Development of CD8/ and CD8/ß T Cells in Major Histocompatibility Complex Class I–deficient Mice

Correspondence to: Charles A. Janeway, Jr., LH-416, Howard Hughes Medical Institute and Yale University School of Medicine, 310 Cedar St., New Haven, CT 06510. Tel:203-785-2793 Fax:203-737-1765 E-mail:charles.janeway{at}yale.edu.

Peripheral CD8⁺ T cells mainly use CD8/ß, and their development is mainly dependent on the major histocompatibility complex (MHC) class I proteins K^b and D^b in H-2^b mice. In this report, we have shown that the development of CD8/ß TCR-/ß cells in lymphoid organs as well as in intestinal intraepithelial lymphocytes (iIELs) is dependent on the MHC class I K^b and D^b proteins. In contrast, TCR-/ß CD8/ cells are found mainly in iIELs, and their numbers are unaffected in K^bD^b double knockout mice. Most of the TCR-/ cells in the iIELs also bear CD8/, and they are also unaffected in K^bD^b -/- mice. In ß2-microglobulin (ß2m)-deficient mice, all of the TCR-/ß CD8/ and CD8/ß T cells disappear, but TCR-/ cells are unaffected by the absence of ß2m.

Key Words: CD8/ T cells, CD8/ß T cells, major histocompatibility complex class I, K^bD^b-deficient mice, ß2m-deficient mice

CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this?

This article has been cited by other articles:

• Smith, T. R. F., Tang, X., Maricic, I., Garcia, Z., Fanchiang, S., Kumar, V. (2009). Dendritic Cells Use Endocytic Pathway for Cross-Priming Class Ib MHC-Restricted CD8{alpha}{alpha}+TCR{alpha}{beta}+ T Cells with Regulatory Properties. J. Immunol. 182: 6959-6968 [Abstract] [Full Text]  
• Denning, T. L., Granger, S., Mucida, D., Graddy, R., Leclercq, G., Zhang, W., Honey, K., Rasmussen, J. P., Cheroutre, H., Rudensky, A. Y., Kronenberg, M. (2007). Mouse TCR{alpha}beta+CD8{alpha}{alpha} Intraepithelial Lymphocytes Express Genes That Down-Regulate Their Antigen Reactivity and Suppress Immune Responses. J. Immunol. 178: 4230-4239 [Abstract] [Full Text]  
• Zhou, R., Wei, H., Sun, R., Tian, Z. (2007). Recognition of Double-Stranded RNA by TLR3 Induces Severe Small Intestinal Injury in Mice. J. Immunol. 178: 4548-4556 [Abstract] [Full Text]  
• Locke, N. R., Stankovic, S., Funda, D. P., Harrison, L. C. (2006). TCR{gamma}{delta} Intraepithelial Lymphocytes Are Required for Self-Tolerance.. J. Immunol. 176: 6553-6559 [Abstract] [Full Text]  
• Davies, A., Lopez-Briones, S., Ong, H., O'Neil-Marshall, C., Lemonnier, F. A., Nagaraju, K., Metcalf, E. S., Soloski, M. J. (2004). Infection-Induced Expansion of a MHC Class Ib-Dependent Intestinal Intraepithelial {gamma}{delta} T Cell Subset. J. Immunol. 172: 6828-6837 [Abstract] [Full Text]  
• Guy-Grand, D., Azogui, O., Celli, S., Darche, S., Nussenzweig, M. C., Kourilsky, P., Vassalli, P. (2003). Extrathymic T Cell Lymphopoiesis: Ontogeny and Contribution to Gut Intraepithelial Lymphocytes in Athymic and Euthymic Mice. JEM 197: 333-341 [Abstract] [Full Text]  
• Podd, B. S., Aberg, C., Kudla, K. L., Keene, L., Tobias, E., Camerini, V. (2001). MHC Class I Allele Dosage Alters CD8 Expression by Intestinal Intraepithelial Lymphocytes. J. Immunol. 167: 2561-2568 [Abstract] [Full Text]  
• Maurice, M. M., Gould, D. S., Carroll, J., Vugmeyster, Y., Ploegh, H. L. (2001). Positive selection of an MHC class-I restricted TCR in the absence of classical MHC class I molecules. Proc. Natl. Acad. Sci. USA 10.1073/pnas.141143298v1 [Abstract] [Full Text]  
• Das, G., Gould, D. S., Augustine, M. M., Fragoso, G., Sciutto, E., Stroynowski, I., Van Kaer, L., Schust, D. J., Ploegh, H., Janeway, C. A. Jr. (2000). Qa-2-dependent Selection of CD8{alpha}/{alpha} T Cell Receptor {alpha}/{beta}+ Cells in Murine Intestinal Intraepithelial Lymphocytes. JEM 192: 1521-1528 [Abstract] [Full Text]  
• Wilson, A., Ferrero, I., MacDonald, H. R., Radtke, F. (2000). Cutting Edge: An Essential Role for Notch-1 in the Development of Both Thymus-Independent and -Dependent T Cells in the Gut. J. Immunol. 165: 5397-5400 [Abstract] [Full Text]  
• Soloski, M. J., Szperka, M. E., Davies, A., Wooden, S. L. (2000). Host Immune Response to Intracellular Bacteria: A Role for MHC-Linked Class-Ib Antigen-Presenting Molecules. Exp. Biol. Med. 224: 231-239 [Abstract] [Full Text]  
• Shinkai, K., Locksley, R. M. (2000). CD1, Tuberculosis, and the Evolution of Major Histocompatibility Complex Molecules. JEM 191: 907-914 [Full Text]  
• Maurice, M. M., Gould, D. S., Carroll, J., Vugmeyster, Y., Ploegh, H. L. (2001). Positive selection of an MHC class-I restricted TCR in the absence of classical MHC class I molecules. Proc. Natl. Acad. Sci. USA 98: 7437-7442 [Abstract] [Full Text]  

Home | Help | Feedback | Subscriptions | Archive | Search

TABLE OF CONTENTS