoxie, J. A. (2001). CD4-Independent Use of Rhesus CCR5 by Human Immunodeficiency Virus Type 2 Implicates an Electrostatic Interaction between the CCR5 N Terminus and the gp120 C4 Domain. J. Virol. 75: 10766-10778 [Abstract] [Full Text]
Baribaud, F., Pohlmann, S., Sparwasser, T., Kimata, M. T. Y., Choi, Y.-K., Haggarty, B. S., Ahmad, N., Macfarlan, T., Edwards, T. G., Leslie, G. J., Arnason, J., Reinhart, T. A., Kimata, J. T., Littman, D. R., Hoxie, J. A., Doms, R. W. (2001). Functional and Antigenic Characterization of Human, Rhesus Macaque, Pigtailed Macaque, and Murine DC-SIGN. J. Virol. 75: 10281-10289 [Abstract] [Full Text]
Pohlmann, S., Leslie, G. J., Edwards, T. G., Macfarlan, T., Reeves, J. D., Hiebenthal-Millow, K., Kirchhoff, F., Baribaud, F., Doms, R. W. (2001). DC-SIGN Interactions with Human Immunodeficiency Virus: Virus Binding and Transfer Are Dissociable Functions. J. Virol. 75: 10523-10526 [Abstract] [Full Text]
Park, C. G., Takahara, K., Umemoto, E., Yashima, Y., Matsubara, K., Matsuda, Y., Clausen, B. E., Inaba, K., Steinman, R. M. (2001). Five mouse homologues of the human dendritic cell C-type lectin, DC-SIGN. Int Immunol 13: 1283-1290 [Abstract] [Full Text]
Mitchell, D. A., Fadden, A. J., Drickamer, K. (2001). A Novel Mechanism of Carbohydrate Recognition by the C-type Lectins DC-SIGN and DC-SIGNR. SUBUNIT ORGANIZATION AND BINDING TO MULTIVALENT LIGANDS. J. Biol. Chem. 276: 28939-28945 [Abstract] [Full Text]
Wu, L., Bashirova, A. A., Martin, T. D., Villamide, L., Mehlhop, E., Chertov, A. O., Unutmaz, D., Pope, M., Carrington, M., KewalRamani, V. N. (2002). Rhesus macaque dendritic cells efficiently transmit primate lentiviruses independently of DC-SIGN. Proc. Natl. Acad. Sci. USA 99: 1568-1573 [Abstract] [Full Text]