Crucial Role of the Interleukin 1 Receptor Family Member T1/ST2 in T Helper Cell Type 2–mediated Lung Mucosal Immune Responses

doi:10.1084/jem.190.7.895

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© The Rockefeller University Press, 0022-1007/1999/10/895/ $5.00
The Journal of Experimental Medicine, Volume 190, Number 7, October 4, 1999 895-902

Crucial Role of the Interleukin 1 Receptor Family Member T1/ST2 in T Helper Cell Type 2–mediated Lung Mucosal Immune Responses

Anthony J. Coyle^a, Clare Lloyd^a, Jane Tian^a, Trang Nguyen^a, Christina Erikkson^b, Lin Wang^a, Par Ottoson^b, Per Persson^b, Tracy Delaney^a, Sophie Lehar^a, Steve Lin^a, Louis Poisson^a, Christian Meisel^c,d, Thomas Kamradt^c,d, Torbjorn Bjerke^b, Douglas Levinson^a, and Jose Carlos Gutierrez-Ramos^a
^a Department of Biology, Inflammation Division, Millennium Pharmaceuticals, Inc., Cambridge, Massachusetts 02139
^b Astra Draco, Inflammation Pharmacology, Preclinical Research and Development, S-221 00 Lund, Sweden
^c Deutsches Rheumaforschungs Zentrum, Berlin D-10117, Germany
^d Universitätsklinikum Charite, Rheumatologie und Klinische Immunologie, D-10098 Berlin, Germany

Correspondence to: Anthony J. Coyle, Inflammation Division, Millennium Pharmaceuticals, Inc., 75 Sidney St., Cambridge, MA 02139. Tel:617-679-7347 Fax:617-551-8910 E-mail:coyle{at}mpi.com.

T1/ST2 is an orphan receptor of unknown function that is expressedon the surface of murine T helper cell type 2 (Th2), but notTh1 effector cells. In vitro blockade of T1/ST2 signaling withan immunoglobulin (Ig) fusion protein suppresses both differentiationto and activation of Th2, but not Th1 effector populations.In a nascent Th2-dominated response, anti-T1/ST2 monoclonalantibody (mAb) inhibited eosinophil infiltration, interleukin5 secretion, and IgE production. To determine if these effectswere mediated by a direct effect on Th2 cells, we next useda murine adoptive transfer model of Th1- and Th2-mediated lungmucosal immune responses. Administration of either T1/ST2 mAbor T1/ST2-Ig abrogated Th2 cytokine production in vivo and theinduction of an eosinophilic inflammatory response, but failedto modify Th1-mediated inflammation. Taken together, our datademonstrate an important role of T1/ST2 in Th2-mediated inflammatoryresponses and suggest that T1/ST2 may prove to be a novel targetfor the selective suppression of Th2 immune responses.

Key Words: inflammation, eosinophil, asthma, cytokines, immunoglobulinsuperfamily

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