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Original Article

Nuclear Factor b Is Required for the Development of Marginal Zone B Lymphocytes

^a Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, Massachusetts 02129
^b Division of Immunology, Department of Medicine, Cornell University Medical College, New York, New York 10021
^c Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115
Massachusetts General Hospital Cancer Center, Bldg. 149, 13th St., Charlestown, MA 02129.617-724-9648617-726-5619

Although immunoglobulin (Ig)M^hiIgD^lo/–CD21^hi marginal zone B cells represent a significant proportion of naive peripheral splenic B lymphocytes, few of the genes that regulate their development have been identified. This subset of peripheral B cells fails to emerge in mice that lack nuclear factor (NF)-Bp50. Less drastic reductions in marginal zone B cell numbers are also seen in the spleens of recombination activating gene (Rag)-2^–/– mice reconstituted with NF-Bp65^–/– fetal liver cells and in c-Rel^–/– mice. In contrast, steady-state levels of IgD^hi splenic follicular B cells are not significantly reduced in the absence of NF-Bp50, NF-Bp65, or c-Rel. Reconstitution of B cells in Rag-2^–/– mice with a mixture of p50^–/–/p65^–/– fetal liver cells and Rag-2^–/– bone marrow cells revealed that the generation of marginal zone B cells requires the expression of NF-B in developing B cells, as opposed to supporting cells.

Key Words: transcription factors • lymphocyte development • recombination activating gene-2^–/– mice • peripheral B cells • Bruton's tyrosine kinase

© 2000 The Rockefeller University Press

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This article has been cited by other articles:

• Li, Z., Wang, H., Xue, L., Shin, D.-M., Roopenian, D., Xu, W., Qi, C.-F., Sangster, M. Y., Orihuela, C. J., Tuomanen, E., Rehg, J. E., Cui, X., Zhang, Q., Morse, H. C. III, Morris, S. W. (2009). E{micro}-BCL10 mice exhibit constitutive activation of both canonical and noncanonical NF-{kappa}B pathways generating marginal zone (MZ) B-cell expansion as a precursor to splenic MZ lymphoma. Blood 114: 4158-4168 [Abstract] [Full Text]  

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