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Original Article

^a Institute for Genetics, Institute for Pathology, University of Cologne, 50931 Cologne, Germany
^b Department of Neuropathology, Institute for Pathology, University of Cologne, 50931 Cologne, Germany
^c Department of Neuroimmunology, Brain Research Institute, University of Vienna, 1090 Vienna, Austria
^d Department of Neuroimmunology, Max-Planck-Institute for Neurobiology, 82152 Martinsried, Germany
^e Department of Neuropathology, University of Bonn, 53105 Bonn, Germany
^f Department of Neurology, University of Bonn, 53105 Bonn, Germany
^g Netherlands Brain Bank, 1105 AZ Amsterdam, The Netherlands
Department of Immunology, Institute for Genetics, University of Cologne, Weyertal 121, 50931 Cologne, Germany.49-221-478-636049-221-478-4543

axel.roers{at}uni-koeln.de

Clonal composition and T cell receptor (TCR) repertoire of CD4⁺ and CD8⁺ T cells infiltrating actively demyelinating multiple sclerosis (MS) lesions were determined with unprecedented resolution at the level of single cells. Individual CD4⁺ or CD8⁺ T cells were isolated from frozen sections of lesional tissue by micromanipulation and subjected to single target amplification of TCR-β gene rearrangements. This strategy allows the assignment of a TCR variable region (V region) sequence to the particular T cell from which it was amplified. Sequence analysis revealed that in both cases investigated, the majority of CD8⁺ T cells belonged to few clones. One of these clones accounted for 35% of CD8⁺ T cells in case 1. V region sequence comparison revealed signs of selection for common peptide specificities for some of the CD8⁺ T cells in case 1. In both cases, the CD4⁺ T cell population was more heterogeneous. Most CD4⁺ and CD8⁺ clones were represented in perivascular infiltrates as well as among parenchymal T cells. In case 2, two of the CD8⁺ clones identified in brain tissue were also detected in peripheral blood. Investigation of the antigenic specificities of expanded clones may help to elucidate their functional properties.

Key Words: autoimmunity • demyelinating disease • T cell receptor β chain • gene rearrangement • peripheral blood

Abbreviations used in this paper: CSF, cerebrospinal fluid; EAE, experimental autoimmune encephalomyelitis; GFAP, glial fibrillary acidic protein; MS, multiple sclerosis; ORO, Oil Red O; PLP, proteolipid protein; WM, white matter.

© 2000 The Rockefeller University Press

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• Friese, M. A., Fugger, L. (2005). Autoreactive CD8+ T cells in multiple sclerosis: a new target for therapy?. Brain 128: 1747-1763 [Abstract] [Full Text]  
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• Chen, A. M., Khanna, N., Stohlman, S. A., Bergmann, C. C. (2005). Virus-Specific and Bystander CD8 T Cells Recruited during Virus-Induced Encephalomyelitis. J. Virol. 79: 4700-4708 [Abstract] [Full Text]  
• Krumbholz, M., Theil, D., Derfuss, T., Rosenwald, A., Schrader, F., Monoranu, C.-M., Kalled, S. L., Hess, D. M., Serafini, B., Aloisi, F., Wekerle, H., Hohlfeld, R., Meinl, E. (2005). BAFF is produced by astrocytes and up-regulated in multiple sclerosis lesions and primary central nervous system lymphoma. JEM 201: 195-200 [Abstract] [Full Text]  
• Theil, D, Farina, C, Meinl, E (2005). Differential expression of CD150 (SLAM) on monocytes and macrophages in chronic inflammatory contexts: abundant in Crohn's disease, but not in multiple sclerosis. J. Clin. Pathol. 58: 110-111 [Full Text]  
• Hohlfeld, R., Wekerle, H. (2004). Autoimmune concepts of multiple sclerosis as a basis for selective immunotherapy: From pipe dreams to (therapeutic) pipelines. Proc. Natl. Acad. Sci. USA 101: 14599-14606 [Abstract] [Full Text]  
• Pellkofer, H., Schubart, A. S., Hoftberger, R., Schutze, N., Pagany, M., Schuller, M., Lassmann, H., Hohlfeld, R., Voltz, R., Linington, C. (2004). Modelling paraneoplastic CNS disease: T-cells specific for the onconeuronal antigen PNMA1 mediate autoimmune encephalomyelitis in the rat. Brain 127: 1822-1830 [Abstract] [Full Text]  
• Hohlfeld, R. (2004). Immunologic factors in primary progressive multiple sclerosis. Mult Scler 10: S16-S22 [Abstract]  
• Whitacre, C. C. (2004). Spotlight on CD8 T cells in MS. Blood 103: 3999-4000 [Full Text]  
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• Laplaud, D.-A., Ruiz, C., Wiertlewski, S., Brouard, S., Berthelot, L., Guillet, M., Melchior, B., Degauque, N., Edan, G., Brachet, P., Damier, P., Soulillou, J.-P. (2004). Blood T-cell receptor {beta} chain transcriptome in multiple sclerosis. Characterization of the T cells with altered CDR3 length distribution. Brain 127: 981-995 [Abstract] [Full Text]  
• Hayashi, Y., Tsukumo, S.-i., Shiota, H., Kishihara, K., Yasutomo, K. (2004). Antigen-Specific T Cell Repertoire Modification of CD4+CD25+ Regulatory T Cells. J. Immunol. 172: 5240-5248 [Abstract] [Full Text]  
• Hohlfeld, R. (2004). Immunologic factors in primary progressive multiple sclerosis. Mult Scler 10: S16-S22 [Abstract]  
• Skulina, C., Schmidt, S., Dornmair, K., Babbe, H., Roers, A., Rajewsky, K., Wekerle, H., Hohlfeld, R., Goebels, N. (2004). Multiple sclerosis: Brain-infiltrating CD8+ T cells persist as clonal expansions in the cerebrospinal fluid and blood. Proc. Natl. Acad. Sci. USA 101: 2428-2433 [Abstract] [Full Text]  
• Dandekar, A. A., Anghelina, D., Perlman, S. (2004). Bystander CD8 T-Cell-Mediated Demyelination is Interferon-{gamma}-Dependent in a Coronavirus Model of Multiple Sclerosis. Am. J. Pathol. 164: 363-369 [Abstract] [Full Text]  
• Nakane, S., Matsuo, H., Goto, H., Yoshinaga-Matsumoto, M., Ohtsuru, I., Ichinose, K., Onodera, H., Yoshida, M., Shibuya, N. (2003). Cytapheresis with a filter for selective removal of CD4+ T cells in experimental autoimmune encephalomyelitis. Mult Scler 9: 579-584 [Abstract]  
• Bradl, M, Hohlfeld, R (2003). Molecular pathogenesis of neuroinflammation. J. Neurol. Neurosurg. Psychiatry 74: 1364-1370 [Abstract] [Full Text]  
• Dornmair, K., Goebels, N., Weltzien, H.-U., Wekerle, H., Hohlfeld, R. (2003). T-Cell-Mediated Autoimmunity: Novel Techniques to Characterize Autoreactive T-Cell Receptors. Am. J. Pathol. 163: 1215-1226 [Abstract] [Full Text]  
• Schroeter, M., Stoll, G., Weissert, R., Hartung, H.-P., Lassmann, H., Jander, S. (2003). CD8+ Phagocyte Recruitment in Rat Experimental Autoimmune Encephalomyelitis: Association with Inflammatory Tissue Destruction. Am. J. Pathol. 163: 1517-1524 [Abstract] [Full Text]  
• Buch, T., Uthoff-Hachenberg, C., Waisman, A. (2003). Protection from autoimmune brain inflammation in mice lacking IFN-regulatory factor-1 is associated with Th2-type cytokines. Int Immunol 15: 855-859 [Abstract] [Full Text]  
• Battistini, L., Piccio, L., Rossi, B., Bach, S., Galgani, S., Gasperini, C., Ottoboni, L., Ciabini, D., Caramia, M. D., Bernardi, G., Laudanna, C., Scarpini, E., McEver, R. P., Butcher, E. C., Borsellino, G., Constantin, G. (2003). CD8+ T cells from patients with acute multiple sclerosis display selective increase of adhesiveness in brain venules: a critical role for P-selectin glycoprotein ligand-1. Blood 101: 4775-4782 [Abstract] [Full Text]  
• Kang, H., Liesenfeld, O., Remington, J. S., Claflin, J., Wang, X., Suzuki, Y. (2003). TCR V{beta}8+ T Cells Prevent Development of Toxoplasmic Encephalitis in BALB/c Mice Genetically Resistant to the Disease. J. Immunol. 170: 4254-4259 [Abstract] [Full Text]  
• Hofbauer, M., Wiesener, S., Babbe, H., Roers, A., Wekerle, H., Dornmair, K., Hohlfeld, R., Goebels, N. (2003). Clonal tracking of autoaggressive T cells in polymyositis by combining laser microdissection, single-cell PCR, and CDR3-spectratype analysis. Proc. Natl. Acad. Sci. USA 100: 4090-4095 [Abstract] [Full Text]  
• Gianfrani, C., Troncone, R., Mugione, P., Cosentini, E., De Pascale, M., Faruolo, C., Senger, S., Terrazzano, G., Southwood, S., Auricchio, S., Sette, A. (2003). Celiac Disease Association with CD8+ T Cell Responses: Identification of a Novel Gliadin-Derived HLA-A2-Restricted Epitope. J. Immunol. 170: 2719-2726 [Abstract] [Full Text]  
• Hohlfeld, R. (2003). Hunting (auto)immune T cells in neuroimmunological diseases. Brain 126: 2-4 [Full Text]  
• Hodges, E, Krishna, M T, Pickard, C, Smith, J L (2003). Diagnostic role of tests for T cell receptor (TCR) genes. J. Clin. Pathol. 56: 1-11 [Abstract] [Full Text]  
• Scheckelhoff, M., Deepe, G. S. Jr. (2002). The Protective Immune Response to Heat Shock Protein 60 of Histoplasma capsulatum Is Mediated by a Subset of V{beta}8.1/8.2+ T Cells. J. Immunol. 169: 5818-5826 [Abstract] [Full Text]  
• Nicolson, K., Freland, S., Weir, C., Delahunt, B., Flavell, R. A., Backstrom, B. T. (2002). Induction of experimental autoimmune encephalomyelitis in the absence of c-Jun N-terminal kinase 2. Int Immunol 14: 849-856 [Abstract] [Full Text]  
• Wiendl, H., Malotka, J., Holzwarth, B., Weltzien, H.-U., Wekerle, H., Hohlfeld, R., Dornmair, K. (2002). An Autoreactive {gamma}{delta} TCR Derived from a Polymyositis Lesion. J. Immunol. 169: 515-521 [Abstract] [Full Text]  
• Meehan, T. F., DeLuca, H. F. (2002). CD8+ T cells are not necessary for 1alpha ,25-dihydroxyvitamin D3 to suppress experimental autoimmune encephalomyelitis in mice. Proc. Natl. Acad. Sci. USA 99: 5557-5560 [Abstract] [Full Text]  
• Sakkas, L. I., Xu, B., Artlett, C. M., Lu, S., Jimenez, S. A., Platsoucas, C. D. (2002). Oligoclonal T Cell Expansion in the Skin of Patients with Systemic Sclerosis. J. Immunol. 168: 3649-3659 [Abstract] [Full Text]  
• Jacobsen, M., Cepok, S., Quak, E., Happel, M., Gaber, R., Ziegler, A., Schock, S., Oertel, W. H., Sommer, N., Hemmer, B. (2002). Oligoclonal expansion of memory CD8+ T cells in cerebrospinal fluid from multiple sclerosis patients. Brain 125: 538-550 [Abstract] [Full Text]  
• Pewe, L., Perlman, S. (2002). Cutting Edge: CD8 T Cell-Mediated Demyelination Is IFN-{gamma} Dependent in Mice Infected with a Neurotropic Coronavirus. J. Immunol. 168: 1547-1551 [Abstract] [Full Text]  
• Muraro, P. A., Wandinger, K.-P., Bielekova, B., Gran, B., Marques, A., Utz, U., McFarland, H. F., Jacobson, S., Martin, R. (2002). Molecular tracking of antigen-specific T cell clones in neurological immune-mediated disorders. Brain 126: 20-31 [Abstract] [Full Text]  
• Morice, W. G., Kurtin, P. J., Tefferi, A., Hanson, C. A. (2002). Distinct bone marrow findings in T-cell granular lymphocytic leukemia revealed by paraffin section immunoperoxidase stains for CD8, TIA-1, and granzyme B. Blood 99: 268-274 [Abstract] [Full Text]  
• Huseby, E. S., Liggitt, D., Brabb, T., Schnabel, B., Ohlen, C., Goverman, J. (2001). A Pathogenic Role for Myelin-Specific Cd8+ T Cells in a Model for Multiple Sclerosis. JEM 194: 669-676 [Abstract] [Full Text]  
• Steinman, L. (2001). Myelin-Specific Cd8 T Cells in the Pathogenesis of Experimental Allergic Encephalitis and Multiple Sclerosis. JEM 194: F27-F30 [Full Text]  
• Sun, D., Whitaker, J. N., Huang, Z., Liu, D., Coleclough, C., Wekerle, H., Raine, C. S. (2001). Myelin Antigen-Specific CD8+ T Cells Are Encephalitogenic and Produce Severe Disease in C57BL/6 Mice. J. Immunol. 166: 7579-7587 [Abstract] [Full Text]  
• Meehan, T. F., DeLuca, H. F. (2002). CD8+ T cells are not necessary for 1alpha ,25-dihydroxyvitamin D3 to suppress experimental autoimmune encephalomyelitis in mice. Proc. Natl. Acad. Sci. USA 99: 5557-5560 [Abstract] [Full Text]  

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