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Original Article

^a Baylor Institute for Immunology Research and Department of Pathology, Baylor University Medical Center, Dallas, Texas 75204
^b Schering-Plough Laboratory for Immunological Research, 69571 Dardilly, France
Baylor Institute for Immunology Research, 3434 Live Oak St., Dallas, TX 75204.214-820-4813214-820-7450

j.banchereau{at}baylordallas.edu

We have analyzed the presence of immature and mature dendritic cells (DCs) within adenocarcinoma of the breast using immunohistochemistry. Immature DCs were defined by expression of CD1a-, Langerin-, and intracellular major histocompatibility complex class II–rich vesicles. Mature DCs were defined by expression of CD83 and DC-Lamp. Breast carcinoma cells were defined by morphology and/or cytokeratin expression. We demonstrate two levels of heterogeneity of DCs infiltrating breast carcinoma tissue: (a) immature CD1a⁺ DCs, mostly of the Langerhans cell type (Langerin⁺), were retained within the tumor bed in 32/32 samples and (b) mature DCs, CD83⁺DC-Lamp⁺, present in 20/32 samples, are confined to peritumoral areas. The high numbers of immature DCs found in the tumor may be best explained by high levels of macrophage inflammatory protein 3 expression by virtually all tumor cells. Confirming the immature/mature DC compartmentalization pattern, in vitro–generated immature DCs adhere to the tumor cells, whereas mature DCs adhere selectively to peritumoral areas. In some cases, T cells are clustering around the mature DCs in peritumoral areas, thus resembling the DC–T cell clusters of secondary lymphoid organs, which are characteristic of ongoing immune reactions.

Key Words: breast cancer • dendritic cells • tumor immunity • MHC class II • chemokines

Presented partly at the 5th International Symposium on Dendritic Cells in Fundamental and Clinical Immunology, Pittsburgh, Pennsylvania, September 23–28, 1998.

© 1999 The Rockefeller University Press

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