Distinct Role of Antigen-specific T Helper Type 1 (Th1) and Th2 Cells in Tumor Eradication In Vivo

Correspondence to: Takashi Nishimura, Section of Bacterial Infection, Institute of Immunological Science, Hokkaido University, Sapporo 060-0815, Japan. Tel:81-11-706-5521 Fax:81-11-707-6835

The role of T helper type 1 (Th1) and Th2 cells in tumor immunity was investigated using Th cells induced from ovalbumin (OVA)-specific T cell receptor transgenic mice. Although Th1 cells exhibited stronger cytotoxicity than Th2 cells, both cell types completely eradicated tumors when transferred into mice bearing A20 tumor cells transfected with the OVA gene (A20-OVA). Th1 cells eradicated the tumor mass by inducing cellular immunity, whereas Th2 cells destroyed the tumor by inducing tumor necrosis. Both Th1 and Th2 cells required CD8⁺ T cells to eliminate tumors, and neither of these cells were able to completely eliminate A20-OVA tumors from T and B cell–deficient RAG2^-/- mice. Mice cured from tumors by Th1 and Th2 cell therapy rejected A20-OVA upon rechallenge, but CD8⁺ cytotoxic T lymphocytes were induced only from spleen cells prepared from cured mice by Th1 cell therapy. Moreover, we demonstrated that Th1 and Th2 cells used distinct adhesion mechanisms during tumor eradication: the leukocyte function-associated antigen (LFA)-1–dependent cell–cell adhesion step was essential for Th1 cell therapy, but not for Th2 cell therapy. These findings demonstrated for the first time the distinct role of antigen-specific Th1 and Th2 cells during eradication of established tumors in vivo.

Key Words: Th1, Th2, tumor, adoptive immunotherapy, cytokine

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• Tatsumi, T., Kierstead, L. S., Ranieri, E., Gesualdo, L., Schena, F. P., Finke, J. H., Bukowski, R. M., Mueller-Berghaus, J., Kirkwood, J. M., Kwok, W. W., Storkus, W. J. (2002). Disease-associated Bias in T Helper Type 1 (Th1)/Th2 CD4+ T Cell Responses Against MAGE-6 in HLA-DRB10401+ Patients With Renal Cell Carcinoma or Melanoma. JEM 196: 619-628 [Abstract] [Full Text]  
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• Liu, J., Anderson, B. E., Robert, M. E., McNiff, J. M., Emerson, S. G., Shlomchik, W. D., Shlomchik, M. J. (2001). Selective T-cell subset ablation demonstrates a role for T1 and T2 cells in ongoing acute graft-versus-host disease: a model system for the reversal of disease. Blood 98: 3367-3375 [Abstract] [Full Text]  
• Faries, M. B., Bedrosian, I., Xu, S., Koski, G., Roros, J. G., Moise, M. A., Nguyen, H. Q., Engels, F. H. C., Cohen, P. A., Czerniecki, B. J. (2001). Calcium signaling inhibits interleukin-12 production and activates CD83+ dendritic cells that induce Th2 cell development. Blood 98: 2489-2497 [Abstract] [Full Text]  
• Tanigawa, K., Takeshita, N., Craig, R. A., Phillips, K., Knibbs, R. N., Chang, A. E., Stoolman, L. M. (2001). Tumor-Specific Responses in Lymph Nodes Draining Murine Sarcomas Are Concentrated in Cells Expressing P-Selectin Binding Sites. J. Immunol. 167: 3089-3098 [Abstract] [Full Text]  
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• Grohmann, U., Bianchi, R., Belladonna, M. L., Silla, S., Fallarino, F., Fioretti, M. C., Puccetti, P. (2000). IFN-{gamma} Inhibits Presentation of a Tumor/Self Peptide by CD8{alpha}- Dendritic Cells Via Potentiation of the CD8{alpha}+ Subset. J. Immunol. 165: 1357-1363 [Abstract] [Full Text]  
• Ohta, A., Sekimoto, M., Sato, M., Koda, T., Nishimura, S.-i., Iwakura, Y., Sekikawa, K., Nishimura, T. (2000). Indispensable Role for TNF-{alpha} and IFN-{gamma} at the Effector Phase of Liver Injury Mediated by Th1 Cells Specific to Hepatitis B Virus Surface Antigen. J. Immunol. 165: 956-961 [Abstract] [Full Text]  
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