|
||
Brief Definitive Report |
/
and Cd8
/β T Cells in Major Histocompatibility Complex Class I–Deficient Mice
charles.janeway{at}yale.edu
Peripheral CD8+ T cells mainly use CD8
/β, and their development is mainly dependent on the major histocompatibility complex (MHC) class I proteins Kb and Db in H-2b mice. In this report, we have shown that the development of CD8
/β TCR-
/β cells in lymphoid organs as well as in intestinal intraepithelial lymphocytes (iIELs) is dependent on the MHC class I Kb and Db proteins. In contrast, TCR-
/β CD8
/
cells are found mainly in iIELs, and their numbers are unaffected in KbDb double knockout mice. Most of the TCR-
/
cells in the iIELs also bear CD8
/
, and they are also unaffected in KbDb –/– mice. In β2-microglobulin (β2m)-deficient mice, all of the TCR-
/β CD8
/
and CD8
/β T cells disappear, but TCR-
/
cells are unaffected by the absence of β2m.
Key Words: CD8
/
T cells CD8
/β T cells major histocompatibility complex class I KbDb-deficient mice β2m-deficient mice
![]()
CiteULike
Complore
Connotea
Del.icio.us
Digg
Facebook
Reddit
Technorati
Twitter What's this?
| TABLE OF CONTENTS |
|