The Journal of Experimental Medicine
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© The Rockefeller University Press, 0022-1007/2000/1/381/ $5.00
The Journal of Experimental Medicine, Volume 191, Number 2, January 17, 2000 381-386

Brief Definitive Report

Lineage-Restricted Function of Nuclear Factor {kappa}B–Inducing Kinase (Nik) in Transducing Signals via Cd40

Norman Garceaua, Yoko Kosakaa, Sally Mastersa, John Hamborb, Reiko Shinkurac, Tasuku Honjoc, and Randolph J. Noellea

a Department of Microbiology, Dartmouth Medical School, Lebanon, New Hampshire 03756
b Department of Molecular Sciences, Pfizer Central Research, Groton, Connecticut 06340
c Department of Medical Chemistry, Kyoto University, Kyoto, 606-8501, Japan

CD40 signaling in B cells and dendritic cells (DCs) is critical for the development of humoral and cell-mediated immunity, respectively. Nuclear factor {kappa}B (NF-{kappa}B)–inducing kinase (NIK) has been implicated as a central transducing kinase in CD40-dependent activation. Here, we show that although NIK is essential for B cell activation, it is dispensable for activation of DCs. Such data provide compelling evidence that different intermediary kinases are used by different cellular lineages to trigger NF-{kappa}B activation via CD40.

Key Words: CD40 signaling • nuclear factor {kappa}B–inducing kinase • dendritic cell • nuclear factor {kappa}B activation • alymphoplasia mice

Address correspondence to Randolph J. Noelle, Department of Microbiology, Dartmouth Medical School, 1 Medical Center Dr., Lebanon, NH 03756. Phone: 603-650-7670; Fax: 603-650-6223; E-mail: rjn@dartmouth.edu

© 2000 The Rockefeller University Press


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