Development of Cd8{alpha}/{alpha} and Cd8{alpha}/{beta} T Cells in Major Histocompatibility Complex Class I-Deficient Mice

doi:10.1084/jem.190.6.881

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© The Rockefeller University Press, 0022-1007/1999/9/881/ $5.00
The Journal of Experimental Medicine, Volume 190, Number 6, September 20, 1999 881-884

Brief Definitive Report

Development of Cd8 ${alpha}$ / ${alpha}$ and Cd8 ${alpha}$ /β T Cells in Major Histocompatibility Complex Class I–Deficient Mice

Gobardhan Das^a and Charles A. Janeway, Jr.^a

^a Howard Hughes Medical Institute and Yale University Medical School, New Haven, Connecticut 06510
LH-416, Howard Hughes Medical Institute and Yale University School of Medicine, 310 Cedar St., New Haven, CT 06510.203-737-1765203-785-2793

charles.janeway{at}yale.edu

Peripheral CD8⁺ T cells mainly use CD8 ${alpha}$ /β, and their developmentis mainly dependent on the major histocompatibility complex(MHC) class I proteins K^b and D^b in H-2^b mice. In this report,we have shown that the development of CD8 ${alpha}$ /β TCR- ${alpha}$ /βcells in lymphoid organs as well as in intestinal intraepitheliallymphocytes (iIELs) is dependent on the MHC class I K^b and D^bproteins. In contrast, TCR- ${alpha}$ /β CD8 ${alpha}$ / ${alpha}$ cells are found mainlyin iIELs, and their numbers are unaffected in K^bD^b double knockoutmice. Most of the TCR- ${gamma}$ / ${delta}$ cells in the iIELs also bear CD8 ${alpha}$ / ${alpha}$ , andthey are also unaffected in K^bD^b –/– mice. In β2-microglobulin(β2m)-deficient mice, all of the TCR- ${alpha}$ /β CD8 ${alpha}$ / ${alpha}$ and CD8 ${alpha}$ /βT cells disappear, but TCR- ${gamma}$ / ${delta}$ cells are unaffected by the absenceof β2m.

Key Words: CD8 ${alpha}$ / ${alpha}$ T cells • CD8 ${alpha}$ /β T cells • major histocompatibility complex class I • K^bD^b-deficient mice • β2m-deficient mice

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