The Journal of Experimental Medicine
for flow cytometry > invitrogen
  Home | Help | Feedback | Subscriptions | Archive | Search | Table of Contents
Published online 3 July 2000.
This Article
Right arrow Full Text
Right arrow Full Text (PDF, 180K)
Right arrow PPT slides of all figures
Right arrow Alert me when this article is cited
Right arrow Citation Map
Services
Right arrow Email this article
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new content in the JEM
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via CrossRef
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Thompson, J. S.
Right arrow Articles by Ambrose, C.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Thompson, J. S.
Right arrow Articles by Ambrose, C.
Right arrowPubmed/NCBI databases
*Compound via MeSH
*Substance via MeSH
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Facebook   Add to Reddit   Add to Technorati   Add to Twitter  
What's this?
© The Rockefeller University Press, 0022-1007/2000/7/129/ $5.00
The Journal of Experimental Medicine, Volume 192, Number 1, July 3, 2000 129-136

Brief Definitive Reports

Baff Binds to the Tumor Necrosis Factor Receptor–Like Molecule B Cell Maturation Antigen and Is Important for Maintaining the Peripheral B Cell Population

Jeffrey S. Thompsona, Pascal Schneiderd, Susan L. Kalledb, LiChun Wangb, Eric A. Lefevree, Teresa G. Cacheroc, Fabienne MacKayf, Sarah A. Bixlera, Mohammad Zafarib, Zhong-Ying Liub, Stephen A. Woodcockb, Fang Qianc, Marcel Battenf, Christine Madrye, Yolande Richarde, Christopher D. Benjaminb, Jeffrey L. Browningb, Andreas Tsapise, Jurg Tschoppd, and Christine Ambrosea

a Department of Molecular Genetics, Biogen, Incorporated, Cambridge, Massachusetts 02142
b Department of Immunology and Inflammation, Biogen, Incorporated, Cambridge, Massachusetts 02142
c Department of Protein Engineering, Biogen, Incorporated, Cambridge, Massachusetts 02142
d Institute of Biochemistry, University of Lausanne, CH-1066 Epalinges, Switzerland
e Institut National de la Santé et de la Recherche Médicale U131, 92140 Clamart, France
f Garvan Institute of Medical Research, St. Vincent's Hospital, Darlinghurst NSW 2010, Australia
Biogen, Inc., 12 Cambridge Center, Cambridge, MA 02142.617-679-2304617-679-3340

christine_ambrose{at}biogen.com

The tumor necrosis factor (TNF) family member B cell activating factor (BAFF) binds B cells and enhances B cell receptor–triggered proliferation. We find that B cell maturation antigen (BCMA), a predicted member of the TNF receptor family expressed primarily in mature B cells, is a receptor for BAFF. Although BCMA was previously localized to the Golgi apparatus, BCMA was found to be expressed on the surface of transfected cells and tonsillar B cells. A soluble form of BCMA, which inhibited the binding of BAFF to a B cell line, induced a dramatic decrease in the number of peripheral B cells when administered in vivo. Moreover, culturing splenic cells in the presence of BAFF increased survival of a percentage of the B cells. These results are consistent with a role for BAFF in maintaining homeostasis of the B cell population.

Key Words: tumor necrosis factor • B lymphocyte • receptor • cell survival • homeostasis

J.S. Thompson and P. Schneider contributed equally to this work.

Portions of this work have appeared in abstract form (2000. Scand. J. Immunol. 51:65).

© 2000 The Rockefeller University Press


Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Facebook Facebook   Add to Reddit Reddit   Add to Technorati Technorati   Add to Twitter Twitter    What's this?


This article has been cited by other articles:



  Home | Help | Feedback | Subscriptions | Archive | Search
TABLE OF CONTENTS