The Journal of Experimental Medicine
CSHL 2010 Immunology Conference
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© The Rockefeller University Press, 0022-1007/2000/2/731/ $5.00
The Journal of Experimental Medicine, Volume 191, Number 4, February 21, 2000 731-736

Brief Definitive Report

B1 B Lymphocytes Play a Critical Role in Host Protection against Lymphatic Filarial Parasites

Natalia Paciorkowskia, Patricia Portea, Leonard D. Shultzb, and T.V. Rajana

a From the University of Connecticut Health Center, Farmington, Connecticut 06030-3105
b The Jackson Laboratory, Bar Harbor, Maine 04609
Department of Pathology, University of Connecticut Health Center, Farmington, CT 06030-3105.860-679-2936860-679-2196

rajan{at}neuron.uchc.edu

Host defense against multicellular, extracellular pathogens such as nematode parasites is believed to be mediated largely, if not exclusively, by T lymphocytes. During our investigations into the course of Brugia malayi and Brugia pahangi infections in immunodeficient mouse models, we found that mice lacking B lymphocytes were permissive for Brugian infections, whereas immunocompetent mice were uniformly resistant. Mice bearing the Btkxid mutation were as permissive as those lacking all B cells, suggesting that the B1 subset may be responsible for host protection. Reconstitution of immunodeficient recombination activating gene (Rag)-1–/– mice with B1 B cells conferred resistance, even in the absence of conventional B2 lymphocytes and most T cells. These results suggest that B1 B cells are necessary to mediate host resistance to Brugian infection. Our data are consistent with a model wherein early resistance to B. malayi is mediated by humoral immune response, with a significant attrition of the incoming infectious larval load. Sterile clearance of the remaining parasite burden appears to require cell-mediated immunity. These data raise the possibility that the identification of molecule(s) recognized by humoral immune mechanisms might help generate prophylactic vaccines.

Key Words: B cells • lymphatic filariasis • Brugia malayi • Brugia pahangi • host protection

© 2000 The Rockefeller University Press


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