Activation of Lipoxin A4 Receptors by Aspirin-triggered Lipoxins and Select Peptides Evokes Ligand-specific Responses in Inflammation

doi:10.1084/jem.191.7.1197

Published online 3 April 2000.

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© The Rockefeller University Press, 0022-1007/2000/4/1197/ $5.00
The Journal of Experimental Medicine, Volume 191, Number 7, April 3, 2000 1197-1208

Original Article

Activation of Lipoxin A₄ Receptors by Aspirin-triggered Lipoxins and Select Peptides Evokes Ligand-specific Responses in Inflammation

Nan Chiang^a, Iolanda M. Fierro^a, Karsten Gronert^a, and Charles N. Serhan^a
^a Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts 02115

Correspondence to: Charles N. Serhan, Center for Experimental Therapeutics and Reperfusion Injury, Brigham and Women's Hospital, 75 Francis St., Boston, MA 02115. Tel:617-732-8822 Fax:617-278-6957 E-mail:cnserhan{at}zeus.bwh.harvard.edu.

Lipoxin (LX) A₄ and aspirin-triggered LX (ATL) are endogenouslipids that regulate leukocyte trafficking via specific LXA₄receptors (ALXRs) and mediate antiinflammation and resolution.ATL analogues dramatically inhibited human neutrophil (polymorphonuclearleukocyte [PMN]) responses evoked by a potent necrotactic peptidederived from mitochondria as well as a rogue synthetic chemotacticpeptide. These bioactive lipid analogues and small peptideseach selectively competed for specific ³H-LXA₄ binding withrecombinant human ALXR, and its N-glycosylation proved essentialfor peptide but not LXA₄ recognition. Chimeric receptors constructedfrom receptors with opposing functions, namely ALXR and leukotrieneB₄ receptors (BLTs), revealed that the seventh transmembranesegment and adjacent regions of ALXR are essential for LXA₄recognition, and additional regions of ALXR are required forhigh affinity binding of the peptide ligands. Together, thesefindings are the first to indicate that a single seven-transmembranereceptor can switch recognition as well as function with certainchemotactic peptides to inhibitory with ATL and LX (lipid ligands).Moreover, they suggest that ALXR activation by LX or ATL canprotect the host from potentially deleterious PMN responsesassociated with innate immunity as well as direct effector responsesin tissue injury by recognition of peptide fragments.

Key Words: inhibitory receptors, antiinflammation, resolution, leukocytes,MHC binding peptide

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