The Journal of Experimental Medicine
Aegean Conferences: 2009 Conferences
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© The Rockefeller University Press, 0022-1007/2000/2/567/ $5.00
The Journal of Experimental Medicine, Volume 191, Number 3, February 7, 2000 567-572

Brief Definitive Report

Evidence for the Chronic In Vivo Production of Human T Cell Leukemia Virus Type I Rof and Tof Proteins from Cytotoxic T Lymphocytes Directed against Viral Peptides

Claudine Piquea,b, Abel Ureta-Vidald, Antoine Gessaine, Bruno Chancerelf, Olivier Goutg, Riad Tamouzac, Frantz Agisf, and Marie-Christine Dokhélara
a Institut National de la Santé et de la Recherche Médicale, U332, Institut Cochin de Génétique Moléculaire, 75014 Paris, France
b Centre National de la Recherche Scientifique, UPR 9051,
c Laboratoire d'Immunologie et d'Histocompatibilité, Hôpital St. Louis, 75010 Paris, France
d Unité d'Immunité Cellulaire Antivirale, Institut Pasteur, 75015 Paris, France
e Unité d'Oncologie Virale, Institut Pasteur, 75015 Paris, France
f Etablissement de Transfusion Sanguine, Guadeloupe, 97171 Pointe-à-Pitre, Guadeloupe
g Fédération de Neurologie, Hôpital de la Pitié-Salpétrière, 75013 Paris, France

Correspondence to: Claudine Pique, CNRS UPR 9051, Hôpital St. Louis, 1 Avenue Claude Vellefaux, 75010 Paris, France. Tel:33-1-53-72-40-95 Fax:33-1-53-72-40-90 E-mail:pique{at}chu-stlouis.fr.

Human T cell leukemia virus type I (HTLV-I) is a persistent virus that causes adult T cell leukemia and tropical spastic paraparesis/HTLV-I–associated myelopathy. Studies on rabbits have shown that viral proteins encoded by the open reading frames pX-I and pX-II are required for the establishment of the persistent infection. To examine the in vivo production of these proteins in humans, we have investigated whether cytotoxic T lymphocytes isolated from HTLV-I–infected individuals recognized pX-I and pX-II peptides. CD8+ T lymphocytes to pX-I and pX-II peptides were detected in HTLV-I–infected individuals, whatever their clinical status, and even in the absence of any antigenic restimulation. These findings indicate that the HTLV-I pX-I and pX-II proteins are chronically synthesized in vivo, and are targets of the natural immune response to the virus.

Key Words: retrovirus, regulatory proteins, cytotoxic epitopes, HLA-A2, interferon {gamma}


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