Original Article

Engagement of the PD-1 Immunoinhibitory Receptor by a Novel B7 Family Member Leads to Negative Regulation of Lymphocyte Activation

Correspondence to: Tasuku Honjo, Department of Medical Chemistry, Graduate School of Medicine, Kyoto University, Kyoto 606-8501, Japan. Tel:81-75-753-4371 Fax:81-75-753-4388

PD-1 is an immunoinhibitory receptor expressed by activated T cells, B cells, and myeloid cells. Mice deficient in PD-1 exhibit a breakdown of peripheral tolerance and demonstrate multiple autoimmune features. We report here that the ligand of PD-1 (PD-L1) is a member of the B7 gene family. Engagement of PD-1 by PD-L1 leads to the inhibition of T cell receptor–mediated lymphocyte proliferation and cytokine secretion. In addition, PD-1 signaling can inhibit at least suboptimal levels of CD28-mediated costimulation. PD-L1 is expressed by antigen-presenting cells, including human peripheral blood monocytes stimulated with interferon , and activated human and murine dendritic cells. In addition, PD-L1 is expressed in nonlymphoid tissues such as heart and lung. The relative levels of inhibitory PD-L1 and costimulatory B7-1/B7-2 signals on antigen-presenting cells may determine the extent of T cell activation and consequently the threshold between tolerance and autoimmunity. PD-L1 expression on nonlymphoid tissues and its potential interaction with PD-1 may subsequently determine the extent of immune responses at sites of inflammation.

Key Words: binding, proliferation inhibition, cytokine secretion inhibition, tissue expression, peripheral tolerance

CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this?

This article has been cited by other articles:

• Kuang, D.-M., Zhao, Q., Peng, C., Xu, J., Zhang, J.-P., Wu, C., Zheng, L. (2009). Activated monocytes in peritumoral stroma of hepatocellular carcinoma foster immune privilege and disease progression through PD-L1. JEM 206: 1327-1337 [Abstract] [Full Text]  
• Yao, S., Wang, S., Zhu, Y., Luo, L., Zhu, G., Flies, S., Xu, H., Ruff, W., Broadwater, M., Choi, I.-H., Tamada, K., Chen, L. (2009). PD-1 on dendritic cells impedes innate immunity against bacterial infection. Blood 113: 5811-5818 [Abstract] [Full Text]  
• Vassalli, G., Roehrich, M.-E., Vogt, P., Pedrazzini, G. B., Siclari, F., Moccetti, T., von Segesser, L. K. (2009). Modalities and future prospects of gene therapy in heart transplantation. Eur. J. Cardiothorac. Surg. 35: 1036-1044 [Abstract] [Full Text]  
• Sugita, S., Usui, Y., Horie, S., Futagami, Y., Aburatani, H., Okazaki, T., Honjo, T., Takeuchi, M., Mochizuki, M. (2009). T-Cell Suppression by Programmed Cell Death 1 Ligand 1 on Retinal Pigment Epithelium during Inflammatory Conditions. IOVS 50: 2862-2870 [Abstract] [Full Text]  
• Grosso, J. F., Goldberg, M. V., Getnet, D., Bruno, T. C., Yen, H.-R., Pyle, K. J., Hipkiss, E., Vignali, D. A. A., Pardoll, D. M., Drake, C. G. (2009). Functionally Distinct LAG-3 and PD-1 Subsets on Activated and Chronically Stimulated CD8 T Cells. J. Immunol. 182: 6659-6669 [Abstract] [Full Text]  
• Nikolova, M., Lelievre, J.-D., Carriere, M., Bensussan, A., Levy, Y. (2009). Regulatory T cells differentially modulate the maturation and apoptosis of human CD8+ T-cell subsets. Blood 113: 4556-4565 [Abstract] [Full Text]  
• Fourcade, J., Kudela, P., Sun, Z., Shen, H., Land, S. R., Lenzner, D., Guillaume, P., Luescher, I. F., Sander, C., Ferrone, S., Kirkwood, J. M., Zarour, H. M. (2009). PD-1 Is a Regulator of NY-ESO-1-Specific CD8+ T Cell Expansion in Melanoma Patients. J. Immunol. 182: 5240-5249 [Abstract] [Full Text]  
• Mott, K. R., Bresee, C. J., Allen, S. J., BenMohamed, L., Wechsler, S. L., Ghiasi, H. (2009). Level of Herpes Simplex Virus Type 1 Latency Correlates with Severity of Corneal Scarring and Exhaustion of CD8+ T Cells in Trigeminal Ganglia of Latently Infected Mice. J. Virol. 83: 2246-2254 [Abstract] [Full Text]  
• Li, B., VanRoey, M., Wang, C., Chen, T.-h. T., Korman, A., Jooss, K. (2009). Anti-Programmed Death-1 Synergizes with Granulocyte Macrophage Colony-Stimulating Factor-Secreting Tumor Cell Immunotherapy Providing Therapeutic Benefit to Mice with Established Tumors. Clin. Cancer Res. 15: 1623-1634 [Abstract] [Full Text]  
• Reynoso, E. D., Elpek, K. G., Francisco, L., Bronson, R., Bellemare-Pelletier, A., Sharpe, A. H., Freeman, G. J., Turley, S. J. (2009). Intestinal Tolerance Is Converted to Autoimmune Enteritis upon PD-1 Ligand Blockade. J. Immunol. 182: 2102-2112 [Abstract] [Full Text]  
• Sugita, S., Usui, Y., Horie, S., Futagami, Y., Yamada, Y., Ma, J., Kezuka, T., Hamada, H., Usui, T., Mochizuki, M., Yamagami, S. (2009). Human Corneal Endothelial Cells Expressing Programmed Death-Ligand 1 (PD-L1) Suppress PD-1+ T Helper 1 Cells by a Contact-Dependent Mechanism. IOVS 50: 263-272 [Abstract] [Full Text]  
• Yang, W., Li, H., Chen, P. W., Alizadeh, H., He, Y., Hogan, R. N., Niederkorn, J. Y. (2009). PD-L1 Expression on Human Ocular Cells and Its Possible Role in Regulating Immune-Mediated Ocular Inflammation. IOVS 50: 273-280 [Abstract] [Full Text]  
• Rutebemberwa, A., Ray, S. C., Astemborski, J., Levine, J., Liu, L., Dowd, K. A., Clute, S., Wang, C., Korman, A., Sette, A., Sidney, J., Pardoll, D. M., Cox, A. L. (2008). High-Programmed Death-1 Levels on Hepatitis C Virus-Specific T Cells during Acute Infection Are Associated with Viral Persistence and Require Preservation of Cognate Antigen during Chronic Infection. J. Immunol. 181: 8215-8225 [Abstract] [Full Text]  
• Muthumani, K., Choo, A. Y., Shedlock, D. J., Laddy, D. J., Sundaram, S. G., Hirao, L., Wu, L., Thieu, K. P., Chung, C. W., Lankaraman, K. M., Tebas, P., Silvestri, G., Weiner, D. B. (2008). Human Immunodeficiency Virus Type 1 Nef Induces Programmed Death 1 Expression through a p38 Mitogen-Activated Protein Kinase-Dependent Mechanism. J. Virol. 82: 11536-11544 [Abstract] [Full Text]  
• Kinter, A. L., Godbout, E. J., McNally, J. P., Sereti, I., Roby, G. A., O'Shea, M. A., Fauci, A. S. (2008). The Common {gamma}-Chain Cytokines IL-2, IL-7, IL-15, and IL-21 Induce the Expression of Programmed Death-1 and Its Ligands. J. Immunol. 181: 6738-6746 [Abstract] [Full Text]  
• Kryczek, I., Wei, S., Gong, W., Shu, X., Szeliga, W., Vatan, L., Chen, L., Wang, G., Zou, W. (2008). Cutting Edge: IFN-{gamma} Enables APC to Promote Memory Th17 and Abate Th1 Cell Development. J. Immunol. 181: 5842-5846 [Abstract] [Full Text]  
• Kim, Y. S., Park, G. B., Lee, H.-K., Song, H., Choi, I.-H., Lee, W. J., Hur, D. Y. (2008). Cross-Linking of B7-H1 on EBV-Transformed B Cells Induces Apoptosis through Reactive Oxygen Species Production, JNK Signaling Activation, and fasL Expression. J. Immunol. 181: 6158-6169 [Abstract] [Full Text]  
• Taglauer, E. S., Trikhacheva, A. S., Slusser, J. G., Petroff, M. G. (2008). Expression and Function of PDCD1 at the Human Maternal-Fetal Interface. Biol. Reprod. 79: 562-569 [Abstract] [Full Text]  
• Mozaffarian, N., Wiedeman, A. E., Stevens, A. M. (2008). Active systemic lupus erythematosus is associated with failure of antigen-presenting cells to express programmed death ligand-1. Rheumatology (Oxford) 47: 1335-1341 [Abstract] [Full Text]  
• Lazar-Molnar, E., Yan, Q., Cao, E., Ramagopal, U., Nathenson, S. G., Almo, S. C. (2008). From the Cover: Crystal structure of the complex between programmed death-1 (PD-1) and its ligand PD-L2. Proc. Natl. Acad. Sci. USA 105: 10483-10488 [Abstract] [Full Text]  
• Wang, L., Pino-Lagos, K., de Vries, V. C., Guleria, I., Sayegh, M. H., Noelle, R. J. (2008). Programmed death 1 ligand signaling regulates the generation of adaptive Foxp3+CD4+ regulatory T cells. Proc. Natl. Acad. Sci. USA 105: 9331-9336 [Abstract] [Full Text]  
• Wei, S., Shreiner, A. B., Takeshita, N., Chen, L., Zou, W., Chang, A. E. (2008). Tumor-Induced Immune Suppression of In vivo Effector T-Cell Priming Is Mediated by the B7-H1/PD-1 Axis and Transforming Growth Factor {beta}. Cancer Res. 68: 5432-5438 [Abstract] [Full Text]  
• Jurado, J. O., Alvarez, I. B., Pasquinelli, V., Martinez, G. J., Quiroga, M. F., Abbate, E., Musella, R. M., Chuluyan, H. E., Garcia, V. E. (2008). Programmed Death (PD)-1:PD-Ligand 1/PD-Ligand 2 Pathway Inhibits T Cell Effector Functions during Human Tuberculosis. J. Immunol. 181: 116-125 [Abstract] [Full Text]  
• Wang, C.-J., Chou, F.-C., Chu, C.-H., Wu, J.-C., Lin, S.-H., Chang, D.-M., Sytwu, H.-K. (2008). Protective Role of Programmed Death 1 Ligand 1 (PD-L1)in Nonobese Diabetic Mice: The Paradox in Transgenic Models. Diabetes 57: 1861-1869 [Abstract] [Full Text]  
• Hayashi, M., Kouki, T., Takasu, N., Sunagawa, S., Komiya, I. (2008). Association of an A/C single nucleotide polymorphism in programmed cell death-ligand 1 gene with Graves' disease in Japanese patients.. Eur J Endocrinol 158: 817-822 [Abstract] [Full Text]  
• Yang, W., Chen, P. W., Li, H., Alizadeh, H., Niederkorn, J. Y. (2008). PD-L1: PD-1 Interaction Contributes to the Functional Suppression of T-Cell Responses to Human Uveal Melanoma Cells In Vitro. IOVS 49: 2518-2525 [Abstract] [Full Text]  
• Estes, J. D., Gordon, S. N., Zeng, M., Chahroudi, A. M., Dunham, R. M., Staprans, S. I., Reilly, C. S., Silvestri, G., Haase, A. T. (2008). Early Resolution of Acute Immune Activation and Induction of PD-1 in SIV-Infected Sooty Mangabeys Distinguishes Nonpathogenic from Pathogenic Infection in Rhesus Macaques. J. Immunol. 180: 6798-6807 [Abstract] [Full Text]  
• Berger, R., Rotem-Yehudar, R., Slama, G., Landes, S., Kneller, A., Leiba, M., Koren-Michowitz, M., Shimoni, A., Nagler, A. (2008). Phase I Safety and Pharmacokinetic Study of CT-011, a Humanized Antibody Interacting with PD-1, in Patients with Advanced Hematologic Malignancies. Clin. Cancer Res. 14: 3044-3051 [Abstract] [Full Text]  
• Azuma, T., Yao, S., Zhu, G., Flies, A. S., Flies, S. J., Chen, L. (2008). B7-H1 is a ubiquitous antiapoptotic receptor on cancer cells. Blood 111: 3635-3643 [Abstract] [Full Text]  
• Green, K. A., Okazaki, T., Honjo, T., Cook, W. J., Green, W. R. (2008). The Programmed Death-1 and Interleukin-10 Pathways Play a Down-Modulatory Role in LP-BM5 Retrovirus-Induced Murine Immunodeficiency Syndrome. J. Virol. 82: 2456-2469 [Abstract] [Full Text]  
• Wiesemann, E., Deb, M., Trebst, C., Hemmer, B., Stangel, M., Windhagen, A. (2008). Effects of interferon-{beta} on co-signaling molecules: upregulation of CD40, CD86 and PD-L2 on monocytes in relation to clinical response to interferon-{beta} treatment in patients with multiple sclerosis. Mult Scler 14: 166-176 [Abstract]  
• Alderson, K. L., Zhou, Q., Berner, V., Wilkins, D. E. C., Weiss, J. M., Blazar, B. R., Welniak, L. A., Wiltrout, R. H., Redelman, D., Murphy, W. J. (2008). Regulatory and Conventional CD4+ T Cells Show Differential Effects Correlating with PD-1 and B7-H1 Expression after Immunotherapy. J. Immunol. 180: 2981-2988 [Abstract] [Full Text]  
• Lin, D. Y.-w., Tanaka, Y., Iwasaki, M., Gittis, A. G., Su, H.-P., Mikami, B., Okazaki, T., Honjo, T., Minato, N., Garboczi, D. N. (2008). The PD-1/PD-L1 complex resembles the antigen-binding Fv domains of antibodies and T cell receptors. Proc. Natl. Acad. Sci. USA 105: 3011-3016 [Abstract] [Full Text]  
• Lazar-Molnar, E., Gacser, A., Freeman, G. J., Almo, S. C., Nathenson, S. G., Nosanchuk, J. D. (2008). The PD-1/PD-L costimulatory pathway critically affects host resistance to the pathogenic fungus Histoplasma capsulatum. Proc. Natl. Acad. Sci. USA 105: 2658-2663 [Abstract] [Full Text]  
• Palmer, B. E., Mack, D. G., Martin, A. K., Gillespie, M., Mroz, M. M., Maier, L. A., Fontenot, A. P. (2008). Up-Regulation of Programmed Death-1 Expression on Beryllium-Specific CD4+ T Cells in Chronic Beryllium Disease. J. Immunol. 180: 2704-2712 [Abstract] [Full Text]  
• Dal Secco, V., Riccioli, A., Padula, F., Ziparo, E., Filippini, A. (2008). Mouse Sertoli Cells Display Phenotypical and Functional Traits of Antigen-Presenting Cells in Response to Interferon Gamma. Biol. Reprod. 78: 234-242 [Abstract] [Full Text]  
• Katou, F., Ohtani, H., Watanabe, Y., Nakayama, T., Yoshie, O., Hashimoto, K. (2007). Differing Phenotypes between Intraepithelial and Stromal Lymphocytes in Early-Stage Tongue Cancer. Cancer Res. 67: 11195-11201 [Abstract] [Full Text]  
• Menke, J., Lucas, J. A., Zeller, G. C., Keir, M. E., Huang, X. R., Tsuboi, N., Mayadas, T. N., Lan, H. Y., Sharpe, A. H., Kelley, V. R. (2007). Programmed Death 1 Ligand (PD-L) 1 and PD-L2 Limit Autoimmune Kidney Disease: Distinct Roles. J. Immunol. 179: 7466-7477 [Abstract] [Full Text]  
• Chung, J.-S., Dougherty, I., Cruz, P. D. Jr., Ariizumi, K. (2007). Syndecan-4 Mediates the Coinhibitory Function of DC-HIL on T Cell Activation. J. Immunol. 179: 5778-5784 [Abstract] [Full Text]  
• Senju, S., Suemori, H., Zembutsu, H., Uemura, Y., Hirata, S., Fukuma, D., Matsuyoshi, H., Shimomura, M., Haruta, M., Fukushima, S., Matsunaga, Y., Katagiri, T., Nakamura, Y., Furuya, M., Nakatsuji, N., Nishimura, Y. (2007). Genetically Manipulated Human Embryonic Stem Cell-Derived Dendritic Cells with Immune Regulatory Function. Stem Cells 25: 2720-2729 [Abstract] [Full Text]  
• Chemnitz, J. M., Eggle, D., Driesen, J., Classen, S., Riley, J. L., Debey-Pascher, S., Beyer, M., Popov, A., Zander, T., Schultze, J. L. (2007). RNA fingerprints provide direct evidence for the inhibitory role of TGF{beta} and PD-1 on CD4+ T cells in Hodgkin lymphoma. Blood 110: 3226-3233 [Abstract] [Full Text]  
• Tanaka, K., Albin, M. J., Yuan, X., Yamaura, K., Habicht, A., Murayama, T., Grimm, M., Waaga, A. M., Ueno, T., Padera, R. F., Yagita, H., Azuma, M., Shin, T., Blazar, B. R., Rothstein, D. M., Sayegh, M. H., Najafian, N. (2007). PDL1 Is Required for Peripheral Transplantation Tolerance and Protection from Chronic Allograft Rejection. J. Immunol. 179: 5204-5210 [Abstract] [Full Text]  
• Gregerson, D. S., Heuss, N. D., Lew, K. L., McPherson, S. W., Ferrington, D. A. (2007). Interaction of Retinal Pigmented Epithelial Cells and CD4 T Cells Leads to T-Cell Anergy. IOVS 48: 4654-4663 [Abstract] [Full Text]  
• Shen, L., Jin, Y., Freeman, G. J., Sharpe, A. H., Dana, M. R. (2007). The Function of Donor versus Recipient Programmed Death-Ligand 1 in Corneal Allograft Survival. J. Immunol. 179: 3672-3679 [Abstract] [Full Text]  
• Gajewski, T. F. (2007). Failure at the Effector Phase: Immune Barriers at the Level of the Melanoma Tumor Microenvironment. Clin. Cancer Res. 13: 5256-5261 [Abstract] [Full Text]  
• Zang, X., Allison, J. P. (2007). The B7 Family and Cancer Therapy: Costimulation and Coinhibition. Clin. Cancer Res. 13: 5271-5279 [Abstract] [Full Text]  
• Webster, W. S., Thompson, R. H., Harris, K. J., Frigola, X., Kuntz, S., Inman, B. A., Dong, H. (2007). Targeting Molecular and Cellular Inhibitory Mechanisms for Improvement of Antitumor Memory Responses Reactivated by Tumor Cell Vaccine. J. Immunol. 179: 2860-2869 [Abstract] [Full Text]  
• D'Souza, M., Fontenot, A. P., Mack, D. G., Lozupone, C., Dillon, S., Meditz, A., Wilson, C. C., Connick, E., Palmer, B. E. (2007). Programmed Death 1 Expression on HIV-Specific CD4+ T Cells Is Driven by Viral Replication and Associated with T Cell Dysfunction. J. Immunol. 179: 1979-1987 [Abstract] [Full Text]  
• Kasler, H. G., Verdin, E. (2007). Histone Deacetylase 7 Functions as a Key Regulator of Genes Involved in both Positive and Negative Selection of Thymocytes. Mol. Cell. Biol. 27: 5184-5200 [Abstract] [Full Text]  
• van der Marel, A. P. J., Samsom, J. N., Greuter, M., van Berkel, L. A., O'Toole, T., Kraal, G., Mebius, R. E. (2007). Blockade of IDO Inhibits Nasal Tolerance Induction. J. Immunol. 179: 894-900 [Abstract] [Full Text]  
• Okazaki, T., Honjo, T. (2007). PD-1 and PD-1 ligands: from discovery to clinical application. Int Immunol 0: dxm057v1- [Abstract] [Full Text]  
• Terawaki, S., Tanaka, Y., Nagakura, T., Hayashi, T., Shibayama, S., Muroi, K., Okazaki, T., Mikami, B., Garboczi, D. N., Honjo, T., Minato, N. (2007). Specific and high-affinity binding of tetramerized PD-L1 extracellular domain to PD-1-expressing cells: possible application to enhance T cell function. Int Immunol 0: dxm059v1- [Abstract] [Full Text]  
• Tsushima, F., Yao, S., Shin, T., Flies, A., Flies, S., Xu, H., Tamada, K., Pardoll, D. M., Chen, L. (2007). Interaction between B7-H1 and PD-1 determines initiation and reversal of T-cell anergy. Blood 110: 180-185 [Abstract] [Full Text]  
• Liu, J., Hamrouni, A., Wolowiec, D., Coiteux, V., Kuliczkowski, K., Hetuin, D., Saudemont, A., Quesnel, B. (2007). Plasma cells from multiple myeloma patients express B7-H1 (PD-L1) and increase expression after stimulation with IFN-{gamma} and TLR ligands via a MyD88-, TRAF6-, and MEK-dependent pathway. Blood 110: 296-304 [Abstract] [Full Text]  
• Goldberg, M. V., Maris, C. H., Hipkiss, E. L., Flies, A. S., Zhen, L., Tuder, R. M., Grosso, J. F., Harris, T. J., Getnet, D., Whartenby, K. A., Brockstedt, D. G., Dubensky, T. W. Jr, Chen, L., Pardoll, D. M., Drake, C. G. (2007). Role of PD-1 and its ligand, B7-H1, in early fate decisions of CD8 T cells. Blood 110: 186-192 [Abstract] [Full Text]  
• Seko, Y., Yagita, H., Okumura, K., Azuma, M., Nagai, R. (2007). Roles of programmed death-1 (PD-1)/PD-1 ligands pathway in the development of murine acute myocarditis caused by coxsackievirus B3. Cardiovasc Res 75: 158-167 [Abstract] [Full Text]  
• Zhang, J.-Y., Zhang, Z., Wang, X., Fu, J.-L., Yao, J., Jiao, Y., Chen, L., Zhang, H., Wei, J., Jin, L., Shi, M., Gao, G. F., Wu, H., Wang, F.-S. (2007). PD-1 up-regulation is correlated with HIV-specific memory CD8+ T-cell exhaustion in typical progressors but not in long-term nonprogressors. Blood 109: 4671-4678 [Abstract] [Full Text]  
• Chung, J.-S., Sato, K., Dougherty, I. I., Cruz, P. D. Jr, Ariizumi, K. (2007). DC-HIL is a negative regulator of T lymphocyte activation. Blood 109: 4320-4327 [Abstract] [Full Text]  
• Van Hove, C. L., Maes, T., Joos, G. F., Tournoy, K. G. (2007). Prolonged Inhaled Allergen Exposure Can Induce Persistent Tolerance. Am. J. Respir. Cell Mol. Bio. 36: 573-584 [Abstract] [Full Text]  
• Nazareth, M. R., Broderick, L., Simpson-Abelson, M. R., Kelleher, R. J. Jr., Yokota, S. J., Bankert, R. B. (2007). Characterization of Human Lung Tumor-Associated Fibroblasts and Their Ability to Modulate the Activation of Tumor-Associated T Cells. J. Immunol. 178: 5552-5562 [Abstract] [Full Text]  
• Sevigny, C. P., Li, L., Awad, A. S., Huang, L., McDuffie, M., Linden, J., Lobo, P. I., Okusa, M. D. (2007). Activation of Adenosine 2A Receptors Attenuates Allograft Rejection and Alloantigen Recognition. J. Immunol. 178: 4240-4249 [Abstract] [Full Text]  
• Nomi, T., Sho, M., Akahori, T., Hamada, K., Kubo, A., Kanehiro, H., Nakamura, S., Enomoto, K., Yagita, H., Azuma, M., Nakajima, Y. (2007). Clinical Significance and Therapeutic Potential of the Programmed Death-1 Ligand/Programmed Death-1 Pathway in Human Pancreatic Cancer. Clin. Cancer Res. 13: 2151-2157 [Abstract] [Full Text]  
• Mostbock, S., Catalfamo, M., Tagaya, Y., Schlom, J., Sabzevari, H. (2007). Acquisition of antigen presentasome (APS), an MHC/costimulatory complex, is a checkpoint of memory T-cell homeostasis. Blood 109: 2488-2495 [Abstract] [Full Text]  
• Maier, H., Isogawa, M., Freeman, G. J., Chisari, F. V. (2007). PD-1:PD-L1 Interactions Contribute to the Functional Suppression of Virus-Specific CD8+ T Lymphocytes in the Liver. J. Immunol. 178: 2714-2720 [Abstract] [Full Text]  
• Hamanishi, J., Mandai, M., Iwasaki, M., Okazaki, T., Tanaka, Y., Yamaguchi, K., Higuchi, T., Yagi, H., Takakura, K., Minato, N., Honjo, T., Fujii, S. (2007). Programmed cell death 1 ligand 1 and tumor-infiltrating CD8+ T lymphocytes are prognostic factors of human ovarian cancer. Proc. Natl. Acad. Sci. USA 104: 3360-3365 [Abstract] [Full Text]  
• Meraner, P., Horejsi, V., Wolpl, A., Fischer, G. F., Stingl, G., Maurer, D. (2007). Dendritic Cells Sensitize TCRs through Self-MHC-Mediated Src Family Kinase Activation. J. Immunol. 178: 2262-2271 [Abstract] [Full Text]  
• Arnett, H. A., Escobar, S. S., Gonzalez-Suarez, E., Budelsky, A. L., Steffen, L. A., Boiani, N., Zhang, M., Siu, G., Brewer, A. W., Viney, J. L. (2007). BTNL2, a Butyrophilin/B7-Like Molecule, Is a Negative Costimulatory Molecule Modulated in Intestinal Inflammation. J. Immunol. 178: 1523-1533 [Abstract] [Full Text]  
• Piconi, S., Trabattoni, D., Saresella, M., Iemoli, E., Schenal, M., Fusi, A., Borelli, M., Chen, L., Mascheri, A., Clerici, M. (2007). Effects of Specific Immunotherapy on the B7 Family of Costimulatory Molecules in Allergic Inflammation. J. Immunol. 178: 1931-1937 [Abstract] [Full Text]  
• Wan, B., Nie, H., Liu, A., Feng, G., He, D., Xu, R., Zhang, Q., Dong, C., Zhang, J. Z. (2006). Aberrant Regulation of Synovial T Cell Activation by Soluble Costimulatory Molecules in Rheumatoid Arthritis. J. Immunol. 177: 8844-8850 [Abstract] [Full Text]  
• Taqueti, V. R., Grabie, N., Colvin, R., Pang, H., Jarolim, P., Luster, A. D., Glimcher, L. H., Lichtman, A. H. (2006). T-bet Controls Pathogenicity of CTLs in the Heart by Separable Effects on Migration and Effector Activity. J. Immunol. 177: 5890-5901 [Abstract] [Full Text]  
• Hori, J., Wang, M., Miyashita, M., Tanemoto, K., Takahashi, H., Takemori, T., Okumura, K., Yagita, H., Azuma, M. (2006). B7-H1-Induced Apoptosis as a Mechanism of Immune Privilege of Corneal Allografts. J. Immunol. 177: 5928-5935 [Abstract] [Full Text]  
• Chang, C.-J., Yen, M.-L., Chen, Y.-C., Chien, C.-C., Huang, H.-I., Bai, C.-H., Yen, B. L. (2006). Placenta-Derived Multipotent Cells Exhibit Immunosuppressive Properties That Are Enhanced in the Presence of Interferon-{gamma}. Stem Cells 24: 2466-2477 [Abstract] [Full Text]  
• Ejrnaes, M., Filippi, C. M., Martinic, M. M., Ling, E. M., Togher, L. M., Crotty, S., von Herrath, M. G. (2006). Resolution of a chronic viral infection after interleukin-10 receptor blockade. JEM 203: 2461-2472 [Abstract] [Full Text]  
• Petrovas, C., Casazza, J. P., Brenchley, J. M., Price, D. A., Gostick, E., Adams, W. C., Precopio, M. L., Schacker, T., Roederer, M., Douek, D. C., Koup, R. A. (2006). PD-1 is a regulator of virus-specific CD8+ T cell survival in HIV infection. JEM 203: 2281-2292 [Abstract] [Full Text]  
• Freeman, G. J., Wherry, E. J., Ahmed, R., Sharpe, A. H. (2006). Reinvigorating exhausted HIV-specific T cells via PD-1-PD-1 ligand blockade. JEM 203: 2223-2227 [Abstract] [Full Text]  
• Meng, Q., Yang, P., Li, B., Zhou, H., Huang, X., Zhu, L., Ren, Y., Kijlstra, A. (2006). CD4+PD-1+ T Cells Acting as Regulatory Cells during the Induction of Anterior Chamber-Associated Immune Deviation.. IOVS 47: 4444-4452 [Abstract] [Full Text]  
• Usui, Y., Okunuki, Y., Hattori, T., Takeuchi, M., Kezuka, T., Goto, H., Usui, M. (2006). Expression of Costimulatory Molecules on Human Retinoblastoma Cells Y-79: Functional Expression of CD40 and B7H1.. IOVS 47: 4607-4613 [Abstract] [Full Text]  
• Ding, Q., Lu, L., Wang, B., Zhou, Y., Jiang, Y., Zhou, X., Xin, L., Jiao, Z., Chou, K.-Y. (2006). B7H1-Ig Fusion Protein Activates the CD4+ IFN-{gamma} Receptor+ Type 1 T Regulatory Subset through IFN-{gamma}-Secreting Th1 Cells. J. Immunol. 177: 3606-3614 [Abstract] [Full Text]  
• Suh, W.-K., Wang, S., Duncan, G. S., Miyazaki, Y., Cates, E., Walker, T., Gajewska, B. U., Deenick, E., Dawicki, W., Okada, H., Wakeham, A., Itie, A., Watts, T. H., Ohashi, P. S., Jordana, M., Yoshida, H., Mak, T. W. (2006). Generation and Characterization of B7-H4/B7S1/B7x-Deficient Mice.. Mol. Cell. Biol. 26: 6403-6411 [Abstract] [Full Text]  
• Hickman, S. P., Yang, J., Thomas, R. M., Wells, A. D., Turka, L. A. (2006). Defective Activation of Protein Kinase C and Ras-ERK Pathways Limits IL-2 Production and Proliferation by CD4+CD25+ Regulatory T Cells. J. Immunol. 177: 2186-2194 [Abstract] [Full Text]  
• Watson, M. P., George, A. J. T., Larkin, D. F. P. (2006). Differential effects of costimulatory pathway modulation on corneal allograft survival.. IOVS 47: 3417-3422 [Abstract] [Full Text]  
• Zhang, Y., Chung, Y., Bishop, C., Daugherty, B., Chute, H., Holst, P., Kurahara, C., Lott, F., Sun, N., Welcher, A. A., Dong, C. (2006). Regulation of T cell activation and tolerance by PDL2. Proc. Natl. Acad. Sci. USA 103: 11695-11700 [Abstract] [Full Text]  
• Lau, A. H., Abe, M., Thomson, A. W. (2006). Ethanol affects the generation, cosignaling molecule expression, and function of plasmacytoid and myeloid dendritic cell subsets in vitro and in vivo. J. Leukoc. Biol. 79: 941-953 [Abstract] [Full Text]  
• Kim, H. K., Guan, H., Zu, G., Li, H., Wu, L., Feng, X., Elmets, C., Fu, Y., Xu, H. (2006). High-level expression of B7-H1 molecules by dendritic cells suppresses the function of activated T cells and desensitizes allergen-primed animals. J. Leukoc. Biol. 79: 686-695 [Abstract] [Full Text]  
• Zhu, B., Guleria, I., Khosroshahi, A., Chitnis, T., Imitola, J., Azuma, M., Yagita, H., Sayegh, M. H., Khoury, S. J. (2006). Differential Role of Programmed Death-Ligand 1 and Programmed Death-Ligand 2 in Regulating the Susceptibility and Chronic Progression of Experimental Autoimmune Encephalomyelitis. J. Immunol. 176: 3480-3489 [Abstract] [Full Text]  
• Stagg, J., Pommey, S., Eliopoulos, N., Galipeau, J. (2006). Interferon-{gamma}-stimulated marrow stromal cells: a new type of nonhematopoietic antigen-presenting cell. Blood 107: 2570-2577 [Abstract] [Full Text]  
• Das, S., Suarez, G., Beswick, E. J., Sierra, J. C., Graham, D. Y., Reyes, V. E. (2006). Expression of B7-H1 on Gastric Epithelial Cells: Its Potential Role in Regulating T Cells during Helicobacter pylori Infection.. J. Immunol. 176: 3000-3009 [Abstract] [Full Text]  
• Holets, L. M., Hunt, J. S., Petroff, M. G. (2006). Trophoblast CD274 (B7-H1) Is Differentially Expressed Across Gestation: Influence of Oxygen Concentration. Biol. Reprod. 74: 352-358 [Abstract] [Full Text]  
• Neild, A. L., Shin, S., Roy, C. R. (2005). Activated Macrophages Infected with Legionella Inhibit T Cells by Means of MyD88-Dependent Production of Prostaglandins. J. Immunol. 175: 8181-8190 [Abstract] [Full Text]  
• Keir, M. E., Latchman, Y. E., Freeman, G. J., Sharpe, A. H. (2005). Programmed Death-1 (PD-1):PD-Ligand 1 Interactions Inhibit TCR-Mediated Positive Selection of Thymocytes. J. Immunol. 175: 7372-7379 [Abstract] [Full Text]  
• Yoshida, T., Hanawa, H., Toba, K., Watanabe, H., Watanabe, R., Yoshida, K., Abe, S., Kato, K., Kodama, M., Aizawa, Y. (2005). Expression of immunological molecules by cardiomyocytes and inflammatory and interstitial cells in rat autoimmune myocarditis. Cardiovasc Res 68: 278-288 [Abstract] [Full Text]  
• Blazar, B. R, Murphy, W. J (2005). Bone marrow transplantation and approaches to avoid graft-versus-host disease (GVHD). Phil Trans R Soc B 360: 1747-1767 [Abstract] [Full Text]  
• Kim, J., Myers, A. C., Chen, L., Pardoll, D. M., Truong-Tran, Q.-A., Lane, A. P., McDyer, J. F., Fortuno, L., Schleimer, R. P. (2005). Constitutive and Inducible Expression of B7 Family of Ligands by Human Airway Epithelial Cells. Am. J. Respir. Cell Mol. Bio. 33: 280-289 [Abstract] [Full Text]  

Home | Help | Feedback | Subscriptions | Archive | Search

TABLE OF CONTENTS