The Reduced Expression of 6ckine in the plt Mouse Results from the Deletion of One of Two 6ckine Genes

doi:10.1084/jem.190.8.1183

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© The Rockefeller University Press, 0022-1007/1999/10/1183/ $5.00
The Journal of Experimental Medicine, Volume 190, Number 8, October 18, 1999 1183-1188

Brief Definitive Report

The Reduced Expression of 6ckine in the plt Mouse Results from the Deletion of One of Two 6ckine Genes

Galya Vassileva^a, Hortensia Soto^c, Albert Zlotnik^c, Hideki Nakano^d, Terutaka Kakiuchi^d, Joseph A. Hedrick^b, and Sergio A. Lira^a

^a Department of Immunology, Schering-Plough Research Institute, Kenilworth, New Jersey 07033
^b Human Genome Research, Schering-Plough Research Institute, Kenilworth, New Jersey 07033
^c DNAX Research Institute for Cellular and Molecular Biology, Palo Alto, California 94304
^d Department of Immunology, Toho University School of Medicine, Tokyo 143-8540, Japan
Dept. of Immunology, Schering-Plough Research Institute, 2015 Galloping Hill Rd., Kenilworth, NJ 07033.908-740-3084908-740-3088

sergio.lira{at}spcorp.com

6Ckine is an unusual chemokine capable of attracting naive Tlymphocytes in vitro. It has been recently reported that lackof 6Ckine expression in lymphoid organs is a prominent characteristicof mice homozygous for the paucity of lymph node T cell (plt)mutation. These mice show reduced numbers of T cells in lymphnodes, Peyer's patches, and the white pulp of the spleen. Thegenetic reason for the lack of 6Ckine expression in the pltmouse, however, has remained unknown. Here we demonstrate thatmouse 6Ckine is encoded by two genes, one of which is expressedin lymphoid organs and is deleted in plt mice. A second 6Ckinegene is intact and expressed in the plt mouse.

Key Words: chemokines • cell trafficking • leukocyte chemotaxis • T lymphocytes • mutation

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