Freshly Isolated Peyer's Patch, But Not Spleen, Dendritic Cells Produce Interleukin 10 and Induce the Differentiation of T Helper Type 2 Cells

Correspondence to: Brian Lee Kelsall, Mucosal Immunity Section, Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892-1890., bkelsall{at}nih.gov (E-mail), 301-496-7473 (phone), 301-402-2240 (fax)

Orally administered antigens often generate immune responses that are distinct from those injected systemically. The role of antigen-presenting cells in determining the type of T helper cell response induced at mucosal versus systemic sites is unclear. Here we examine the phenotypic and functional differences between dendritic cells (DCs) freshly isolated from Peyer's patches (PP) and spleen (SP). Surface phenotypic analysis of CD11c⁺ DC populations revealed that PP DCs expressed higher levels of major histocompatibility complex class II molecules, but similar levels of costimulatory molecules and adhesion molecules compared with SP DCs. Freshly isolated, flow cytometrically sorted 98–100% pure CD11c⁺ DC populations from PP and SP were compared for their ability to stimulate naive T cells. First, PP DCs were found to be much more potent in stimulating allogeneic T cell proliferation compared with SP DCs. Second, by using naive T cells from ovalbumin peptide–specific T cell receptor transgenic mice, these ex vivo DCs derived from PP, but not from SP, were found to prime for the production of interleukin (IL)-4 and IL-10 (Th2 cytokines). In addition, PP DCs were found to prime T cells for the production of much lower levels of interferon (IFN)- (Th1) compared with SP DCs. The presence of neutralizing antibody against IL-10 in the priming culture dramatically enhanced IFN- production by T cells stimulated with PP DCs. Furthermore, stimulation of freshly isolated PP DCs via the CD40 molecule resulted in secretion of high levels of IL-10, whereas the same stimulus induced no IL-10 secretion from SP DCs. These results suggest that DCs residing in different tissues are capable of inducing distinct immune responses and that this may be related to the distinct cytokines produced by the DCs from these tissues.

Key Words: antigen presentation, cytokine, mucosal immunity

CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this?

This article has been cited by other articles:

• Bamboat, Z. M., Stableford, J. A., Plitas, G., Burt, B. M., Nguyen, H. M., Welles, A. P., Gonen, M., Young, J. W., DeMatteo, R. P. (2009). Human Liver Dendritic Cells Promote T Cell Hyporesponsiveness. J. Immunol. 182: 1901-1911 [Abstract] [Full Text]  
• Cerovic, V., Jenkins, C. D., Barnes, A. G. C., Milling, S. W. F., MacPherson, G. G., Klavinskis, L. S. (2009). Hyporesponsiveness of Intestinal Dendritic Cells to TLR Stimulation Is Limited to TLR4. J. Immunol. 182: 2405-2415 [Abstract] [Full Text]  
• Salim, S. Y., Silva, M. A., Keita, A. V., Larsson, M., Andersson, P., Magnusson, K.-E., Perdue, M. H., Soderholm, J. D. (2009). CD83+CCR7- Dendritic Cells Accumulate in the Subepithelial Dome and Internalize Translocated Escherichia coli HB101 in the Peyer's Patches of Ileal Crohn's Disease. Am. J. Pathol. 174: 82-90 [Abstract] [Full Text]  
• Ahrendt, M., Hammerschmidt, S. I., Pabst, O., Pabst, R., Bode, U. (2008). Stromal Cells Confer Lymph Node-Specific Properties by Shaping a Unique Microenvironment Influencing Local Immune Responses. J. Immunol. 181: 1898-1907 [Abstract] [Full Text]  
• Elgueta, R., Sepulveda, F. E., Vilches, F., Vargas, L., Mora, J. R., Bono, M. R., Rosemblatt, M. (2008). Imprinting of CCR9 on CD4 T Cells Requires IL-4 Signaling on Mesenteric Lymph Node Dendritic Cells. J. Immunol. 180: 6501-6507 [Abstract] [Full Text]  
• Flores-Mendoza, L., Silva-Campa, E., Resendiz, M., Osorio, F. A., Hernandez, J. (2008). Porcine Reproductive and Respiratory Syndrome Virus Infects Mature Porcine Dendritic Cells and Up-Regulates Interleukin-10 Production. CVI 15: 720-725 [Abstract] [Full Text]  
• Blazquez, A. B., Berin, M. C. (2008). Gastrointestinal Dendritic Cells Promote Th2 Skewing via OX40L. J. Immunol. 180: 4441-4450 [Abstract] [Full Text]  
• Hussain, S., Delovitch, T. L. (2007). Intravenous Transfusion of BCR-Activated B Cells Protects NOD Mice from Type 1 Diabetes in an IL-10-Dependent Manner. J. Immunol. 179: 7225-7232 [Abstract] [Full Text]  
• Kadaoui, K. A., Corthesy, B. (2007). Secretory IgA Mediates Bacterial Translocation to Dendritic Cells in Mouse Peyer's Patches with Restriction to Mucosal Compartment. J. Immunol. 179: 7751-7757 [Abstract] [Full Text]  
• Iliev, I. D., Matteoli, G., Rescigno, M. (2007). The yin and yang of intestinal epithelial cells in controlling dendritic cell function. JEM 204: 2253-2257 [Abstract] [Full Text]  
• Contractor, N., Louten, J., Kim, L., Biron, C. A., Kelsall, B. L. (2007). Cutting Edge: Peyer's Patch Plasmacytoid Dendritic Cells (pDCs) Produce Low Levels of Type I Interferons: Possible Role for IL-10, TGFbeta, and Prostaglandin E2 in Conditioning a Unique Mucosal pDC Phenotype. J. Immunol. 179: 2690-2694 [Abstract] [Full Text]  
• Moretto, M. M., Weiss, L. M., Combe, C. L., Khan, I. A. (2007). IFN-{gamma}-Producing Dendritic Cells Are Important for Priming of Gut Intraepithelial Lymphocyte Response Against Intracellular Parasitic Infection. J. Immunol. 179: 2485-2492 [Abstract] [Full Text]  
• Shen, L., Barabino, S., Taylor, A. W., Dana, M. R. (2007). Effect of the Ocular Microenvironment in Regulating Corneal Dendritic Cell Maturation. Arch Ophthalmol 125: 908-915 [Abstract] [Full Text]  
• Lamb, R. J., Capocasale, R. J., Duffy, K. E., Sarisky, R. T., Mbow, M. L. (2007). Identification and Characterization of Novel Bone Marrow Myeloid DEC205+Gr-1+ Cell Subsets That Differentially Express Chemokine and TLRs. J. Immunol. 178: 7833-7839 [Abstract] [Full Text]  
• Takenaka, S., Safroneeva, E., Xing, Z., Gauldie, J. (2007). Dendritic Cells Derived from Murine Colonic Mucosa Have Unique Functional and Phenotypic Characteristics. J. Immunol. 178: 7984-7993 [Abstract] [Full Text]  
• Corthesy, B., Gaskins, H. R., Mercenier, A. (2007). Cross-Talk between Probiotic Bacteria and the Host Immune System. J. Nutr. 137: 781S-790S [Abstract] [Full Text]  
• Zarnani, A.-H., Moazzeni, S.-M., Shokri, F., Salehnia, M., Jeddi-Tehrani, M. (2007). Kinetics of murine decidual dendritic cells. Reproduction 133: 275-283 [Abstract] [Full Text]  
• Corthesy, B. (2007). Roundtrip Ticket for Secretory IgA: Role in Mucosal Homeostasis?. J. Immunol. 178: 27-32 [Abstract] [Full Text]  
• Chieppa, M., Rescigno, M., Huang, A. Y.C., Germain, R. N. (2006). Dynamic imaging of dendritic cell extension into the small bowel lumen in response to epithelial cell TLR engagement. JEM 203: 2841-2852 [Abstract] [Full Text]  
• Qualls, J. E., Kaplan, A. M., van Rooijen, N., Cohen, D. A. (2006). Suppression of experimental colitis by intestinal mononuclear phagocytes. J. Leukoc. Biol. 80: 802-815 [Abstract] [Full Text]  
• Alaniz, R. C., Cummings, L. A., Bergman, M. A., Rassoulian-Barrett, S. L., Cookson, B. T. (2006). Salmonella typhimurium Coordinately Regulates FliC Location and Reduces Dendritic Cell Activation and Antigen Presentation to CD4+ T cells. J. Immunol. 177: 3983-3993 [Abstract] [Full Text]  
• Han, X., Wang, S., Fan, Y., Yang, J., Jiao, L., Qiu, H., Yang, X. (2006). Chlamydia Infection Induces ICOS Ligand-Expressing and IL-10-Producing Dendritic Cells That Can Inhibit Airway Inflammation and Mucus Overproduction Elicited by Allergen Challenge in BALB/c Mice. J. Immunol. 176: 5232-5239 [Abstract] [Full Text]  
• O'Mahony, L., O'Callaghan, L., McCarthy, J., Shilling, D., Scully, P., Sibartie, S., Kavanagh, E., Kirwan, W. O., Redmond, H. P., Collins, J. K., Shanahan, F. (2006). Differential cytokine response from dendritic cells to commensal and pathogenic bacteria in different lymphoid compartments in humans. Am. J. Physiol. Gastrointest. Liver Physiol. 290: G839-G845 [Abstract] [Full Text]  
• Galdeano, C. M., Perdigon, G. (2006). The Probiotic Bacterium Lactobacillus casei Induces Activation of the Gut Mucosal Immune System through Innate Immunity. CVI 13: 219-226 [Abstract] [Full Text]  
• Weiss, D. J., Evanson, O. A., Souza, C. D. (2006). Mucosal Immune Response in Cattle with Subclinical Johne's Disease.. Vet Pathol 43: 127-135 [Abstract] [Full Text]  
• Jang, M. H., Sougawa, N., Tanaka, T., Hirata, T., Hiroi, T., Tohya, K., Guo, Z., Umemoto, E., Ebisuno, Y., Yang, B.-G., Seoh, J.-Y., Lipp, M., Kiyono, H., Miyasaka, M. (2006). CCR7 Is Critically Important for Migration of Dendritic Cells in Intestinal Lamina Propria to Mesenteric Lymph Nodes. J. Immunol. 176: 803-810 [Abstract] [Full Text]  
• Chen, C.-C., Louie, S., McCormick, B. A., Walker, W. A., Shi, H. N. (2006). Helminth-Primed Dendritic Cells Alter the Host Response to Enteric Bacterial Infection. J. Immunol. 176: 472-483 [Abstract] [Full Text]  
• Narvaez, C. F., Angel, J., Franco, M. A. (2005). Interaction of Rotavirus with Human Myeloid Dendritic Cells. J. Virol. 79: 14526-14535 [Abstract] [Full Text]  
• Drakes, M. L., Blanchard, T. G., Czinn, S. J. (2005). Colon lamina propria dendritic cells induce a proinflammatory cytokine response in lamina propria T cells in the SCID mouse model of colitis. J. Leukoc. Biol. 78: 1291-1300 [Abstract] [Full Text]  
• Annacker, O., Coombes, J. L., Malmstrom, V., Uhlig, H. H., Bourne, T., Johansson-Lindbom, B., Agace, W. W., Parker, C. M., Powrie, F. (2005). Essential role for CD103 in the T cell-mediated regulation of experimental colitis. JEM 202: 1051-1061 [Abstract] [Full Text]  
• Safadi, R., Alvarez, C. E., Ohta, M., Brimnes, J., Kraus, T., Mehal, W., Bromberg, J., Mayer, L., Friedman, S. L. (2005). Enhanced Oral Tolerance in Transgenic Mice with Hepatocyte Secretion of IL-10. J. Immunol. 175: 3577-3583 [Abstract] [Full Text]  
• Favre, L., Spertini, F., Corthesy, B. (2005). Secretory IgA Possesses Intrinsic Modulatory Properties Stimulating Mucosal and Systemic Immune Responses. J. Immunol. 175: 2793-2800 [Abstract] [Full Text]  
• Hausmann, M., Bataille, F., Spoettl, T., Schreiter, K., Falk, W., Schoelmerich, J., Herfarth, H., Rogler, G. (2005). Physiological Role of Macrophage Inflammatory Protein-3{alpha} Induction during Maturation of Intestinal Macrophages. J. Immunol. 175: 1389-1398 [Abstract] [Full Text]  
• Porporatto, C., Bianco, I. D., Correa, S. G. (2005). Local and systemic activity of the polysaccharide chitosan at lymphoid tissues after oral administration. J. Leukoc. Biol. 78: 62-69 [Abstract] [Full Text]  
• Lin, H.-H., Faunce, D. E., Stacey, M., Terajewicz, A., Nakamura, T., Zhang-Hoover, J., Kerley, M., Mucenski, M. L., Gordon, S., Stein-Streilein, J. (2005). The macrophage F4/80 receptor is required for the induction of antigen-specific efferent regulatory T cells in peripheral tolerance. JEM 201: 1615-1625 [Abstract] [Full Text]  
• Gurney, K. B., Elliott, J., Nassanian, H., Song, C., Soilleux, E., McGowan, I., Anton, P. A., Lee, B. (2005). Binding and Transfer of Human Immunodeficiency Virus by DC-SIGN+ Cells in Human Rectal Mucosa. J. Virol. 79: 5762-5773 [Abstract] [Full Text]  
• Li, G., Kim, Y.-J., Broxmeyer, H. E. (2005). Macrophage Colony-Stimulating Factor Drives Cord Blood Monocyte Differentiation into IL-10highIL-12absent Dendritic Cells with Tolerogenic Potential. J. Immunol. 174: 4706-4717 [Abstract] [Full Text]  
• Smith, D. W., Nagler-Anderson, C. (2005). Preventing Intolerance: The Induction of Nonresponsiveness to Dietary and Microbial Antigens in the Intestinal Mucosa. J. Immunol. 174: 3851-3857 [Abstract] [Full Text]  
• Shanahan, F. (2005). Physiological Basis for Novel Drug Therapies Used to Treat the Inflammatory Bowel Diseases I. Pathophysiological basis and prospects for probiotic therapy in inflammatory bowel disease. Am. J. Physiol. Gastrointest. Liver Physiol. 288: G417-G421 [Abstract] [Full Text]  
• Pulendran, B. (2005). Variegation of the Immune Response with Dendritic Cells and Pathogen Recognition Receptors. J. Immunol. 174: 2457-2465 [Abstract] [Full Text]  
• Baumgart, D C, Metzke, D, Schmitz, J, Scheffold, A, Sturm, A, Wiedenmann, B, Dignass, A U (2005). Patients with active inflammatory bowel disease lack immature peripheral blood plasmacytoid and myeloid dendritic cells. Gut 54: 228-236 [Abstract] [Full Text]  
• Turnbull, E. L., Yrlid, U., Jenkins, C. D., MacPherson, G. G. (2005). Intestinal Dendritic Cell Subsets: Differential Effects of Systemic TLR4 Stimulation on Migratory Fate and Activation In Vivo. J. Immunol. 174: 1374-1384 [Abstract] [Full Text]  
• Niess, J. H., Brand, S., Gu, X., Landsman, L., Jung, S., McCormick, B. A., Vyas, J. M., Boes, M., Ploegh, H. L., Fox, J. G., Littman, D. R., Reinecker, H.-C. (2005). CX3CR1-Mediated Dendritic Cell Access to the Intestinal Lumen and Bacterial Clearance. Science 307: 254-258 [Abstract] [Full Text]  
• Roers, A., Siewe, L., Strittmatter, E., Deckert, M., Schluter, D., Stenzel, W., Gruber, A. D., Krieg, T., Rajewsky, K., Muller, W. (2004). T Cell-specific Inactivation of the Interleukin 10 Gene in Mice Results in Enhanced T Cell Responses but Normal Innate Responses to Lipopolysaccharide or Skin Irritation. JEM 200: 1289-1297 [Abstract] [Full Text]  
• Hart, A L, Lammers, K, Brigidi, P, Vitali, B, Rizzello, F, Gionchetti, P, Campieri, M, Kamm, M A, Knight, S C, Stagg, A J (2004). Modulation of human dendritic cell phenotype and function by probiotic bacteria. Gut 53: 1602-1609 [Abstract] [Full Text]  
• Liu, Z., Lefrancois, L. (2004). Intestinal Epithelial Antigen Induces Mucosal CD8 T Cell Tolerance, Activation, and Inflammatory Response. J. Immunol. 173: 4324-4330 [Abstract] [Full Text]  
• Chang-Rodriguez, S., Ecker, R., Stingl, G., Elbe-Burger, A. (2004). Autocrine IL-10 partially prevents differentiation of neonatal dendritic epidermal leukocytes into Langerhans cells. J. Leukoc. Biol. 76: 657-666 [Abstract] [Full Text]  
• Epardaud, M., Bonneau, M., Payot, F., Cordier, C., Megret, J., Howard, C., Schwartz-Cornil, I. (2004). Enrichment for a CD26hi SIRP- subset in lymph dendritic cells from the upper aero-digestive tract. J. Leukoc. Biol. 76: 553-561 [Abstract] [Full Text]  
• Burke, F., Stagg, A. J., Bedford, P. A., English, N., Knight, S. C. (2004). IL-10-Producing B220+CD11c- APC in Mouse Spleen. J. Immunol. 173: 2362-2372 [Abstract] [Full Text]  
• Drakes, M., Blanchard, T., Czinn, S. (2004). Bacterial Probiotic Modulation of Dendritic Cells. Infect. Immun. 72: 3299-3309 [Abstract] [Full Text]  
• Lavelle, E. C., Jarnicki, A., McNeela, E., Armstrong, M. E., Higgins, S. C., Leavy, O., Mills, K. H. G. (2004). Effects of cholera toxin on innate and adaptive immunity and its application as an immunomodulatory agent. J. Leukoc. Biol. 75: 756-763 [Abstract] [Full Text]  
• Mazzoni, A., Segal, D. M. (2004). Controlling the Toll road to dendritic cell polarization. J. Leukoc. Biol. 75: 721-730 [Abstract] [Full Text]  
• Mathers, A. R., Cuff, C. F. (2004). Role of Interleukin-4 (IL-4) and IL-10 in Serum Immunoglobulin G Antibody Responses following Mucosal or Systemic Reovirus Infection. J. Virol. 78: 3352-3360 [Abstract] [Full Text]  
• Spahn, T W, Kucharzik, T (2004). Modulating the intestinal immune system: the role of lymphotoxin and GALT organs. Gut 53: 456-465 [Full Text]  
• Rey, J., Garin, N., Spertini, F., Corthesy, B. (2004). Targeting of Secretory IgA to Peyer's Patch Dendritic and T Cells after Transport by Intestinal M Cells. J. Immunol. 172: 3026-3033 [Abstract] [Full Text]  
• Johansson, C., Wick, M. J. (2004). Liver Dendritic Cells Present Bacterial Antigens and Produce Cytokines upon Salmonella Encounter. J. Immunol. 172: 2496-2503 [Abstract] [Full Text]  
• Goddard, S., Youster, J., Morgan, E., Adams, D. H. (2004). Interleukin-10 Secretion Differentiates Dendritic Cells from Human Liver and Skin. Am. J. Pathol. 164: 511-519 [Abstract] [Full Text]  
• Burzyn, D., Rassa, J. C., Kim, D., Nepomnaschy, I., Ross, S. R., Piazzon, I. (2004). Toll-Like Receptor 4-Dependent Activation of Dendritic Cells by a Retrovirus. J. Virol. 78: 576-584 [Abstract] [Full Text]  
• Unger, W. W. J., Hauet-Broere, F., Jansen, W., van Berkel, L. A., Kraal, G., Samsom, J. N. (2003). Early Events in Peripheral Regulatory T Cell Induction via the Nasal Mucosa. J. Immunol. 171: 4592-4603 [Abstract] [Full Text]  
• Dubois, B., Chapat, L., Goubier, A., Papiernik, M., Nicolas, J.-F., Kaiserlian, D. (2003). Innate CD4+CD25+ regulatory T cells are required for oral tolerance and inhibition of CD8+ T cells mediating skin inflammation. Blood 102: 3295-3301 [Abstract] [Full Text]  
• Stagg, A J, Hart, A L, Knight, S C, Kamm, M A (2003). The dendritic cell: its role in intestinal inflammation and relationship with gut bacteria. Gut 52: 1522-1529 [Abstract] [Full Text]  
• Sato, A., Hashiguchi, M., Toda, E., Iwasaki, A., Hachimura, S., Kaminogawa, S. (2003). CD11b+ Peyer's Patch Dendritic Cells Secrete IL-6 and Induce IgA Secretion from Naive B Cells. J. Immunol. 171: 3684-3690 [Abstract] [Full Text]  
• Dimier-Poisson, I., Aline, F., Mevelec, M.-N., Beauvillain, C., Buzoni-Gatel, D., Bout, D. (2003). Protective Mucosal Th2 Immune Response against Toxoplasma gondii by Murine Mesenteric Lymph Node Dendritic Cells. Infect. Immun. 71: 5254-5265 [Abstract] [Full Text]  
• Lavelle, E. C., McNeela, E., Armstrong, M. E., Leavy, O., Higgins, S. C., Mills, K. H. G. (2003). Cholera Toxin Promotes the Induction of Regulatory T Cells Specific for Bystander Antigens by Modulating Dendritic Cell Activation. J. Immunol. 171: 2384-2392 [Abstract] [Full Text]  
• Iwasaki, A. (2003). The Importance of CD11b+ Dendritic Cells in CD4+ T Cell Activation In Vivo: With Help from Interleukin 1. JEM 198: 185-190 [Full Text]  
• Qi, H., Denning, T. L., Soong, L. (2003). Differential Induction of Interleukin-10 and Interleukin-12 in Dendritic Cells by Microbial Toll-Like Receptor Activators and Skewing of T-Cell Cytokine Profiles. Infect. Immun. 71: 3337-3342 [Abstract] [Full Text]  
• Cavanaugh, V. J., Deng, Y., Birkenbach, M. P., Slater, J. S., Campbell, A. E. (2003). Vigorous Innate and Virus-Specific Cytotoxic T-Lymphocyte Responses to Murine Cytomegalovirus in the Submaxillary Salivary Gland. J. Virol. 77: 1703-1717 [Abstract] [Full Text]  
• Kato, H., Fujihashi, K., Kato, R., Dohi, T., Fujihashi, K., Hagiwara, Y., Kataoka, K., Kobayashi, R., McGhee, J. R. (2003). Lack of oral tolerance in aging is due to sequential loss of Peyer's patch cell interactions. Int Immunol 15: 145-158 [Abstract] [Full Text]  
• Zhao, X., Deak, E., Soderberg, K., Linehan, M., Spezzano, D., Zhu, J., Knipe, D. M., Iwasaki, A. (2003). Vaginal Submucosal Dendritic Cells, but Not Langerhans Cells, Induce Protective Th1 Responses to Herpes Simplex Virus-2. JEM 197: 153-162 [Abstract] [Full Text]  
• Boonstra, A., Asselin-Paturel, C., Gilliet, M., Crain, C., Trinchieri, G., Liu, Y.-J., O'Garra, A. (2003). Flexibility of Mouse Classical and Plasmacytoid-derived Dendritic Cells in Directing T Helper Type 1 and 2 Cell Development: Dependency on Antigen Dose and Differential Toll-like Receptor Ligation. JEM 197: 101-109 [Abstract] [Full Text]  
• Erlebacher, A., Lukens, A. K., Glimcher, L. H. (2002). Intrinsic susceptibility of mouse trophoblasts to natural killer cell-mediated attack invivo. Proc. Natl. Acad. Sci. USA 99: 16940-16945 [Abstract] [Full Text]  
• Woo, A. L., Gildea, L. A., Tack, L. M., Miller, M. L., Spicer, Z., Millhorn, D. E., Finkelman, F. D., Hassett, D. J., Shull, G. E. (2002). In Vivo Evidence for Interferon-gamma -mediated Homeostatic Mechanisms in Small Intestine of the NHE3 Na+/H+ Exchanger Knockout Model of Congenital Diarrhea. J. Biol. Chem. 277: 49036-49046 [Abstract] [Full Text]  
• Spahn, T. W., Herbst, H., Rennert, P. D., Lugering, N., Maaser, C., Kraft, M., Fontana, A., Weiner, H. L., Domschke, W., Kucharzik, T. (2002). Induction of Colitis in Mice Deficient of Peyer's Patches and Mesenteric Lymph Nodes Is Associated with Increased Disease Severity and Formation of Colonic Lymphoid Patches. Am. J. Pathol. 161: 2273-2282 [Abstract] [Full Text]  
• Williamson, E., Bilsborough, J. M., Viney, J. L. (2002). Regulation of Mucosal Dendritic Cell Function by Receptor Activator of NF-{kappa}B (RANK)/RANK Ligand Interactions: Impact on Tolerance Induction. J. Immunol. 169: 3606-3612 [Abstract] [Full Text]  
• Ohman, L, Franzen, L, Rudolph, U, Birnbaumer, L, Hornquist, E H. (2002). Regression of Peyer's patches in G{alpha}i2 deficient mice prior to colitis is associated with reduced expression of Bcl-2 and increased apoptosis. Gut 51: 392-397 [Abstract] [Full Text]  
• Park, M. K., Amichay, D., Love, P., Wick, E., Liao, F., Grinberg, A., Rabin, R. L., Zhang, H. H., Gebeyehu, S., Wright, T. M., Iwasaki, A., Weng, Y., DeMartino, J. A., Elkins, K. L., Farber, J. M. (2002). The CXC Chemokine Murine Monokine Induced by IFN-{gamma} (CXC Chemokine Ligand 9) Is Made by APCs, Targets Lymphocytes Including Activated B Cells, and Supports Antibody Responses to a Bacterial Pathogen In Vivo. J. Immunol. 169: 1433-1443 [Abstract] [Full Text]  
• Martin, P., del Hoyo, G. M., Anjuere, F., Arias, C. F., Vargas, H. H., Fernandez-L, A., Parrillas, V., Ardavin, C. (2002). Characterization of a new subpopulation of mouse CD8alpha + B220+ dendritic cells endowed with type 1 interferon production capacity and tolerogenic potential. Blood 100: 383-390 [Abstract] [Full Text]  
• Jump, R. L., Levine, A. D. (2002). Murine Peyer's Patches Favor Development of an IL-10-Secreting, Regulatory T Cell Population. J. Immunol. 168: 6113-6119 [Abstract] [Full Text]  
• Aline, F., Bout, D., Dimier-Poisson, I. (2002). Dendritic Cells as Effector Cells: Gamma Interferon Activation of Murine Dendritic Cells Triggers Oxygen-Dependent Inhibition of Toxoplasma gondii Replication. Infect. Immun. 70: 2368-2374 [Abstract] [Full Text]  
• Jaimes, M. C., Rojas, O. L., Gonzalez, A. M., Cajiao, I., Charpilienne, A., Pothier, P., Kohli, E., Greenberg, H. B., Franco, M. A., Angel, J. (2002). Frequencies of Virus-Specific CD4+ and CD8+ T Lymphocytes Secreting Gamma Interferon after Acute Natural Rotavirus Infection in Children and Adults. J. Virol. 76: 4741-4749 [Abstract] [Full Text]  
• Kaya, Z., Dohmen, K. M., Wang, Y., Schlichting, J., Afanasyeva, M., Leuschner, F., Rose, N. R. (2002). Cutting Edge: A Critical Role for IL-10 in Induction of Nasal Tolerance in Experimental Autoimmune Myocarditis. J. Immunol. 168: 1552-1556 [Abstract] [Full Text]  
• de Jong, E. C., Vieira, P. L., Kalinski, P., Schuitemaker, J. H. N., Tanaka, Y., Wierenga, E. A., Yazdanbakhsh, M., Kapsenberg, M. L. (2002). Microbial Compounds Selectively Induce Th1 Cell-Promoting or Th2 Cell-Promoting Dendritic Cells In Vitro with Diverse Th Cell-Polarizing Signals. J. Immunol. 168: 1704-1709 [Abstract] [Full Text]  
• Xia, C.-Q., Kao, K.-J. (2002). Heparin Induces Differentiation of CD1a+ Dendritic Cells from Monocytes: Phenotypic and Functional Characterization. J. Immunol. 168: 1131-1138 [Abstract] [Full Text]  
• McGuirk, P., McCann, C., Mills, K. H.G. (2002). Pathogen-specific T Regulatory 1 Cells Induced in the Respiratory Tract by a Bacterial Molecule that Stimulates Interleukin 10 Production by Dendritic Cells: A Novel Strategy for Evasion of Protective T Helper Type 1 Responses by Bordetella pertussis. JEM 195: 221-231 [Abstract] [Full Text]  
• Christensen, H. R., Frokiar, H., Pestka, J. J. (2002). Lactobacilli Differentially Modulate Expression of Cytokines and Maturation Surface Markers in Murine Dendritic Cells. J. Immunol. 168: 171-178 [Abstract] [Full Text]  
• Steinman, R. M., Nussenzweig, M. C. (2002). Avoiding horror autotoxicus: The importance of dendritic cells in peripheral T cell tolerance. Proc. Natl. Acad. Sci. USA 10.1073/pnas.231606698v1 [Abstract] [Full Text]  
• Menges, M., Ro{beta}ner, S., Voigtlander, C., Schindler, H., Kukutsch, N. A., Bogdan, C., Erb, K., Schuler, G., Lutz, M. B. (2001). Repetitive Injections of Dendritic Cells Matured with Tumor Necrosis Factor {alpha} Induce Antigen-specific Protection of Mice from Autoimmunity. JEM 195: 15-22 [Abstract] [Full Text]  
• Nakano, H., Yanagita, M., Gunn, M. D. (2001). CD11c+B220+Gr-1+ Cells in Mouse Lymph Nodes and Spleen Display Characteristics of Plasmacytoid Dendritic Cells. JEM 194: 1171-1178 [Abstract] [Full Text]  
• Maldonado-Lopez, R., Maliszewski, C., Urbain, J., Moser, M. (2001). Cytokines Regulate the Capacity of CD8{alpha}+ and CD8{alpha}- Dendritic Cells to Prime Th1/Th2 Cells In Vivo. J. Immunol. 167: 4345-4350 [Abstract] [Full Text]  
• Qi, H., Popov, V., Soong, L. (2001). Leishmania amazonensis-Dendritic Cell Interactions In Vitro and the Priming of Parasite-Specific CD4+ T Cells In Vivo. J. Immunol. 167: 4534-4542 [Abstract] [Full Text]  
• Jotwani, R., Palucka, A. K., Al-Quotub, M., Nouri-Shirazi, M., Kim, J., Bell, D., Banchereau, J., Cutler, C. W. (2001). Mature Dendritic Cells Infiltrate the T Cell-Rich Region of Oral Mucosa in Chronic Periodontitis: In Situ, In Vivo, and In Vitro Studies. J. Immunol. 167: 4693-4700 [Abstract] [Full Text]  
• Morelli, A. E., Zahorchak, A. F., Larregina, A. T., Colvin, B. L., Logar, A. J., Takayama, T., Falo, L. D., Thomson, A. W. (2001). Cytokine production by mouse myeloid dendritic cells in relation to differentiation and terminal maturation induced by lipopolysaccharide or CD40 ligation. Blood 98: 1512-1523 [Abstract] [Full Text]  
• Kellermann, S.-A., McEvoy, L. M. (2001). The Peyer's Patch Microenvironment Suppresses T Cell Responses to Chemokines and Other Stimuli. J. Immunol. 167: 682-690 [Abstract] [Full Text]  

Home | Help | Feedback | Subscriptions | Archive | Search

TABLE OF CONTENTS