Cc Chemokine Receptor (Ccr)3/Eotaxin Is Followed by Ccr4/Monocyte-Derived Chemokine in Mediating Pulmonary T Helper Lymphocyte Type 2 Recruitment after Serial Antigen Challenge in Vivo

doi:10.1084/jem.191.2.265

This Article

	Full Text
	Full Text (PDF, 365K)
	PPT slides of all figures
	Alert me when this article is cited
	Citation Map

Services

	Email this article
	Similar articles in this journal
	Similar articles in PubMed
	Alert me to new content in the JEM
	Download to citation manager

Citing Articles

	Citing Articles via HighWire
	Citing Articles via CrossRef
	Citing Articles via Google Scholar

Google Scholar

	Articles by Lloyd, C. M.
	Articles by Gutierrez-Ramos, J.-C.
	Search for Related Content

PubMed

	PubMed Citation
	Articles by Lloyd, C. M.
	Articles by Gutierrez-Ramos, J.-C.


Social Bookmarking

	What's this?

© The Rockefeller University Press, 0022-1007/2000/1/265/ $5.00
The Journal of Experimental Medicine, Volume 191, Number 2, January 17, 2000 265-274

Original Article

Cc Chemokine Receptor (Ccr)3/Eotaxin Is Followed by Ccr4/Monocyte-Derived Chemokine in Mediating Pulmonary T Helper Lymphocyte Type 2 Recruitment after Serial Antigen Challenge in Vivo

Clare M. Lloyd^a, Tracy Delaney^a, Trang Nguyen^a, Jane Tian^a, Carlos Martinez-A^b, Anthony J. Coyle^a, and Jose-Carlos Gutierrez-Ramos^a

^a Millennium Pharmaceuticals, Inc., Cambridge, Massachusetts 02139
^b Department of Immunology and Oncology, Centro Nacional de Biotecnologia, Consejo Superior de Investigaciones Cientificas, Universidad Autonoma, Centroblanco, E28049 Madrid, Spain
Millennium Pharmaceuticals, Inc., 45 Sidney St., Cambridge, MA 02139.617-551-8910617-679-7262

gutierrez{at}mpi.com

Isolated peripheral blood CD4 cells from allergic individualsexpress CC chemokine receptor (CCR)3 and CCR4 after expansionin vitro. In addition, human T helper type 2 (Th2) cells polarizedin vitro selectively express CCR3 and CCR4 at certain stagesof activation/differentiation and respond preferentially tothe ligands eotaxin and monocyte-derived chemokine (MDC). However,controversy arises when the in vivo significance of this distinctexpression is discussed. To address the functional role of CCR3/eotaxinand CCR4/MDC during the in vivo recruitment of Th2 cells, wehave transferred effector Th cells into naive mice to induceallergic airway disease. Tracking of these cells after repeatedantigen challenge has established that both CCR3/eotaxin andCCR4/MDC axes contribute to the recruitment of Th2 cells tothe lung, demonstrating the in vivo relevance of the expressionof these receptors on Th2 cells. We have shown that involvementof the CCR3/eotaxin pathway is confined to early stages of theresponse in vivo, whereas repeated antigen stimulation resultsin the predominant use of the CCR4/MDC pathway. We propose thateffector Th2 cells respond to both CCR3/eotaxin and CCR4/MDCpathways initially, but that a progressive increase in CCR4-positivecells results in the predominance of the CCR4/MDC axis in thelong-term recruitment of Th2 cells in vivo.

Key Words: chemokines • effector T helper type 2 cells • migration • allergic airway disease • chemokine receptors

Abbreviations used in this paper: AAD, allergic airway disease;BAL, bronchoalveolar lavage; BHR, bronchial hyperresponsiveness;CCR, CC chemokine receptor; hpf, high-power field(s); MDC, monocyte-derivedchemokine; P_enh, enhanced pause; TARC, thymus and activation-regulatedchemokine.

Add to CiteULike CiteULike Add to Complore Complore Add to Connotea Connotea Add to Del.icio.us Del.icio.us Add to Digg Digg Facebook Add to Reddit Reddit Add to Technorati Technorati Twitter What's this?

This article has been cited by other articles:

Yi, T., Chen, Y., Wang, L., Du, G., Huang, D., Zhao, D., Johnston, H., Young, J., Todorov, I., Umetsu, D. T., Chen, L., Iwakura, Y., Kandeel, F., Forman, S., Zeng, D. (2009). Reciprocal differentiation and tissue-specific pathogenesis of Th1, Th2, and Th17 cells in graft-versus-host disease. Blood 114: 3101-3112 [Abstract] [Full Text]
Campbell, J. D., Buckland, K. F., McMillan, S. J., Kearley, J., Oldfield, W. L.G., Stern, L. J., Gronlund, H., van Hage, M., Reynolds, C. J., Boyton, R. J., Cobbold, S. P., Kay, A. B., Altmann, D. M., Lloyd, C. M., Larche, M. (2009). Peptide immunotherapy in allergic asthma generates IL-10-dependent immunological tolerance associated with linked epitope suppression. JEM 206: 1535-1547 [Abstract] [Full Text]
Kearley, J., Buckland, K. F., Mathie, S. A., Lloyd, C. M. (2009). Resolution of Allergic Inflammation and Airway Hyperreactivity Is Dependent upon Disruption of the T1/ST2-IL-33 Pathway. Am. J. Respir. Crit. Care Med. 179: 772-781 [Abstract] [Full Text]
Medoff, B. D., Seung, E., Hong, S., Thomas, S. Y., Sandall, B. P., Duffield, J. S., Kuperman, D. A., Erle, D. J., Luster, A. D. (2009). CD11b+ Myeloid Cells Are the Key Mediators of Th2 Cell Homing into the Airway in Allergic Inflammation. J. Immunol. 182: 623-635 [Abstract] [Full Text]
Olson, M. R., Hartwig, S. M., Varga, S. M. (2008). The Number of Respiratory Syncytial Virus (RSV)-Specific Memory CD8 T Cells in the Lung Is Critical for Their Ability to Inhibit RSV Vaccine-Enhanced Pulmonary Eosinophilia. J. Immunol. 181: 7958-7968 [Abstract] [Full Text]
Saito, K., Torii, M., Ma, N., Tsuchiya, T., Wang, L., Hori, T., Nagakubo, D., Nitta, N., Kanegasaki, S., Hieshima, K., Yoshie, O., Gabazza, E. C., Katayama, N., Shiku, H., Kuribayashi, K., Kato, T. (2008). Differential Regulatory Function of Resting and Preactivated Allergen-Specific CD4+CD25+ Regulatory T Cells in Th2-Type Airway Inflammation. J. Immunol. 181: 6889-6897 [Abstract] [Full Text]
Walsh, E. R., Sahu, N., Kearley, J., Benjamin, E., Kang, B. H., Humbles, A., August, A. (2008). Strain-specific requirement for eosinophils in the recruitment of T cells to the lung during the development of allergic asthma. JEM 205: 1285-1292 [Abstract] [Full Text]
Jacobsen, E. A., Ochkur, S. I., Pero, R. S., Taranova, A. G., Protheroe, C. A., Colbert, D. C., Lee, N. A., Lee, J. J. (2008). Allergic pulmonary inflammation in mice is dependent on eosinophil-induced recruitment of effector T cells. JEM 205: 699-710 [Abstract] [Full Text]
Mellado, M., de Ana, A. M., Gomez, L., Martinez-A, C., Rodriguez-Frade, J. M. (2008). Chemokine Receptor 2 Blockade Prevents Asthma in a Cynomolgus Monkey Model. J. Pharmacol. Exp. Ther. 324: 769-775 [Abstract] [Full Text]
Meyer, E. H., Wurbel, M.-A., Staton, T. L., Pichavant, M., Kan, M. J., Savage, P. B., DeKruyff, R. H., Butcher, E. C., Campbell, J. J., Umetsu, D. T. (2007). iNKT Cells Require CCR4 to Localize to the Airways and to Induce Airway Hyperreactivity. J. Immunol. 179: 4661-4671 [Abstract] [Full Text]
Mori, A., Ogawa, K., Someya, K., Kunori, Y., Nagakubo, D., Yoshie, O., Kitamura, F., Hiroi, T., Kaminuma, O. (2007). Selective suppression of Th2-mediated airway eosinophil infiltration by low-molecular weight CCR3 antagonists. Int Immunol 19: 913-921 [Abstract] [Full Text]
Kurashima, Y., Kunisawa, J., Higuchi, M., Gohda, M., Ishikawa, I., Takayama, N., Shimizu, M., Kiyono, H. (2007). Sphingosine 1-Phosphate-Mediated Trafficking of Pathogenic Th2 and Mast Cells for the Control of Food Allergy. J. Immunol. 179: 1577-1585 [Abstract] [Full Text]
Beaty, S. R., Rose, C. E. Jr., Sung, S.-s. J. (2007). Diverse and Potent Chemokine Production by Lung CD11bhigh Dendritic Cells in Homeostasis and in Allergic Lung Inflammation. J. Immunol. 178: 1882-1895 [Abstract] [Full Text]
Hintzen, G., Ohl, L., del Rio, M.-L., Rodriguez-Barbosa, J.-I., Pabst, O., Kocks, J. R., Krege, J., Hardtke, S., Forster, R. (2006). Induction of Tolerance to Innocuous Inhaled Antigen Relies on a CCR7-Dependent Dendritic Cell-Mediated Antigen Transport to the Bronchial Lymph Node. J. Immunol. 177: 7346-7354 [Abstract] [Full Text]
Biedermann, T., Lametschwandtner, G., Tangemann, K., Kund, J., Hinteregger, S., Carballido-Perrig, N., Rot, A., Schwarzler, C., Carballido, J. M. (2006). IL-12 Instructs Skin Homing of Human Th2 Cells. J. Immunol. 177: 3763-3770 [Abstract] [Full Text]
Das, A. M., Vaddi, K. G., Solomon, K. A., Krauthauser, C., Jiang, X., McIntyre, K. W., Yang, X. X., Wadman, E., Welch, P., Covington, M., Graden, D., Yeleswaram, K., Trzaskos, J. M., Newton, R. C., Mandlekar, S., Ko, S. S., Carter, P. H., Davies, P. (2006). Selective Inhibition of Eosinophil Influx into the Lung by Small Molecule CC Chemokine Receptor 3 Antagonists in Mouse Models of Allergic Inflammation. J. Pharmacol. Exp. Ther. 318: 411-417 [Abstract] [Full Text]
Culley, F. J., Pennycook, A. M. J., Tregoning, J. S., Hussell, T., Openshaw, P. J. M. (2006). Differential Chemokine Expression following Respiratory Virus Infection Reflects Th1- or Th2-Biased Immunopathology. J. Virol. 80: 4521-4527 [Abstract] [Full Text]
Carpenter, K. J., Hogaboam, C. M. (2005). Immunosuppressive Effects of CCL17 on Pulmonary Antifungal Responses during Pulmonary Invasive Aspergillosis. Infect. Immun. 73: 7198-7207 [Abstract] [Full Text]
Xu, J., Park, P. W., Kheradmand, F., Corry, D. B. (2005). Endogenous Attenuation of Allergic Lung Inflammation by Syndecan-1. J. Immunol. 174: 5758-5765 [Abstract] [Full Text]
Matthews, S. P., Tregoning, J. S., Coyle, A. J., Hussell, T., Openshaw, P. J. M. (2005). Role of CCL11 in Eosinophilic Lung Disease during Respiratory Syncytial Virus Infection. J. Virol. 79: 2050-2057 [Abstract] [Full Text]
Barnes, P. J. (2004). Mediators of Chronic Obstructive Pulmonary Disease. Pharmacol. Rev. 56: 515-548 [Abstract] [Full Text]
Mullick, A., Elias, M., Picard, S., Bourget, L., Jovcevski, O., Gauthier, S., Tuite, A., Harakidas, P., Bihun, C., Massie, B., Gros, P. (2004). Dysregulated Inflammatory Response to Candida albicans in a C5-Deficient Mouse Strain. Infect. Immun. 72: 5868-5876 [Abstract] [Full Text]
Jakubzick, C., Wen, H., Matsukawa, A., Keller, M., Kunkel, S. L., Hogaboam, C. M. (2004). Role of CCR4 Ligands, CCL17 and CCL22, During Schistosoma mansoni Egg-Induced Pulmonary Granuloma Formation in Mice. Am. J. Pathol. 165: 1211-1221 [Abstract] [Full Text]
Cronshaw, D. G., Owen, C., Brown, Z., Ward, S. G. (2004). Activation of Phosphoinositide 3-Kinases by the CCR4 Ligand Macrophage-Derived Chemokine Is a Dispensable Signal for T Lymphocyte Chemotaxis. J. Immunol. 172: 7761-7770 [Abstract] [Full Text]
Pilette, C., Francis, J.N., Till, S.J., Durham, S.R. (2004). CCR4 ligands are up-regulated in the airways of atopic asthmatics after segmental allergen challenge. Eur Respir J 23: 876-884 [Abstract] [Full Text]
Liu, L., Jarjour, N. N., Busse, W. W., Kelly, E. A. B. (2004). Enhanced Generation of Helper T Type 1 and 2 Chemokines in Allergen-induced Asthma. Am. J. Respir. Crit. Care Med. 169: 1118-1124 [Abstract] [Full Text]
Angeli, V., Staumont, D., Charbonnier, A.-S., Hammad, H., Gosset, P., Pichavant, M., Lambrecht, B. N., Capron, M., Dombrowicz, D., Trottein, F. (2004). Activation of the D Prostanoid Receptor 1 Regulates Immune and Skin Allergic Responses. J. Immunol. 172: 3822-3829 [Abstract] [Full Text]
Dudda, J. C., Simon, J. C., Martin, S. (2004). Dendritic Cell Immunization Route Determines CD8+ T Cell Trafficking to Inflamed Skin: Role for Tissue Microenvironment and Dendritic Cells in Establishment of T Cell-Homing Subsets. J. Immunol. 172: 857-863 [Abstract] [Full Text]
Francis, J. N., Jacobson, M. R., Lloyd, C. M., Sabroe, I., Durham, S. R., Till, S. J. (2004). CXCR1+CD4+ T Cells in Human Allergic Disease. J. Immunol. 172: 268-273 [Abstract] [Full Text]
Conroy, D. M., Jopling, L. A., Lloyd, C. M., Hodge, M. R., Andrew, D. P., Williams, T. J., Pease, J. E., Sabroe, I. (2003). CCR4 blockade does not inhibit allergic airways inflammation. J. Leukoc. Biol. 74: 558-563 [Abstract] [Full Text]
Johansson-Lindbom, B., Ingvarsson, S., Borrebaeck, C. A. K. (2003). Germinal Centers Regulate Human Th2 Development. J. Immunol. 171: 1657-1666 [Abstract] [Full Text]
Lippert, E., Yowe, D. L., Gonzalo, J.-A., Justice, J. P., Webster, J. M., Fedyk, E. R., Hodge, M., Miller, C., Gutierrez-Ramos, J.-C., Borrego, F., Keane-Myers, A., Druey, K. M. (2003). Role of Regulator of G Protein Signaling 16 in Inflammation- Induced T Lymphocyte Migration and Activation. J. Immunol. 171: 1542-1555 [Abstract] [Full Text]
Vermaelen, K. Y., Cataldo, D., Tournoy, K., Maes, T., Dhulst, A., Louis, R., Foidart, J.-M., Noel, A., Pauwels, R. (2003). Matrix Metalloproteinase-9-Mediated Dendritic Cell Recruitment into the Airways Is a Critical Step in a Mouse Model of Asthma. J. Immunol. 171: 1016-1022 [Abstract] [Full Text]
Lukacs, N. W., Miller, A. L., Hogaboam, C. M. (2003). Chemokine Receptors in Asthma: Searching for the Correct Immune Targets. J. Immunol. 171: 11-15 [Full Text]
Mueller, C., August, A. (2003). Attenuation of Immunological Symptoms of Allergic Asthma in Mice Lacking the Tyrosine Kinase ITK. J. Immunol. 170: 5056-5063 [Abstract] [Full Text]
Bishop, B., Lloyd, C. M. (2003). CC Chemokine Ligand 1 Promotes Recruitment of Eosinophils But Not Th2 Cells During the Development of Allergic Airways Disease. J. Immunol. 170: 4810-4817 [Abstract] [Full Text]
Pinho, V., Oliveira, S. H., Souza, D. G., Vasconcelos, D., Alessandri, A. L., Lukacs, N. W., Teixeira, M. M. (2003). The role of CCL22 (MDC) for the recruitment of eosinophils during allergic pleurisy in mice. J. Leukoc. Biol. 73: 356-362 [Abstract] [Full Text]
Soler, D., Humphreys, T. L., Spinola, S. M., Campbell, J. J. (2003). CCR4 versus CCR10 in human cutaneous TH lymphocyte trafficking. Blood 101: 1677-1682 [Abstract] [Full Text]
Goya, I., Villares, R., Zaballos, A., Gutierrez, J., Kremer, L., Gonzalo, J.-A., Varona, R., Carramolino, L., Serrano, A., Pallares, P., Criado, L. M., Kolbeck, R., Torres, M., Coyle, A. J., Gutierrez-Ramos, J.-C., Martinez-A, C., Marquez, G. (2003). Absence of CCR8 Does Not Impair the Response to Ovalbumin-Induced Allergic Airway Disease. J. Immunol. 170: 2138-2146 [Abstract] [Full Text]
Stephens, R., Chaplin, D. D. (2002). IgE Cross-Linking or Lipopolysaccharide Treatment Induces Recruitment of Th2 Cells to the Lung in the Absence of Specific Antigen. J. Immunol. 169: 5468-5476 [Abstract] [Full Text]
El-Asrar, A M A., Struyf, S, Al-Kharashi, S A, Missotten, L, Van Damme, J, Geboes, K (2002). Expression of T lymphocyte chemoattractants and activation markers in vernal keratoconjunctivitis. Br J Ophthalmol 86: 1175-1180 [Abstract] [Full Text]
Olson, T. S., Ley, K. (2002). Chemokines and chemokine receptors in leukocyte trafficking. Am. J. Physiol. Regul. Integr. Comp. Physiol. 283: R7-R28 [Abstract] [Full Text]
Shang, X.-Z., Chiu, B.-C., Stolberg, V., Lukacs, N. W., Kunkel, S. L., Murphy, H. S., Chensue, S. W. (2002). Eosinophil Recruitment in Type-2 Hypersensitivity Pulmonary Granulomas : Source and Contribution of Monocyte Chemotactic Protein-3 (CCL7). Am. J. Pathol. 161: 257-266 [Abstract] [Full Text]
Schuh, J. M., Blease, K., Kunkel, S. L., Hogaboam, C. M. (2002). Eotaxin/CCL11 is involved in acute, but not chronic, allergic airway responses to Aspergillus fumigatus. Am. J. Physiol. Lung Cell. Mol. Physiol. 283: L198-L204 [Abstract] [Full Text]
Bryan, S. A., Jose, P. J., Topping, J. R., Wilhelm, R., Soderberg, C., Kertesz, D., Barnes, P. J., Williams, T. J., Hansel, T. T., Sabroe, I. (2002). Responses of Leukocytes to Chemokines in Whole Blood and Their Antagonism by Novel CC-Chemokine Receptor 3 Antagonists. Am. J. Respir. Crit. Care Med. 165: 1602-1609 [Abstract] [Full Text]
Gurish, M. F., Humbles, A., Tao, H., Finkelstein, S., Boyce, J. A., Gerard, C., Friend, D. S., Austen, K. F. (2002). CCR3 Is Required for Tissue Eosinophilia and Larval Cytotoxicity After Infection with Trichinella spiralis. J. Immunol. 168: 5730-5736 [Abstract] [Full Text]
Jopling, L. A., Sabroe, I., Andrew, D. P., Mitchell, T. J., Li, Y., Hodge, M. R., Williams, T. J., Pease, J. E. (2002). The Identification, Characterization, and Distribution of Guinea Pig CCR4 and Epitope Mapping of a Blocking Antibody. J. Biol. Chem. 277: 6864-6873 [Abstract] [Full Text]
Sabroe, I., Lloyd, C.M., Whyte, M.K.B., Dower, S.K., Williams, T.J., Pease, J.E. (2002). Chemokines, innate and adaptive immunity, and respiratory disease. Eur Respir J 19: 350-355 [Abstract] [Full Text]
Kunkel, E. J., Boisvert, J., Murphy, K., Vierra, M. A., Genovese, M. C., Wardlaw, A. J., Greenberg, H. B., Hodge, M. R., Wu, L., Butcher, E. C., Campbell, J. J. (2002). Expression of the Chemokine Receptors CCR4, CCR5, and CXCR3 by Human Tissue-Infiltrating Lymphocytes. Am. J. Pathol. 160: 347-355 [Abstract] [Full Text]
Hase, K., Tani, K., Shimizu, T., Ohmoto, Y., Matsushima, K., Sone, S. (2001). Increased CCR4 expression in active systemic lupus erythematosus. J. Leukoc. Biol. 70: 749-755 [Abstract] [Full Text]
Scotet, E., Schroeder, S., Lanzavecchia, A. (2001). Molecular regulation of CC-chemokine receptor 3 expression in human T helper 2 cells. Blood 98: 2568-2570 [Abstract] [Full Text]
D'AMBROSIO, D., MARIANI, M., PANINA-BORDIGNON, P., SINIGAGLIA, F. (2001). Chemokines and Their Receptors Guiding T Lymphocyte Recruitment in Lung Inflammation. Am. J. Respir. Crit. Care Med. 164: 1266-1275 [Full Text]
Tesciuba, A. G., Subudhi, S., Rother, R. P., Faas, S. J., Frantz, A. M., Elliot, D., Weinstock, J., Matis, L. A., Bluestone, J. A., Sperling, A. I. (2001). Inducible Costimulator Regulates Th2-Mediated Inflammation, but Not Th2 Differentiation, in a Model of Allergic Airway Disease. J. Immunol. 167: 1996-2003 [Abstract] [Full Text]
Mattes, J., Yang, M., Siqueira, A., Clark, K., MacKenzie, J., McKenzie, A. N. J., Webb, D. C., Matthaei, K. I., Foster, P. S. (2001). IL-13 Induces Airways Hyperreactivity Independently of the IL-4R{alpha} Chain in the Allergic Lung. J. Immunol. 167: 1683-1692 [Abstract] [Full Text]
Barnes, P.J. (2001). Cytokine modulators as novel therapies for airway disease. Eur Respir J 18: 67S-77s [Abstract] [Full Text]
ZHU, J., QIU, Y. S., MAJUMDAR, S., GAMBLE, E., MATIN, D., TURATO, G., FABBRI, L. M., BARNES, N., SAETTA, M., JEFFERY, P. K. (2001). Exacerbations of Bronchitis . Bronchial Eosinophilia and Gene Expression for Interleukin-4, Interleukin-5, and Eosinophil Chemoattractants. Am. J. Respir. Crit. Care Med. 164: 109-116 [Abstract] [Full Text]
Mathew, A., MacLean, J. A., DeHaan, E., Tager, A. M., Green, F. H.Y., Luster, A. D. (2001). Signal Transducer and Activator of Transcription 6 Controls Chemokine Production and T Helper Cell Type 2 Cell Trafficking in Allergic Pulmonary Inflammation. JEM 193: 1087-1096 [Abstract] [Full Text]
Qiu, B., Frait, K. A., Reich, F., Komuniecki, E., Chensue, S. W. (2001). Chemokine Expression Dynamics in Mycobacterial (Type-1) and Schistosomal (Type-2) Antigen-Elicited Pulmonary Granuloma Formation. Am. J. Pathol. 158: 1503-1515 [Abstract] [Full Text]
Chensue, S. W., Lukacs, N. W., Yang, T.-Y., Shang, X., Frait, K. A., Kunkel, S. L., Kung, T., Wiekowski, M. T., Hedrick, J. A., Cook, D. N., Zingoni, A., Narula, S. K., Zlotnik, A., Barrat, F. J., O'Garra, A., Napolitano, M., Lira, S. A. (2001). Aberrant in Vivo T Helper Type 2 Cell Response and Impaired Eosinophil Recruitment in Cc Chemokine Receptor 8 Knockout Mice. JEM 193: 573-584 [Abstract] [Full Text]
Till, S. J., Jopling, L. A., Wachholz, P. A., Robson, R. L., Qin, S., Andrew, D. P., Wu, L., van Neerven, J., Williams, T. J., Durham, S. R., Sabroe, I. (2001). T Cell Phenotypes of the Normal Nasal Mucosa: Induction of Th2 Cytokines and CCR3 Expression by IL-4. J. Immunol. 166: 2303-2310 [Abstract] [Full Text]
Wiley, R. E., Palmer, K., Gajewska, B. U., Stampfli, M. R., Alvarez, D., Coyle, A. J., Gutierrez-Ramos, J.-C., Jordana, M. (2001). Expression of the Th1 Chemokine IFN-{{gamma}}-Inducible Protein 10 in the Airway Alters Mucosal Allergic Sensitization in Mice. J. Immunol. 166: 2750-2759 [Abstract] [Full Text]
Kuroda, E., Sugiura, T., Okada, K., Zeki, K., Yamashita, U. (2001). Prostaglandin E2 Up-Regulates Macrophage-Derived Chemokine Production but Suppresses IFN-Inducible Protein-10 Production by APC. J. Immunol. 166: 1650-1658 [Abstract] [Full Text]
Sung, S.-s. J., Rose, C. E. Jr., Fu, S. M. (2001). Intratracheal Priming with Ovalbumin- and Ovalbumin 323-339 Peptide-Pulsed Dendritic Cells Induces Airway Hyperresponsiveness, Lung Eosinophilia, Goblet Cell Hyperplasia, and Inflammation. J. Immunol. 166: 1261-1271 [Abstract] [Full Text]
SINIGAGLIA, F., D'AMBROSIO, D. (2000). Regulation of Helper T Cell Differentiation and Recruitment in Airway Inflammation. Am. J. Respir. Crit. Care Med. 162: S157-160 [Abstract] [Full Text]
COYLE, A. J., LLOYD, C. M., GUTIERREZ-RAMOS, J.-C. (2000). Biotherapeutic Targets for the Treatment of Allergic Airway Disease. Am. J. Respir. Crit. Care Med. 162: S179-184 [Abstract] [Full Text]
Zimmermann, N., Daugherty, B. L., Kavanaugh, J. L., El-Awar, F. Y., Moulton, E. A., Rothenberg, M. E. (2000). Analysis of the CC chemokine receptor 3 gene reveals a complex 5' exon organization, a functional role for untranslated exon 1, and a broadly active promoter with eosinophil-selective elements. Blood 96: 2346-2354 [Abstract] [Full Text]
Mantovani, A., Gray, P. A., Van Damme, J., Sozzani, S. (2000). Macrophage-derived chemokine (MDC). J. Leukoc. Biol. 68: 400-404 [Abstract] [Full Text]
Sekiya, T., Miyamasu, M., Imanishi, M., Yamada, H., Nakajima, T., Yamaguchi, M., Fujisawa, T., Pawankar, R., Sano, Y., Ohta, K., Ishii, A., Morita, Y., Yamamoto, K., Matsushima, K., Yoshie, O., Hirai, K. (2000). Inducible Expression of a Th2-Type CC Chemokine Thymus- and Activation-Regulated Chemokine by Human Bronchial Epithelial Cells. J. Immunol. 165: 2205-2213 [Abstract] [Full Text]
Zhang, S., Lukacs, N. W., Lawless, V. A., Kunkel, S. L., Kaplan, M. H. (2000). Cutting Edge: Differential Expression of Chemokines in Th1 and Th2 Cells Is Dependent on Stat6 But Not Stat4. J. Immunol. 165: 10-14 [Abstract] [Full Text]