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Original Article

^a Department of Immunology, Inflammation and Cell Biology, Biogen, Cambridge, Massachusetts 02142
^b Oregon Health Sciences University, Portland, Oregon 97201-9847
^c Institute of Biochemistry, University of Lausanne, CH-1066 Epalinges, Switzerland
Biogen, 12 Cambridge Center, Cambridge, MA 02142.617-679-2304617-679-2161

fabienne_mackay{at}biogen.com

The cause of many autoimmune and inflammatory diseases is unresolved, although dysregulated production of tumor necrosis factor (TNF) family members appears to be important in many cases. BAFF, a new member of the TNF family, binds to B cells and costimulates their growth in vitro. Mice transgenic for BAFF have vastly increased numbers of mature B and effector T cells, and develop autoimmune-like manifestations such as the presence of high levels of rheumatoid factors, circulating immune complexes, anti–DNA autoantibodies, and immunoglobulin deposition in the kidneys. This phenotype is reminiscent of certain human autoimmune disorders and suggests that dysregulation of BAFF expression may be a critical element in the chain of events leading to autoimmunity.

Key Words: autoantibodies • tumor necrosis factor–related • B cell • rheumatoid factors • transgenic

© 1999 The Rockefeller University Press

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• Ueda, Y., Liao, D., Yang, K., Patel, A., Kelsoe, G. (2007). T-Independent Activation-Induced Cytidine Deaminase Expression, Class-Switch Recombination, and Antibody Production by Immature/Transitional 1 B Cells. J. Immunol. 178: 3593-3601 [Abstract] [Full Text]  
• Carlucci, F., Cortes-Hernandez, J., Fossati-Jimack, L., Bygrave, A. E., Walport, M. J., Vyse, T. J., Cook, H. T., Botto, M. (2007). Genetic Dissection of Spontaneous Autoimmunity Driven by 129-Derived Chromosome 1 Loci When Expressed on C57BL/6 Mice. J. Immunol. 178: 2352-2360 [Abstract] [Full Text]  
• He, J. Q., Saha, S. K., Kang, J. R., Zarnegar, B., Cheng, G. (2007). Specificity of TRAF3 in Its Negative Regulation of the Noncanonical NF-{kappa}B Pathway. J. Biol. Chem. 282: 3688-3694 [Abstract] [Full Text]  
• Kothlow, S., Morgenroth, I., Graef, Y., Schneider, K., Riehl, I., Staeheli, P., Schneider, P., Kaspers, B. (2007). Unique and conserved functions of B cell-activating factor of the TNF family (BAFF) in the chicken. Int Immunol 19: 203-215 [Abstract] [Full Text]  
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• Wang, S. H., Baker, J. R. Jr. (2006). Targeting B cells in graves' disease.. Endocrinology 147: 4559-4560 [Full Text]  
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• Yoshimoto, K., Takahashi, Y., Ogasawara, M., Setoyama, Y., Suzuki, K., Tsuzaka, K., Abe, T., Takeuchi, T. (2006). Aberrant expression of BAFF in T cells of systemic lupus erythematosus, which is recapitulated by a human T cell line, Loucy. Int Immunol 18: 1189-1196 [Abstract] [Full Text]  
• Halpern, W. G., Lappin, P., Zanardi, T., Cai, W., Corcoran, M., Zhong, J., Baker, K. P. (2006). Chronic Administration of Belimumab, a BLyS Antagonist, Decreases Tissue and Peripheral Blood B-Lymphocyte Populations in Cynomolgus Monkeys: Pharmacokinetic, Pharmacodynamic, and Toxicologic Effects. Toxicol Sci 91: 586-599 [Abstract] [Full Text]  
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• Vugmeyster, Y., Seshasayee, D., Chang, W., Storn, A., Howell, K., Sa, S., Nelson, T., Martin, F., Grewal, I., Gilkerson, E., Wu, B., Thompson, J., Ehrenfels, B. N., Ren, S., Song, A., Gelzleichter, T. R., Danilenko, D. M. (2006). A Soluble BAFF Antagonist, BR3-Fc, Decreases Peripheral Blood B Cells and Lymphoid Tissue Marginal Zone and Follicular B Cells in Cynomolgus Monkeys. Am. J. Pathol. 168: 476-489 [Abstract] [Full Text]  
• Wheway, J., Mackay, C. R., Newton, R. A., Sainsbury, A., Boey, D., Herzog, H., Mackay, F. (2005). A fundamental bimodal role for neuropeptide Y1 receptor in the immune system. JEM 202: 1527-1538 [Abstract] [Full Text]  
• Rutella, S., Zavala, F., Danese, S., Kared, H., Leone, G. (2005). Granulocyte Colony-Stimulating Factor: A Novel Mediator of T Cell Tolerance. J. Immunol. 175: 7085-7091 [Abstract] [Full Text]  
• Craxton, A., Draves, K. E., Gruppi, A., Clark, E. A. (2005). BAFF regulates B cell survival by downregulating the BH3-only family member Bim via the ERK pathway. JEM 202: 1363-1374 [Abstract] [Full Text]  
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• Zheng, Y., Gallucci, S., Gaughan, J. P., Gross, J. A., Monestier, M. (2005). A Role for B Cell-Activating Factor of the TNF Family in Chemically Induced Autoimmunity. J. Immunol. 175: 6163-6168 [Abstract] [Full Text]  
• Yang, M., Hase, H., Legarda-Addison, D., Varughese, L., Seed, B., Ting, A. T. (2005). B Cell Maturation Antigen, the Receptor for a Proliferation-Inducing Ligand and B Cell-Activating Factor of the TNF Family, Induces Antigen Presentation in B Cells. J. Immunol. 175: 2814-2824 [Abstract] [Full Text]  
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• Zhang, M., Ko, K.-H., Lam, Q. L. K., Lo, C. K. C., Srivastava, G., Zheng, B., Lau, Y.-L., Lu, L. (2005). Expression and function of TNF family member B cell-activating factor in the development of autoimmune arthritis. Int Immunol 17: 1081-1092 [Abstract] [Full Text]  
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• Gavin, A. L., Duong, B., Skog, P., Ait-Azzouzene, D., Greaves, D. R., Scott, M. L., Nemazee, D. (2005). {Delta}BAFF, a Splice Isoform of BAFF, Opposes Full-Length BAFF Activity In Vivo in Transgenic Mouse Models. J. Immunol. 175: 319-328 [Abstract] [Full Text]  
• Koyama, T, Tsukamoto, H, Miyagi, Y, Himeji, D, Otsuka, J, Miyagawa, H, Harada, M, Horiuchi, T (2005). Raised serum APRIL levels in patients with systemic lupus erythematosus. Ann Rheum Dis 64: 1065-1067 [Abstract] [Full Text]  
• Gottenberg, J-E, Busson, M, Cohen-Solal, J, Lavie, F, Abbed, K, Kimberly, R P, Sibilia, J, Mariette, X (2005). Correlation of serum B lymphocyte stimulator and {beta}2 microglobulin with autoantibody secretion and systemic involvement in primary Sjogren's syndrome. Ann Rheum Dis 64: 1050-1055 [Abstract] [Full Text]  
• Zhang, X., Park, C.-S., Yoon, S.-O., Li, L., Hsu, Y.-M., Ambrose, C., Choi, Y. S. (2005). BAFF supports human B cell differentiation in the lymphoid follicles through distinct receptors. Int Immunol 17: 779-788 [Abstract] [Full Text]  
• Sutherland, A. P. R., Ng, L. G., Fletcher, C. A., Shum, B., Newton, R. A., Grey, S. T., Rolph, M. S., Mackay, F., Mackay, C. R. (2005). BAFF Augments Certain Th1-Associated Inflammatory Responses. J. Immunol. 174: 5537-5544 [Abstract] [Full Text]  
• Schaller, M, Stohl, W, Tan, S M, Benoit, V M, Hilbert, D M, Ditzel, H J (2005). Raised levels of anti-glucose-6-phosphate isomerase IgG in serum and synovial fluid from patients with inflammatory arthritis. Ann Rheum Dis 64: 743-749 [Abstract] [Full Text]  
• Rolf, J., Motta, V., Duarte, N., Lundholm, M., Berntman, E., Bergman, M.-L., Sorokin, L., Cardell, S. L., Holmberg, D. (2005). The Enlarged Population of Marginal Zone/CD1dhigh B Lymphocytes in Nonobese Diabetic Mice Maps to Diabetes Susceptibility Region Idd11. J. Immunol. 174: 4821-4827 [Abstract] [Full Text]  

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