The Journal of Experimental Medicine
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Published online 3 April 2000.
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© The Rockefeller University Press, 0022-1007/2000/4/1137/ $5.00
The Journal of Experimental Medicine, Volume 191, Number 7, April 3, 2000 1137-1148

Original Article

T Cells Can Use Either T Cell Receptor or Cd28 Receptors to Absorb and Internalize Cell Surface Molecules Derived from Antigen-Presenting Cells

Inkyu Hwanga, Jing-Feng Huangb, Hidehiro Kishimotoa, Anders Brunmarkb, Per A. Petersonb, Michael R. Jacksonb, Charles D. Surha, Zeling Caib, and Jonathan Sprenta

a Department of Immunology, IMM4, The Scripps Research Institute, La Jolla, California 92037
b R.W. Johnson Pharmaceutical Research Institute, San Diego, California 92121
Department of Immunology, IMM4, The Scripps Research Institute, 10550 N. Torrey Pines Rd., La Jolla, CA 92037.858-784-8839858-784-8619

jsprent{at}scripps.edu

At the site of contact between T cells and antigen-presenting cells (APCs), T cell receptor (TCR)–peptide–major histocompatibility complex (MHC) interaction is intensified by interactions between other molecules, notably by CD28 and lymphocyte function-associated antigen 1 (LFA-1) on T cells interacting with B7 (B7-1 and B7-2), and intracellular adhesion molecule 1 (ICAM-1), respectively, on APCs. Here, we show that during T cell–APC interaction, T cells rapidly absorb various molecules from APCs onto the cell membrane and then internalize these molecules. This process is dictated by at least two receptors on T cells, namely CD28 and TCR molecules. The biological significance of T cell uptake of molecules from APCs is unclear. One possibility is that this process may allow activated T cells to move freely from one APC to another and eventually gain entry into the circulation.

Key Words: T cell receptor • CD28 • absorption • internalization • antigen presenting cells

Abbreviations used in this paper: B6, C57BL/6J; DC, dendritic cell; ICAM, intracellular adhesion molecule; MFI, mean fluorescence intensity; PI, propidium iodide.

© 2000 The Rockefeller University Press


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