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Original Article

^a Graduate Program in Immunology and Molecular Pathogenesis, Emory University School of Medicine, Atlanta, Georgia 30322
^b Department of Pathology and Graduate Program in Genetics and Molecular Biology, Emory University School of Medicine, Atlanta, Georgia 30322
^c Department of Neurology, Emory University School of Medicine, Atlanta, Georgia 30322
^d Immunology Branch, Division of Parasitic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30341
Emory University, Dept. of Pathology, 1639 Pierce Dr., Atlanta, GA 30322.404-727-5764404-727-9364

mbrow18{at}emory.edu

In addition to their well characterized role in allergic inflammation, recent data confirm that mast cells play a more extensive role in a variety of immune responses. However, their contribution to autoimmune and neurologic disease processes has not been investigated. Experimental allergic encephalomyelitis (EAE) and its human disease counterpart, multiple sclerosis, are considered to be CD4⁺ T cell–mediated autoimmune diseases affecting the central nervous system. Several lines of indirect evidence suggest that mast cells could also play a role in the pathogenesis of both the human and murine disease. Using a myelin oligodendrocyte glycoprotein (MOG)-induced model of acute EAE, we show that mast cell–deficient W/W^v mice exhibit significantly reduced disease incidence, delayed disease onset, and decreased mean clinical scores when compared with their wild-type congenic littermates. No differences were observed in MOG-specific T and B cell responses between the two groups, indicating that a global T or B cell defect is not present in W/W^v animals. Reconstitution of the mast cell population in W/W^v mice restores induction of early and severe disease to wild-type levels, suggesting that mast cells are critical for the full manifestation of disease. These data provide a new mechanism for immune destruction in EAE and indicate that mast cells play a broader role in neurologic inflammation.

Key Words: autoimmunity • demyelinating diseases • experimental allergic encephalomyelitis • inflammation • myelin-associated glycoprotein

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This article has been cited by other articles:

• Duelli, A., Ronnberg, E., Waern, I., Ringvall, M., Kolset, S. O., Pejler, G. (2009). Mast Cell Differentiation and Activation Is Closely Linked to Expression of Genes Coding for the Serglycin Proteoglycan Core Protein and a Distinct Set of Chondroitin Sulfate and Heparin Sulfotransferases. J. Immunol. 183: 7073-7083 [Abstract] [Full Text]  
• Gurish, M. F., Austen, K. F. (2001). The Diverse Roles of Mast Cells. JEM 194: f1-f6 [Full Text]  

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