Home | Help | Feedback | Subscriptions | Archive | Search | Table of Contents

This Article Full Text Full Text (PDF, 197K) PPT slides of all figures Alert me when this article is cited Citation Map Services Email this article Similar articles in this journal Similar articles in PubMed Alert me to new content in the JEM Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Izikson, L. Articles by Luster, A. D. Search for Related Content PubMed PubMed Citation Articles by Izikson, L. Articles by Luster, A. D. Social Bookmarking                            What's this?

Brief Definitive Report

^a Center for Neurologic Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115
^b Center for Immunology and Inflammatory Diseases, Division of Rheumatology, Allergy, and Immunology, Massachussetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114
^c Gladstone Institute, University of California at San Francisco, San Francisco, California 94141
Massachusetts General Hospital-East, Bldg. 149 13th St., Charlestown, MA 02129.617-726-5651617-726-5710

Monocyte recruitment to the central nervous system (CNS) is a necessary step in the development of pathologic inflammatory lesions in experimental autoimmune encephalomyelitis (EAE), a murine model of multiple sclerosis. Monocyte chemoattractant protein (MCP)-1, a potent agonist for directed monocyte migration, has been implicated in the pathogenesis of EAE. Here we report that deficiency in CC chemokine receptor (CCR)2, the receptor for MCP-1, confers resistance to EAE induced with a peptide derived from myelin oligodendrocyte glycoprotein peptide 35–55 (MOGp35–55). CCR2^–/– mice immunized with MOGp35–55 failed to develop mononuclear cell inflammatory infiltrates in the CNS and failed to increase CNS levels of the chemokines RANTES (regulated on activation, normal T cell expressed and secreted), MCP-1, and interferon (IFN)-inducible protein 10 (IP-10) as well the chemokine receptors CCR1, CCR2, and CCR5. Additionally, T cells from CCR2^–/– immunized mice showed decreased antigen-induced proliferation and production of IFN- compared with wild-type immunized controls, suggesting that CCR2 enhances the T helper cell type 1 immune response in EAE. These data indicate that CCR2 plays a necessary and nonredundant role in the pathogenesis of EAE.

Key Words: receptors, chemokine • chemokines • macrophages • encephalomyelitis • cytokines

CiteULike    Complore    Connotea    Del.icio.us    Digg    Facebook    Reddit    Technorati    Twitter    What's this?

This article has been cited by other articles:

• Popivanova, B. K., Kostadinova, F. I., Furuichi, K., Shamekh, M. M., Kondo, T., Wada, T., Egashira, K., Mukaida, N. (2009). Blockade of a Chemokine, CCL2, Reduces Chronic Colitis-Associated Carcinogenesis in Mice. Cancer Res. 69: 7884-7892 [Abstract] [Full Text]  
• Dagkalis, A., Wallace, C., Xu, H., Liebau, S., Manivannan, A., Stone, M. A., Mack, M., Liversidge, J., Crane, I. J. (2009). Development of Experimental Autoimmune Uveitis: Efficient Recruitment of Monocytes Is Independent of CCR2. IOVS 50: 4288-4294 [Abstract] [Full Text]  
• Crane, M. J., Hokeness-Antonelli, K. L., Salazar-Mather, T. P. (2009). Regulation of Inflammatory Monocyte/Macrophage Recruitment from the Bone Marrow during Murine Cytomegalovirus Infection: Role for Type I Interferons in Localized Induction of CCR2 Ligands. J. Immunol. 183: 2810-2817 [Abstract] [Full Text]  
• Quintana, A., Muller, M., Frausto, R. F., Ramos, R., Getts, D. R., Sanz, E., Hofer, M. J., Krauthausen, M., King, N. J. C., Hidalgo, J., Campbell, I. L. (2009). Site-Specific Production of IL-6 in the Central Nervous System Retargets and Enhances the Inflammatory Response in Experimental Autoimmune Encephalomyelitis. J. Immunol. 183: 2079-2088 [Abstract] [Full Text]  
• Izhak, L., Wildbaum, G., Zohar, Y., Anunu, R., Klapper, L., Elkeles, A., Seagal, J., Yefenof, E., Ayalon-Soffer, M., Karin, N. (2009). A Novel Recombinant Fusion Protein Encoding a 20-Amino Acid Residue of the Third Extracellular (E3) Domain of CCR2 Neutralizes the Biological Activity of CCL2. J. Immunol. 183: 732-739 [Abstract] [Full Text]  
• Klemann, C., Raveney, B. J.E., Klemann, A. K., Ozawa, T., von Horsten, S., Shudo, K., Oki, S., Yamamura, T. (2009). Synthetic Retinoid AM80 Inhibits Th17 Cells and Ameliorates Experimental Autoimmune Encephalomyelitis. Am. J. Pathol. 174: 2234-2245 [Abstract] [Full Text]  
• D'Mello, C., Le, T., Swain, M. G. (2009). Cerebral Microglia Recruit Monocytes into the Brain in Response to Tumor Necrosis Factor{alpha} Signaling during Peripheral Organ Inflammation. J. Neurosci. 29: 2089-2102 [Abstract] [Full Text]  
• Omari, K. M., Lutz, S. E., Santambrogio, L., Lira, S. A., Raine, C. S. (2009). Neuroprotection and Remyelination after Autoimmune Demyelination in Mice that Inducibly Overexpress CXCL1. Am. J. Pathol. 174: 164-176 [Abstract] [Full Text]  
• Buntinx, M., Hermans, B., Goossens, J., Moechars, D., Gilissen, R. A. H. J., Doyon, J., Boeckx, S., Coesemans, E., Van Lommen, G., Van Wauwe, J. P. (2008). Pharmacological Profile of JNJ-27141491 [(S)-3-[3,4-Difluorophenyl)-propyl]-5-isoxazol-5-yl-2-thioxo-2,3-dihydro-1H-imidazole-4-carboxyl Acid Methyl Ester], as a Noncompetitive and Orally Active Antagonist of the Human Chemokine Receptor CCR2. J. Pharmacol. Exp. Ther. 327: 1-9 [Abstract] [Full Text]  
• Webb, A., Johnson, A., Fortunato, M., Platt, A., Crabbe, T., Christie, M. I., Watt, G. F., Ward, S. G., Jopling, L. A. (2008). Evidence for PI-3K-dependent migration of Th17-polarized cells in response to CCR2 and CCR6 agonists. J. Leukoc. Biol. 84: 1202-1212 [Abstract] [Full Text]  
• Handel, T. M., Johnson, Z., Rodrigues, D. H., dos Santos, A. C., Cirillo, R., Muzio, V., Riva, S., Mack, M., Deruaz, M., Borlat, F., Vitte, P.-A., Wells, T. N. C., Teixeira, M. M., Proudfoot, A. E. I. (2008). An engineered monomer of CCL2 has anti-inflammatory properties emphasizing the importance of oligomerization for chemokine activity in vivo. J. Leukoc. Biol. 84: 1101-1108 [Abstract] [Full Text]  
• Dogan, R.-N. E., Elhofy, A., Karpus, W. J. (2008). Production of CCL2 by Central Nervous System Cells Regulates Development of Murine Experimental Autoimmune Encephalomyelitis through the Recruitment of TNF- and iNOS-Expressing Macrophages and Myeloid Dendritic Cells. J. Immunol. 180: 7376-7384 [Abstract] [Full Text]  
• Wang, T., Dai, H., Wan, N., Moore, Y., Dai, Z. (2008). The Role for Monocyte Chemoattractant Protein-1 in the Generation and Function of Memory CD8+ T Cells. J. Immunol. 180: 2886-2893 [Abstract] [Full Text]  
• Miu, J., Mitchell, A. J., Muller, M., Carter, S. L., Manders, P. M., McQuillan, J. A., Saunders, B. M., Ball, H. J., Lu, B., Campbell, I. L., Hunt, N. H. (2008). Chemokine Gene Expression during Fatal Murine Cerebral Malaria and Protection Due to CXCR3 Deficiency. J. Immunol. 180: 1217-1230 [Abstract] [Full Text]  
• Sinha, S., Subramanian, S., Proctor, T. M., Kaler, L. J., Grafe, M., Dahan, R., Huan, J., Vandenbark, A. A., Burrows, G. G., Offner, H. (2007). A Promising Therapeutic Approach for Multiple Sclerosis: Recombinant T-Cell Receptor Ligands Modulate Experimental Autoimmune Encephalomyelitis by Reducing Interleukin-17 Production and Inhibiting Migration of Encephalitogenic Cells into the CNS. J. Neurosci. 27: 12531-12539 [Abstract] [Full Text]  
• Shaftel, S. S., Carlson, T. J., Olschowka, J. A., Kyrkanides, S., Matousek, S. B., O'Banion, M. K. (2007). Chronic Interleukin-1{beta} Expression in Mouse Brain Leads to Leukocyte Infiltration and Neutrophil-Independent Blood Brain Barrier Permeability without Overt Neurodegeneration. J. Neurosci. 27: 9301-9309 [Abstract] [Full Text]  
• Sato, W., Aranami, T., Yamamura, T. (2007). Cutting Edge: Human Th17 Cells Are Identified as Bearing CCR2+CCR5- Phenotype. J. Immunol. 178: 7525-7529 [Abstract] [Full Text]  
• Silva, T.A., Garlet, G.P., Fukada, S.Y., Silva, J.S., Cunha, F.Q. (2007). Chemokines in Oral Inflammatory Diseases: Apical Periodontitis and Periodontal Disease. JDR 86: 306-319 [Abstract] [Full Text]  
• Odegaard, J. I., Vats, D., Zhang, L., Ricardo-Gonzalez, R., Smith, K. L., Sykes, D. B., Kamps, M. P., Chawla, A. (2007). Quantitative expansion of ES cell-derived myeloid progenitors capable of differentiating into macrophages. J. Leukoc. Biol. 81: 711-719 [Abstract] [Full Text]  
• Vroon, A., Heijnen, C. J., Kavelaars, A. (2006). GRKs and arrestins: regulators of migration and inflammation. J. Leukoc. Biol. 80: 1214-1221 [Abstract] [Full Text]  
• Furtado, G. C., Pina, B., Tacke, F., Gaupp, S., van Rooijen, N., Moran, T. M., Randolph, G. J., Ransohoff, R. M., Chensue, S. W., Raine, C. S., Lira, S. A. (2006). A Novel Model of Demyelinating Encephalomyelitis Induced by Monocytes and Dendritic Cells. J. Immunol. 177: 6871-6879 [Abstract] [Full Text]  
• Huang, D., Shi, F.-D., Jung, S., Pien, G. C., Wang, J., Salazar-Mather, T. P., He, T. T., Weaver, J. T., Ljunggren, H.-G., Biron, C. A., Littman, D. R., Ransohoff, R. M. (2006). The neuronal chemokine CX3CL1/fractalkine selectively recruits NK cells that modify experimental autoimmune encephalomyelitis within the central nervous system. FASEB J. 20: 896-905 [Abstract] [Full Text]  
• Mahad, D., Callahan, M. K., Williams, K. A., Ubogu, E. E., Kivisakk, P., Tucky, B., Kidd, G., Kingsbury, G. A., Chang, A., Fox, R. J., Mack, M., Sniderman, M. B., Ravid, R., Staugaitis, S. M., Stins, M. F., Ransohoff, R. M. (2006). Modulating CCR2 and CCL2 at the blood-brain barrier: relevance for multiple sclerosis pathogenesis. Brain 129: 212-223 [Abstract] [Full Text]  
• de Lema, G. P., Maier, H., Franz, T. J., Escribese, M., Chilla, S., Segerer, S., Camarasa, N., Schmid, H., Banas, B., Kalaydjiev, S., Busch, D. H., Pfeffer, K., Mampaso, F., Schlondorff, D., Luckow, B. (2005). Chemokine Receptor Ccr2 Deficiency Reduces Renal Disease and Prolongs Survival in MRL/lpr Lupus-Prone Mice. J. Am. Soc. Nephrol. 16: 3592-3601 [Abstract] [Full Text]  
• Bullard, D. C., Hu, X., Schoeb, T. R., Axtell, R. C., Raman, C., Barnum, S. R. (2005). Critical Requirement of CD11b (Mac-1) on T Cells and Accessory Cells for Development of Experimental Autoimmune Encephalomyelitis. J. Immunol. 175: 6327-6333 [Abstract] [Full Text]  
• Terwey, T. H., Kim, T. D., Kochman, A. A., Hubbard, V. M., Lu, S., Zakrzewski, J. L., Ramirez-Montagut, T., Eng, J. M., Muriglan, S. J., Heller, G., Murphy, G. F., Liu, C., Budak-Alpdogan, T., Alpdogan, O., van den Brink, M. R. M. (2005). CCR2 is required for CD8-induced graft-versus-host disease. Blood 106: 3322-3330 [Abstract] [Full Text]  
• Brodmerkel, C. M., Huber, R., Covington, M., Diamond, S., Hall, L., Collins, R., Leffet, L., Gallagher, K., Feldman, P., Collier, P., Stow, M., Gu, X., Baribaud, F., Shin, N., Thomas, B., Burn, T., Hollis, G., Yeleswaram, S., Solomon, K., Friedman, S., Wang, A., Xue, C. B., Newton, R. C., Scherle, P., Vaddi, K. (2005). Discovery and Pharmacological Characterization of a Novel Rodent-Active CCR2 Antagonist, INCB3344. J. Immunol. 175: 5370-5378 [Abstract] [Full Text]  
• Kihara, Y., Ishii, S., Kita, Y., Toda, A., Shimada, A., Shimizu, T. (2005). Dual phase regulation of experimental allergic encephalomyelitis by platelet-activating factor. JEM 202: 853-863 [Abstract] [Full Text]  
• de Jong, E. K., Dijkstra, I. M., Hensens, M., Brouwer, N., van Amerongen, M., Liem, R. S. B., Boddeke, H. W. G. M., Biber, K. (2005). Vesicle-Mediated Transport and Release of CCL21 in Endangered Neurons: A Possible Explanation for Microglia Activation Remote from a Primary Lesion. J. Neurosci. 25: 7548-7557 [Abstract] [Full Text]  
• Jones, T. B., Hart, R. P., Popovich, P. G. (2005). Molecular Control of Physiological and Pathological T-Cell Recruitment after Mouse Spinal Cord Injury. J. Neurosci. 25: 6576-6583 [Abstract] [Full Text]  
• Huang, D., Wujek, J., Kidd, G., He, T. T., Cardona, A., Sasse, M. E., Stein, E. J., Kish, J., Tani, M., Charo, I. F., Proudfoot, A. E., Rollins, B. J., Handel, T., Ransohoff, R. M. (2005). Chronic expression of monocyte chemoattractant protein-1 in the central nervous system causes delayed encephalopathy and impaired microglial function in mice. FASEB J. 19: 761-772 [Abstract] [Full Text]  
• Omari, K. M., John, G. R., Sealfon, S. C., Raine, C. S. (2005). CXC chemokine receptors on human oligodendrocytes: implications for multiple sclerosis. Brain 128: 1003-1015 [Abstract] [Full Text]  
• Elhofy, A., Wang, J., Tani, M., Fife, B. T., Kennedy, K. J., Bennett, J., Huang, D., Ransohoff, R. M., Karpus, W. J. (2005). Transgenic expression of CCL2 in the central nervous system prevents experimental autoimmune encephalomyelitis. J. Leukoc. Biol. 77: 229-237 [Abstract] [Full Text]  
• Hokeness, K. L., Kuziel, W. A., Biron, C. A., Salazar-Mather, T. P. (2005). Monocyte Chemoattractant Protein-1 and CCR2 Interactions Are Required for IFN-{alpha}/{beta}-Induced Inflammatory Responses and Antiviral Defense in Liver. J. Immunol. 174: 1549-1556 [Abstract] [Full Text]  
• De Bolle, L., Naesens, L., De Clercq, E. (2005). Update on Human Herpesvirus 6 Biology, Clinical Features, and Therapy. Clin. Microbiol. Rev. 18: 217-245 [Abstract] [Full Text]  
• Polanczyk, M. J., Jones, R. E., Subramanian, S., Afentoulis, M., Rich, C., Zakroczymski, M., Cooke, P., Vandenbark, A. A., Offner, H. (2004). T Lymphocytes Do Not Directly Mediate the Protective Effect of Estrogen on Experimental Autoimmune Encephalomyelitis. Am. J. Pathol. 165: 2069-2077 [Abstract] [Full Text]  
• Johnson, Z., Kosco-Vilbois, M. H., Herren, S., Cirillo, R., Muzio, V., Zaratin, P., Carbonatto, M., Mack, M., Smailbegovic, A., Rose, M., Lever, R., Page, C., Wells, T. N. C., Proudfoot, A. E. I. (2004). Interference with Heparin Binding and Oligomerization Creates a Novel Anti-Inflammatory Strategy Targeting the Chemokine System. J. Immunol. 173: 5776-5785 [Abstract] [Full Text]  
• Chiu, B.-C., Freeman, C. M., Stolberg, V. R., Hu, J. S., Zeibecoglou, K., Lu, B., Gerard, C., Charo, I. F., Lira, S. A., Chensue, S. W. (2004). Impaired Lung Dendritic Cell Activation in CCR2 Knockout Mice. Am. J. Pathol. 165: 1199-1209 [Abstract] [Full Text]  
• Fukumoto, N., Shimaoka, T., Fujimura, H., Sakoda, S., Tanaka, M., Kita, T., Yonehara, S. (2004). Critical Roles of CXC Chemokine Ligand 16/Scavenger Receptor that Binds Phosphatidylserine and Oxidized Lipoprotein in the Pathogenesis of Both Acute and Adoptive Transfer Experimental Autoimmune Encephalomyelitis. J. Immunol. 173: 1620-1627 [Abstract] [Full Text]  
• Kitagawa, K., Wada, T., Furuichi, K., Hashimoto, H., Ishiwata, Y., Asano, M., Takeya, M., Kuziel, W. A., Matsushima, K., Mukaida, N., Yokoyama, H. (2004). Blockade of CCR2 Ameliorates Progressive Fibrosis in Kidney. Am. J. Pathol. 165: 237-246 [Abstract] [Full Text]  
• Ogilvie, P., Thelen, S., Moepps, B., Gierschik, P., da Silva Campos, A. C., Baggiolini, M., Thelen, M. (2004). Unusual Chemokine Receptor Antagonism Involving a Mitogen-Activated Protein Kinase Pathway. J. Immunol. 172: 6715-6722 [Abstract] [Full Text]  
• Tsunoda, I., Lane, T. E, Blackett, J., Fujinami, R. S (2004). Distinct roles for IP-10/C XC L10 in three animal models, Theiler's virus infection, EA E, and MHV infection, for multiple sclerosis: implication of differing roles for IP-10. Mult Scler 10: 26-34 [Abstract]  
• Panoskaltsis-Mortari, A., Hermanson, J. R., Taras, E., Wangensteen, O. D., Charo, I. F., Rollins, B. J., Blazar, B. R. (2004). Post-BMT lung injury occurs independently of the expression of CCL2 or its receptor, CCR2, on host cells. Am. J. Physiol. Lung Cell. Mol. Physiol. 286: L284-L292 [Abstract] [Full Text]  
• Abdi, R., Means, T. K., Ito, T., Smith, R. N., Najafian, N., Jurewicz, M., Tchipachvili, V., Charo, I., Auchincloss, H. Jr., Sayegh, M. H., Luster, A. D. (2004). Differential Role of CCR2 in Islet and Heart Allograft Rejection: Tissue Specificity of Chemokine/Chemokine Receptor Function In Vivo. J. Immunol. 172: 767-775 [Abstract] [Full Text]  
• Klein, R. S., Izikson, L., Means, T., Gibson, H. D., Lin, E., Sobel, R. A., Weiner, H. L., Luster, A. D. (2004). IFN-Inducible Protein 10/CXC Chemokine Ligand 10-Independent Induction of Experimental Autoimmune Encephalomyelitis. J. Immunol. 172: 550-559 [Abstract] [Full Text]  
• Lee, I., Wang, L., Wells, A. D., Ye, Q., Han, R., Dorf, M. E., Kuziel, W. A., Rollins, B. J., Chen, L., Hancock, W. W. (2003). Blocking the Monocyte Chemoattractant Protein-1/CCR2 Chemokine Pathway Induces Permanent Survival of Islet Allografts through a Programmed Death-1 Ligand-1-Dependent Mechanism. J. Immunol. 171: 6929-6935 [Abstract] [Full Text]  
• Babcock, A. A., Kuziel, W. A., Rivest, S., Owens, T. (2003). Chemokine Expression by Glial Cells Directs Leukocytes to Sites of Axonal Injury in the CNS. J. Neurosci. 23: 7922-7930 [Abstract] [Full Text]  
• Ogilvie, P., Paoletti, S., Clark-Lewis, I., Uguccioni, M. (2003). Eotaxin-3 is a natural antagonist for CCR2 and exerts a repulsive effect on human monocytes. Blood 102: 789-794 [Abstract] [Full Text]  
• Brown, C. R., Blaho, V. A., Loiacono, C. M. (2003). Susceptibility to Experimental Lyme Arthritis Correlates with KC and Monocyte Chemoattractant Protein-1 Production in Joints and Requires Neutrophil Recruitment Via CXCR2. J. Immunol. 171: 893-901 [Abstract] [Full Text]  
• Abbadie, C., Lindia, J. A., Cumiskey, A. M., Peterson, L. B., Mudgett, J. S., Bayne, E. K., DeMartino, J. A., MacIntyre, D. E., Forrest, M. J. (2003). Impaired neuropathic pain responses in mice lacking the chemokine receptor CCR2. Proc. Natl. Acad. Sci. USA 100: 7947-7952 [Abstract] [Full Text]  
• Luttichau, H. R., Clark-Lewis, I., Jensen, P. O., Moser, C., Gerstoft, J., Schwartz, T. W. (2003). A Highly Selective CCR2 Chemokine Agonist Encoded by Human Herpesvirus 6. J. Biol. Chem. 278: 10928-10933 [Abstract] [Full Text]  
• Gonnella, P. A., Kodali, D., Weiner, H. L. (2003). Induction of Low Dose Oral Tolerance in Monocyte Chemoattractant Protein-1- and CCR2-Deficient Mice. J. Immunol. 170: 2316-2322 [Abstract] [Full Text]  
• Subramanian, S., Matejuk, A., Zamora, A., Vandenbark, A. A., Offner, H. (2003). Oral Feeding with Ethinyl Estradiol Suppresses and Treats Experimental Autoimmune Encephalomyelitis in SJL Mice and Inhibits the Recruitment of Inflammatory Cells into the Central Nervous System. J. Immunol. 170: 1548-1555 [Abstract] [Full Text]  
• Gaupp, S., Pitt, D., Kuziel, W. A., Cannella, B., Raine, C. S. (2003). Experimental Autoimmune Encephalomyelitis (EAE) in CCR2-/- Mice: Susceptibility in Multiple Strains. Am. J. Pathol. 162: 139-150 [Abstract] [Full Text]  
• Omata, N., Yasutomi, M., Yamada, A., Iwasaki, H., Mayumi, M., Ohshima, Y. (2002). Monocyte Chemoattractant Protein-1 Selectively Inhibits the Acquisition of CD40 Ligand-Dependent IL-12-Producing Capacity of Monocyte-Derived Dendritic Cells and Modulates Th1 Immune Response. J. Immunol. 169: 4861-4866 [Abstract] [Full Text]  
• Abdi, R., Thi Bich Huong, T., Sahagun-Ruiz, A., Murphy, P. M., Brenner, B. M., Milford, E. L., McDermott, D. H. (2002). Chemokine Receptor Polymorphism and Risk of Acute Rejection in Human Renal Transplantation. J. Am. Soc. Nephrol. 13: 754-758 [Abstract] [Full Text]  
• Dzenko, K. A., Andjelkovic, A. V., Kuziel, W. A., Pachter, J. S. (2001). The Chemokine Receptor CCR2 Mediates the Binding and Internalization of Monocyte Chemoattractant Protein-1 along Brain Microvessels. J. Neurosci. 21: 9214-9223 [Abstract] [Full Text]  
• Trebst, C., Ransohoff, R. M. (2001). Investigating Chemokines and Chemokine Receptors in Patients With Multiple Sclerosis: Opportunities and Challenges. Arch Neurol 58: 1975-1980 [Abstract] [Full Text]  
• Janatpour, M. J., Hudak, S., Sathe, M., Sedgwick, J. D., McEvoy, L. M. (2001). Tumor Necrosis Factor-dependent Segmental Control of MIG Expression by High Endothelial Venules in Inflamed Lymph Nodes Regulates Monocyte Recruitment. JEM 194: 1375-1384 [Abstract] [Full Text]  
• Sorensen, T. L., Sellebjerg, F. (2001). Distinct chemokine receptor and cytokine expression profile in secondary progressive MS. Neurology 57: 1371-1376 [Abstract] [Full Text]  
• Chen, B. P., Kuziel, W. A., Lane, T. E. (2001). Lack of CCR2 Results in Increased Mortality and Impaired Leukocyte Activation and Trafficking Following Infection of the Central Nervous System with a Neurotropic Coronavirus. J. Immunol. 167: 4585-4592 [Abstract] [Full Text]  
• McMahon, E. J., Cook, D. N., Suzuki, K., Matsushima, G. K. (2001). Absence of Macrophage-Inflammatory Protein-1{alpha} Delays Central Nervous System Demyelination in the Presence of an Intact Blood-Brain Barrier. J. Immunol. 167: 2964-2971 [Abstract] [Full Text]  
• Fife, B. T., Kennedy, K. J., Paniagua, M. C., Lukacs, N. W., Kunkel, S. L., Luster, A. D., Karpus, W. J. (2001). CXCL10 (IFN-{{gamma}}-Inducible Protein-10) Control of Encephalitogenic CD4+ T Cell Accumulation in the Central Nervous System During Experimental Autoimmune Encephalomyelitis. J. Immunol. 166: 7617-7624 [Abstract] [Full Text]  
• Huang, D., Wang, J., Kivisakk, P., Rollins, B. J., Ransohoff, R. M. (2001). Absence of Monocyte Chemoattractant Protein 1 in Mice Leads to Decreased Local Macrophage Recruitment and Antigen-Specific T Helper Cell Type 1 Immune Response in Experimental Autoimmune Encephalomyelitis. JEM 193: 713-726 [Abstract] [Full Text]  
• Ko, Y.-G., Park, H., Kim, T., Lee, J.-W., Park, S. G., Seol, W., Kim, J. E., Lee, W.-H., Kim, S.-H., Park, J.-E., Kim, S. (2001). A Cofactor of tRNA Synthetase, p43, Is Secreted to Up-regulate Proinflammatory Genes. J. Biol. Chem. 276: 23028-23033 [Abstract] [Full Text]  

Home | Help | Feedback | Subscriptions | Archive | Search

TABLE OF CONTENTS