The Journal of Experimental Medicine
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© The Rockefeller University Press, 0022-1007/1999/9/881/ $5.00
The Journal of Experimental Medicine, Volume 190, Number 6, September 20, 1999 881-884

Brief Definitive Report

Development of Cd8{alpha}/{alpha} and Cd8{alpha}/β T Cells in Major Histocompatibility Complex Class I–Deficient Mice

Gobardhan Dasa and Charles A. Janeway, Jr.a

a Howard Hughes Medical Institute and Yale University Medical School, New Haven, Connecticut 06510
LH-416, Howard Hughes Medical Institute and Yale University School of Medicine, 310 Cedar St., New Haven, CT 06510.203-737-1765203-785-2793

charles.janeway{at}yale.edu

Peripheral CD8+ T cells mainly use CD8{alpha}/β, and their development is mainly dependent on the major histocompatibility complex (MHC) class I proteins Kb and Db in H-2b mice. In this report, we have shown that the development of CD8{alpha}/β TCR-{alpha}/β cells in lymphoid organs as well as in intestinal intraepithelial lymphocytes (iIELs) is dependent on the MHC class I Kb and Db proteins. In contrast, TCR-{alpha}/β CD8{alpha}/{alpha} cells are found mainly in iIELs, and their numbers are unaffected in KbDb double knockout mice. Most of the TCR-{gamma}/{delta} cells in the iIELs also bear CD8{alpha}/{alpha}, and they are also unaffected in KbDb –/– mice. In β2-microglobulin (β2m)-deficient mice, all of the TCR-{alpha}/β CD8{alpha}/{alpha} and CD8{alpha}/β T cells disappear, but TCR-{gamma}/{delta} cells are unaffected by the absence of β2m.

Key Words: CD8{alpha}/{alpha} T cells • CD8{alpha}/β T cells • major histocompatibility complex class I • KbDb-deficient mice • β2m-deficient mice

© 1999 The Rockefeller University Press


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