The Journal of Experimental Medicine
Torrey Pines Biolabs
  Home | Help | Feedback | Subscriptions | Archive | Search | Table of Contents
Published online 6 November 2000.
This Article
Right arrow Full Text
Right arrow Full Text (PDF, 390K)
Right arrow PPT slides of all figures
Right arrow Alert me when this article is cited
Right arrow Citation Map
Services
Right arrow Email this article
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new content in the JEM
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via CrossRef
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Flaishon, L.
Right arrow Articles by Shachar, I.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Flaishon, L.
Right arrow Articles by Shachar, I.
Right arrowPubmed/NCBI databases
*Gene*GEO Profiles
*HomoloGene*UniGene
*Compound via MeSH
*Substance via MeSH
Hazardous Substances DB
*12-O-TETRADECANOYLPHORBOL-13-ACETATE
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Facebook   Add to Reddit   Add to Technorati   Add to Twitter  
What's this?
© The Rockefeller University Press, 0022-1007/2000/11/1381/ $5.00
The Journal of Experimental Medicine, Volume 192, Number 9, November 6, 2000 1381-1388

Brief Definitive Report

Autocrine Secretion of Interferon {gamma} Negatively Regulates Homing of Immature B Cells

Liat Flaishona,b, Rami Hershkoviza, Frida Lantnera, Ofer Lidera, Ronen Alona, Yoram Levob, Richard A. Flavellc, and Idit Shachara

a Department of Immunology, The Weizmann Institute of Science, Rehovot 76100, Israel
b Sourasky Medical Center, Tel-Aviv 64239, Israel
c Howard Hughes Medical Institute, Section of Immunobiology, Yale School of Medicine, New Haven, Connecticut 06510
Department of Immunology, The Weizmann Institute of Science, Rehovot 76100, Israel.972-8-934-4141972-8-934-4257

The mechanism by which immature B cells are sequestered from encountering foreign antigens present in lymph nodes or sites of inflammation, before their final maturation in the spleen, has not been elucidated. We show here that immature B cells fail to home to the lymph nodes. These cells can actively exclude themselves from antigen-enriched sites by downregulating their integrin-mediated adhesion to the extracellular matrix protein, fibronectin. This inhibition is mediated by interferon {gamma} secretion. Perturbation of interferon {gamma} activity in vivo leads to the homing of immature B cells to the lymph nodes. This is the first example of autocrine regulation of immune cell migration to sites of foreign antigen presentation.

Key Words: lymph nodes • adhesion • migration • interferon {gamma} • invariant chain–/– mice

© 2000 The Rockefeller University Press


Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Facebook Facebook   Add to Reddit Reddit   Add to Technorati Technorati   Add to Twitter Twitter    What's this?




  Home | Help | Feedback | Subscriptions | Archive | Search
TABLE OF CONTENTS